Burden of Migraine in Japan: Results of the ObserVational Survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) Study
ConclusionIn Japan, the burden of migraine and barriers to migraine care are substantial. Improving patient awareness and healthcare provider vigilance may help improve patient outcomes. (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 3, 2021 Category: Neurology Source Type: research

A Clinical Predictive Nomogram for Traumatic Brain Parenchyma Hematoma Progression
ConclusionsThe main predictive factors in the TPHEA nomogram are the monocyte-to-lymphocyte ratio, baseline tICH volume, and multihematoma fuzzy sign. This user-friendly tool can estimate acute tICH expansion and optimize personalized treatments for individuals with brain contusion. (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 2, 2021 Category: Neurology Source Type: research

Marburg Multiple Sclerosis Variant: Complete Remission with Very Early Administration of Mitoxantrone —A Case Report
We report the inflammatory explosive case of a 31-year-old woman presenting with rapid neurological degradation of histology proven Marburg’s disease, successfully treated with early administration of Mitoxantrone (MITX). To our knowledge, it is the fi rst case describing complete remission after MITX in a biopsy-proven condition. (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 2, 2021 Category: Neurology Source Type: research

Healthcare Resource Utilization Among Patients with Focal Seizures Treated with Eslicarbazepine Acetate in the US Long-Term Care Setting: A Retrospective Claims Database Analysis
AbstractIntroductionThe aim of this study was to compare healthcare resource utilization (HCRU) before and after initiation of eslicarbazepine acetate (ESL) in the long-term care (LTC) setting (rehabilitation center, mental health center, LTC non-skilled nursing facility/assisted-living facility, home health, assisted living, nursing home, other/unknown).MethodsThis retrospective analysis used IQVIA ’s New Data Warehouse, which includes deterministically linked LTC, prescription, and professional fee claims data and IQVIA Hospital Charge Data Master database. The study period was 1 April 2013 to 31 December 2019. The...
Source: Neurology and Therapy - November 6, 2021 Category: Neurology Source Type: research

Effects of Gocovri (Amantadine) Extended-Release Capsules on Motor Aspects of Experiences of Daily Living in People with Parkinson ’s Disease and Dyskinesia
AbstractIntroductionGocovri, a bedtime-administered delayed-release/extended-release capsule formulation of amantadine, is the only drug approved by the US Food and Drug Administration as levodopa-adjunctive therapy for the treatment of OFF episodes and/or dyskinesia in Parkinson ’s disease (PD). Part II of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) assesses patient-perceived disability on experiences of daily living affected by PD motor symptoms. We analyzed Gocovri-related changes in MDS-UPDRS Part II ratings in two placebo-contr olled clinical trials.MethodsBaseline to...
Source: Neurology and Therapy - November 6, 2021 Category: Neurology Source Type: research

Characteristics of Patients with Late- vs. Early-Onset Val30Met Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey (THAOS)
AbstractIntroductionHereditary transthyretin amyloidosis (ATTRv amyloidosis) is a clinically heterogeneous disease caused by mutations in the transthyretin (TTR) gene. The most common mutation, Val30Met, can manifest as an early- or late-onset disease.MethodsThe Transthyretin Amyloidosis Outcomes Survey (THAOS) is an ongoing, global, longitudinal, observational survey of patients with transthyretin amyloidosis, including both inherited and wild-type disease and asymptomatic patients withTTR mutations. This is a descriptive analysis of symptomatic patients with ATTRv Val30Met amyloidosis with late- (age at least 50  ye...
Source: Neurology and Therapy - November 6, 2021 Category: Neurology Source Type: research

Risk Factors for Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study
In this study we explored the risk factors for generalization in non-immunosuppressed and non-thymectomized patients with OMG.MethodsData from patients with OMG treated at seven tertiary hospitals in China were retrospectively reviewed. Clinical characteristics, including sex, age at onset, symptoms at onset, comorbid autoimmune diseases, neostigmine test response, repetitive nerve stimulation (RNS) findings, presence of serum anti-acetylcholine receptor antibody (AChR-Ab), and thymic status based on radiological and pathological studies, were collected. The main outcome measure was disease generalization. The follow-up pe...
Source: Neurology and Therapy - November 2, 2021 Category: Neurology Source Type: research

