What is the nutritional status of your patients suffering from strokes.
The objective of our study was to evaluate, through a questionnaire, the opinion of prescribing doctors working in the Department of Neurology of The FANN National Teaching Hospital in Dakar. The interest of the question resides in the fact that the Center does not have a dedicated nutritionist for inpatients. This was an opinion poll about their concerns about the nutritional status of patients in the therapeutic projects they propose during the stroke. The type of the chosen opinion poll was elementary, type random. The questionnaire was individual and consisted of five items of single-response and multiple-choice questi...
Source: Revue Neurologique - March 25, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Developmental venous anomalies and seizures: Coincidence or causation?
Authors: Zouari R, Sakka S, Ketata S, Farhat N, Hdiji O, Hajkacem H, Dammak M, Mhiri C PMID: 32199611 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 24, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Clinical features related to CSF level of amyloid A β42 and Aβ40 proteins in presence of lobar microbleeds.
Clinical features related to CSF level of amyloid Aβ42 and Aβ40 proteins in presence of lobar microbleeds. Rev Neurol (Paris). 2020 Mar 14;: Authors: Girard-Stein L, Dumurgier J, Paquet C, Chabriat H Abstract In presence of lobar microbleeds, the exact clinical features related to the level of Aβ42, Aβ40 and to the Aβ40/Aβ42 ratio in the cerebrospinal fluid (CSF) are poorly known. We analyzed in 28 consecutive patients with such lesions, whose clinical or additional magnetic resonance imaging features are related to these biomarkers. The results showed that the presence of...
Source: Revue Neurologique - March 19, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

No laughing matter!
Authors: Brosset C, Nguyen Ngoc T, Nguyen Quang H, Tran Auh D, Dao Thi Bich H, Van Tu T PMID: 32171451 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 18, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Atypical clinical presentation and typical FTD atrophy: 17-year clinical follow-up and MRI analysis of a slowly progressive bvFTD associated with C9orf72 expansion.
Authors: Géraudie A, Guerrier L, Le Ber I, Clot F, Péran P, Pariente J PMID: 32178877 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 18, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Clinical and biological assessment of lamotrigine and levetiracetam plasma assays at the Rennes University Hospital.
CONCLUSION: The analysis of requests for antiepileptic drug assays at the University Hospital of Rennes revealed that clinicians were well aware of the HAS guidelines. In addition, the assay results were mainly consistent with clinical intuition, suggesting a real added value for patient management. However, the consequences in terms of changes in medical care seem limited. This assessment illustrates the importance of strengthening the dialogue between pharmacists, biologists and clinicians. PMID: 32178878 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 18, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Cognitive deficit, and neuropathological correlates, in the oldest-old.
Authors: Verny M, Duyckaerts C Abstract Several disorders are usually involved in the cognitive deficit of the oldest old. Alzheimer disease is the commonest. It is usually characterized by progressive memory impairment - neocortical symptoms occurring much later in the course of the disease. Alzheimer disease should not be considered any more as the single cause of a cognitive deficit in a very old patient. Vascular alterations, possibly causing microinfarcts, are commonly associated, especially in cerebral amyloid angiopathy. A slowly progressive memory deficit with negative CSF biomarkers of Alzheimer's disease ...
Source: Revue Neurologique - March 18, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Prevalence and characterisation of vocal fold motion impairment (VFMI) in patients with Multiple system atrophy compared with Parkinson's disease.
Authors: Grimaldi S, Renaud M, Robert D, Lagier A, Somma H, Soulayrol S, Korchia D, Fluchère F, Lagha-Boukbiza O, Schaeffer M, Witjas T, Azulay JP, Eusebio A Abstract INTRODUCTION: Multiple system atrophy (MSA) is a neurodegenerative disorder in which vocal fold mobility can be affected, sometimes leading to life-threatening situations. Our aim was to know if laryngeal examination could help differentiate MSA from Parkinson's disease (PD). MATERIALS AND METHODS: Between 2004 to 2014, all consecutive patients diagnosed with probable MSA were included in this retrospective, monocentric study. Flexible lary...
