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Cerebral imaging of post-stroke plasticity and tissue repair.
Authors: Loubinoux I, Brihmat N, Castel-Lacanal E, Marque P Abstract Six months after stroke onset, 50 % of patients are still disabled and dependent, while many brain mechanisms of recovery remain partially unknown or misunderstood. However, brain imaging and cerebral connectivity analytical techniques have provided invaluable insights into such mechanisms and identified two main patterns of brain reorganization depending on stroke severity. The contralesional primary motor cortex can take over motor function in severely impaired patients, whereas the ipsilesional motor cortex or hemisphere reorganize themsel...
Source: Revue Neurologique - October 9, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Techniques for endovascular treatment of acute ischemic stroke.
Authors: Pierot L, Gawlitza M, Soize S Abstract Early recanalization of occluded vessels in patients with acute ischemic stroke (AIS) by either intravenous thrombolysis (IVT) or endovascular revascularization has been shown to be associated with improved clinical outcomes and reduced mortality. Since the initial report regarding endovascular treatment (EVT) of AIS in 1983, endovascular techniques have been tremendously improved, advancing from intra-arterial administration of thrombolytic drugs to stent retrievers. IVT has been evaluated in several large randomized trials and has been shown to improve clinical outc...
Source: Revue Neurologique - October 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Foreword.
Authors: Ceccaldi M, Pariente J PMID: 28915976 [PubMed - in process] (Source: Revue Neurologique)
Source: Revue Neurologique - September 18, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Dissociative amnesia: Disproportionate retrograde amnesia, stressful experiences and neurological circumstances.
Authors: Thomas-Antérion C Abstract Dissociative amnesias have been reported in neurological episodes mild enough to not cause any visible lesions on morphological examination. Disproportionate retrograde amnesia with or without identity loss happens in the context of psychological trauma (known or not). In metabolic imaging studies, some authors have reported functional alterations, particularly in the bilateral hippocampus, right temporal regions and inferolateral prefrontal cortex, despite normal morphological imaging. To avoid the presumption of an organic, psychogenic or mixed origin for such changes, D...
Source: Revue Neurologique - September 3, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Attention-deficit/hyperactivity disorder during adulthood.
Authors: Magnin E, Maurs C Abstract Attention-Deficit/Hyperactivity Disorder (ADHD), although considered a childhood-onset neurodevelopmental condition, is nevertheless a frequent and disabling condition in adults. A proportion of such patients are not diagnosed during childhood or adolescence, as diagnosis of the syndrome is rather complex, especially when other psychiatric, neurological or other neurodevelopmental conditions are also associated, yet comorbidities and consequences of ADHD are frequently observed in adults and older populations. As ADHD patients present to memory clinics with attentional and execut...
Source: Revue Neurologique - August 30, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Gestural apraxia.
Authors: Etcharry-Bouyx F, Le Gall D, Jarry C, Osiurak F Abstract Gestural apraxia was first described in 1905 by Hugo Karl Liepmann. While his description is still used, the actual terms are often confusing. The cognitive approach using models proposes thinking of the condition in terms of production and conceptual knowledge. The underlying cognitive processes are still being debated, as are also the optimal ways to assess them. Several neuroimaging studies have revealed the involvement of a left-lateralized frontoparietal network, with preferential activation of the superior parietal lobe, intraparietal sulcus an...
Source: Revue Neurologique - August 30, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Neuropsychology of traumatic brain injury: An expert overview.
Authors: Azouvi P, Arnould A, Dromer E, Vallat-Azouvi C Abstract Traumatic brain injury (TBI) is a serious healthcare problem, and this report is a selective review of recent findings on the epidemiology, pathophysiology and neuropsychological impairments following TBI. Patients who survive moderate-to-severe TBI frequently suffer from a wide range of cognitive deficits and behavioral changes due to diffuse axonal injury. These deficits include slowed information-processing and impaired long-term memory, attention, working memory, executive function, social cognition and self-awareness. Mental fatigue is frequently...
