Intravenous immunoglobulin and rituximab in a treatment ‐refractory COVID‐19‐associated central nervous system vasculitis: A case report and literature review
In this study, we present the first case of treatment-refractory CNS vasculitis associated with COVID-19, which was treated successfully with intravenous immunoglobulin and rituximab. Second, we repo rt a review of COVID-19-related CNS vasculitis articles and applied treatment strategies published in English. To elucidate the mechanism of COVID-19-related CNS vasculitis, further research is needed. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 19, 2023 Category: Neurology Authors: Onur Anil Mutlu, Merve İriş, Nursena Erener, Osman Kizilkiliç, Civan Işlak, Emire Seyahi, Sabahattin Saip, Uğur Uygunoğlu Tags: REVIEW ARTICLE Source Type: research

Impact of early introduction of biologics on internal medications for neuromyelitis optica spectrum disorder
ConclusionsBiologics can be introduced early after NMOSD relapse to reduce prednisolone dosage and counteract polypharmacy. The high relapse prevention rate of biologics makes them a valuable option for preventing relapse in patients with NMOSD. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 14, 2023 Category: Neurology Authors: Kenzo Sakurai, Kenji Isahaya, Takeshi Imai, Yoshihisa Yamano Tags: ORIGINAL ARTICLE Source Type: research

Pathogenesis, clinical features and treatment of anti ‐IgLON5 disease
Anti-immunoglobulin-like cell adhesion molecule  5 (IgLON5) disease is an autoimmune encephalitis that presents with various symptoms, including sleep disorders, bulbar palsy, movement disorders, cognitive dysfunction and neuromuscular manifestations. Some patients have features mimicking neurodegenerative diseases, such as progressive supranuc lear palsy and amyotrophic lateral sclerosis. In this review, we summarize the pathogenesis, clinical manifestations, diagnostic examination and treatment of anti-immunoglobulin-like cell adhesion molecule 5 disease. AbstractAnti-immunoglobulin-like cell adhesion molecule  5 (...
Source: Clinical and Experimental Neuroimmunology - July 7, 2023 Category: Neurology Authors: Yoya Ono, Akio Kimura, Takayoshi Shimohata Tags: INVITED REVIEW Source Type: research

Twenty ‐nail dystrophy and alopecia areata in an adult male with thymoma‐associated myasthenia gravis: A case report
ConclusionThymoma is the possible risk factor and link for the co-occurrence of the three conditions in the present patient. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - June 21, 2023 Category: Neurology Authors: Mario B. Prado, Maria Franchesca Quinio, Karen Joy B. Adiao Tags: CASE REPORT Source Type: research

Invited review article: Autoimmune cerebellar ataxia
AbstractAmong the different forms of cerebellar ataxia, autoimmune cerebellar ataxia (ACA) or immune-mediated cerebellar ataxia (IMCA), which appears to be based on an autoimmune mechanism, has long been considered important from the viewpoint of paraneoplastic syndrome. With the expansion of the concept of immune-mediated neurological diseases and the identification of many novel autoantibodies, ACA has recently become an important neurological syndrome. Although no definitive diagnostic criteria of ACA exist, Hadjivassilou et al suggested diagnostic criteria for primary ACA in 2020 and Dalmau and Graus showed proposed di...
Source: Clinical and Experimental Neuroimmunology - May 24, 2023 Category: Neurology Authors: Hiroaki Yaguchi, Akihiko Kudo, Ichiro Yabe Tags: INVITED REVIEW Source Type: research

Autoimmune cerebellar ataxia
AbstractAmong the different forms of cerebellar ataxia, autoimmune cerebellar ataxia (ACA) or immune-mediated cerebellar ataxia (IMCA), which appears to be based on an autoimmune mechanism, has long been considered important from the viewpoint of paraneoplastic syndrome. With the expansion of the concept of immune-mediated neurological diseases and the identification of many novel autoantibodies, ACA has recently become an important neurological syndrome. Although no definitive diagnostic criteria of ACA exist, Hadjivassilou et al suggested diagnostic criteria for primary ACA in 2020 and Dalmau and Graus showed proposed di...
Source: Clinical and Experimental Neuroimmunology - May 23, 2023 Category: Neurology Authors: Hiroaki Yaguchi, Akihiko Kudo, Ichiro Yabe Tags: INVITED REVIEW Source Type: research

