Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
The level of cytokines in tears as a novel indicator of demyelinating diseases
CONCLUSIONS: Our results show that MS and other demyelination diseases lead to decrease in the overall level of cytokines in tears. Further research is needed to determine the role of tear fluid in the assessment of demyelinating disorders like MS.PMID:38602307 | DOI:10.1080/01616412.2024.2337502 (Source: Neurological Research)
Source: Neurological Research - April 11, 2024 Category: Neurology Authors: Jowita Adamczyk-Zostawa Adam Wyl ęgała Martyna Lis Jacek Zostawa Rafa ł Fiolka Edward Wyl ęgała Monika Adamczyk-Sowa Zenon Czuba Source Type: research
Iraqi experts consensus on the management of relapsing remitting multiple sclerosis in adults
This study aimed to develop consensus recommendations regarding the diagnosis and management of MS in Iraq, specifically focusing on treatment-naïve patients, suboptimal responders, and women of childbearing age during preconception, pregnancy planning, and lactation. A survey was conducted to collect feedback from a panel of ten key opinion leaders (KOLs), who evaluated and discussed the statements to determine agreement levels. The mini-Delphi method was employed to establish a consensus on the management recommendations, and a meeting was held to analyze the responses and ensure that the recommendations were based on c...
Source: Current Medical Research and Opinion - April 11, 2024 Category: Research Authors: Hayder K Hassoun Anmar Oday Hatem Akram Al-Mahdawi Sarwer Jamal Al-Bajalan Ali Kadim Karim Sarmad Abdulrasool Al-Mashta Saif Mohammed Tawfeeq Majeed Salih Hamad Nawfal M Sheaheed Samer Mohammed Ridha Murad Al-Naqshbandi Hasan Aziz Al-Hamadani Source Type: research
The level of cytokines in tears as a novel indicator of demyelinating diseases
CONCLUSIONS: Our results show that MS and other demyelination diseases lead to decrease in the overall level of cytokines in tears. Further research is needed to determine the role of tear fluid in the assessment of demyelinating disorders like MS.PMID:38602307 | DOI:10.1080/01616412.2024.2337502 (Source: Neurological Research)
Source: Neurological Research - April 11, 2024 Category: Neurology Authors: Jowita Adamczyk-Zostawa Adam Wyl ęgała Martyna Lis Jacek Zostawa Rafa ł Fiolka Edward Wyl ęgała Monika Adamczyk-Sowa Zenon Czuba Source Type: research
Expert teleconsultation involving patients and their primary neurologists for the management of multiple sclerosis in regions without specialists
ConclusionsThe present study suggested that our expert teleconsultation system for MS reduces the burden on patients of visiting distant MS-specialized clinics, and enhances knowledge of MS management for the primary neurologists. It also promotes trust between patients and their primary neurologists, and taken together, these aspects could collectively lead to independent and sustainable MS management in regions without MS specialists. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 11, 2024 Category: Neurology Authors: Yusei Miyazaki,
Shigehisa Ura,
Kazuhiro Horiuchi,
Takeshi Matsuoka,
Hideki Houzen,
Kazufumi Tsuzaka,
Yuichi Makino,
Manami Koshida,
Genko Oyama,
Chika Sato,
Ryoji Naganuma,
Itaru Amino,
Sachiko Akimoto,
Masaaki Niino,
Naoya Minami,
Eri Taka Tags: ORIGINAL ARTICLE Source Type: research
Anti-CD20 monoclonal antibodies in multiple sclerosis: Rethinking the current treatment strategy
Rev Neurol (Paris). 2024 Apr 9:S0035-3787(24)00474-0. doi: 10.1016/j.neurol.2023.12.013. Online ahead of print.ABSTRACTAnti-CD20 monoclonal antibodies are highly-effective B-cell-depleting therapies in multiple sclerosis (MS). These treatments have expanded the arsenal of highly effective disease-modifying therapies, and have changed the landscape in understanding the pathophysiology of MS and the natural course of the disease. Nevertheless, these treatments come at the cost of immunosuppression and risk of serious infections, diminished vaccination response and treatment-related secondary hypogammaglobulinemia. However, t...