Source: Revue Neurologique - August 30, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Accelerated long-term forgetting and autobiographical memory disorders in temporal lobe epilepsy: One entity or two?
Authors: Lemesle B, Planton M, Pagès B, Pariente J Abstract Temporal lobe epilepsy (TLE) is a type of epilepsy that often has a negative impact on patients' memory. Despite the importance of patients' complaints in this regard, the difficulties described by these patients are often not easy to demonstrate through a standard neuropsychological assessment. Accelerated long-term forgetting and autobiographical memory disorders are the two main memory impairments reported in the literature in patients with TLE. However, the methods used by different authors to evaluate long-term memory and autobiographical memor...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Disentangling conscious from unconscious cognitive processing with event-related EEG potentials.
Authors: Rohaut B, Naccache L Abstract By looking for properties of consciousness, cognitive neuroscience studies have dramatically enlarged the scope of unconscious cognitive processing. This emerging knowledge inspired the development of new approaches allowing clinicians to probe and disentangle conscious from unconscious cognitive processes in non-communicating brain-injured patients both in terms of behaviour and brain activity. This information is extremely valuable in order to improve diagnosis and prognosis in such patients both at acute and chronic settings. Reciprocally, the growing observations coming fr...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Complexity vs. unity in unilateral spatial neglect.
Authors: Rode G, Fourtassi M, Pagliari C, Pisella L, Rossetti Y Abstract Unilateral spatial neglect constitutes a heterogeneous syndrome characterized by two main entangled components: a contralesional bias of spatial attention orientation; and impaired building and/or exploration of mental representations of space. These two components are present in different subtypes of unilateral spatial neglect (visual, auditory, somatosensory, motor, allocentric, egocentric, personal, representational and productive manifestations). Detailed anatomical and clinical analyses of these conditions and their underlying disorders s...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Visual agnosia and focal brain injury.
Authors: Martinaud O Abstract Visual agnosia encompasses all disorders of visual recognition within a selective visual modality not due to an impairment of elementary visual processing or other cognitive deficit. Based on a sequential dichotomy between the perceptual and memory systems, two different categories of visual object agnosia are usually considered: 'apperceptive agnosia' and 'associative agnosia'. Impaired visual recognition within a single category of stimuli is also reported in: (i) visual object agnosia of the ventral pathway, such as prosopagnosia (for faces), pure alexia (for words), or topographagn...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Long-term memory deficits in temporal lobe epilepsy.
Authors: Tramoni-Negre E, Lambert I, Bartolomei F, Felician O Abstract Memory complaints and deficits are common in patients with epilepsy, especially temporal lobe epilepsy (TLE), where memory-related brain structures are directly involved in the epileptic process. In recent years, substantial progress has been made in delineating memory impairment in TLE, challenging the traditional neuropsychological approach of the disorder. In particular, several lines of evidence have suggested that, beyond the apparent deficit demonstrable by standardized neuropsychological evaluations, TLE may also negatively interact with ...
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Impact of spontaneous intracerebral hemorrhage on cognitive functioning: An update.
Authors: Planton M, Raposo N, Danet L, Albucher JF, Péran P, Pariente J Abstract Intracerebral hemorrhage (ICH) accounts for 15% of all strokes and approximately 50% of stroke-related mortality and disability worldwide. Patients who have experienced ICH are at high risk of negative outcome, including stroke and cognitive disorders. Vascular cognitive impairment are frequently seen after brain hemorrhage, yet little is known about them, as most studies have focused on neuropsychological outcome in ischemic stroke survivors, using well-documented acute and chronic cognitive scores. However, recent evidence sup...
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Causality and complex disease: The example of multiple sclerosis.
Authors: Bach JF PMID: 28838791 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Vascular cognitive impairment: Advances and trends.
