Clinical and Experimental Neuroimmunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Accelerating clinical research in neuromyelitis optica spectrum disorders
AbstractNeuromyelitis optica spectrum disorders are rare relapsing inflammatory central nervous system diseases with a heterogenous immunological and clinical spectrum. International collaborations are required to: (i) reach a better understanding of the disease and its subtypes; (ii) develop laboratory and imaging biomarkers; and (iii) ultimately improve treatments. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 27, 2021 Category: Neurology Authors: Frederike C. Oertel, Friedemann Paul Tags: COMMENTARY Source Type: research

Gluten intolerance antibodies in multiple sclerosis and clinically isolated syndrome : Coexistent or coincidental?
ConclusionWe observed that celiac antibodies were not more common in MS patients than healthy controls. However, these antibodies are important to suggest gastrointestinal complaints in MS patients. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 26, 2021 Category: Neurology Authors: Zeynep Ünlütürk, Levent Sinan Bir, Melek Demir Tags: ORIGINAL ARTICLE Source Type: research

Pembrolizumab ‐Induced Hypophysitis with Acute Progression of Rathke’s Cyst
AbstractImmune checkpoint inhibitor –induced hypophysitis is a rare complication of pembrolizumab, but the effects of drug‐induced hypophysitis on pre‐existing pituitary lesions are unknown. The authors treated an unusual case of pembrolizumab‐induced hypophysitis that resulted in acute exacerbation of a pre‐existing pituita ry cystic lesion causing severe intractable headaches. Before initiation of pembrolizumab therapy, magnetic resonance imaging should be carefully reviewed for sellar pathology. Patients demonstrating a Rathke’s cleft cyst should consider other forms of treatment first or be carefully counse...
Source: Clinical and Experimental Neuroimmunology - March 23, 2021 Category: Neurology Authors: Austin S. Gamblin, Spencer Twitchell, Bornali Kundu, William T. Couldwell, Sarah T. Menacho Tags: CASE REPORT Source Type: research

Neuroimmunology in neurological and psychiatric disorders
AbstractThe central nervous system (CNS) has long been considered as an immunological privileged site where the surveillance of the immune system does not reach out. However, it is now recognized that this CNS homeostasis is collapsed by neuroinflammation such as influx of pro ‐inflammatory factors and cells, neuronal dysfunction, and glial activation. Currently, CNS neuroinflammation is considered as a main pathomechanism to mediate disease progression in not only neurotrauma and neuroinflammatory disorders but also neurodegenerative diseases including dementia. Moreov er, growing evidence indicates that chronic CNS neu...
Source: Clinical and Experimental Neuroimmunology - March 17, 2021 Category: Neurology Authors: Hideyuki Takeuchi Tags: REVIEW ARTICLE Source Type: research

Insights from the differences in clinical profiles of neuroimmune disorders between patients in Japan and those in Western countries
AbstractFew studies have investigated the differences in the clinical profiles of neuroimmune disorders between patients in Japan and those in Western countries.1 ‐5 In 1981, Shibasaki et al. first reported the difference in clinical features of multiple sclerosis (MS) between Japanese patients and British patients.2 Japanese patients with MS had a higher prevalence of and more severe visual involvement and were more likely to have myelitis and brainstem syndrome compared to British patients with MS. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 12, 2021 Category: Neurology Authors: Masahiro Mori Tags: NEW DEVELOPMENTS IN NEUROIMMUNOLOGY Source Type: research

Checkpoint inhibitor –induced autoimmune central nervous system disorder in patients with metastatic melanoma and Hodgkin’s lymphoma
ConclusionsWe demonstrate that symptoms of immune checkpoint inhibitor –induced encephalitis can be unspecific, and radiological findings are often inconspicuous. Thus, cerebrospinal fluid analysis is the most important examination to achieve a correct diagnosis, which in turn is decisive for a rapid start of therapy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 11, 2021 Category: Neurology Authors: Nora M öhn, Kurt‐Wolfram Sühs, Yenny Angela, Martin Stangel, Philipp Ivanyi, Gernot Beutel, Ralf Gutzmer, Thomas Skripuletz, Imke Grimmelmann Tags: ORIGINAL ARTICLE Source Type: research

Gluten intolerance antibodies in Multiple Sclerosis and clinically isolated syndrome: coexistent or coincidental?
ConclusionWe observed that Celiac antibodies were not more common in MS than healthy controls.However these antibodies are important to suggest gastrointestinal complaints in MS. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 8, 2021 Category: Neurology Authors: Zeynep Ünlütürk, Levent Sinan Bir, Melek Demir Tags: ORIGINAL ARTICLE Source Type: research