Source: Revue Neurologique - March 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The Marquise de Dampierre identified at last, the first described clinical case of Gilles de la Tourette syndrome.
This article examines the life of this woman, her disease, her identification and the connection with the Duchesse de Guermantes, heroine of LaRecherchedutempsperdu written by Marcel Proust. PMID: 32164973 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Interest of biological biomarkers in the diagnostic approach of neurocognitive disorders in the elderly.
Authors: Lilamand M, Hourregue C, Paquet C Abstract Alzheimer's disease (AD) is the most common cause of major neurocognitive disorders in older adults, affecting millions of individuals worldwide and leading to irreversible cognitive decline. The main neuropathological features of AD are brain amyloid deposition and neurofibrillary tangles. The biomarkers of AD are highly accurate in detecting these pathophysiological and neuropathological changes, up to several decades before the onset of cognitive impairment. They specifically reflect the presence of abnormal proteins in the brain, and can be measured reliably i...
Source: Revue Neurologique - March 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Nonconvulsive status epilepticus in the elderly.
Authors: Dupont S, Kinugawa K Abstract There is a higher incidence of status epilepticus in the older adult population that commonly presents as nonconvulsive status epilepticus (NCSE). NCSE most often corresponds to prolonged focal seizures with impaired consciousness with three main clinical presentations: i) an unexplained acute confusional state, ii) subtle eye, motor or behavioral signs or mood changes and iii) typical temporal or frontal seizures with impaired consciousness. Focal seizures without impaired consciousness or de novo absence status of late onset may also be met. The identified risk factors for N...
Source: Revue Neurologique - March 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

From the wax cast of brain ventricles (1508-9) by Leonardo da Vinci to air cast ventriculography (1918) by Walter E. Dandy.
Authors: da Mota Gomes M Abstract The mold of the human cerebral ventricles produced in 1918 by Walter E. Dandy had an experimental precedent, a wax cast of ox ventricles made four hundred years earlier (1508-9) by Leonardo da Vinci (1452-1519). This paper is an homage to the epitome of Renaissance and polymath Leonard da Vinci, as well as to Walter Edward Dandy (1886-1946) who developed the ventriculography (1918) and pneumoencephalography (1919) techniques. Pneumoencephalography was applied broadly up to the late 1970s, when it was replaced by less invasive and more accurate neuroimaging techniques. PMID: 321...
Source: Revue Neurologique - March 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Efficacy of microvascular decompression on the vascular compression type of neurogenic hypertension: A meta-analysis.
CONCLUSION: MVD as a treatment option of the vascular compression type of neurogenic hypertension is effective and safe. In spite of this conclusion, more prospective studies are needed to confirm it. On the other hand, a diagnostic method with higher sensitivity and specificity is necessary. PMID: 32169328 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Acute telestroke in France: A systematic review.
CONCLUSION: Implementation of acute telestroke in France had a positive clinical and public health impact but the evaluation remained limited and needs to be supported. PMID: 32147201 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 11, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis mimicking pseudotumor cerebri: A case report.
Authors: Cescutti M, Davenas C, Tilikete C, Durand-Dubief F, Marignier R, Vukusic S PMID: 32147202 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 11, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Negative motor networks: Electric cortical stimulation and diffusion tensor imaging.
CONCLUSION: This study found the characteristic cortical network of each NMA, and especially revealed new insight of pre-SMA-NMA and PPC NMA. These NMAs might be associated with different mechanism of negative motor response. PMID: 32147203 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 11, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The effects of diet and sex in amyotrophic lateral sclerosis.