Authors: Barbay M, Taillia H, Nedelec-Ciceri C, Arnoux A, Puy L, Wiener E, Canaple S, Lamy C, Godefroy O, Roussel M, GRECOGVASC Study Group Abstract The presence of vascular neurocognitive impairment (whatever the severity) is always associated with a functional impact and increased risk of dependency and institutionalization. However, vascular cognitive impairment remains underdiagnosed, and the mechanisms underlying post-stroke cognitive disorders are still poorly understood. However, the advent of new criteria and a standardized international neuropsychological battery is expected to lead to improved diagnosis a...
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

C-reactive protein: A promising biomarker in ALS?
Authors: Corcia P, Blasco H, Beltran S, Andres C, Vourc'h P, Couratier P PMID: 28797688 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - August 13, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Can the benefits of rtPA treatment for stroke be improved?
Authors: Vivien D Abstract Tissue-type plasminogen activator (tPA) is a serine protease well known to promote fibrinolysis. This is why: its recombinant form (rtPA) can be used, either alone or combined with thrombectomy, to promote recanalization/reperfusion following ischemic stroke. However, its overall benefits are counteracted by some of its side-effects, including incomplete lysis of clots, an increased risk of hemorrhagic transformation and the possibility of neurotoxicity. Nevertheless, better understanding of the mechanisms by which tPA influences brain function and promotes its alteration may help in the ...
Source: Revue Neurologique - August 13, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Should we broaden indications for anti-JCV antibody tests in multiple sclerosis patients? YES.
Authors: Wiertlewski S PMID: 28760447 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - August 3, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

A clinical and neurophysiological motor signature of Unverricht-Lundborg disease.
CONCLUSION: A homogeneous motor pattern was delineated that may represent a ULD clinical and neurophysiological signature. Clinical and neurophysiological findings confirmed the pure cortical origin of the permanent myoclonus. Also, oculomotor findings shed new light on ULD pathophysiology by evidencing combined midbrain and cerebellar dysfunction. PMID: 28688606 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - July 11, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Stroke is now a brain disease: Revising ICD-11.
Authors: Giroud M, Béjot Y PMID: 28687140 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - July 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Rates of serum level determinations of antiepileptic drugs in accord with guidelines: A clinical study at a tertiary center.
CONCLUSION: At our center, 84% of AED level determinations had an appropriate indication according to a priori defined and reliable criteria. Moreover, it was noted that a specific educational intervention substantially increased rates of appropriateness. Thus, it appears to be crucial to ensure that medical and paramedical staff are aware of the official recommendations to avoid taking unnecessary drug level measurements. PMID: 28669391 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - July 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Joseph Jumenti é (1879-1928), a forgotten neurologist.
Joseph Jumentié (1879-1928), a forgotten neurologist. Rev Neurol (Paris). 2017 Jun 30;: Authors: Walusinski O Abstract Joseph Jumentié (1879-1928), through his clinical skill and expertise in anatomical pathology, enhanced the prestige of the master neurologists he studied under- Jules Dejerine, Augusta Dejerine-Klumpke and Joseph Babiński -and their fame overshadowed the crucial support that Jumentié provided them. Following a remarkable doctoral thesis in 1911, which defined the semiology of tumors in the cerebellopontine angle, Jumentié conducted research into ...
Source: Revue Neurologique - July 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The RAPID-II Neuropsychological Test battery for subjects aged 20 to 49 years: Norms and cognitive profile.
Authors: Binetruy M, Mauny F, Lavaux M, Meyer A, Sylvestre G, Puyraveau M, Berger E, Magnin E, Vandel P, Galmiche J, Chopard G, RAPID-II study group Abstract INTRODUCTION: Cognitive evaluation of young subjects is now widely carried out for non-traumatic diseases such as multiple sclerosis, HIV, or sleep disorders. This evaluation requires normative data based on healthy adult samples. However, most clinicians use a set of tests that were normed in an isolated manner from different samples using different cutoff criteria. Thus, the score of an individual may be considered either normal or impaired according to the ...
Source: Revue Neurologique - July 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Behavior, brain and astrocytes.