Use of a Novel EEG-Based Objective Test, the Cognalyzer ®, in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework
ConclusionThe findings show that the Cognalyzer® can be used to objectively determine the strength of cannabis psychoactive effects that cannabis products create on consumers and how it changes depending on their experience with cannabis. The Cognalyzer® can be used to conduct scientific consumer research to generate trustworthy informational material about the psychoactive experience of cannabis products. For clinical research, the Cognalyzer® can be used to study the pharmacodynamics of cannabinoids or delivery systems, such as nano-emulsifications. (Source: Neurology and Therapy)
Source: Neurology and Therapy - November 2, 2021 Category: Neurology Source Type: research

Association Between Serum C1q Tumor Necrosis Factor-Related Protein 9 and the Clinical Characteristics and Prognosis of Ischemic Stroke
ConclusionsAll the findings indicated that serum CTRP9 could be a promising blood-derived biomarker for the early evaluation and prognosis assessment of IS.Trial RegistrationChinese Clinical Trial Registry, ChiCTR1800020330. (Source: Neurology and Therapy)
Source: Neurology and Therapy - November 2, 2021 Category: Neurology Source Type: research

Pivotal Trials in Multiple Sclerosis: Similarities Prove Not to Be Useful
We present a commentary on the inclusion criteria and outcome measures of the major randomized trials on multiple sclerosis. A qualitative comparison of the characteristics of the enrolled patients is done. The objective is to stimulate a discussion about the need to improve research strategies. The discovery of new drugs studied without personalized criteria does not allow for useful advances in knowledge. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 30, 2021 Category: Neurology Source Type: research

Effects of Pregnancy and Breastfeeding on Clinical Outcomes and MRI Measurements of Women with Multiple Sclerosis: An Exploratory Real-World Cohort Study
ConclusionsOur study underlines the importance of considering the effects of pregnancy and breastfeeding on short- and long-term MS outcomes. In the current therapeutic landscape, pregnancy planning and treatment optimisation in the post-partum period, in particular for women who choose to breastfeed, are fundamental for the management of these biological phases so central in a woman ’s life. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 29, 2021 Category: Neurology Source Type: research

Simultaneous Occurrence of Cerebral Venous Sinus Thrombosis and Immune Thrombocytopenic Purpura in a Patient with a History of COVID-19 Infection
AbstractSince the emergence of the coronavirus disease 2019 (COVID-19) pandemic, multiple but rare complications of this infection have been described, comprising cerebral venous sinus thrombosis (CVST) and immune thrombocytopenic purpura (ITP). Although these two complications have been reported as separate entities, to the best of our knowledge, their concurrent presentation has not been reported. In this case report, we present a middle-aged man with a history of COVID-19 infection who developed a sudden-onset severe occipital headache followed by right-sided blindness (right homonymous hemianopia). Upon his diagnostic ...
Source: Neurology and Therapy - October 29, 2021 Category: Neurology Source Type: research

The Lived Experience of Myasthenia Gravis: A Patient-Led Analysis
ConclusionThis patient-driven analysis enriches our understanding of the reality of living with MG from the patient perspective. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2021 Category: Neurology Source Type: research

Sleep Apnea and Serum Serotonin Level Pre- and Post-PAP Therapy: A Preliminary Study
AbstractIntroductionThe high prevalence of obstructive sleep apnea (OSA), which impairs quality of life for numerous patients and leads to various OSA complications, has contributed to the continued interest in this disorder. The role of serotonin (5-HT) in many physiological processes, studies on its connection with the circadian system, and relationship to changes in sleep architecture are insufficient to assess the interaction of this neurotransmitter with nocturnal hypoxia. The aim of this study was to determine changes in sleep patterns and serum serotonin levels before and after positive airway pressure (PAP) therapy...
Source: Neurology and Therapy - October 20, 2021 Category: Neurology Source Type: research

