Clinical and Experimental Neuroimmunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Role of effector T cells in multiple sclerosis
AbstractMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and the imbalance between autoimmunity and immune tolerance is considered to be the key factor for its pathogenesis. Effector T cells are shown to be involved not only in the early relapse ‐remitting phase of this disease but also in the later progressive phase, which is thought to further promote the disease pathogenesis. Given the clinical benefits of the immune modulating reagents, which are designated as disease‐modifying treatments, growing evidences have demonstrated their a ssociation with the amelioration of pathogen...
Source: Clinical and Experimental Neuroimmunology - May 3, 2020 Category: Neurology Authors: Norio Chihara Tags: REVIEW ARTICLE (INVITED) Source Type: research

Serum anti ‐thyroid antibodies in Hashimoto’s Encephalopathy: a never‐ending story
ABSTRACTHashimoto ’s encephalopathy (HE) is a neurological disorder characterized by high serum concentration of anti‐thyroid antibodies (ATA), a wide array of neurological disorders (i.e. seizures, cerebellar syndrome, psychiatric symptoms, etc), and responsiveness to steroid therapy1. Although the detection of serum ATA [namely anti ‐thyroid peroxidase (TPO) antibodies and anti‐thyroglobulin (TG) antibodies] is a hallmark of HE, comparable increased serum ATA levels can also be detected in normal subjects2. The precise role of these antibodies in the aetiopathogenesis of HE is therefore not clear. An open questio...
Source: Clinical and Experimental Neuroimmunology - May 1, 2020 Category: Neurology Authors: Tommaso Ercoli, Federica Genitori, Giovanni Defazio, Antonella Muroni Tags: LETTER TO THE EDITOR Source Type: research

CNS Lupus presenting as rhombencephalitis responding to aggressive immunotherapy: A unique case
ConclusionsCNS lupus should be included in the provisional diagnosis of any young female patient presenting with complicated neurological manifestations over the background of joint pain or fever or headache or confusion or psychosis, in order to avoid misdiagnosis and aid in timely institution of aggressive immunotherapy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 24, 2020 Category: Neurology Authors: Harleen Kaur, Gaurav Kumar Mittal, Jennifer Singhdev Tags: CASE REPORT Source Type: research

Regulatory T cells in multiple sclerosis
AbstractRegulatory T (Treg) cells are known to suppress excessive inflammation in autoimmune diseases, including multiple sclerosis (MS). Accumulating evidence suggests that the frequency and suppressive function of Treg cells are altered in patients with MS, which might be involved in development and exacerbation of the disease. Besides, there are several Treg cell populations with distinct functions, which are differently affected by MS. The importance of these observations is supported by studies using an animal disease model, experimental autoimmune encephalomyelitis (EAE). The environmental factors are also discussed ...
Source: Clinical and Experimental Neuroimmunology - April 23, 2020 Category: Neurology Authors: Kimitoshi Kimura Tags: REVIEW ARTICLE Source Type: research

Long ‐term prognosis of Japanese Lambert–Eaton myasthenic syndrome patients with or without small‐cell lung carcinoma
ConclusionsIn Japanese LEMS patients, the long ‐term neurological outcome is generally favorable. Our results also suggest that even in LEMS with SCLC patients, successful treatment for their cancer could result in sustained improvement in neurological symptoms. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 19, 2020 Category: Neurology Authors: Yuta Kojima, Akiyuki Uzawa, Kazumoto Shibuya, Manato Yasuda, Yukiko Ozawa, Fumiko Oda, Hirokazu Shiraishi, Masakatsu Motomura, Satoshi Kuwabara Tags: ORIGINAL ARTICLE Source Type: research