Clinical and Experimental Neuroimmunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Systematic review and network meta ‐analysis comparing ofatumumab with other disease‐modifying therapies available in Japan for the treatment of patients with relapsing multiple sclerosis
ConclusionThese findings, although limited by the paucity of evidence for Japanese patients, suggest that monoclonal antibody therapies (ie, natalizumab and ofatumumab) may provide improved efficacy compared with other DMTs available in Japan for patients with RMS. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 13, 2022 Category: Neurology Authors: Christopher Drudge, Melody Zhao, Satoru Tanaka, Nozomu Tanaka, Hiromichi Otaka, Izumi Kawachi, Dieter A. H äring, Róisín Brennan, Nicholas Adlard, Imtiaz A. Samjoo Tags: ORIGINAL ARTICLE Source Type: research

Disease Perception impacts Quality of Life and Fatigue in Relapsing ‐remitting Multiple Sclerosis patients
ConclusionsOur study showed no association between disease duration and disease perception. Patients with less disease knowledge reported more problems in self-care and higher fatigue scores. Patients with worst disease expectations were more anxious and reported a worst health status. More attention should be driven to perceived health status in MS patients. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 7, 2022 Category: Neurology Authors: Ana Rita Silva, Helena Felgueiras, Ana Isabel Gon çalves, Andreia Fernandes, Bruna Meira, Diana Melância, José Rosa, Maria Teresa Silvério, Ana Macedo Tags: ORIGINAL ARTICLE Source Type: research

Acute disseminated encephalomyelitis in an elderly patient following pneumococcal vaccination with extremely high cerebrospinal fluid interleukin ‐6
ConclusionAlthough PPSV23 is recommended for elderly individuals, this case highlights the risk of ADEM caused by unexpected immune activation following repeated administration of the vaccine. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 6, 2022 Category: Neurology Authors: Yuu ‐ichi Kira, Takumi Tashiro, Norihisa Maeda Tags: CASE REPORT Source Type: research

A systematic review and network meta ‐analysis comparing ofatumumab with other disease‐modifying therapies available in Japan for the treatment of patients with relapsing multiple sclerosis
ConclusionsThese findings, although limited by the paucity of evidence for Japanese patients, suggest that monoclonal antibody therapies (i.e. natalizumab and ofatumumab) may provide improved efficacy compared with other DMTs available in Japan for patients with RMS. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 1, 2022 Category: Neurology Authors: Christopher Drudge, Melody Zhao, Satoru Tanaka, Nozomu Tanaka, Hiromichi Otaka, Izumi Kawachi, Dieter A. H äring, Róisín Brennan, Nicholas Adlard, Imtiaz A. Samjoo Tags: ORIGINAL ARTICLE Source Type: research

MOG antibody ‐related disorder associated with peripheral facial nerve palsy
We report here a rare case of a MOG antibody-related disorder with peripheral facial nerve palsy as a predominant symptom. We should be aware of this disease even in a case of peripheral facial nerve palsy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - June 13, 2022 Category: Neurology Authors: Yuto Morishima, Akane Satake, Takanori Hata, Kishin Koh, Takamura Nagasaka, Toshiyuki Takahashi, Kazumasa Shindo, Yoshihisa Takiyama Tags: CASE REPORT Source Type: research

Double trouble: A case of spinal muscular atrophy type  III found to be complicated by myasthenia gravis due to subacute dysphagia
ConclusionsSMA type  III is a disease manifesting as slowly progressive muscle weakness. When the muscle weakness progresses and dysphagia appears subacutely in SMA type III patients, it is necessary to consider the complications of other diseases, such as MG. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - June 10, 2022 Category: Neurology Authors: Ruoyi Ishikawa, Takamichi Sugimoto, Takafumi Abe, Narumi Ohno, Mayumi Giga, Hiroyuki Naito, Tomoyuki Kono, Eiichi Nomura, Takemori Yamawaki Tags: CASE REPORT Source Type: research

Safety and effectiveness of eculizumab in Japanese patients with generalized myasthenia gravis: Analysis of 1 ‐year post‐marketing surveillance
ConclusionEculizumab was well tolerated and effective in treating AChR Ab+ gMG across a broad spectrum of adult Japanese patients with difficult-to-control gMG. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - June 3, 2022 Category: Neurology Authors: Hiroyuki Murai, Shigeaki Suzuki, Yuji Fukamizu, Takehiko Osawa, Hidekazu Kikui, Kimiaki Utsugisawa Tags: ORIGINAL ARTICLE Source Type: research

