The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases
This study provides a concise overview of sphingolipid metabolism, the mechanism by which S1P receptors are af-fected, and the structural characteristics of several small molecule S1P modulators, with a particu-lar focus on their structure-activity connections.PMID:38676503 | DOI:10.2174/0115680266288509240422112839 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sidharth Sankar Kar Soumya Ranjan Gharai Sujit Kumar Sahu V Ravichandiran Sharada Prasanna Swain Source Type: research
Comparing the Risk of Infusion-Related Reactions and Tolerability in Patients Given Cetirizine or Diphenhydramine Prior to Ocrelizumab Infusion (PRECEPT)
Conclusions: Overall, our results suggest that cetirizine does not increase the risk of infusion-related reactions compared to diphenhydramine.PMID:38674305 | PMC:PMC11051876 | DOI:10.3390/medicina60040659 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Kyle Smoot Horia Marginean Tiffany Gervasi-Follmar Chiayi Chen Source Type: research
The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases
This study provides a concise overview of sphingolipid metabolism, the mechanism by which S1P receptors are af-fected, and the structural characteristics of several small molecule S1P modulators, with a particu-lar focus on their structure-activity connections.PMID:38676503 | DOI:10.2174/0115680266288509240422112839 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sidharth Sankar Kar Soumya Ranjan Gharai Sujit Kumar Sahu V Ravichandiran Sharada Prasanna Swain Source Type: research
Comparing the Risk of Infusion-Related Reactions and Tolerability in Patients Given Cetirizine or Diphenhydramine Prior to Ocrelizumab Infusion (PRECEPT)
Conclusions: Overall, our results suggest that cetirizine does not increase the risk of infusion-related reactions compared to diphenhydramine.PMID:38674305 | PMC:PMC11051876 | DOI:10.3390/medicina60040659 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Kyle Smoot Horia Marginean Tiffany Gervasi-Follmar Chiayi Chen Source Type: research
Dietary Modification Combined with Nutrition Education and Counseling for Metabolic Comorbidities in Multiple Sclerosis: Implications for Clinical Practice and Research
AbstractPurpose of ReviewMetabolic comorbidities such as obesity, diabetes, hypertension, and dyslipidemia are common to multiple sclerosis (MS) and are associated with negative outcomes of the disease. Dietary intervention has the potential to improve MS co-morbidities; thus, it is a high priority for people living with MS to self-manage their disease. The present review aimed to summarize the recent evidence on the impacts of combining dietary modification with nutrition education and counseling on managing metabolic comorbidity markers in MS.Recent Findings Evidence suggests important roles for tailored dietary change...
Source: Current Nutrition Reports - April 27, 2024 Category: Nutrition Source Type: research
The Impact of Infectious Mononucleosis History on the Risk of Developing Lymphoma and Nasopharyngeal Carcinoma: a Retrospective Large-Scale Cohort Study using National Health Insurance Data in South Korea
CONCLUSION: This study suggests that individuals with a history of IM have an elevated risk of developing lymphoma and NPC in South Korea, emphasizing the importance of vigilant follow-up and monitoring. The results advocate for heightened awareness and potential national monitoring policies to address the long-term health implications of EBV infection and to implement preventive measures.PMID:38665055 | DOI:10.4143/crt.2023.1356 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: So Hee Kang Yun-Hee Lee Jun-Pyo Myong Minsu Kwon Source Type: research
Nestorone (segesterone acetate) effects on neuroregeneration
Front Neuroendocrinol. 2024 Apr 24:101136. doi: 10.1016/j.yfrne.2024.101136. Online ahead of print.ABSTRACTNestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was foun...
Source: Frontiers in Neuroendocrinology - April 26, 2024 Category: Endocrinology Authors: Regine Sitruk-Ware Heather Sussman Roberta Brinton Michael Schumacher Patrick Singer Narender Kumar Alejandro F De Nicola Martine El-Etr Rachida Guennoun Cesar V Borlongan Source Type: research
Nestorone (segesterone acetate) effects on neuroregeneration
Front Neuroendocrinol. 2024 Apr 24:101136. doi: 10.1016/j.yfrne.2024.101136. Online ahead of print.ABSTRACTNestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was foun...
Source: Frontiers in Neuroendocrinology - April 26, 2024 Category: Endocrinology Authors: Regine Sitruk-Ware Heather Sussman Roberta Brinton Michael Schumacher Patrick Singer Narender Kumar Alejandro F De Nicola Martine El-Etr Rachida Guennoun Cesar V Borlongan Source Type: research
Nestorone (segesterone acetate) effects on neuroregeneration
Front Neuroendocrinol. 2024 Apr 24:101136. doi: 10.1016/j.yfrne.2024.101136. Online ahead of print.ABSTRACTNestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was foun...
Source: Frontiers in Neuroendocrinology - April 26, 2024 Category: Endocrinology Authors: Regine Sitruk-Ware Heather Sussman Roberta Brinton Michael Schumacher Patrick Singer Narender Kumar Alejandro F De Nicola Martine El-Etr Rachida Guennoun Cesar V Borlongan Source Type: research
Feasibility of exergaming for upper extremity rehabilitation in people with multiple sclerosis: prospective clinical trial
ConclusionThese results showed that our custom-made exergaming scenario could be feasible in upper extremity rehabilitation in MS. More research is needed to investigate its effectiveness in the rehabilitation of upper limbs. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Dental Adverse Effects of Anti-CD20 Therapies
ConclusionTo our knowledge, this is the first case series reporting dental conditions developed in patients long-term treated with anti-CD20 treatments. This issue, literature data, and Vigilyze ® analysis might be considered a safety signal that necessitates being confirmed with more robust data, such as a retrospective study with a control group. Meanwhile, proactive measures are essential like frequent dental checkups and dental hygienic measures to prevent oral health problems associat ed with anti-CD20 therapies. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 26, 2024 Category: Neurology Source Type: research
Enlargement of the choroid plexus in pediatric multiple sclerosis
This study shows an enlargement of the CP and lower thalamic volume in POMS patients compared to HC. (Source: Neuroradiology)
Source: Neuroradiology - April 26, 2024 Category: Radiology Source Type: research
Cross-cultural validity and reliability of the comprehensive assessment of acceptance and commitment therapy processes (CompACT) in people with multiple sclerosis
ConclusionResults support using the refined CompACT-18 as a three-factor measure of psychological flexibility in PwMS. Paper and eCompACT-18 versions are equivalent. CompACT-18 can be used cross-culturally, but sub-optimal scalar invariance suggests that direct comparison between the three language versions should be interpreted with caution. (Source: Quality of Life Research)
Source: Quality of Life Research - April 25, 2024 Category: Health Management Source Type: research
Narratives of Space and Time in Multiple Sclerosis Diagnosis
This article examines the complexity of narratives of space and time which support the diagnosis of multiple sclerosis, and the consequences for patients disadvantaged by deficits in social cognition or socioeconomic status in areas relating to literacy. In the context of demonstrating the significance of narratives of space and time in the diagnostic process for multiple sclerosis, the article discusses new strategies for treatment that engage the arts and humanities and presents a brief history of the disease and current diagnostic criteria, before discussing the MS Society of Great Britain and Ireland's awareness and fu...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Paula Leverage Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