Current Management of Residual Excessive Daytime Sleepiness Due to Obstructive Sleep Apnea: Insights for Optimizing Patient Outcomes
AbstractAlthough excessive daytime sleepiness (EDS) attributable to obstructive sleep apnea (OSA) can be resolved by consistent usage of and effective treatment (often with the use of continuous positive airway pressure therapy), 12 –58% of patients report residual EDS (REDS). While REDS is difficult to treat, a proportion of cases are possibly due to reversible issues, and wake-promoting medications can prove useful for the remaining cases. Given the challenges associated with effective management of REDS and its relationshi p to multiple comorbidities, multidisciplinary management of patients with REDS is often rec...
Source: Neurology and Therapy - October 18, 2021 Category: Neurology Source Type: research

Editorial: A Time of Transition of Alzheimer's Disease in the Advent of Anti-Amyloid Monoclonal Antibodies
(Source: Neurology and Therapy)
Source: Neurology and Therapy - October 13, 2021 Category: Neurology Source Type: research

Multiple Sclerosis, COVID-19 and Vaccines: Making the Point
AbstractOn 11 March 2020, the World Health Organization declared the coronavirus disease 19 (COVID-19) outbreak a pandemic. In this context, several studies and clinical trials have been conducted since then, and many are currently ongoing, leading to the development of several COVID-19 vaccines with different mechanisms of action. People affected by multiple sclerosis (MS) have been considered high-risk subjects in most countries and prioritized for COVID-19 vaccination. However, the management of MS during the COVID-19 pandemic has represented a new challenge for MS specialists, particularly because of the initial lack o...
Source: Neurology and Therapy - October 8, 2021 Category: Neurology Source Type: research

Emotional and Attentional Bias in Fibromyalgia: A Pilot ERP Study of the Dot-Probe Task
ConclusionIn summary, while the P300 results suggest that patients allocate less attentional resources to the task, the increased amplitudes of their LPP suggest augmented emotional processing of the target stimuli. Altogether, our results seem to support the thesis of generalized attentional deficits in FM. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 7, 2021 Category: Neurology Source Type: research

A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave ® l-Theanine on Stress in a Healthy Adult Population
The objective of this study was to investigate the efficacy and safety of AlphaWave®l-Theanine on whole-scalp and frontal alpha power, midline theta power, and salivary cortisol in healthy, moderately stressed adults.MethodsThis was a randomized, triple-blind, placebo-controlled, crossover study that consisted of two study periods with a 7-day washout. A single dose of AlphaWave®l-Theanine (200  mg) or placebo was administered. To induce stress, a mental arithmetic test (MAT) was administered before and after the dose. Electroencephalogram, salivary cortisol, blood pressure, heart rate, self-reported stress, a...
Source: Neurology and Therapy - September 25, 2021 Category: Neurology Source Type: research

Prognostic Value of Circadian Brain Temperature Rhythm in Basal Ganglia Hemorrhage After Surgery
ConclusionFor patients with ICH, brain temperature rhythm analysis is an improved prognostic tool for mortality and functional outcome predictions. (Source: Neurology and Therapy)
Source: Neurology and Therapy - September 24, 2021 Category: Neurology Source Type: research

Characteristics and Outcomes of the Idiopathic Intracranial Hypertension Treatment in Intrinsic and Extrinsic Stenosis: A Single-Center Experience in China
This study aimed to explore the precipitating factors and evaluate the impact of different stenosis types on treatment outcomes in patients with idiopathic intracranial hypertension (IIH) and venous sinus stenosis (VSS).MethodsWe recruited patients with IIH who presented with VSS, either intrinsic or extrinsic. We observed the clinical and laboratory findings, and we then compared the outcomes of stenting and medical treatment in different stenosis types.ResultsAmong 145 patients with IIH and VSS, 59 were of the intrinsic type and 86 were of the extrinsic type. Patients in the intrinsic group were older (42 vs. 34  years old,P 
Source: Neurology and Therapy - September 20, 2021 Category: Neurology Source Type: research

