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Causality and complex disease: The example of multiple sclerosis.
Authors: Bach JF PMID: 29273173 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - December 25, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Introduction.
Authors: Bossi L, Agid Y, Scientific Committee PMID: 29179836 [PubMed - in process] (Source: Revue Neurologique)
Source: Revue Neurologique - November 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Historical reflections on neurosyphilis based on the 1826 treatise on general paralysis in demented patients by Louis Florentin Calmeil (1798-1895).
Authors: Macia F, Ardagna Y Abstract General paralysis is a neurological symptom of tertiary syphilis that was first identified in asylums as paralytic madness. The enlightened discussion of 60 clinicopathological cases provided by Louis Florentin Calmeil in his 1826 treatise greatly improved our knowledge of general paralysis. However, Calmeil was unable to relate this symptom to syphilis, although the latter was quite widespread at that time. Following a detailed reanalysis of Calmeil's observations with special attention to his clinical and demographic data, we conclude that this eminent clinician was unable to ...
Source: Revue Neurologique - November 26, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Subacute corticobasal syndrome following internal carotid endarterectomy.
Authors: Marques A, Bourgois N, Vidal T, Ferrier A, Mathais S, Merlin C, Valla C, De Schlichting E, Jean B, Deffond D, Durif F Abstract The present report is of two patients who, immediately after internal carotid endarterectomy, presented with unexplained hemiplegia, despite normal findings on repeated MRI scans, which secondarily evolved into homolateral subacute corticobasal syndrome (CBS), with asymmetrical hemispheric hypometabolism and evidence of dopaminergic denervation. This prompted us to propose an hypothesis of transient cerebral hypoxia arising during the surgical clamping period that might have provok...
Source: Revue Neurologique - November 22, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Movement disorders in a cohort of Algerian patients with multiple sclerosis.
Authors: Hatteb SA, Daoudi S Abstract Multiple sclerosis is an inflammatory demyelinating disease of central nervous system. Except for cerebellar tremor, occurence of other movement disorders remains rare. Our study aimed to evaluate their prevalence in our population of patients with multiple sclerosis, and to compare it with literature data. Our results showed higher prevalence compared to European studies, raising the question of mechanisms of the disorder. MRI correlation was also studied, in 3 cases over 8 and a possible correlation was found. PMID: 29153981 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 22, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Use of a high-fidelity patient simulator for training 200 medical students in seizure management: A pilot study at the PRESAGE simulation center in Lille.
Authors: Moreau C, Delval A, Grolez G, Moulin S, Chen Y, Lebouvier T, Defebvre L, Poissy J, Jourdain M PMID: 29146115 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 19, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Complications of dexamethasone prescribed for Streptococcus pneumoniae meningitis associated with cerebral vasculitis involving large- to medium-sized vessels.
Authors: Corchia A, Gouvion A, Deguelte-Lardiere S, Vernet Garnier V, Raclot P, N'Guyen Y PMID: 29146116 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 19, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Dystonia of the soft palate: Mutation of the THAP1 (DYT6) gene in a 42-year-old patient.
Authors: Grimaldi S, Lagier A, Robert D, Korchia D, Soulayrol S, Azulay JP PMID: 29129324 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 15, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Validity of Arabic version of the two-question Quick Inventory of Depression (QID-2-Ar): Screening for multiple sclerosis in an Arab environment and during the Syrian war.
This study aimed to validate the Arabic version of the two-question Quick Inventory of Depression (QID-2-Ar) in multiple sclerosis (MS) patients living in Syria during the war. METHODS: A total of 100 Syrian MS patients, aged 18-60 years, were recruited at Damascus Hospital and Ibn Al-Nafees Hospital to validate the QID-2-Ar, including analyses of its screening test parameters and its construct validity. RESULTS: The QID-2-Ar screening parameters for depression tested very positively, and its construct validity was also favorable (P
Source: Revue Neurologique - November 15, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Guillain-Barr é syndrome due to hepatitis E.
Guillain-Barré syndrome due to hepatitis E. Rev Neurol (Paris). 2017 Nov 10;: Authors: Troussière AC, Sudaveschi V, Collardelle P, Marque Julliet S, Servan J, Pico F PMID: 29132643 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 15, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Is the Choosing Wisely( ®) campaign model applicable to the management of multiple sclerosis in France? A GRESEP pilot study.
