An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
Narratives of Space and Time in Multiple Sclerosis Diagnosis
This article examines the complexity of narratives of space and time which support the diagnosis of multiple sclerosis, and the consequences for patients disadvantaged by deficits in social cognition or socioeconomic status in areas relating to literacy. In the context of demonstrating the significance of narratives of space and time in the diagnostic process for multiple sclerosis, the article discusses new strategies for treatment that engage the arts and humanities and presents a brief history of the disease and current diagnostic criteria, before discussing the MS Society of Great Britain and Ireland's awareness and fu...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Paula Leverage Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
Narratives of Space and Time in Multiple Sclerosis Diagnosis
This article examines the complexity of narratives of space and time which support the diagnosis of multiple sclerosis, and the consequences for patients disadvantaged by deficits in social cognition or socioeconomic status in areas relating to literacy. In the context of demonstrating the significance of narratives of space and time in the diagnostic process for multiple sclerosis, the article discusses new strategies for treatment that engage the arts and humanities and presents a brief history of the disease and current diagnostic criteria, before discussing the MS Society of Great Britain and Ireland's awareness and fu...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Paula Leverage Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
Narratives of Space and Time in Multiple Sclerosis Diagnosis
This article examines the complexity of narratives of space and time which support the diagnosis of multiple sclerosis, and the consequences for patients disadvantaged by deficits in social cognition or socioeconomic status in areas relating to literacy. In the context of demonstrating the significance of narratives of space and time in the diagnostic process for multiple sclerosis, the article discusses new strategies for treatment that engage the arts and humanities and presents a brief history of the disease and current diagnostic criteria, before discussing the MS Society of Great Britain and Ireland's awareness and fu...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Paula Leverage Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
Clinical variables influencing the perception of fatigue in people with multiple sclerosis: a cross-sectional study using FSIQ-RMS
Physical fatigue is one of the most disabling symptoms in people with Multiple Sclerosis (PwMS). Several factors might influence the development of fatigue, such as gender, education, body mass index (BMI), Ex... (Source: BMC Neurology)
Source: BMC Neurology - April 25, 2024 Category: Neurology Authors: Giovanni Sellitto, Ilaria Ruotolo, Antonio Ianniello, Federica Felicetti, Giorgia D ’Ambrosi, Anna Berardi, Giovanni Galeoto, Antonella Conte and Carlo Pozzilli Tags: Research Source Type: research
Network Analysis in Multiple Sclerosis and Related Disorders
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease of the central nervous system, commonly featuring disability and cognitive impairment. The pathologic hallmark of MS lies in demyelination and hence impaired structural and functional neuronal pathways. Recent studies have shown that MS shows extensive structural disconnection of key network hub areas like the thalamus, combined with a functional network reorganization that can mostly be related to poorer clinical functioning. As MS can, therefore, be considered a network disorder, this review outlines recent innovations in the field of network ne...
Source: Neuroimaging Clinics - April 25, 2024 Category: Radiology Authors: Giuseppe Pontillo, Mar Barrantes Cepas, Tommy A.A. Broeders, Ismail Koubiyr, Menno M. Schoonheim Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
CONCLUSIONS: The HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe.PMID:38656653 | DOI:10.1007/s40121-024-00963-w (Source: Herpes)
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Alen Marijam Nikki Vroom Amit Bhavsar Inga Posiuniene Nicolas Lecrenier Hilde Vroling Source Type: research
Mesenchymal Stem Cells in Autoimmune Disease: A Systematic Review and Meta-Analysis of Pre-Clinical Studies
Biochimie. 2024 Apr 22:S0300-9084(24)00084-1. doi: 10.1016/j.biochi.2024.04.009. Online ahead of print.ABSTRACTMesenchymal Stem Cells (MSCs) are of interest in the clinic because of their immunomodulation capabilities, capacity to act upstream of inflammation, and ability to sense metabolic environments. In standard physiologic conditions, they play a role in maintaining the homeostasis of tissues and organs; however, there is evidence that they can contribute to some autoimmune diseases. Gaining a deeper understanding of the factors that transition MSCs from their physiological function to a pathological role in their nat...
Source: Biochimie - April 24, 2024 Category: Biochemistry Authors: Hailey N Swain Parker D Boyce Bradley A Bromet Kaiden Barozinksy Lacy Hance Dakota Shields Gayla R Olbricht Julie A Semon Source Type: research
IJERPH, Vol. 21, Pages 529: A Rapid Review of Interventions to Improve Care for People Who Are Medically Underserved with Multiple Sclerosis, Diabetic Retinopathy, and Lung Cancer
r
Marwa Aly
In the United States, patients with chronic conditions experience disparities in health outcomes across the care continuum. Among patients with multiple sclerosis, diabetic retinopathy, and lung cancer, there is a lack of evidence summarizing interventions to improve care and decrease these disparities. The aim of this rapid literature review was to identify interventions among patients with these chronic conditions to improve health and reduce disparities in screening, diagnosis, access to treatment and specialists, adherence, and retention in care. Using structured search terms in PubMed and Web of Scie...
Source: International Journal of Environmental Research and Public Health - April 24, 2024 Category: Environmental Health Authors: Sarah Mossburg Mona Kilany Kimberly Jinnett Charlene Nguyen Elena Soles Drew Wood-Palmer Marwa Aly Tags: Review Source Type: research
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
AbstractIn multiple sclerosis (MS), persisting disability can occur independent of relapse activity or development of new central nervous system (CNS) inflammatory lesions, termed chronic progression. This process occurs early and it is mostly driven by cells within the CNS. One promising strategy to control progression of MS is the inhibition of the enzyme Bruton's tyrosine kinase (BTK), which is centrally involved in the activation of both B cells and myeloid cells, such as macrophages and microglia. The benefit of BTK inhibition by evobrutinib was shown as we observed reduced pro-inflammatory activation of microglia whe...
Source: Acta Neuropathologica - April 24, 2024 Category: Neurology Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research