The Development of Pharmacological Therapies for Alzheimer ’s Disease
AbstractAlzheimer ’s disease (AD) is a progressive neurodegenerative disorder that currently has no cure. The aged population is growing globally, creating an urgent need for more promising therapies for this debilitating disease. Much effort has been made in recent decades, and the field is highly dynamic, with nu merous trials. The main focus of these trials includes disease modification and symptomatic treatment. Some have shown beneficial outcomes, while others have shown no significant benefits. Here, we cover the outcome of recently published AD clinical trials, as well as the mechanism of action of thes e ther...
Source: Neurology and Therapy - September 16, 2021 Category: Neurology Source Type: research

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training
ConclusionThis systematic review reveals that exercise training principles were not respected in the majority of included RCTs. The weak quality of reported exercise interventions limits the interpretation of the studies ’ results and potentially leads to an underestimation of ‘exercise as medicine’ in pwMS. Also, the vague descriptions of exercise prescription and adherence impede the reproducibility of results. Future studies must attend to all principles of exercise training and provide transparent informat ion on the prescribed and performed programmes to develop specific and valid exercise recommenda...
Source: Neurology and Therapy - September 14, 2021 Category: Neurology Source Type: research

Investigation of the Number of Tests Required for Assaying Plasma Biomarkers Associated with Alzheimer ’s Disease Using Immunomagnetic Reduction
ConclusionBased on this study, a single assay of A β1 –40, A β1 –42 and T-Tau, respectively, provides reliable results in terms of the measurement of that plasma biomarker. (Source: Neurology and Therapy)
Source: Neurology and Therapy - September 13, 2021 Category: Neurology Source Type: research

Hematoma Evacuation via Image-Guided Para-Corticospinal Tract Approach in Patients with Spontaneous Intracerebral Hemorrhage
ConclusionHematoma evacuation via image-guided para-corticospinal tract approach based on the protection of compressed or residual corticospinal tract seems to be safer in patients with ICH with a relatively higher functional independence. (Source: Neurology and Therapy)
Source: Neurology and Therapy - September 12, 2021 Category: Neurology Source Type: research

Management of Neurogenic Orthostatic Hypotension in Neurodegenerative Disorders: A Collaboration Between Cardiology and Neurology
In conclusion, collaboration between neurologists and cardiologists is an efficient method to improve outcomes for patients with nOH because this care model allows specialist providers to leverage their areas of expertise to manage the wide spectrum of clinical features associat ed with nOH. Further, communication and cooperation of the patient care team can lead to reduced patient morbidity, optimal relief of nOH symptoms, improvements in activities of daily living and quality of life, and decreased caregiver burden.Management of Neurogenic Orthostatic Hypotension in Neurodegenerative Disorders: A Collaboration Between Ca...
Source: Neurology and Therapy - September 7, 2021 Category: Neurology Source Type: research

Cryptogenic Stroke Caused by Pulmonary Arterial Venous Malformation with Massive Right-to-Left Shunt: A Case Report
ConclusionsPAVM is an important risk factor for PE and CS and should not be ignored as a possible etiology in stroke patients without any other risk factors. CTA of the pulmonary artery is the recommended gold standard for diagnosing and locating a PAVM. Thrombolytic therapy within the time window combined with transcatheter device occlusion of arteriovenous malformation and rehabilitation training may benefit the recovery of patients with CS caused by PE resulting from PAVM. (Source: Neurology and Therapy)
Source: Neurology and Therapy - September 3, 2021 Category: Neurology Source Type: research

Validation of the Clinical Assessment Scale for Autoimmune Encephalitis: A Multicenter Study
In this study, our primary objective was to validate the performance of CASE through a multicenter study in China.MethodsBetween July 2014 and December 2019, 143 consecutive patients with definite neuronal surface antibody-associated AE from three tertiary hospitals were enrolled in the study. We validated the reliability, internal consistency, and validity of CASE. We further compared CASE with the modified Rankin scale (mRS) among different subtypes of AE in terms of its sensitivity to disease dynamics. Statistical analyses were performed using GraphPad Prism and R software.ResultsOur analyses showed that CASE had good i...
Source: Neurology and Therapy - September 2, 2021 Category: Neurology Source Type: research