Authors: Pape JA, Grose JH Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no known cure. Approximately 90% of ALS cases are sporadic, suggesting there are multiple contributing factors that influence the disease risk, onset, and progression. Diet and sex are two factors that have been reported to alter ALS risk, onset and progression in humans and in animal models, providing potential modifiers of disease. Several epidemiological studies have identified diets that positively affect ALS patients, including various high-calorie fat or sugar-based diets, while animal model...
Source: Revue Neurologique - March 11, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Brainstem Posterior Reversible Encephalopathy Syndrome With Spinal Cord Involvement (PRES-SCI).
Authors: Bing F, M'Biene S, Gay S PMID: 32145980 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 9, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Epidemiology of neurological diseases in older adults.
Authors: Dumurgier J, Tzourio C Abstract Neurological diseases refer to the diseases that target the nervous system (brain, spine or nerves). They are the second leading cause of death, and the first cause of severe long-term disability in the world. The prevalence of most neurological diseases increases sharply with age, and age also modulates the impact of risk factors, clinical presentation and the natural course of these diseases. Longitudinal population-based studies provide useful insights for a better understanding of the specificities of neurological diseases in older adults by assessment of a wide range of...
Source: Revue Neurologique - March 9, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Impulse control disorder-linked hypersexuality complicated by disseminated gonococcal infection in a patient with Parkinson's disease.
Authors: Moegle C, Grillon A, Anheim M, Lipsker D, Velter C PMID: 32139181 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 8, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Major response to temozolomide as first-line treatment for newly-diagnosed DDR2-mutated glioblastoma: A case report.
Authors: El Husseini K, Marguet F, Lamy A, Magne N, Fontanilles M PMID: 32139182 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - March 8, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Neuromuscular manifestations of lead poisoning in opium and herbal users in Iran.
Authors: Okhovat AA, Ansari B, Basiri K, Fatehi F Abstract Opium sale is prohibited in Iran, and sellers mix it with lead to increase the weight. Herein, we describe neuromuscular findings in nine patients who developed lead poisoning due to opium/drug consumption. The mean age of patients was 53±3.5 years and their mean blood lead level was 122.6±20.8μg/dL. Most of the patients had an acute/subacute course presenting as axonal or demyelinating sensorimotor polyneuropathy, motor neuron disease, and multiple mononeuropathies with favorable response to the chelation therapy. Lead poisoning should be ...
Source: Revue Neurologique - March 8, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Multifocal arterial wall contrast - enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke.
CONCLUSION: At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state. PMID: 31987628 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 30, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Serum cortisol levels in patients with a transient global amnesia.
Authors: Schneckenburger R, Hainselin M, Viader F, Eustache F, Quinette P Abstract Transient global amnesia (TGA) can be triggered by a high level of blood cortisol. We assessed whether patients had a higher level of cortisol during the TGA than shortly after. We included 52 patients, 21 with blood collected during the TGA episode and 31 shortly thereafter. We compared these two groups after adjustment for time of blood collection. The cortisol level was significantly higher in the per-ictal group (P=0.03) and negatively correlated with the time elapsed from symptom onset (P=0.005). The results are consistent with ...
Source: Revue Neurologique - January 30, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Repair strategies for traumatic spinal cord injury, with special emphasis on novel biomaterial-based approaches.
Authors: Soares S, von Boxberg Y, Nothias F Abstract As a part of the central nervous system (CNS), the adult mammalian spinal cord displays only very poor ability for self-repair in response to traumatic lesions, which mostly lead to more or less severe, life-long disability. While even adult CNS neurons have a certain plastic potential, their intrinsic regenerative capacity highly varies among different neuronal populations and in the end, regeneration is almost completely inhibited due to extrinsic factors such as glial scar and cystic cavity formation, excessive and persistent inflammation, presence of various ...
Source: Revue Neurologique - January 28, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Benign hereditary chorea: From benign to serious.