Source: Revue Neurologique - April 10, 2024 Category: Neurology Authors: S A Freeman H Z éphir Source Type: research
Spinet-QSM: model-based deep learning with schatten p-norm regularization for improved quantitative susceptibility mapping
CONCLUSION: The proposed SpiNet-QSM showed a consistent improvement of at least 5% in terms of the high-frequency error norm (HFEN) and normalized root mean squared error (NRMSE) over other QSM reconstruction methods with limited training data.PMID:38598165 | DOI:10.1007/s10334-024-01158-7 (Source: Magma)
Source: Magma - April 10, 2024 Category: Radiology Authors: Vaddadi Venkatesh Raji Susan Mathew Phaneendra K Yalavarthy Source Type: research
Patient With Gender Dysphoria Diagnosed With Multiple Sclerosis Following Takotsubo Cardiomyopathy and Ventricular Arrhythmia: A Case Report and Systematic Literature Review
In this report, we also systematically reviewed published cases of takotsubo cardiomyopathy and MS and found that basal type takotsubo cardiomyopathy was the most common, and most patients presented with brainstem involvement of MS. An awareness of these associations by physicians, along with multidisciplinary collaboration, may facilitate the early diagnosis and improve the prognosis of these patients.PMID:38599863 | DOI:10.2169/internalmedicine.3442-23 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Shinya Yamanaka Mariko Nishihara Madoka Kondo Kotaro Miyata Zhehao Dai Fujimi Kawai Nobuyuki Komiyama Source Type: research
Synthesis, radiosynthesis and biochemical evaluation of fluorinated analogues of sphingosine-1-phosphate receptor 3 specific antagonists using PET
Bioorg Med Chem. 2024 Mar 26;104:117697. doi: 10.1016/j.bmc.2024.117697. Online ahead of print.ABSTRACTSphingosine-1-phosphate and its receptors (S1PRs) are involved in several diseases such as auto immunity, inflammation and cardiovascular disorders. The S1P analogue fingolimod (Gilenya®) is currently in use for the treatment of relapsing multiple sclerosis. S1PRs are also promising targets for clinical molecular imaging in vivo. The organ distribution of individual S1PRs can be potentially achieved by using S1PR subtype-specific (radiolabeled) chemical probes. Here, we report our efforts on synthesis and in vivo potency...
Source: Bioorganic and Medicinal Chemistry - April 10, 2024 Category: Chemistry Authors: Vysakh Puspha Prasad Stefan Wagner Petra Keul Sven Hermann Bodo Levkau Michael Sch äfers G ünter Haufe Source Type: research
Anti-CD20 monoclonal antibodies in multiple sclerosis: Rethinking the current treatment strategy
Rev Neurol (Paris). 2024 Apr 9:S0035-3787(24)00474-0. doi: 10.1016/j.neurol.2023.12.013. Online ahead of print.ABSTRACTAnti-CD20 monoclonal antibodies are highly-effective B-cell-depleting therapies in multiple sclerosis (MS). These treatments have expanded the arsenal of highly effective disease-modifying therapies, and have changed the landscape in understanding the pathophysiology of MS and the natural course of the disease. Nevertheless, these treatments come at the cost of immunosuppression and risk of serious infections, diminished vaccination response and treatment-related secondary hypogammaglobulinemia. However, t...
