Clinical and Experimental Neuroimmunology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Pathology of myelin oligodendrocyte glycoprotein antibody associated disease
AbstractThe antibody against myelin oligodendrocyte glycoprotein (MOG), localized at the outermost layers of myelin sheaths, was revealed in acute demyelinating diseases such as acute or multiphasic disseminated encephalomyelitis (ADEM/MDEM), optic neuritis, aquaporin ‐4 antibody negative neuromyelitis optica spectrum disorder (NMOSD), and brainstem or cerebral cortical encephalitis(1). However, MOG antibody is rarely observed in classical type multiple sclerosis (MS). There are some pathology‐proven cases of MOG antibody positive disease, reported as MS type II pathology(2). (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - October 26, 2020 Category: Neurology Authors: Tatsuro Misu Tags: NEW DEVELOPMENTS IN NEUROIMMUNOLOGY Source Type: research
Seeking ideal clinical guidelines for myasthenia gravis
AbstractA new version of the Japanese clinical guidelines for myasthenia gravis is under development. The current version was published in 2014, in which the top priority in treatment was to maintain patients ’ health‐related quality of life. The treatment goal was to achieve a post‐intervention status of minimal manifestations or better (according to the Myasthenia Gravis Foundation of America classification), with an oral prednisolone dose of 5 mg/day or less. The guidelines recommend minimizing the oral prednisolone dose, starting calcineurin inhibitors early in the course of treatment, and effectively treating pa...
Source: Clinical and Experimental Neuroimmunology - October 16, 2020 Category: Neurology Authors: Hiroyuki Murai,
Kimiaki Utsugisawa,
Masakatsu Motomura,
Shigeaki Suzuki,
Tomihiro Imai Tags: REVIEW ARTICLE (INVITED) Source Type: research
Clinically based score predicting cryptogenic NORSE
We reported our preliminary results by compar ing the clinical features of 11 adult patients with C‐NORSE with those of 32 patients with anti‐NMDA receptor (NMDAR) encephalitis.2 The C ‐NORSE score was higher in patients with C‐NORSE than those with anti‐NMDAR encephalitis.2 However, the scale score has not been validated yet. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - October 16, 2020 Category: Neurology Authors: Takahiro Iizuka,
Atsuko Yanagida Tags: NEW DEVELOPMENTS IN NEUROIMMUNOLOGY Source Type: research
Circulating inflammatory cytokines level correlates with cognitive impairment severity in Alzheimer ’s disease
ConclusionThe TNF ‐α and IL‐6 levels are significantly higher in patients with moderate‐severe stage of AD. Inflammatory cytokines levels could predict the cognitive impairment severity in AD patients. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - October 1, 2020 Category: Neurology Authors: Leila Rasi Marzabadi,
Saeed Sadigh ‐Eteghad,
Mahnaz Talebi Tags: ORIGINAL ARTICLE Source Type: research
Magnetic resonance imaging of Bal ó’s concentric sclerosis: Literature review and presentation of two focused cases
This review aims to describe two cases of Bal ò’s Concentric Sclerosis (BCS) and to review the state‐of‐the‐art literature. Through the analysis of current imaging practice, our purpose is to help clinicians reach early diagnosis, thus enhancing the chances of a more successful outcome for the patients. AbstractThe aim of this study was to describe two cases of Bal ó’s concentric sclerosis, and to review the state‐of‐the‐art literature. This dissertation is the result of a critical analysis matching the literature and our professional experience. Data were synthesized into a narrative review. BCS is often...
Source: Clinical and Experimental Neuroimmunology - September 29, 2020 Category: Neurology Authors: Chiara Ballini,
Francesco Destro,
Paolo Garofalo,
Jasjit S. Suri,
Tommaso Ercoli,
Antonella Muroni,
Giancarlo Caddeo,
Yang Qi,
Giovanni Defazio,
Luca Saba Tags: REVIEW ARTICLE Source Type: research
Magnetic resonance imaging of Balo ’s concentric sclerosis: literature review and presentation of two focused cases
AbstractThe aim of our study was to describe two cases of Bal ò’s Concentric Sclerosis (BCS) and further to review the state‐of‐the‐art literature.This dissertation is the result of a critical analysis matching the literature and our professional experience. Data were synthesized into a narrative review.BCS is often referred to as a variant of Multiple Sclerosis (MS), it is still unclear whether BCS is an acute variant of MS or a distinct entity that happens to coexist with MS. BCS and MS ‐like lesions might be present at the same time. BCS lesions are characterized by large concentric “onion‐like” shape o...