Inflammation in psychiatry especially focused on depression
The pathology of depression is closely associated with inflammatory processes. These processes might account for the underlying mechanism between depression and other disorders, including metabolic disorders and dementia. AbstractThe etiology of depression remains unclear, while, in many aspects, the pathology of depression has recently been reported to be closely associated with inflammation. The inflammatory processes often found in the acute stage of depression might have a profound influence of the prognosis of depression. These processes might account for the underlying mechanism between depression and other disorders...
Source: Clinical and Experimental Neuroimmunology - March 1, 2021 Category: Neurology Authors: Akira Monji Tags: REVIEW ARTICLE Source Type: research

Multiple sclerosis limited to spinal cord lesions
ConclusionsThe identified phenotype of MS seems to be female dominant and presents a relatively mild clinical course without pathological brain atrophy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 23, 2021 Category: Neurology Authors: Wataru Takeuchi, Juichi Fujimori, Ichiro Nakashima Tags: ORIGINAL ARTICLE Source Type: research

Cerebral amyloid angiopathy ‐related inflammation and dementia
AbstractCerebral amyloid angiopathy (CAA) is a disorder characterized by deposition of amyloid on the leptomeningeal and cortical blood vessels. Sporadic amyloid β (Aβ)‐type CAA is the most common type of CAA. Although CAA has been well known as a cause of recurrent cerebral lobar hemorrhage, inflammation and vasculitis (CAA‐related inflammation: CAA‐ri) induced by deposited Aβ on the vessel walls is emerging as a treatable condition. Furthermore, d ementia could be developed regardless of presence of Alzheimer’s disease pathology. Estimated total number and prevalence of CAA‐ri in Japan was reported as follow...
Source: Clinical and Experimental Neuroimmunology - February 20, 2021 Category: Neurology Authors: Kenji Sakai, Masahito Yamada Tags: REVIEW ARTICLE Source Type: research

Pediatric demyelinating disease and anti ‐MOG antibody
The wide spectrum of MOG ‐associated CNS demyelination, including monophasic and relapsing forms, seems to be now better understood. Although most children have a good clinical outcome, MOGAD may be a severe relapsing and devastating disorder for a subgroup of patients. Considering the moderate response to current standar d relapse prevention therapies additional safe and long‐term efficacious treatment options are still much needed for children with relapsing MOG demyelination. AbstractSignificant progress has been made in the field of pediatric neuroimmunology over the past few years. With the detection of conformati...
Source: Clinical and Experimental Neuroimmunology - February 18, 2021 Category: Neurology Authors: Silvia N. Tenembaum Tags: REVIEW ARTICLE Source Type: research

Practical recognition tools of immunoglobulin  G serum antibodies against the myelin oligodendrocyte glycoprotein‐positive optic neuritis and its clinical implications
In this review, we discuss the clinical and paraclinical features of immunoglobulin  G serum antibodies against myelin oligodendrocyte glycoprotein‐positive optic neuritis in adults, and focus on the distinctive features that can enable its early diagnosis. Therapeutical considerations at the acute stage and for relapse prevention are further deliberated. AbstractMyelin oligodendrocyte glycoprotein (MOG) ‐associated disease is an autoimmune disease of the central nervous system, associated with the presence of immunoglobulin G serum antibodies against MOG. Recent data have allowed characterization of the clinical spe...
Source: Clinical and Experimental Neuroimmunology - February 18, 2021 Category: Neurology Authors: Itay Lotan, Frederike C. Oertel, Claudia Chien, Susanna Asseyer, Friedemann Paul, Hadas Stiebel ‐Kalish Tags: REVIEW ARTICLE Source Type: research

Treatment of myelin oligodendrocyte glycoprotein immunoglobulin  G–associated disease
This review summarizes the current understanding of acute and chronic treatments for MOGAD. Timing and duration of treatment, pregnancy, and emerging therapies are also discussed. AbstractMyelin oligodendrocyte glycoprotein (MOG) immunoglobulin  G (IgG)–associated disease (MOGAD) is increasingly recognized as a distinct nosological entity from aquaporin‐4 antibody IgG–positive neuromyelitis optica spectrum disorder (AQP4‐IgG NMOSD). The advent of highly specific MOG‐IgG cell‐based diagnostic assays have helped to refine our un derstanding of the clinical spectrum of MOGAD. To date, treatment approaches have be...
Source: Clinical and Experimental Neuroimmunology - February 18, 2021 Category: Neurology Authors: Sarah Healy, Kariem Tarik Elhadd, Emily Gibbons, Dan Whittam, Michael Griffiths, Anu Jacob, Saif Huda Tags: REVIEW ARTICLE Source Type: research