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Efficacy of Monoclonal Antibodies in Neuromyelitis Optica: An Updated Systematic Review with Meta ‐analysis
AbstractThis is a critical review of studies aiming to assess the safety and efficacy of monoclonal antibodies as compared to the classical regimen in patients with NMOSD.Various electronic databases were searched for original articles reporting results from the use of monoclonal antibodies in NMOSD. EDSS and ARR score before and after treatment were the primary effect measure. The pooled standardized mean difference with 95% CI was calculated via the Random effect model. The heterogeneity of the included studies was calculated using Cochran ’s Q test and I2 statistics.Of 36 included studies, meta-analysis was conducted ...
Source: Clinical and Experimental Neuroimmunology - March 8, 2022 Category: Neurology Authors: Prajjwol Luitel, Anup Ghimire, Devansh Upadhyay, Rajeev Ojha Tags: REVIEW ARTICLE Source Type: research

Demyelinating neuropathy requires differential diagnosis with vasculitic neuropathy in rheumatoid arthritis: Significance of sural nerve electrophysiology findings
ConclusionDemyelinating neuropathy was found more often in patients with RA neuropathy than expected. Sural nerve sparing as well as the absence of SNAP or CMAP are useful for the differential diagnosis of demyelinating neuropathy with RV in RA patients with neuropathy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 20, 2022 Category: Neurology Authors: Masaki Kobayashi, Megumi Takeuchi, Miki Suzuki, Kazuo Kitagawa Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 15, 2022 Category: Neurology Tags: Issue Information Source Type: research

A thank you note to our reviewers
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 15, 2022 Category: Neurology Tags: ACKNOWLEDGEMENT Source Type: research

Current topics in neuroimmunology and neuroinfectious diseases
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 15, 2022 Category: Neurology Authors: Mineki Saito Tags: EDITORIAL Source Type: research

Radiological characteristics of Neuromyelitis Optica Spectrum Disorder in Egypt
ConclusionHigh frequency of abnormal Spine and Brain MRI findings in Egyptian population. Even though no specific patterns were typical for AQP4-specific serostatus, certain findings may suggest NMOSD diagnosis and warrant AQP4-IgGs testing. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 11, 2022 Category: Neurology Authors: Ahmed Nasreldein, Hasan Farweez, Noha abo Elfetoh, Eman R. Badawy, Doaa M. Mahmoud, Sara Hassanein, Eman Khedr Tags: ORIGINAL ARTICLE (DIRECT VIA EEO) Source Type: research

Nerve conduction studies support the classification of SARS ‐CoV‐2 associated Guillain‐Barre subtypes
Abstract- (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 10, 2022 Category: Neurology Authors: Josef Finsterer, Daniel Matovu, Fulvio A Scorza Tags: LETTER TO THE EDITOR Source Type: research

Coronavirus disease 2019 ‐associated encephalopathy: Characteristic brainstem and bilateral temporal lobe involvement
ConclusionsThe mechanisms of neuronal damage in COVID-19 remain undetermined, but pathogenesis of this case should be considered an autoimmune mechanism rather than direct viral damage to the central nervous system in COVID-19. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 3, 2022 Category: Neurology Authors: Yasutaka Tajima, Chika Sato, Yasunori Mito Tags: CLINICAL LETTER Source Type: research

Forefront studies on human T ‐cell leukemia virus type 1‐associated myelopathy/tropical spastic paraparesis
This study intends to describe the pathophysiology and treatments for human T-cell leukemia virus type  1-associated myelopathy/tropical spastic paraparesis elucidated from recent studies and the human T-cell leukemia virus type 1-associated myelopathy patient registry. AbstractHuman T-cell leukemia virus type  1 can cause human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma in some infected individuals. HAM/TSP is a rare progressive neurological disease characterized by spastic spinal paralysis. The developments in previous r esearch have id...
Source: Clinical and Experimental Neuroimmunology - January 31, 2022 Category: Neurology Authors: Naoki Takao, Yoshihisa Yamano Tags: INVITED REVIEW Source Type: research

Reply
Abstract- (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - January 28, 2022 Category: Neurology Authors: Takayoshi Shimohata Tags: LETTER TO THE EDITOR Source Type: research

Coronavirus ‐disease‐2019‐associated encephalopathy: characteristic brainstem and bilateral temporal lobe involvement
Abstract- (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - January 20, 2022 Category: Neurology Authors: Yasutaka Tajima, Chika Sato, Yasunori Mito Tags: CLINICAL LETTER Source Type: research

Transverse myelitis and coronavirus disease 2019 vaccine: A temporal association
ConclusionsIn the absence of other causes, the diagnosis of TM was made with evidence of a possible temporal association with ChAdOx1 nCoV-19 vaccine. It is important to emphasize that it is a temporal association only and the benefits of vaccination continue to outweigh the risk of TM. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - January 15, 2022 Category: Neurology Authors: Gustavo Figueiredo Silva, Caroline Figueiredo Silva, Raddib Eduardo Noleto da Nobrega Oliveira, Felipe William Dias Silva, Jo ão Pedro Ribeiro Baptista, Sabrina Hafemann Loz, Carla Heloisa Cabral Moro, Alexandre Luiz Longo, Gustavo da Cunha Ribas Tags: CASE REPORT Source Type: research

Forefront studies on HTLV ‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP)
This study intends to describe the pathophysiology and treatments for HAM/TSP elucidated from recent studies and the HAM/TSP patient registry. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - January 11, 2022 Category: Neurology Authors: Naoki Takao, Yoshihisa Yamano Tags: INVITED REVIEW Source Type: research

The spectrum of neuro ‐COVID is broadening
Abstract- (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - January 9, 2022 Category: Neurology Authors: Josef Finsterer, Daniel Matovu, Fulvio A Scorza Tags: LETTER TO THE EDITOR Source Type: research

Bornavirus infection in human diseases and its molecular neuropathology
AbstractBornavirus is a noncytolytic, neurotropic RNA virus that persistently infects the central nervous systems of vertebrates. Although bornavirus epidemiology has been investigated mainly in human psychiatric diseases for several decades, the involvement of persistent bornavirus infection in these diseases remains controversial. Recent studies have shown that two bornaviruses, Borna disease virus 1 and variegated squirrel bornavirus 1, can cause fatal encephalomyelitis in humans. In animal models, acute bornavirus infection causes immune-mediated encephalomyelitis, whereas persistent infection induces neurobehavioral d...
Source: Clinical and Experimental Neuroimmunology - January 7, 2022 Category: Neurology Authors: Tomoyuki Honda Tags: INVITED REVIEW Source Type: research