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Therapeutic progress and future prospects for immune ‐mediated neuropathy
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 26, 2024 Category: Neurology Authors: Kenichi Kaida Tags: EDITORIAL Source Type: research

Autoimmune nodopathy
AbstractAutoimmune nodopathy (AN) is characterized by the presence of autoantibodies targeting molecules essential for saltatory conduction in myelinated nerves. Clinical manifestations of AN show similarities with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), including progressive and symmetrical sensorimotor deficits with electrophysiological demyelinating features in nerve conduction studies. Although no common autoantibodies have yet been identified in CIDP, AN is characterized by autoantibodies that primarily target specific molecular complex structures represented by the Ranvier node and paranode....
Source: Clinical and Experimental Neuroimmunology - April 26, 2024 Category: Neurology Authors: Masahiro Iijima Tags: INVITED REVIEW Source Type: research

Therapeutic progress and future prospects of chronic inflammatory demyelinating polyradiculoneuropathy
AbstractChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare and heterogeneous but treatable immune-mediated neuropathy. The pathogenesis of CIDP is complex interplay of diverse immune mechanisms involving cellular and humoral pathways. The European Academy of Neurology/Peripheral Nerve Society guidelines were reissued in 2021, and the classification and diagnostic criteria were changed. Treatments include immunoglobulin, steroid, and plasmapheresis are effective, including remission induction and maintenance therapy. Maintenance treatments are often required for years, and treatment regimens require ...
Source: Clinical and Experimental Neuroimmunology - April 24, 2024 Category: Neurology Authors: Tomoko Okamoto Tags: INVITED REVIEW Source Type: research

Eculizumab administration for myasthenia gravis also stabilizes thrombogenicity of catastrophic antiphospholipid syndrome
ConclusionsEculizumab can be effective for controlling multiple complement-mediated pathophysiology. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 23, 2024 Category: Neurology Authors: Sunao Takahashi, Nobuo Sanjo, Ryuji Koike, Takanori Yokota Tags: CASE REPORT Source Type: research

Radiotherapy and stereotactic radiotherapy for multifocal intracranial and intramedullary Rosai –Dorfman disease
ConclusionsAdjuvant therapy with radiotherapy and steroidal therapy is a valid option in multicentric Rosai –Dorfman disease patients not eligible for surgery. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 12, 2024 Category: Neurology Authors: Salvatore D'Oria, Martina Rossitto, David Giraldi, Vincenzo Fanelli, Ilaria Bonaparte, Maria Paola Ciliberti, Alba Fiorentino Tags: CASE REPORT Source Type: research

Expert teleconsultation involving patients and their primary neurologists for the management of multiple sclerosis in regions without specialists
ConclusionsThe present study suggested that our expert teleconsultation system for MS reduces the burden on patients of visiting distant MS-specialized clinics, and enhances knowledge of MS management for the primary neurologists. It also promotes trust between patients and their primary neurologists, and taken together, these aspects could collectively lead to independent and sustainable MS management in regions without MS specialists. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 11, 2024 Category: Neurology Authors: Yusei Miyazaki, Shigehisa Ura, Kazuhiro Horiuchi, Takeshi Matsuoka, Hideki Houzen, Kazufumi Tsuzaka, Yuichi Makino, Manami Koshida, Genko Oyama, Chika Sato, Ryoji Naganuma, Itaru Amino, Sachiko Akimoto, Masaaki Niino, Naoya Minami, Eri Taka Tags: ORIGINAL ARTICLE Source Type: research