Authors: Lamiral A, El Chehadeh S, Chelly J, Anheim M, Laugel V, Tranchant C PMID: 31983472 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 28, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

What are the infectious risks with disease-modifying drugs for multiple sclerosis and how to reduce them? A review of literature.
Authors: Pourcher V Abstract Patients with multiple sclerosis taking immunosuppressive therapy may be at risk of reactivating latent pathogens, community-acquired infections, worsening asymptomatic chronic infections, and contracting de novo infections. This risk was evaluated mainly in short-term clinical trials and few studies have investigated this risk in real-life settings. In clinical practice, this infectious risk should be evaluated when a multiple sclerosis diagnosis is made in order to propose specific follow-up or immunization as soon as possible and thus avoid contraindications or risk of lowered vaccin...
Source: Revue Neurologique - January 28, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Fluoroquinolone-induced motor neuron hyperexcitability.
Authors: Posener S, Dinh A, Davido B, Paquereau J PMID: 31980136 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 27, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Skew deviation after blunt head trauma.
Authors: Anagnostou E, Zachou A, Kararizou E PMID: 31955856 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 22, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Health issues in polyhandicapped patients according to age: Results of a large French cross-sectional study.
CONCLUSION: Early detection and management of impairments and comorbidities may improve the disease course of the patients. PMID: 31959355 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 22, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Parkinson's disease: From bench to bedside.
Authors: Draoui A, El Hiba O, Aimrane A, El Khiat A, Gamrani H Abstract Parkinson's disease is a very complex public health problem with different etiologies and a wide range of clinical features including motor and non-motor symptoms. The aim of the current report is to review the latest advances in the understanding of PD etiologies, diagnosis, epidemiology and an overview of the earlier and latest advances in the management of PD, from L-DOPA to adult astroglia reprogramming into dopaminergic neurons in vivo. PMID: 31928746 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Pre-symptomatic diagnosis in ALS.
Authors: Corcia P, Lumbroso S, Cazeneuve C, Mouzat K, Camu W, Vourc'h P, on Behalf the FILSLAN network Abstract Pathophysiology of amyotrophic lateral sclerosis (ALS) remains partially understood even though it is accepted worldwide that motor neuron death results from a pluri-factorial process with a variable role of genetic factors. Although not distinguishable from a clinical point of view, familial forms of ALS (fALS, 10% of cases) and sporadic forms (sALS, 90% of cases) can be described. Since the identification of superoxide dismutase 1 gene (SOD1) mutations, more than 30 genes have been linked to fALS. Among...
Source: Revue Neurologique - January 15, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Comparisons of electrophysiological and clinical findings between young and elderly patients with Carpal Tunnel Syndrome.
Authors: Aghda AK, Asheghan M, Amanollahi A Abstract BACKGROUND: Few studies have been published on differences between young and old patients with Carpal Tunnel Syndrome regarding clinical and electrophysiological findings. We compared the findings in participants of two age ranges. METHODS: For one year from August 2016, we performed a two-group cross-sectional study in an outpatient clinic of physical medicine and rehabilitation at a University Hospital. Two samples of young and old women with a diagnosis of the syndrome without known risk factors affecting electrophysiological findings were selected. We mea...
Source: Revue Neurologique - January 12, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Armand Trousseau (1801-1867), a neurologist before neurology.
Authors: Walusinski O Abstract Armand Trousseau is the emblematic figure of the prominent mid-19th century clinician, owing to the quality of his teaching and the influence of French medicine, which during his time brought students from around the world to Paris. A student of Pierre Bretonneau (1778-1862), the famous physician from the western French city of Tours, Trousseau carried forward Bretonneau's clinical description of infectious diseases, developing the notion of their contagion and paving the way toward the discovery of their microbial aetiology by Louis Pasteur (1822-1895) at the end of the century. His ...
Source: Revue Neurologique - January 12, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Therapeutic patient education in Alzheimer's disease and related disorders: Clinical experience and perspectives.
