Clinical and Experimental Neuroimmunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Myelin oligodendrocyte glycoprotein antibody ‐associated disorders: An overview
AbstractIn recent years, there is growing evidence of associations between antibodies against myelin oligodendrocyte glycoprotein (MOG) and several phenotypes of acute inflammatory demyelinating diseases such as acute disseminated encephalomyelitis (ADEM), optic neuritis, brainstem, and cerebral cortical encephalitis, called MOG antibody associated disorders (MOGAD). Monophasic course is known in about half of cases especially in pediatric onset ADEM and optic neuritis, mainly in cases with transient positivity of MOG antibody. Pathological features of MOGAD are considered as acute demyelinating lesions with CD4 dominant c...
Source: Clinical and Experimental Neuroimmunology - December 20, 2023 Category: Neurology Authors: Tatsuro Misu, Yuki Matsumoto, Kimihiko Kaneko, Toshiyuki Takahashi, Yoshiki Takai, Hirohiko Ono, Chihiro Namatame, Shuhei Nishiyama, Juichi Fujimori, Hiroshi Kuroda, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki Tags: INVITED REVIEW Source Type: research

Holmes tremor in progressive multifocal leukoencephalopathy: A video case report
ConclusionsAlthough tremors are rarely observed in PML, HT might be a common tremor phenotype in patients with PML. If the neurologist observes HT in patients with multiple brain lesions, PML should be considered. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - November 28, 2023 Category: Neurology Authors: Takako Matsushima, Ryotaro Ikeguchi, Mutsumi Iijima, Ayato Shimomura, Shuntaro Takahashi, Kazuo Nakamichi, Yuko Shimizu, Kazuo Kitagawa Tags: CASE REPORT Source Type: research

Performance evaluation of the EUROIMMUN anti ‐acetylcholine receptor enzyme‐linked immunoassay
ConclusionsThe AchR Ab ELISA provides a reliable tool for the quantification of AchR Ab, supporting the diagnosis of MG. As a non-isotopic assay with good precision, shorter handling time and high correlation with the conventional RIA, the AChR ELISA could be a useful alternative in the laboratory routine. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - November 21, 2023 Category: Neurology Authors: Naoki Kawaguchi, Asami Imafuku, Satoshi Fujii, Ji ‐Hoon Sohn Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - November 13, 2023 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Autoimmune disorders mimicking neurodegenerative diseases
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - November 13, 2023 Category: Neurology Authors: Hideyuki Takeuchi Tags: EDITORIAL Source Type: research

Acute ‐onset distal dominant neuropathy after severe acute respiratory syndrome coronavirus 2 vaccination in a male patient with recent dengue infection: A case report
ConclusionThe enhanced immune response from a recent dengue infection and severe acute respiratory syndrome coronavirus  2 vaccination might increase the risk of GBS. The predominantly distal GBS phenotype has rarely been reported in the literature, adding to the peculiarity of this case. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - November 9, 2023 Category: Neurology Authors: Mario B. Prado Jr, Karen Joy B. Adiao Tags: CASE REPORT Source Type: research

Expanding clinical spectrum from Hashimoto's encephalopathy to anti ‐NAE antibody‐associated disorders (NAEAD)
AbstractUsing proteomic analysis, we identified anti-NAE antibodies (autoantibodies againstNH2-terminal ofalpha-enolase) as a diagnostic marker for Hashimoto's encephalopathy (HE). As cases of HE with serum anti-NAE antibodies accumulated, the clinical spectrum of HE with anti-NAE antibodies became expanded. In addition, it is now known that antibodies can be detected in other diseases that differ from conventional HE. We recently reported the detection of anti-NAE antibodies in patients with a clinical diagnosis of multiple system atrophy or corticobasal syndrome. These findings suggest that anti-NAE antibodies indicate a...
Source: Clinical and Experimental Neuroimmunology - November 3, 2023 Category: Neurology Authors: Akiko Matsunaga, Masamichi Ikawa, Makoto Yoneda Tags: INVITED REVIEW Source Type: research

What might the COVID ‐19 pandemic in regard to people with neuromyelitis optica spectrum disorder teach us regarding the future?
ConclusionsDue to the small sample size, there was no predominant difference in infection between infected and uninfected patients with or without immunosuppressant drugs. However, given that immunosuppressants are a risk for infection, patient decision-making in their selection is important. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - October 9, 2023 Category: Neurology Authors: Cavid Baba, Ipek Yavas, Ulvi Samadzade, Asiye Tuba Ozdogar, Serkan Ozakbas Tags: ORIGINAL ARTICLE Source Type: research