Incidence of the Diagnosis of Anxiety Disorders in the Russian Federation: Results of a Web-Based Survey of Psychiatrists
ConclusionOur survey revealed a serious underdiagnosis of anxiety disorders in Russia that may be associated with complex factors that include, but are not limited to the current stigma associated with the state-operated psychiatric service, which is still the exclusive source of official statistical data in Russia. (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 30, 2021 Category: Neurology Source Type: research

Obesity and Poststroke Fatigue: A 2-Year Longitudinal Study
ConclusionObese patients are less likely to develop fatigue in the acute stage of ischemic stroke. However, they are more prone to late fatigue and exhibit a slower decline in the FSS score in the long term. (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 26, 2021 Category: Neurology Source Type: research

Estimating Progression Rates Across the Spectrum of Alzheimer ’s Disease for Amyloid-Positive Individuals Using National Alzheimer’s Coordinating Center Data
ConclusionsThese transition probabilities reflect the full continuum of AD progression in A β+ individuals and can be used to assess the impact of treatment on expected transitions. (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 24, 2021 Category: Neurology Source Type: research

Predicted Lifetime Health Outcomes for Aducanumab in Patients with Early Alzheimer ’s Disease
ConclusionThe model predicted long-term benefits of aducanumab treatment in patients with MCI due to AD and mild AD dementia and their caregivers. The predicted outcomes provide a foundation for healthcare decision-makers and policymakers to understand the potential clinical and socioeconomic value of aducanumab. (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 23, 2021 Category: Neurology Source Type: research

Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial
ConclusionThese results indicate thattrans-resveratrol has potential neuroprotective roles in the treatment of moderate to mild AD and that its mechanism may involve a reduction in the accumulation and toxicity of A β in the brain of patients, thereby reducing neuroinflammation.Trial RegistrationChinese clinical trial registry: CTR20151780X. (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 16, 2021 Category: Neurology Source Type: research

Patients ’ Experiences in Transitioning to Secondary Progressive Multiple Sclerosis: Qualitative Interviews
ConclusionsThe conceptual model of the transitionary period from RRMS to SPMS expands the current understanding of the progression of MS from the patient and care partner perspectives. (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 14, 2021 Category: Neurology Source Type: research

Early Data on Long-term Impact of Inotersen on Quality-of-Life in Patients with Hereditary Transthyretin Amyloidosis Polyneuropathy: Open-Label Extension of NEURO-TTR
ConclusionLong-term treatment with inotersen preserved HRQOL for patients with ATTRv-PN for periods of up to 3  years. The gap in HRQOL between those who had previously received inotersen or placebo in NEURO-TTR did not close by week 104 of the OLE phase, indicating the importance of early treatment for maintaining HRQOL in these patients.Trial RegistrationClinicalTrials.gov Identifiers NCT01737398 for NEURO-TTR study; NCT02175004 for OLE studyInfographic (Source: Neurology and Therapy)
Source: Neurology and Therapy - August 5, 2021 Category: Neurology Source Type: research

Expert Perspectives on COVID-19 Vaccination for People Living with Multiple Sclerosis
AbstractCOVID-19 vaccines are safe for people living with MS on or off disease-modifying therapies and are important for the prevention of COVID-19. Antibody responses for individuals on certain DMTs may be diminished, however, T-cell responses may be preserved in those individuals. Data are lacking regarding optimal timing of vaccinations, and delaying disease-modifying therapies may increase the risk of disease activity and progression. In this perspective podcast, the authors recommend COVID-19 vaccination as soon as possible, regardless of timing considerations, in most cases.Graphical Plain Language Summary (Source: N...
Source: Neurology and Therapy - August 4, 2021 Category: Neurology Source Type: research

Role of Brain Natriuretic Peptide in the Prediction of Early Postoperative Seizures Following Surgery for Traumatic Acute Subdural Hematoma: A Prospective Study
This study aimed to analyze BNP levels on admission in surgically treated patients and assess their relationship with early postoperative seizures (EPS) and functional outcomes.MethodsPatients with unilateral traumatic aSDH who were surgically treated in our department between July 2017 and May 2020 were included in the study. BNP was preoperatively measured. Patients ’ neurologic condition, radiographic variables on initial cranial computed tomography, sodium serum levels on admission, and occurrence of EPS were prospectively assessed. Functional outcome was assessed using the modified Rankin Scale (mRS) at discharg...
Source: Neurology and Therapy - August 3, 2021 Category: Neurology Source Type: research