CONCLUSION: This pilot study, the first of its kind in France, has demonstrated the relevance and feasibility of adapting the Choosing Wisely(®) model to MS by practitioners specializing in the disorder. However, the acceptability of these recommendations by other practitioners in other specialist fields as well as their impact on everyday clinical practices now need to be studied. PMID: 29128151 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 14, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Intravenous thrombolytic therapy for acute anterior ischemic stroke: Experience at the French Military Teaching Hospital in Toulon from 2003 to 2014.
This report is of the results of our practices compared with those in the literature, as well as our attempts to identify factors predictive of a favorable outcome after thrombolysis. METHODS: All patients treated with rt-PA for IS in the carotid territory between 2003 and 2014 were prospectively included. Disability was assessed at 3 months by modified Rankin Scale (m-RS) scores; outcome was considered unfavorable if the m-RS score was>2. Multivariate analyses were also performed to identify parameters correlating with poor and favorable outcomes. RESULTS: Of the 289 patients prospectively enrolled in the study...
Source: Revue Neurologique - November 14, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Should we broaden indications for anti-JCV antibody tests in multiple sclerosis patients? Comments. Anti-JCV antibody index in multiple sclerosis care.
Authors: Stankoff B PMID: 29128153 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 14, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

A fatal encephalitic case of post-cutaneous leishmaniasis.
Authors: Maguenouche SL, Aissani N, Benalia R, Toumi C, Kessaci F, Makri S PMID: 29128154 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 14, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Motor neuron disease in inherited neurometabolic disorders.
Authors: de Souza PVS, Bortholin T, Naylor FGM, Chieia MAT, de Rezende Pinto WBV, Oliveira ASB Abstract Inherited neurometabolic disorders represent a growing group of inborn errors of metabolism that present with major neurological symptoms or a complex spectrum of symptoms dominated by central or peripheral nervous system dysfunction. Many neurological presentations may arise from the same metabolic defect, especially in autosomal-recessive inherited disorders. Motor neuron disease (MND), mainly represented by amyotrophic lateral sclerosis, may also result from various inborn errors of metabolism, some of which m...
Source: Revue Neurologique - November 14, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Intravascular large B-cell lymphoma mimicking cerebral amyloid angiopathy-related inflammation.
Authors: Leclercq L, Mechtouff L, Hermier M, Cho TH, Nighoghossian N, Ducray F PMID: 29126561 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 12, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Pseudotumoral cerebellitis with acute hydrocephalus as a manifestation of EBV infection.
Authors: Geurten C, De Bilderling G, Nassogne MC, Misson JP, Verghote M PMID: 29108711 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 9, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Multiple sclerosis treatments and the anti-JCV antibody index.
Authors: de Seze J, Lebrun-Frenay C PMID: 29103667 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Foreword.
Authors: Timsit S, Edan G PMID: 29101927 [PubMed - in process] (Source: Revue Neurologique)
Source: Revue Neurologique - November 6, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Should we broaden indications for anti-JCV antibody tests in multiple sclerosis patients? No.
Authors: Labauge P PMID: 29102328 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 6, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Long-lasting active lifestyle and successful cognitive aging in a healthy elderly population: The PROOF cohort.
CONCLUSION: In the healthy elderly, high cognitive ability predicts both cognitive ability and social involvement in later life. Cognitive decline by only one level may also extend the time to reach impairment, underlining the importance of the so-called cognitive reserve. PMID: 29100612 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - November 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Which imaging before reperfusion strategy?
Authors: Olivot JM Abstract The ischemic penumbra is a transient and potentially reversible condition. Therefore, infarct progression and its counterpart penumbral salvage are highly variable and result from the interaction of 3 major factors: collateral flow, revascularization delay and success. Multimodal brain imaging now offers in clinical practice an exhaustive characterization of the acute ischemic injury: vessel site occlusion, infarction/critical hypoperfusion volume, and collateral flow. From 1995 to 2015, IV alteplase administered within 4.5hours after the onset of acute BI diagnosed by the absence of hem...
Source: Revue Neurologique - October 20, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Unruptured intracranial aneurysms: It is not a bomb!
Authors: Pierot L, Gawlitza M, Soize S PMID: 29031554 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - October 17, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

How to use stem cells for repair in stroke patients.
Authors: Detante O, Rome C, Papassin J Abstract Regenerative cell therapy is a promising therapeutic strategy in neurology, most notably to improve stroke recovery. Although tolerability and feasibility have apparently been validated, many questions remain as to what is the best type of cells to use, the best route and the post-stroke delay for administration. Two main strategies have currently emerged: intravenous injection of mesenchymal stem cells with systemic trophic support; and intracerebral grafting of neural stem cells with brain repair effects at the lesion site. Multicenter clinical trials have just begu...