Source: Revue Neurologique - April 10, 2024 Category: Neurology Authors: S A Freeman H Z éphir Source Type: research
Spinet-QSM: model-based deep learning with schatten p-norm regularization for improved quantitative susceptibility mapping
CONCLUSION: The proposed SpiNet-QSM showed a consistent improvement of at least 5% in terms of the high-frequency error norm (HFEN) and normalized root mean squared error (NRMSE) over other QSM reconstruction methods with limited training data.PMID:38598165 | DOI:10.1007/s10334-024-01158-7 (Source: Magma)
Source: Magma - April 10, 2024 Category: Radiology Authors: Vaddadi Venkatesh Raji Susan Mathew Phaneendra K Yalavarthy Source Type: research
Patient With Gender Dysphoria Diagnosed With Multiple Sclerosis Following Takotsubo Cardiomyopathy and Ventricular Arrhythmia: A Case Report and Systematic Literature Review
In this report, we also systematically reviewed published cases of takotsubo cardiomyopathy and MS and found that basal type takotsubo cardiomyopathy was the most common, and most patients presented with brainstem involvement of MS. An awareness of these associations by physicians, along with multidisciplinary collaboration, may facilitate the early diagnosis and improve the prognosis of these patients.PMID:38599863 | DOI:10.2169/internalmedicine.3442-23 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Shinya Yamanaka Mariko Nishihara Madoka Kondo Kotaro Miyata Zhehao Dai Fujimi Kawai Nobuyuki Komiyama Source Type: research
Synthesis, radiosynthesis and biochemical evaluation of fluorinated analogues of sphingosine-1-phosphate receptor 3 specific antagonists using PET
Bioorg Med Chem. 2024 Mar 26;104:117697. doi: 10.1016/j.bmc.2024.117697. Online ahead of print.ABSTRACTSphingosine-1-phosphate and its receptors (S1PRs) are involved in several diseases such as auto immunity, inflammation and cardiovascular disorders. The S1P analogue fingolimod (Gilenya®) is currently in use for the treatment of relapsing multiple sclerosis. S1PRs are also promising targets for clinical molecular imaging in vivo. The organ distribution of individual S1PRs can be potentially achieved by using S1PR subtype-specific (radiolabeled) chemical probes. Here, we report our efforts on synthesis and in vivo potency...
Source: Bioorganic and Medicinal Chemistry - April 10, 2024 Category: Chemistry Authors: Vysakh Puspha Prasad Stefan Wagner Petra Keul Sven Hermann Bodo Levkau Michael Sch äfers G ünter Haufe Source Type: research
Spinet-QSM: model-based deep learning with schatten p-norm regularization for improved quantitative susceptibility mapping
CONCLUSION: The proposed SpiNet-QSM showed a consistent improvement of at least 5% in terms of the high-frequency error norm (HFEN) and normalized root mean squared error (NRMSE) over other QSM reconstruction methods with limited training data.PMID:38598165 | DOI:10.1007/s10334-024-01158-7 (Source: Magma)
Source: Magma - April 10, 2024 Category: Radiology Authors: Vaddadi Venkatesh Raji Susan Mathew Phaneendra K Yalavarthy Source Type: research
Synthesis, radiosynthesis and biochemical evaluation of fluorinated analogues of sphingosine-1-phosphate receptor 3 specific antagonists using PET
Bioorg Med Chem. 2024 Mar 26;104:117697. doi: 10.1016/j.bmc.2024.117697. Online ahead of print.ABSTRACTSphingosine-1-phosphate and its receptors (S1PRs) are involved in several diseases such as auto immunity, inflammation and cardiovascular disorders. The S1P analogue fingolimod (Gilenya®) is currently in use for the treatment of relapsing multiple sclerosis. S1PRs are also promising targets for clinical molecular imaging in vivo. The organ distribution of individual S1PRs can be potentially achieved by using S1PR subtype-specific (radiolabeled) chemical probes. Here, we report our efforts on synthesis and in vivo potency...
Source: Bioorganic and Medicinal Chemistry - April 10, 2024 Category: Chemistry Authors: Vysakh Puspha Prasad Stefan Wagner Petra Keul Sven Hermann Bodo Levkau Michael Sch äfers G ünter Haufe Source Type: research