Immune ‐mediated spastic ataxia masquerading as clinically probable multisystem atrophy in an elderly woman
ConclusionsThis case emphasizes the diagnostic complexity of autoimmune neurological syndromes, particularly spastic ataxia. Autoimmune etiology should be considered even when neurodegenerative conditions seem likely. The presence of neuronal antibodies, inflammatory CSF, and response to immunotherapy underscores the role of autoimmunity in this case. Additionally, the “hot cross bun sign” may not always signify neurodegeneration, but can indicate immune-mediated neural damage. Recognizing autoimmune involvement early offers therapeutic possibilities and highlights the need for a comprehensive diagnostic approach in su...
Source: Clinical and Experimental Neuroimmunology - March 26, 2024 Category: Neurology Authors: Rithvik Ramesh, Anuhya Chadalawada, Pedapati Radhakrishna, Lakshmi Narasimhan Ranganathan, Philo Hazeena, Sundar Shanmugam, Deepa Avadhani Tags: CASE REPORT Source Type: research

Eculizumab use throughout pregnancy in two patients with aquaporin ‐4‐positive neuromyelitis optica spectrum disorder
ConclusionsWe present two cases of pregnant women with AQP4+ NMOSD treated with eculizumab. Both women gave birth to healthy babies, have had no relapses since initiating eculizumab, and continued their treatment after birth. These cases are further evidence of the successful use of eculizumab during pregnancy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 12, 2024 Category: Neurology Authors: Takeshi Fujimoto, Yasuhiro Maeda Tags: CASE REPORT Source Type: research

Paraproteinemia ‐associated neuropathy with or without anti‐myelin‐associated glycoprotein antibody
AbstractParaproteinemia-associated neuropathy (PAN) develops with paraproteinemia and is mainly caused by the monoclonal proliferation of mature B  cells, especially monoclonal gammopathy of undetermined significance (MGUS). PAN tends to increase with age, and in a super-aging society, its frequency is expected to increase. Among paraproteinemias, the immunoglobulin (Ig)G type is most common, but the frequency of PAN is reported to be higher for the IgM type. IgG/IgA-type PAN includes MGUS, plasma cell myeloma, and polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome. IgM-type PAN...
Source: Clinical and Experimental Neuroimmunology - February 27, 2024 Category: Neurology Authors: Masanori Nakajima Tags: INVITED REVIEW Source Type: research

Vasculitic neuropathy: Therapeutic progress and prospects
AbstractVasculitic neuropathy has a broad range of etiologies, and roughly comprises nonsystemic vasculitic neuropathy and neuropathies accompanied by antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Recent morphological analyses of sural nerve specimens from patients with vasculitic neuropathy showed some distinct pathogeneses within vasculitic neuropathy. Several randomized, controlled studies and updated practice guidelines cover immunotherapies for AAV, whereas there is a paucity of evidence for vasculitic neuropathy, including neuropathies associated with AAV. Corticosteroids have been the mainstay of ...
Source: Clinical and Experimental Neuroimmunology - February 21, 2024 Category: Neurology Authors: Michiaki Koga Tags: INVITED REVIEW Source Type: research

Dropped head syndrome in anti ‐MuSK antibody‐positive myasthenia gravis with possible concurrent axial myopathy
ConclusionThymoma-negative MuSK-MG, demonstrating treatment-refractory DHS, may present with concurrent axial myopathy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 19, 2024 Category: Neurology Authors: So Okubo, Mitsuhiro Kainaga, Shin ‐ichi Tokushige, Ayumi Uchibori, Chizuko Oishi, Teruyuki Hirano, Yaeko Ichikawa Tags: CASE REPORT Source Type: research

Successful treatment of multiple sclerosis with refractory rheumatoid arthritis using ofatumumab: A case report
ConclusionThere is growing evidence of significant involvement of B-cells in the pathogenesis of RA and the effectiveness of B-cell depletion therapy in managing RA. Ofatumumab is an effective treatment for patients with MS and refractory RA. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 19, 2024 Category: Neurology Authors: Kenju Hara, Masaru Togashi Tags: CASE REPORT Source Type: research

Issue Information
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 12, 2024 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

A thank you note to our reviewers
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 12, 2024 Category: Neurology Tags: ACKNOWLEDGMENT Source Type: research

The 35th annual meeting of the Japanese Society for Neuroimmunology (JSNI)
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 7, 2024 Category: Neurology Tags: ABSTRACT Source Type: research