Source: Revue Neurologique - October 17, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The next challenges for optimal reperfusion in the era of mechanical thrombectomy.
Authors: Mazighi M Abstract The therapeutic management of acute ischemic stroke has changed tremendously over the past few years. Mechanical thrombectomy in addition to intravenous tissue plasminogen activator (t-PA) is currently the standard of care for patients experiencing acute ischemic stroke as a consequence of large vessel occlusion of the anterior circulation. Yet, despite strong evidence supporting such a therapeutic approach, several issues remain a source of debate, such as the need for intravenous t-PA, the optimal target for blood pressure levels and the opportunity for additional antithrombotic therap...
Source: Revue Neurologique - October 17, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

MRI for in vivo diagnosis of cerebral amyloid angiopathy: Tailoring artifacts to image hemorrhagic biomarkers.
Authors: Boulouis G, Edjlali-Goujon M, Moulin S, Ben Hassen W, Naggara O, Oppenheim C, Cordonnier C Abstract Cerebral amyloid angiopathy (CAA) is a frequent age-related small vessel disease (SVD) with cardinal magnetic resonance imaging (MRI) signatures that are hemorrhagic in nature, and include the presence of strictly lobar (superficial) cerebral microbleeds and intracerebral hemorrhages as well as cortical superficial siderosis. When investigating a patient with suspected CAA in the context of intracranial hemorrhage (parenchymal or subarachnoid) or cognitive dysfunction, various MRI parameters influence the op...
Source: Revue Neurologique - October 12, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Cerebral amyloid angiopathy-related cognitive impairment: The search for a specific neuropsychological pattern.
Authors: Planton M, Raposo N, Albucher JF, Pariente J Abstract Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years. The symptoms most commonly re...
Source: Revue Neurologique - October 12, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Cerebral imaging of post-stroke plasticity and tissue repair.
Authors: Loubinoux I, Brihmat N, Castel-Lacanal E, Marque P Abstract Six months after stroke onset, 50 % of patients are still disabled and dependent, while many brain mechanisms of recovery remain partially unknown or misunderstood. However, brain imaging and cerebral connectivity analytical techniques have provided invaluable insights into such mechanisms and identified two main patterns of brain reorganization depending on stroke severity. The contralesional primary motor cortex can take over motor function in severely impaired patients, whereas the ipsilesional motor cortex or hemisphere reorganize themsel...
Source: Revue Neurologique - October 9, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Techniques for endovascular treatment of acute ischemic stroke.
Authors: Pierot L, Gawlitza M, Soize S Abstract Early recanalization of occluded vessels in patients with acute ischemic stroke (AIS) by either intravenous thrombolysis (IVT) or endovascular revascularization has been shown to be associated with improved clinical outcomes and reduced mortality. Since the initial report regarding endovascular treatment (EVT) of AIS in 1983, endovascular techniques have been tremendously improved, advancing from intra-arterial administration of thrombolytic drugs to stent retrievers. IVT has been evaluated in several large randomized trials and has been shown to improve clinical outc...
Source: Revue Neurologique - October 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Foreword.
Authors: Ceccaldi M, Pariente J PMID: 28915976 [PubMed - in process] (Source: Revue Neurologique)
Source: Revue Neurologique - September 18, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Dissociative amnesia: Disproportionate retrograde amnesia, stressful experiences and neurological circumstances.
Authors: Thomas-Antérion C Abstract Dissociative amnesias have been reported in neurological episodes mild enough to not cause any visible lesions on morphological examination. Disproportionate retrograde amnesia with or without identity loss happens in the context of psychological trauma (known or not). In metabolic imaging studies, some authors have reported functional alterations, particularly in the bilateral hippocampus, right temporal regions and inferolateral prefrontal cortex, despite normal morphological imaging. To avoid the presumption of an organic, psychogenic or mixed origin for such changes, D...
Source: Revue Neurologique - September 3, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Attention-deficit/hyperactivity disorder during adulthood.
Authors: Magnin E, Maurs C Abstract Attention-Deficit/Hyperactivity Disorder (ADHD), although considered a childhood-onset neurodevelopmental condition, is nevertheless a frequent and disabling condition in adults. A proportion of such patients are not diagnosed during childhood or adolescence, as diagnosis of the syndrome is rather complex, especially when other psychiatric, neurological or other neurodevelopmental conditions are also associated, yet comorbidities and consequences of ADHD are frequently observed in adults and older populations. As ADHD patients present to memory clinics with attentional and execut...
Source: Revue Neurologique - August 30, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Gestural apraxia.