Issue Information
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 19, 2023 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Neuroinflammation and neuroimmunology in Alzheimer's disease
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 19, 2023 Category: Neurology Authors: Koji Yamanaka Tags: EDITORIAL Source Type: research

Pathogenesis, clinical features, and treatment of anti ‐IgLON5 disease
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 16, 2023 Category: Neurology Authors: Yoya Ono, Akio Kimura, Takayoshi Shimohata Tags: INVITED REVIEW Source Type: research

Post ‐COVID‐19 vaccination Guillain–Barré syndrome with sensory ataxia, gaze‐evoked nystagmus, mental‐status change and positive pathological reflex
ConclusionsThis is the first coronavirus disease 2019 vaccine-related GBS complicated with such central nervous system manifestations. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 11, 2023 Category: Neurology Authors: Nanami Saso, Shuta Toru, Keiichi Iwasaru, Hiroaki Yokote, Toshiki Uchihara Tags: CASE REPORT Source Type: research

Identification of neuromuscular medullary thymic epithelial cells in thymoma with myasthenia gravis
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 9, 2023 Category: Neurology Authors: Tatsusada Okuno, Yoshiaki Yasumizu, Hideki Mochizuki Tags: HIGHLIGHT Source Type: research

Two cases of unilateral cortical fluid ‐attenuated inversion recovery‐hyperintense lesions in anti‐MOG‐associated encephalitis with seizures (FLAMES)
ConclusionsBoth patients were diagnosed with MOGAD due to characteristic unilateral cortical encephalitis on brain FLAIR MRI. Unilateral cortical FLAMES is an important clue for the clinical diagnosis of MOGAD. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 8, 2023 Category: Neurology Authors: Kunihiko Ishizawa, Osamu Iwasaki, Hironori Oka, Takashi Sugawara, Masakuni Amari, Takeshi Kawarabayashi, Koichi Okamoto, Kimihiko Kaneko, Toshiyuki Takahashi, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji Tags: CASE REPORT Source Type: research

Invited Review Article Autoimmune Cerebellar Ataxia
AbstractAmong the different forms of cerebellar ataxia, autoimmune cerebellar ataxia (ACA) or immune-mediated cerebellar ataxia (IMCA), which appears to be based on an autoimmune mechanism, has long been considered important from the viewpoint of paraneoplastic syndrome. With the expansion of the concept of immune-mediated neurological diseases and the identification of many novel autoantibodies, ACA has recently become an important neurological syndrome. Although no definitive diagnostic criteria of ACA exist, Hadjivassilou et al. suggested diagnostic criteria for primary ACA in 2020 and Dalmau and Graus showed proposed d...
Source: Clinical and Experimental Neuroimmunology - May 3, 2023 Category: Neurology Authors: Hiroaki Yaguchi, Akihiko Kudo, Ichiro Yabe Tags: INVITED REVIEW Source Type: research

Post ‐COVID‐19 vaccination Guillain‐Barré syndrome with sensory ataxia, gaze‐evoked nystagmus, mental‐status change, and positive pathological reflex
ConclusionsThis is the first COVID-19 vaccine-related GBS complicated with such central nervous system manifestations. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 29, 2023 Category: Neurology Authors: Nanami Saso, Shuta Toru, Keiichi Iwasaru, Hiroaki Yokote, Toshiki Uchihara Tags: CASE REPORT Source Type: research

Neuropilin ‐1 (NRP1): A new marker for pathogenic autoreactive T‐helper cells in autoimmune disease
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 27, 2023 Category: Neurology Authors: Ben J. E. Raveney, Takashi Yamamura, Shinji Oki Tags: HIGHLIGHT Source Type: research