Source: Clinical and Experimental Neuroimmunology - September 2, 2020 Category: Neurology Authors: Chiara Ballini,
Francesco Destro,
Paolo Garofalo,
Jasjit S Suri,
Tommaso Ercoli,
Antonella Muroni,
Giancarlo Caddeo,
Yang Qi,
Giovanni Defazio,
Luca Saba Tags: REVIEW ARTICLE Source Type: research
Renal involvement in voltage ‐gated potassium channel complex antibody–associated diseases
ConclusionsImmune mechanisms in VGKC antibody associated disease may sometimes cause renal involvement (MGN) with nephrotic ‐range proteinuria. As all our patients with renal involvement had antibodies against both components of VGKC; this association needs further exploration. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - August 20, 2020 Category: Neurology Authors: Madhura Mulmuley,
Varsha Ambwani,
Sanjeev Jha,
Sunil Pradhan,
Shweta Katiyar,
Nandita Chaudhary Tags: CASE REPORT Source Type: research
Anti ‐striational antibodies: Expanding their clinical significance
AbstractAnti ‐striational antibodies (StrAbs) have been described as serum immunoglobulins that react with cross‐striations of skeletal muscle in patients with myasthenia gravis (MG). StrAbs were expected to be useful biomarkers of MG, however, because of their low specificity, the diagnostic utility of StrA bs has been limited. The main autoantigens of StrAbs included titin, ryanodine receptor, and Kv1.4. MG patients with StrAbs tend to suffer from bulbar symptoms and myasthenic crisis. The most remarkable finding of regarding the clinical significance of StrAbs is their association with myositis conco mitant with MG....
Source: Clinical and Experimental Neuroimmunology - August 18, 2020 Category: Neurology Authors: Shigeaki Suzuki,
Yuriko Nagane,
Akiyuki Uzawa,
Tomihiro Imai,
Hiroyuki Murai,
Jin Nakahara,
Kimiaki Utsugisawa Tags: REVIEW ARTICLE Source Type: research
Health ‐related quality of life and treatment strategies in myasthenia gravis
AbstractOur multicenter studies have repeatedly demonstrated that disease severity and oral steroid dose are major independent factors negatively impacting health ‐related quality of life (QOL) in patients with myasthenia gravis. Even if pharmacologic remission is achieved, QOL is low in patients taking oral prednisolone>10 mg/day. Disease severity tends to affect QOL by decreasing personal activities, whereas insufficiently reduced steroids affects QOL by decreasing social activities. MG patients often experience unemployment and decreased income, and many patients report reduced social positivity. More effort is req...
Source: Clinical and Experimental Neuroimmunology - August 17, 2020 Category: Neurology Authors: Kimiaki Utsugisawa,
Yuriko Nagane,
Akiyuki Uzawa,
Hiroyuki Murai,
Tomihiro Imai,
Shigeaki Suzuki Tags: REVIEW ARTICLE Source Type: research
Issue Information
Clinical and Experimental Neuroimmunology, Volume 11, Issue 3, Page 135-137, August 2020. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - August 4, 2020 Category: Neurology Tags: Issue Information Source Type: research
Voltage ‐gated potassium channel complex (VGKC) antibody encephalitis in a Filipino adult: a reversible cause of early onset neurocognitive disorder
ConclusionThis case highlights VGKC antibody encephalitis as an important diagnostic consideration in patients presenting with subacute onset of memory loss, behavioral changes, and seizures. With prompt initiation of immunosuppressive therapy, neurocognitive changes can be potentially reversed. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 30, 2020 Category: Neurology Authors: Ferron F. Ocampo,
Edmundo G. Saniel,
Ma. Socorro C. Martinez Tags: CASE REPORT Source Type: research
Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis
AbstractIn 2004, Lennon and colleagues identified neuromyelitis optica immunoglobulin G (NMO ‐IgG) in NMO patient sera, which recognized aquaporin‐4 (AQP‐4) on the foot processes of astroglia in the glia‐limitans of central nervous system (CNS) lesions (1). This discovery of an autoantibody that directly attacks a molecule on astroglia was surprising because it was the first evidenc e linking CNS inflammatory demyelinating disorders and a malfunction of glial cells. The activation of glial cells had been already described in many CNS disorders as “reactive gliosis”, but few studies had demonstrated that glial a...
Source: Clinical and Experimental Neuroimmunology - July 20, 2020 Category: Neurology Authors: Ryo Yamasaki Tags: NEW DEVELOPMENTS IN NEUROIMMUNOLOGY Source Type: research
Lenalidomide ‐associated Progressive Multifocal Leukoencephalopathy
ConclusionsAlthough rare, lenalidomide ‐induced PML should be considered in myeloma patients treated with lenalidomide. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 10, 2020 Category: Neurology Authors: Kazutaka Nishimura,
Yuta Iwai,
Mariko Yabuki,
Hiroe Fuse,
Kazuo Nakamichi,
Kenta Takahashi,
Tadaki Suzuki,
Masayuki Saijo,
Takeshi Fukushima,
Satoshi Kuwabara Tags: CASE REPORT Source Type: research
Renal Involvement in Voltage ‐gated potassium channel complex (VGKC) antibody associated diseases
ConclusionsImmune mechanisms in VGKC antibody associated disease may sometimes cause renal involvement (MGN) with nephrotic range proteinuria. As all our patients with renal involvement had antibodies against both the components of VGKC, this association needs further exploration. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 9, 2020 Category: Neurology Authors: Madhura Mulmuley,
Varsha Ambwani,
Sanjeev Jha,
Sunil Pradhan,
Shweta Katiyar,
Nandita Chaudhary,
Sunil Pradhan Tags: CASE REPORT Source Type: research
Lymphocytes are inextricably linked to multiple sclerosis
Clinical and Experimental Neuroimmunology, EarlyView. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - July 5, 2020 Category: Neurology Authors: Sachiko Miyake Tags: EDITORIAL Source Type: research