Authors: Etcharry-Bouyx F, Le Gall D, Jarry C, Osiurak F Abstract Gestural apraxia was first described in 1905 by Hugo Karl Liepmann. While his description is still used, the actual terms are often confusing. The cognitive approach using models proposes thinking of the condition in terms of production and conceptual knowledge. The underlying cognitive processes are still being debated, as are also the optimal ways to assess them. Several neuroimaging studies have revealed the involvement of a left-lateralized frontoparietal network, with preferential activation of the superior parietal lobe, intraparietal sulcus an...
Source: Revue Neurologique - August 30, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Neuropsychology of traumatic brain injury: An expert overview.
Authors: Azouvi P, Arnould A, Dromer E, Vallat-Azouvi C Abstract Traumatic brain injury (TBI) is a serious healthcare problem, and this report is a selective review of recent findings on the epidemiology, pathophysiology and neuropsychological impairments following TBI. Patients who survive moderate-to-severe TBI frequently suffer from a wide range of cognitive deficits and behavioral changes due to diffuse axonal injury. These deficits include slowed information-processing and impaired long-term memory, attention, working memory, executive function, social cognition and self-awareness. Mental fatigue is frequently...
Source: Revue Neurologique - August 30, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Accelerated long-term forgetting and autobiographical memory disorders in temporal lobe epilepsy: One entity or two?
Authors: Lemesle B, Planton M, Pagès B, Pariente J Abstract Temporal lobe epilepsy (TLE) is a type of epilepsy that often has a negative impact on patients' memory. Despite the importance of patients' complaints in this regard, the difficulties described by these patients are often not easy to demonstrate through a standard neuropsychological assessment. Accelerated long-term forgetting and autobiographical memory disorders are the two main memory impairments reported in the literature in patients with TLE. However, the methods used by different authors to evaluate long-term memory and autobiographical memor...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Disentangling conscious from unconscious cognitive processing with event-related EEG potentials.
Authors: Rohaut B, Naccache L Abstract By looking for properties of consciousness, cognitive neuroscience studies have dramatically enlarged the scope of unconscious cognitive processing. This emerging knowledge inspired the development of new approaches allowing clinicians to probe and disentangle conscious from unconscious cognitive processes in non-communicating brain-injured patients both in terms of behaviour and brain activity. This information is extremely valuable in order to improve diagnosis and prognosis in such patients both at acute and chronic settings. Reciprocally, the growing observations coming fr...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Complexity vs. unity in unilateral spatial neglect.
Authors: Rode G, Fourtassi M, Pagliari C, Pisella L, Rossetti Y Abstract Unilateral spatial neglect constitutes a heterogeneous syndrome characterized by two main entangled components: a contralesional bias of spatial attention orientation; and impaired building and/or exploration of mental representations of space. These two components are present in different subtypes of unilateral spatial neglect (visual, auditory, somatosensory, motor, allocentric, egocentric, personal, representational and productive manifestations). Detailed anatomical and clinical analyses of these conditions and their underlying disorders s...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Visual agnosia and focal brain injury.
Authors: Martinaud O Abstract Visual agnosia encompasses all disorders of visual recognition within a selective visual modality not due to an impairment of elementary visual processing or other cognitive deficit. Based on a sequential dichotomy between the perceptual and memory systems, two different categories of visual object agnosia are usually considered: 'apperceptive agnosia' and 'associative agnosia'. Impaired visual recognition within a single category of stimuli is also reported in: (i) visual object agnosia of the ventral pathway, such as prosopagnosia (for faces), pure alexia (for words), or topographagn...
Source: Revue Neurologique - August 29, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Long-term memory deficits in temporal lobe epilepsy.
Authors: Tramoni-Negre E, Lambert I, Bartolomei F, Felician O Abstract Memory complaints and deficits are common in patients with epilepsy, especially temporal lobe epilepsy (TLE), where memory-related brain structures are directly involved in the epileptic process. In recent years, substantial progress has been made in delineating memory impairment in TLE, challenging the traditional neuropsychological approach of the disorder. In particular, several lines of evidence have suggested that, beyond the apparent deficit demonstrable by standardized neuropsychological evaluations, TLE may also negatively interact with ...
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Impact of spontaneous intracerebral hemorrhage on cognitive functioning: An update.
Authors: Planton M, Raposo N, Danet L, Albucher JF, Péran P, Pariente J Abstract Intracerebral hemorrhage (ICH) accounts for 15% of all strokes and approximately 50% of stroke-related mortality and disability worldwide. Patients who have experienced ICH are at high risk of negative outcome, including stroke and cognitive disorders. Vascular cognitive impairment are frequently seen after brain hemorrhage, yet little is known about them, as most studies have focused on neuropsychological outcome in ischemic stroke survivors, using well-documented acute and chronic cognitive scores. However, recent evidence sup...