Thalamic atrophy, duration of illness, and years of education are the best predictors of cognitive impairment in multiple sclerosis
ConclusionWe confirmed the presence of gray matter atrophy of the brain in RRMS patients. Volumetric magnetic resonance imaging measures of thalamus, duration of illness, and years of education could be useful biomarkers of CI in RRMS. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 30, 2022 Category: Neurology Authors: Eman M. Khedr, Tarek Desoky, Ayman Gamea, Mohammed Y. Ezzeldin, Ahmed F. Zaki Tags: ORIGINAL ARTICLE Source Type: research

Anti ‐Zic4 encephalitis in endometrial cancer: autoimmunity triggered by PD‐1 Inhibitor or recent CMV encephalitis?
ConclusionsIn anti-Zic4 encephalitis, both PD-1 inhibitor treatment and recent CMV viral insult may contribute to the development of neurological autoimmunity. Further research is needed to identify ways of predicting neurological damage in oncological patients treated with ICIs. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 27, 2022 Category: Neurology Authors: Eugenia Filippakopoulou, Persefoni Karachalia, Maria Gryllia, Stella Marousi Tags: CASE REPORT Source Type: research

Changes in the amplitude decremental response to repetitive nerve stimulation following fast ‐acting treatment in patients with myasthenia gravis during hospitalization
ConclusionsThe changes in amplitude decrements detected by RNS reflected the therapeutic effect of FT in patients with generalized MG. RNS responses in the proximal muscles may be potentially useful as an objective measure of improvement after aggressive immunotherapy in patients with MG during hospitalization. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 23, 2022 Category: Neurology Authors: Hiroyuki Naito, Takamichi Sugimoto, Katsumi Kurokawa, Kazuki Kimoto, Takafumi Abe, Chika Matsuoka, Narumi Ohno, Mayumi Giga, Tomoyuki Kono, Hiroki Ueno, Eiichi Nomura Tags: ORIGINAL ARTICLE Source Type: research

Intravenous Immunoglobulin in the Management and Outcome of Stiff ‐Person Syndrome: A Systematic Review
ConclusionIVIG may benefit patients with SPS along with other medications. Owing to the rarity of the disease and insufficient studies on the assessment of immunotherapy in SPS, longitudinal studies with a sizable number of patients are required to clarify clinical course, treatment, and outcome in SPS with the use of IVIG. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 23, 2022 Category: Neurology Authors: Roshan Aryal, Suraj Shrestha, Sushan Homagain, Sansar Babu Tiwari, Rajeev Ojha Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 19, 2022 Category: Neurology Tags: Issue Information Source Type: research

A MOG antibody ‐related disorder associated with peripheral facial nerve palsy
We report here a rare case of a MOG antibody-related disorder with peripheral facial nerve palsy as a predominant symptom. We should be aware of this disease even in a case of peripheral facial nerve palsy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 19, 2022 Category: Neurology Authors: Yuto Morishima, Akane Satake, Takanori Hata, Kishin Koh, Takamura Nagasaka, Toshiyuki Takahashi, Kazumasa Shindo, Yoshihisa Takiyama Tags: CASE REPORT Source Type: research

Double trouble: A case of spinal muscular atrophy type III found to be complicated by myasthenia gravis due to subacute dysphagia
ConclusionsSMA type III is a disease manifesting as slowly progressive muscle weakness. When the muscle weakness progresses and dysphagia appears subacutely in SMA type III patients, it is necessary to consider the complications of other diseases such as MG. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 17, 2022 Category: Neurology Authors: Ruoyi Ishikawa, Takamichi Sugimoto, Takafumi Abe, Narumi Ohno, Mayumi Giga, Hiroyuki Naito, Tomoyuki Kono, Eiichi Nomura, Takemori Yamawaki Tags: CASE REPORT Source Type: research

Association of the Processing Speed Test with depression and brain magnetic resonance imaging metrics in Japanese patients with multiple sclerosis
ConclusionPST score was associated with the severity of depression and both global and regional brain volume in Japanese patients with MS. Our findings support the validity of the PST as a useful tool for assessing the cognitive function of MS patients in clinical practice. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - May 16, 2022 Category: Neurology Authors: Yusei Miyazaki, Masaaki Niino, Eri Takahashi, Kei Oiwa, Ryoji Naganuma, Itaru Amino, Sachiko Akimoto, Naoya Minami, Seiji Kikuchi Tags: ORIGINAL ARTICLE Source Type: research