Anti ‐aquaporin‐4 immunoglobulin G/anti‐myelin oligodendrocyte glycoprotein immunoglobulin G double‐positive paraneoplastic neurological syndrome in a patient with triple‐negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40  year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1  year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis...
Source: Clinical and Experimental Neuroimmunology - September 19, 2023 Category: Neurology Authors: Amna Siddiqui, Dylan Ross, Ronak H. Jani, Vikram C. Prabhu, Shelly Lo, Derek A. Wainwright, Stasia Rouse, Tamer Refaat, Yirong Zhu, Jigisha P. Thakkar Tags: CASE REPORT Source Type: research

Efficacy and safety of zilucoplan in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the phase  III randomized RAISE study
ConclusionsIn a subgroup of Japanese patients, zilucoplan showed clinically meaningful improvement in MG-specific outcomes with a favorable safety profile, consistent with the overall RAISE population. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - September 16, 2023 Category: Neurology Authors: Kimiaki Utsugisawa, Kazushi Deguchi, Shingo Konno, Masayuki Masuda, Naoya Minami, Hiroyuki Murai, Shigeaki Suzuki, Yasushi Suzuki, Akira Tsujino, Akiyuki Uzawa, Babak Boroojerdi, Guillemette Borderie, Melissa Brock, Petra W. Duda, Mark Vande Tags: ORIGINAL ARTICLE Source Type: research

Disorders related to antineuronal antibodies: Autoimmune epilepsy
Autoimmune epilepsy is a subtype of autoimmune encephalitis characterized by an increased frequency of epileptic seizures. The clinical diagnosis of this condition is often challenging, particularly in the absence of overt inflammatory indicators. In this review, we present a comprehensive exploration of the existing literature encompassing the clinical features, laboratory findings, underlying pathophysiology, and available treatment modalities associated with this condition. AbstractAutoimmune epilepsy is characterized as a subtype of autoimmune encephalitis, where epileptic seizures serve as the primary or predominant m...
Source: Clinical and Experimental Neuroimmunology - August 31, 2023 Category: Neurology Authors: Shusuke Koto, Norio Chihara, Atsushi Hara, Riki Matsumoto Tags: REVIEW ARTICLE Source Type: research

Guillain –Barré syndrome after COVID‐19 vaccination with suspected concurrent cytomegalovirus reactivation
ConclusionsThe present case suggests that cytomegalovirus reactivation might play a role in the pathogenesis of GBS associated with COVID-19 vaccination. Accounting for cytomegalovirus reactivation might reveal unidentified pathophysiology of GBS after COVID-19 vaccination. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - August 30, 2023 Category: Neurology Authors: Katsuhiro Itogawa, So Okubo, Minako Yamada, Taro Bannai, Tomonari Seki, Ayumi Uchibori, Yasushi Shiio Tags: CASE REPORT Source Type: research

A case of severe paraneoplastic glutamic acid decarboxylase antibody ‐spectrum disorder with improvement through prior immunotherapy before surgical intervention
ConclusionIn paraneoplastic GAD-SD cases with severe symptoms at presentation, prioritizing immunotherapy and considering surgical intervention once the symptoms have stabilized might be advantageous. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - August 18, 2023 Category: Neurology Authors: Satoshi Nozuma, Mika Yuji ‐Takeuchi, Tomonori Nakamura, Ryuji Saigo, Mirai Masuda, Masahiro Ando, Yusuke Sakiyama, Ryo Miyata, Kazuhiro Tabata, Eiji Matsuura, Hiroshi Takashima Tags: CASE REPORT Source Type: research

Issue Information
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - August 10, 2023 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Childhood myasthenia gravis in Japan: Pathophysiology and treatment options
AbstractMyasthenia gravis (MG) is a disease that causes muscle weakness and fatigue due to an abnormality in the neuromuscular junction, which prevents the transmission of information. In the 1970s, it became clear that MG was caused by an autoimmune mechanism, and treatments began to be developed. Most studies on the pathophysiology and treatment of MG have been conducted in adults. However, even in terms of acetylcholine receptor antibodies, which are related to MG pathophysiology, adults and children differ significantly. Moreover, epidemiological studies around the world have revealed significant differences in the pre...
Source: Clinical and Experimental Neuroimmunology - July 20, 2023 Category: Neurology Authors: Masatoshi Hayashi Tags: REVIEW ARTICLE Source Type: research