Authors: Fan X, Agid Y PMID: 28651784 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 28, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Atypical pantothenate kinase-associated neurodegeneration: Clinical description of two brothers and a review of the literature.
This report describes two siblings with the atypical form of PKAN, combining dystonia, irritability and a dysmorphia syndrome. In addition, a review of the literature was carried out for all published cases of atypical PKAN to gather descriptions of its various clinical presentations, age of onset and MRI findings, and to highlight the different treatments used for PKAN patients. PMID: 28629633 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 22, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

(123)I-FP-CIT SPECT imaging in blepharospasm.
CONCLUSION: Our study revealed presynaptic dopaminergic dysfunction, as determined by (123)I-FP-CIT or DAT-SPECT, in nearly half of our blepharospasm patients (with or without apraxia of eyelid opening). Thus, the presence of blepharospasm might be an early sign of a parkinsonian syndrome. PMID: 28629634 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 22, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Primary non-Hodgkin lymphoma of the cranial vault.
Authors: Naama O, Gazzaz M, Boucetta M, Elmoustarchid B PMID: 28629635 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 22, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Amyotrophic lateral sclerosis in Huntington disease gene carrier.
Authors: Bernard E, Mouzat K, Leblanc P, Bost M, Lumbroso S, Thobois S, Broussolle E PMID: 28595974 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 11, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Brain molecular imaging in pharmacoresistant focal epilepsy: Current practice and perspectives.
Authors: Verger A, Lagarde S, Maillard L, Bartolomei F, Guedj E Abstract This review aims to synthesize all the available data on brain molecular imaging, such as single-photon emission computed tomography (SPECT) and interictal fluorodeoxyglucose positron emission tomography (FDG-PET), in focal epilepsies. SPECT imaging is able to measure regional cerebral blood flow and its major innovation remains its ictal imaging value. On the other hand, FDG-PET, which has higher spatial resolution and lower background activity than SPECT, enables glycolytic metabolism to be identified in interictal states. Therefore, interic...
Source: Revue Neurologique - June 11, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Hemorrhagic stroke after cannabis use in a young man.
Authors: El Mesbahy J, Chraa M, Louhab N, Kissani N PMID: 28595976 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 11, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Factors influencing time between onset of signs/symptoms and referral for dementia in elderly outpatients.
CONCLUSION: Our results emphasize the need for more education and information among the general public about the early signs of cognitive impairment, especially in elderly people. PMID: 28595977 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 11, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Central pontine myelinolysis in a type 1 diabetes patient with chronic hepatitis.
Authors: Gourine M, Mostefa-Kara A, Saadi S, Arrar M, Cherrak A PMID: 28583270 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Unruptured intracranial aneurysms: An updated review of current concepts for risk factors, detection and management.
Authors: Boulouis G, Rodriguez-Régent C, Rasolonjatovo EC, Ben Hassen W, Trystram D, Edjlali-Goujon M, Meder JF, Oppenheim C, Naggara O Abstract The management of patients with unruptured intracranial aneurysms (UIAs) is a complex clinical challenge and constitutes an immense field of research. While a preponderant proportion of these aneurysms never rupture, the consequences of such an event are severe and represent an important healthcare problem. To date, however, the natural history of UIAs is not completely understood and there is no accurate means to discriminate the UIAs that will rupture from those t...
Source: Revue Neurologique - June 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Motor neuron disease of very long disease duration or Charcot-Marie-Tooth disease? A novel phenotype related to the SOD1 p.E22G variant.
Authors: Querin G, Corcia P, Lenglet T, Stojkovic T, Leguern E, Cazeneuve C, Pradat PF PMID: 28579206 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 7, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Peripheral nerve involvement in Fabry's disease: Which investigations? A case series and review of the literature.
CONCLUSION: PNS involvement is common in FD and should be suspected in patients exhibiting an acrosyndrome, dyshidrosis and/or cold hypoesthesia. Conventional electrophysiological investigations are normal. New techniques, such as ESC, provide early diagnosis of small fiber involvement that currently requires more sophisticated tests difficult to apply in routine practice. PMID: 28579207 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 7, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Louis Delasiauve (1804-1893), an alienist at the dawn of epileptology and pediatric psychiatry.
