Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis

AbstractIn 2004, Lennon and colleagues identified neuromyelitis optica immunoglobulin G (NMO ‐IgG) in NMO patient sera, which recognized aquaporin‐4 (AQP‐4) on the foot processes of astroglia in the glia‐limitans of central nervous system (CNS) lesions (1). This discovery of an autoantibody that directly attacks a molecule on astroglia was surprising because it was the first evidenc e linking CNS inflammatory demyelinating disorders and a malfunction of glial cells. The activation of glial cells had been already described in many CNS disorders as “reactive gliosis”, but few studies had demonstrated that glial activation or malfunction had a direct role in the pathomechanism s of CNS demyelinating disorders.

Source: Clinical and Experimental Neuroimmunology - July 20, 2020 Category: Neurology Authors: Ryo Yamasaki Tags: NEW DEVELOPMENTS IN NEUROIMMUNOLOGY Source Type: research