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Causality and complex disease: The example of multiple sclerosis.
Authors: Bach JF PMID: 28838791 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Vascular cognitive impairment: Advances and trends.
Authors: Barbay M, Taillia H, Nedelec-Ciceri C, Arnoux A, Puy L, Wiener E, Canaple S, Lamy C, Godefroy O, Roussel M, GRECOGVASC Study Group Abstract The presence of vascular neurocognitive impairment (whatever the severity) is always associated with a functional impact and increased risk of dependency and institutionalization. However, vascular cognitive impairment remains underdiagnosed, and the mechanisms underlying post-stroke cognitive disorders are still poorly understood. However, the advent of new criteria and a standardized international neuropsychological battery is expected to lead to improved diagnosis a...
Source: Revue Neurologique - August 27, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

C-reactive protein: A promising biomarker in ALS?
Authors: Corcia P, Blasco H, Beltran S, Andres C, Vourc'h P, Couratier P PMID: 28797688 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - August 13, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Can the benefits of rtPA treatment for stroke be improved?
Authors: Vivien D Abstract Tissue-type plasminogen activator (tPA) is a serine protease well known to promote fibrinolysis. This is why: its recombinant form (rtPA) can be used, either alone or combined with thrombectomy, to promote recanalization/reperfusion following ischemic stroke. However, its overall benefits are counteracted by some of its side-effects, including incomplete lysis of clots, an increased risk of hemorrhagic transformation and the possibility of neurotoxicity. Nevertheless, better understanding of the mechanisms by which tPA influences brain function and promotes its alteration may help in the ...
Source: Revue Neurologique - August 13, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Should we broaden indications for anti-JCV antibody tests in multiple sclerosis patients? YES.
Authors: Wiertlewski S PMID: 28760447 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - August 3, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

A clinical and neurophysiological motor signature of Unverricht-Lundborg disease.
CONCLUSION: A homogeneous motor pattern was delineated that may represent a ULD clinical and neurophysiological signature. Clinical and neurophysiological findings confirmed the pure cortical origin of the permanent myoclonus. Also, oculomotor findings shed new light on ULD pathophysiology by evidencing combined midbrain and cerebellar dysfunction. PMID: 28688606 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - July 11, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Stroke is now a brain disease: Revising ICD-11.
Authors: Giroud M, Béjot Y PMID: 28687140 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - July 10, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Rates of serum level determinations of antiepileptic drugs in accord with guidelines: A clinical study at a tertiary center.
CONCLUSION: At our center, 84% of AED level determinations had an appropriate indication according to a priori defined and reliable criteria. Moreover, it was noted that a specific educational intervention substantially increased rates of appropriateness. Thus, it appears to be crucial to ensure that medical and paramedical staff are aware of the official recommendations to avoid taking unnecessary drug level measurements. PMID: 28669391 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - July 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Joseph Jumenti é (1879-1928), a forgotten neurologist.
Joseph Jumentié (1879-1928), a forgotten neurologist. Rev Neurol (Paris). 2017 Jun 30;: Authors: Walusinski O Abstract Joseph Jumentié (1879-1928), through his clinical skill and expertise in anatomical pathology, enhanced the prestige of the master neurologists he studied under- Jules Dejerine, Augusta Dejerine-Klumpke and Joseph Babiński -and their fame overshadowed the crucial support that Jumentié provided them. Following a remarkable doctoral thesis in 1911, which defined the semiology of tumors in the cerebellopontine angle, Jumentié conducted research into ...
Source: Revue Neurologique - July 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The RAPID-II Neuropsychological Test battery for subjects aged 20 to 49 years: Norms and cognitive profile.
Authors: Binetruy M, Mauny F, Lavaux M, Meyer A, Sylvestre G, Puyraveau M, Berger E, Magnin E, Vandel P, Galmiche J, Chopard G, RAPID-II study group Abstract INTRODUCTION: Cognitive evaluation of young subjects is now widely carried out for non-traumatic diseases such as multiple sclerosis, HIV, or sleep disorders. This evaluation requires normative data based on healthy adult samples. However, most clinicians use a set of tests that were normed in an isolated manner from different samples using different cutoff criteria. Thus, the score of an individual may be considered either normal or impaired according to the ...
Source: Revue Neurologique - July 5, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research