Authors: Walusinski O Abstract This paper aims to honor the memory of the alienist Louis Delasiauve (1804-1893). His classification of the different types of epilepsy based on clinical symptoms is still relevant today and made him a precursor of contemporary epileptology. In 1851, Delasiauve clinically and etiologically isolated 'acute mental confusion' (acute confusional state) from all other forms of dementia. Never deviating from his republican and progressive ideals, he devoted himself throughout the 19th century to treating those insane asylum patients who received the poorest care: epileptics and children wit...
Source: Revue Neurologique - June 7, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

New advances in the field of motor neuron diseases.
Authors: Couratier P PMID: 28526114 [PubMed - in process] (Source: Revue Neurologique)
Source: Revue Neurologique - May 22, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Charcot: Past and present.
Authors: Goetz CG Abstract Jean-Martin Charcot (1825-1893) was the preeminent neurologist of the nineteenth century. Several of his major contributions remain fully relevant to contemporary neurology, and this essay highlights three areas of particular importance to the modern neurologist: the anatomo-clinical method that Charcot developed as the anchor of neurological study; the integration of new scientific discoveries from other fields as a core strategy for neurological advancement; and the role of heredity as the fundamental etiological focus to the understanding of the pathogenesis of primary neurological dis...
Source: Revue Neurologique - May 16, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Do we know how to diagnose epilepsy early in Alzheimer's disease?
Authors: Cretin B, Philippi N, Bousiges O, Dibitonto L, Sellal F, Martin-Hunyadi C, Blanc F Abstract Epilepsy is an increasingly recognized comorbidity in Alzheimer's disease (AD). First described as generalized in dementia patients, epileptic AD patients are nowadays fully described in earlier stages of the disease (with mild or subjective cognitive impairment). At such early stages, patients may present not only with generalized seizures, but also with focal seizures (commonly localized in the frontal or temporal lobe). Thus, partial or generalized epilepsy is part of the semiological spectrum of AD that should b...
Source: Revue Neurologique - May 16, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Descriptive study of the parkinsonian population in the north of France: Epidemiological analysis and healthcare consumption.
CONCLUSION: The prevalence of PD is high in the Hauts-de-France region with a heterogeneous distribution by health territory. Neurology consultations were attended by a minority of patients in 2014. This work provides perspectives for necessary improvement in specialized care for this disease, both in terms of follow-up consultations and home care. PMID: 28495231 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - May 13, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Management and outcome of cerebral venous thrombosis after head trauma: A case series.
This report describes a case series of five patients admitted for head injury complicated by CVT. The main associated radiological signs were skull fractures crossing the venous sinus and adjacent traumatic hematoma. In four patients, anticoagulation was introduced within 48-72h of CVT diagnosis, with no subsequent hemorrhagic complications. The present report and data from the literature raise the question of systematic additional venoscans when confronted by associated radiological features of post-traumatic CVT. The safety of anticoagulation in selected patients is also discussed. PMID: 28495232 [PubMed - as supplie...
Source: Revue Neurologique - May 13, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Current issues in ALS epidemiology: Variation of ALS occurrence between populations and physical activity as a risk factor.
Authors: Luna J, Logroscino G, Couratier P, Marin B Abstract Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a fatal outcome. This review aims to report key epidemiological features of ALS in relation to the hypothesis of variation between populations, to summarize environmental hypothesis and to highlight current issues that deserve much considerations. Epidemiological ALS studies have shown a variation of incidence, mortality and prevalence between geographical areas and different populations. These data could support the notion that genetic factors, especially populations' ancestries...
Source: Revue Neurologique - May 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Clinical features of amyotrophic lateral sclerosis and their prognostic value.