A Descriptive Analysis of ATTR Amyloidosis in Spain from the Transthyretin Amyloidosis Outcomes Survey
ConclusionsThese results from THAOS highlight the phenotypic heterogeneity associated with ATTR amyloidosis in Spain and the importance of comprehensive neurologic and cardiac evaluations in all patients with ATTR amyloidosis.Trial registration ClinicalTrials.gov: NCT00628745. (Source: Neurology and Therapy)
Source: Neurology and Therapy - July 30, 2021 Category: Neurology Source Type: research

How have Economic Evaluations in Relapsing Multiple Sclerosis Evolved Over Time? A Systematic Literature Review
ConclusionAs expected, similarities as well as differences were observed across the different economic models. Available evidence suggests models should continue using the Markov cohort model with 21 EDSS-based states, however, allowing the transition to a lower EDSS state and assuming a sustained treatment effect. With reference to the data sources, models should consider using a contemporary MS-specific mortality data, recent natural history data, and country-specific utility data if available. In case of data unavailability, a sensitivity analysis using multiple sources of data should be conducted. In addition, future m...
Source: Neurology and Therapy - July 19, 2021 Category: Neurology Source Type: research

A Clinical-Radiomics Nomogram for Functional Outcome Predictions in Ischemic Stroke
ConclusionThis novel noninvasive clinical-radiomics nomogram shows good performance in predicting ischemic stroke prognosis. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 25, 2021 Category: Neurology Source Type: research

Confirmed 6-Month Disability Improvement and Worsening Correlate with Long-term Disability Outcomes in Alemtuzumab-Treated Patients with Multiple Sclerosis: Post Hoc Analysis of the CARE-MS Studies
ConclusionCDI achievement at any point during the CARE-MS studies was associated with improved disability at year 9, highlighting the potential of alemtuzumab to change the multiple sclerosis course. Conversely, CDW at any point was associated with worsened disability at year 9. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 24, 2021 Category: Neurology Source Type: research

Expert Consensus and Narrative Review on the Management of Multiple Sclerosis in the Arabian Gulf in the COVID-19 Era: Focus on Disease-Modifying Therapies and Vaccination Against COVID-19
This article describes consensus recommendations from an expert group of neurologists from the Arabian Gulf region on the management of relapsing multiple sclerosis (RMS) in the COVID-19 era. MS appears not to be a risk factor for severe adverse COVID-19 outcomes (though patients with advanced disability or a progressive phenotype are at higher risk). Disease-modifying therapy (DMT)-based care appears generally safe for patients with MS who develop COVID-19 (although there may be an increased risk of adverse outcomes with anti-CD20 therapy). Interferon- β, teriflunomide, dimethyl fumarate, glatiramer acetate, natalizu...
Source: Neurology and Therapy - June 17, 2021 Category: Neurology Source Type: research

Emerging Infection, Vaccination, and Guillain –Barré Syndrome: A Review
AbstractGuillain –Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system that typically develops within 4 weeks after infection. In addition to conventional infectious diseases with which we are familiar, emerging infectious diseases, such as Zika virus infection and coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have also been suggested to be associated with GBS. GBS is mainly categorized into a demyelinating subtype known as acute inflammatory demyelinating polyneuropathy (AIDP) and an axonal subtype known as acute mot...
Source: Neurology and Therapy - June 12, 2021 Category: Neurology Source Type: research

