Serum anti ‐thyroid antibodies in Hashimoto’s Encephalopathy: a never‐ending story

ABSTRACTHashimoto ’s encephalopathy (HE) is a neurological disorder characterized by high serum concentration of anti‐thyroid antibodies (ATA), a wide array of neurological disorders (i.e. seizures, cerebellar syndrome, psychiatric symptoms, etc), and responsiveness to steroid therapy1. Although the detection of serum ATA [namely anti ‐thyroid peroxidase (TPO) antibodies and anti‐thyroglobulin (TG) antibodies] is a hallmark of HE, comparable increased serum ATA levels can also be detected in normal subjects2. The precise role of these antibodies in the aetiopathogenesis of HE is therefore not clear. An open question is whether ATA serum levels relate to a specific clinical picture.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: LETTER TO THE EDITOR Source Type: research