Authors: Cartz-Piver L, Polin C, Diebolt C, Chouly M, Garçonnot LA, Clément JP, Calvet B, Couratier P Abstract Therapeutic patient education (TPE) is the process by which health professionals impart information to help patients self-manage their chronic disease: it is an essential part of treatment of long-term diseases and conditions. Memory loss and other cognitive disorders are usually considered as obstacles to TPE for patients with Alzheimer's disease or related disorders (ADRD). Over 100 patients with different forms of ADRD and caregivers have benefited from TPE programs since 2011 at the Limog...
Source: Revue Neurologique - January 11, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Limb shaking transient ischemic attacks: A follow-up of 28 patients.
CONCLUSIONS: Limb shaking TIA point to carotid artery disease in the majority of patients and vertebrobasilar artery disease in one third. Fast and timely treatment with either surgical or CAS eliminates the attacks and also reduce their risk of stroke. PMID: 31916976 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 11, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Correlation between blood glucose variability and the risk of death in patients with severe acute stroke.
This study aimed to investigate the correlation between blood glucose variability and the risk of death in patients with severe acute stroke. One hundred and fifty-eight patients diagnosed with severe acute stroke were divided into survival group and death group and were retrospectively analyzed. The baseline National Institutes of Health Stroke Scale (NIHSS) score, Acute Physiology and Chronic Health Evaluation (APACHE) II score, mean blood glucose, blood glucose standard deviation, mean amplitude of glycemic excursion, and mean variation coefficient of blood glucose were obtained and compared. Single-factor binary l...
Source: Revue Neurologique - January 10, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

A historical approach to hereditary spastic paraplegia.
Authors: Walusinski O Abstract Hereditary spastic paraplegia (HSP) is a group of rare neurological disorders, characterised by their extreme heterogeneity in both their clinical manifestations and genetic origins. Although Charles-Prosper Ollivier d'Angers (1796-1845) sketched out a suggestive description in 1827, it was Heinrich Erb (1840-1921) who described the clinical picture, in 1875, for "spastic spinal paralysis". Jean-Martin Charcot (1825-1893) began teaching the disorder as a clinical entity this same year. Adolf von Strümpell (1853-1925) recognised its hereditary nature in 1880 and Maurice ...
Source: Revue Neurologique - January 10, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Pseudo-subarachnoid hemorrhage: Non-contrast computed tomography aspects for diagnostic.
Authors: de Medeiros FC, Barroca AF, Cardoso CDPA, Santos DNC, Pereira CSC, Pereira OP, Dos Santos JVS PMID: 31898951 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 5, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Another extensive nitrous oxide (N2O) myelopathy: The wood for the trees?
Authors: Demas A, Le Boisselier R, Simonnet L, De Menibus-Demas L, Langlois V, Cochin JP PMID: 31889534 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - January 2, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Reprint of : Transcatheter closure of patent foramen ovale to prevent stroke recurrence in patients with otherwise unexplained ischaemic stroke: Expert consensus of the French Neurovascular Society and the French Society of Cardiology.
CONCLUSIONS: Although a big step forward that will benefit many patients has been taken with recent trials, many questions remain unanswered. Pending results from further studies, decision-making regarding management of patients with PFO-associated ischaemic stroke should be based on a close coordination between neurologists/stroke specialists and cardiologists. PMID: 31787326 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - December 5, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Mechanism of action of s1p receptor modulators in multiple sclerosis: The double requirement.
Authors: Bordet R, Camu W, De Seze J, Laplaud DA, Ouallet JC, Thouvenot E Abstract The ideal treatment for multiple sclerosis (MS) would target both the neuroinflammatory component of the disease (peripheral and central) and its neurodegenerative component, via modulation of a ubiquitous and pleiotropic common target. Sphingosine-1-phosphate (S1P), a product of sphingosine metabolism, regulates many biological functions (including cell proliferation and survival, cell migration, the immune response and cardiovascular function) via five subtypes of receptor. These receptors are expressed in all types of brain cells ...