Optimized Propofol Anesthesia Increases Power of Subthalamic Neuronal Activity in Patients with Parkinson ’s Disease Undergoing Deep Brain Stimulation
This study investigated the safety and effectiveness of an optimized propofol anesthesia regimen in asleep DBS.MethodsThis retrospective study enrolled 68 PD patients undergoing bilateral STN-DBS surgery. All patients received local scalp anesthesia, with (asleep group,n = 35) or without (awake group,n = 33) propofol-remifentanil general anesthesia by target-controlled infusion under electroencephalogram monitoring. The primary outcome was subthalamic neuronal spiking characterization during microelectrode recording. The secondary outcomes were clinical outcomes including motor, cognition, mi nd...
Source: Neurology and Therapy - June 6, 2021 Category: Neurology Source Type: research

Efficacy and Safety of Medication for Attention-Deficit Hyperactivity Disorder in Children and Adolescents with Common Comorbidities: A Systematic Review
AbstractIntroductionComorbid psychiatric conditions in children and adolescents with attention-deficit hyperactivity disorder (ADHD) occur frequently, complicate management, and are associated with substantial burden on patients and caregivers. Very few systematic reviews have assessed the efficacy and safety of medications for ADHD in children and adolescents with comorbidities. Of those that were conducted, most focused on a particular comorbidity or medication. In this systematic literature review, we summarize the efficacy and safety of treatments for children and adolescents with ADHD and comorbid autism spectrum diso...
Source: Neurology and Therapy - June 4, 2021 Category: Neurology Source Type: research

Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor
AbstractMigraine involves brain hypersensitivity with episodic dysfunction triggered by behavioral or physiological stressors. During an acute migraine attack the trigeminal nerve is activated (peripheral sensitization). This leads to central sensitization with activation of the central pathways including the trigeminal nucleus caudalis, the trigemino-thalamic tract, and the thalamus. In episodic migraine the sensitization process ends with the individual act, but with chronic migraine central sensitization may continue interictally. Increased allostatic load, the consequence of chronic, repeated exposure to stressors, lea...
Source: Neurology and Therapy - June 2, 2021 Category: Neurology Source Type: research

Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review
AbstractIn mild cognitive impairment (MCI) due to Alzheimer disease (AD), also known as prodromal AD, there is evidence for a pathologic shortage of uridine, choline, and docosahexaenoic acid [DHA]), which are key nutrients needed by the brain. Preclinical and clinical evidence shows the importance of nutrient bioavailability to support the development and maintenance of brain structure and function in MCI and AD. Availability of key nutrients is limited in MCI, creating a distinct nutritional need for uridine, choline, and DHA. Evidence suggests that metabolic derangements associated with ageing and disease-related pathol...
Source: Neurology and Therapy - June 1, 2021 Category: Neurology Source Type: research

Consequences of Insurance Denials Among U.S. Patients Prescribed Repository Corticotropin Injection for Acute Exacerbations of Multiple Sclerosis
ConclusionThe results of this study may aid providers and payers in evaluating scenarios where RCI may be beneficial and improve quality of care for patients experiencing MS relapse. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 22, 2021 Category: Neurology Source Type: research

Effectiveness of Dimethyl Fumarate in Patients With Relapsing Multiple Sclerosis Switching After Suboptimal Response to Glatiramer Acetate, Including Patients With Early Multiple Sclerosis: Subgroup Analysis of RESPOND
ConclusionsDMF may be an effective treatment option in first switch and early MS switch patients with RMS who experience a suboptimal response to GA.Trial RegistrationClinicalTrials.gov identifier: NCT01903291. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 22, 2021 Category: Neurology Source Type: research

Globus Pallidus Internus (GPi) Deep Brain Stimulation for Parkinson ’s Disease: Expert Review and Commentary
ConclusionGPi DBS can be effectively used in select cases of PD. As the ongoing DBS target debate continues (GPi vs. STN as DBS target), clinicians should keep in mind that GPi DBS has been shown to be an effective treatment strategy for a variety of symptoms, including bradykinesia, rigidity and tremor control. GPi DBS also has an important, direct anti-dyskinetic effect. GPi DBS is easier to program in the outpatient setting and will allow for more flexibility in medication adjustments (e.g. levodopa). Emerging technologies, including GPi closed-loop systems, advanced tractography-based targeting and enhanced programming...
Source: Neurology and Therapy - May 22, 2021 Category: Neurology Source Type: research