Authors: Tard C, Defebvre L, Moreau C, Devos D, Danel-Brunaud V Abstract In classic amyotrophic lateral sclerosis (ALS), the relative degree of impairment of cortical vs spinal motor neurons serving the different body regions is highly variable. This means that an accurate, systematic assessment of the patient's clinical presentation is essential for both the diagnosis and prognosis. The patient's phenotype, rate of disease progression, time of onset (if early) of respiratory failure and nutritional status all have prognostic value, and should be specified in the nosological classification of the disease. PMID:...
Source: Revue Neurologique - May 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Ethical considerations and palliative care in patients with amyotrophic lateral sclerosis: A review.
Authors: Danel-Brunaud V, Touzet L, Chevalier L, Moreau C, Devos D, Vandolaeghe S, Defebvre L Abstract Amyotrophic lateral sclerosis (ALS) is not a curable disease, but it is treatable. By definition, much of the care provided to ALS patients is palliative, even though active life-sustaining strategies are available to prolong survival. Healthcare professionals must develop communication skills that help patients cope with the inexorable progression of the disease and the inevitability of death. Symptomatic treatments as well as respiratory insufficiency and nutritional life-sustaining therapies must be regularly e...
Source: Revue Neurologique - May 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Zika virus and Guillain-Barr é syndrome.
Zika virus and Guillain-Barré syndrome. Rev Neurol (Paris). 2017 May 05;: Authors: Dub T, Fontanet A PMID: 28483386 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - May 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Early lesion reversal on DWI and FLAIR after thrombectomy reperfusion in acute ischemic stroke.
Authors: Gory B, Chamard L, Turjman F, Lukaszewicz AC, Nighoghossian N, Berthezène Y PMID: 28483387 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - May 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Kennedy disease (X-linked recessive bulbospinal neuronopathy): A comprehensive review from pathophysiology to therapy.
Authors: Querin G, Sorarù G, Pradat PF Abstract Kennedy's disease, also known as spinal and bulbar muscular atrophy (SBMA), is a rare, adult-onset, X-linked recessive neuromuscular disease caused by expansion of a CAG repeat sequence in exon 1 of the androgen receptor gene (AR) encoding a polyglutamine (polyQ) tract. The polyQ-expanded AR accumulates in nuclei, and initiates degeneration and loss of motor neurons and dorsal root ganglia. While the disease has long been considered a pure lower motor neuron disease, recently, the presence of major hyper-creatine-kinase (CK)-emia and myopathic alterations on mu...
Source: Revue Neurologique - May 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Care management in amyotrophic lateral sclerosis.
Authors: Soriani MH, Desnuelle C Abstract Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal neurodegenerative disease characterized by progressive weakness of voluntary muscles of movement as well as those for swallowing, speech and respiration. In the absence of curative treatment, care can improve quality of life, prolong survival, and support ALS patients and their families, and also help them to anticipate and prepare for the end of life. Multidisciplinary management in tertiary centers is recommended in close collaboration with general practitioners, home carers and a dedicated health...
Source: Revue Neurologique - May 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Amyotrophic lateral sclerosis or not: Keys for the diagnosis.
Authors: Lenglet T, Camdessanché JP Abstract Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease (MND) which prognosis is poor. Early diagnosis permit to set up immediately adapted treatment and cares. Available diagnostic criteria are based on the detection of both central and peripheral motor neuron injury in bulbar, cervical, thoracic and lumbar regions. Electrodiagnostic (EDX) tests are the key tools to identify peripheral motor neuron involvement. Needle examination records abnormal activities at rest, and looks for neurogenic pattern during muscle contraction. Motor unit potentia...
Source: Revue Neurologique - May 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Parkinson's disease associated with 22q11.2 deletion: Clinical characteristics and response to treatment.
CONCLUSION: Searching for 22q11.2-del in PD patients presenting with suggestive features is relevant as the clinical presentation is similar to idiopathic PD, but with other associated characteristics, including a severe evolution. Results with DBS are similar to those reported for idiopathic PD. PMID: 28461026 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - May 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research