Source: Revue Neurologique - November 25, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Nodding syndrome phenotypes.
Authors: Spencer PS, Mazumder R, Palmer VS, Pollanen MS Abstract Nodding syndrome (NS) is a progressive encephalopathy of children and adolescents characterized by seizures, including periodic vertical head nodding. Epidemic NS, which has affected parts of East Africa, appears to have clinical overlap with sub-Saharan Nakalanga syndrome (NLS), a brain disorder associated with pituitary dwarfism that appears to have a patchy distribution across sub-Sahara. Clinical stages of NS include inattention and blank stares, vertical head nodding, convulsive seizures, multiple impairments, and severe cognitive and motorsystem...
Source: Revue Neurologique - November 23, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Melatonin: A review of its potential functions and effects on neurological diseases.
CONCLUSIONS: In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for. PMID: 31718830 [PubMed - as supplied by publ...
Source: Revue Neurologique - November 15, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Organic solvent exposure as a risk factor for multiple sclerosis: An updated review.
Authors: Landtblom AM, Kristoffersson A, Boström I Abstract Organic solvents exposure has for a long time been suspected as a risk factor for developing multiple sclerosis. The evidence, containing case reports, case-control studies and cohort studies has been contradictory. An early meta-analysis, however, pointed to a doubled risk for MS. Recent major case-control studies confirm this, but also have elucidated the risk pattern, being dependent on another risk factor, i.e. smoking. PMID: 31676154 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 6, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Tumefactive demyelinating lesions after initiating fingolimod in patient with multiple sclerosis: A case report.
Authors: Navardi S, Sahraian MA, Naser Moghadasi A PMID: 31668286 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 2, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Safety and effectiveness of levodopa-carbidopa intestinal gel for advanced Parkinson's disease: A large single-center study.
CONCLUSION: Despite the high frequency of AEs, patients with advanced PD gain clinical benefit from treatment with LCIG. This treatment requires a competent, multidisciplinary team on site. PMID: 31668287 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 2, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Neuromyelitis optica spectrum disorders in South of Tunisia: A rare entity with low seroprevalence of anti-aquaporin 4 autoantibodies.
CONCLUSION: NMOSD seem to represent a rare etiology of optic neuritis and/or myelitis in Tunisian patients. Despite its low global seroprevalence in our study population, anti-AQP4 appears to be a very clinically relevant marker for NMOSD diagnosis. Repeating the screening in case of initial negativity could be interesting in clinical practice. PMID: 31668529 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 2, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Medical management, prevention and mitigation of environmental risks factors in Neurology.
Authors: Reis J, Román GC, Giroud M, Palmer VS, Spencer PS Abstract The human environment and exposures arising therefrom are major contributors to neurological disorders ranging from stroke to neurodegenerative diseases. Reduction of exposure to environmental risk factors, with the goal of disease prevention or control, is addressed at the individual as well as the societal level and in recognition of differential subject vulnerability. We examine some practical solutions in high-income countries that may allow a better adaptation to environmental risks and reduce their adverse impact on the nervous system....
Source: Revue Neurologique - October 29, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Bacterial transportable toxins of the nasopharyngeal microbiota in multiple sclerosis. Nose-to-brain direct.
Authors: Gay F Abstract Intranasal administration delivers molecules directly to the brain bypassing the blood-brain barrier. Three distinct routes of access have been identified; olfactory, trigeminal and via the paranasal sub-mucosa of the posterior sinuses. Consequently, environmental toxins may access the CNS directly to induce inflammatory and degenerative disease. They may also activate bacterial species of the nasal mucosal microbiome to release both immune-deviating cell wall antigens and transportable neurotoxins with local direct access to the CNS. Evidence is reviewed that toxins of the nasal bacterial m...
Source: Revue Neurologique - October 22, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research