Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis
Conclusions
Levels of sNfL, sGFAP and sCHI3L1 are prognostic biomarkers associated with disability progression in patients with PPMS, being CHI3L1 findings less dependent on the inflammatory component associated with disease progression. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 12, 2024 Category: Neurosurgery Authors: Fissolo, N., Benkert, P., Sastre-Garriga, J., Mongay-Ochoa, N., Vilaseca-Jolonch, A., Llufriu, S., Blanco, Y., Hegen, H., Berek, K., Perez-Miralles, F., Rejdak, K., Villar, L. M., Monreal, E., Alvarez-Lafuente, R., Soylu, O. K., Abdelhak, A., Bachhuber, F Tags: Multiple sclerosis Source Type: research
Predictive value of retinal atrophy for cognitive decline across disease duration in multiple sclerosis
Conclusions
The progressive retinal thinning is related to cognitive decline, indicating that cognitive dysfunction is a late manifestation of accumulated neuroaxonal damage. Quantifying the pRFNL aids in identifying individuals at risk of cognitive dysfunction. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 12, 2024 Category: Neurosurgery Authors: Alba-Arbalat, S., Solana, E., Lopez-Soley, E., Camos-Carreras, A., Martinez-Heras, E., Vivo, F., Pulido-Valdeolivas, I., Andorra, M., Sepulveda, M., Cabrera, J. M., Fonseca, E., Calvi, A., Alcubierre, R., Dotti-Boada, M., Saiz, A., Martinez-Lapiscina, E. Tags: Multiple sclerosis Source Type: research
Evolution of brain MRI lesions in paediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and its relevance to disease course
Conclusions
These striking differences in lesion dynamics between MOGAD and MS suggest greater potential to repair. Early treatment with steroids and plasma exchange is associated with reduced likelihood of new lesions. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 12, 2024 Category: Neurosurgery Authors: Abdel-mannan, O., Champsas, D., Tur, C., Lee, V., Manivannan, S., Usman, H., Skippen, A., Desai, I., Chitre, M., Forsyth, R., Kneen, R., Ram, D., Ramdas, S., Rossor, T., West, S., Wright, S., Palace, J., Wassmer, E., Hemingway, C., Lim, M. J., Mankad, K., Tags: Multiple sclerosis Source Type: research
Examination of the shared genetic architecture between multiple sclerosis and systemic lupus erythematosus facilitates discovery of novel lupus risk loci
AbstractSystemic Lupus Erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations, including neurological and psychiatric symptoms. Genetic association studies in SLE have been hampered by insufficient sample size and limited power compared to many other diseases. Multiple Sclerosis (MS) is a chronic relapsing autoimmune disease of the central nervous system (CNS) that also manifests neurological and immunological features. Here, we identify a method of leveraging large-scale genome wide association studies (GWAS) in MS to identify novel genetic risk loci in SLE. Statistical genetic comparison methods i...
Source: Human Genetics - April 12, 2024 Category: Genetics & Stem Cells Source Type: research
Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 12, 2024 Category: Neurology Authors: Maria T. Cencioni, Roberta Magliozzi, Ilaria Palmisano, Keittisak Suwan, Antonella Mensi, Laura Fuentes-Font, Luisa M. Villar, Jos é I. Fernández-Velasco, Noelia Villarrubia Migallón, Lucienne Costa-Frossard, Enric Monreal, Rehiana Ali, Marina Romozzi, Tags: Research Source Type: research
Geographical variation in medication and health resource use in multiple sclerosis
Can J Neurol Sci. 2024 Apr 11:1-21. doi: 10.1017/cjn.2024.54. Online ahead of print.NO ABSTRACTPMID:38600770 | DOI:10.1017/cjn.2024.54 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - April 11, 2024 Category: Neurology Authors: Erin F Balcom Jennifer A McCombe Mahesh Kate Khanh Vu Karen Jb Martins Sylvia Aponte-Hao Huong Luu Lawrence Richer Tyler Williamson Scott W Klarenbach Penelope Smyth Source Type: research
The level of cytokines in tears as a novel indicator of demyelinating diseases
CONCLUSIONS: Our results show that MS and other demyelination diseases lead to decrease in the overall level of cytokines in tears. Further research is needed to determine the role of tear fluid in the assessment of demyelinating disorders like MS.PMID:38602307 | DOI:10.1080/01616412.2024.2337502 (Source: Neurological Research)
Source: Neurological Research - April 11, 2024 Category: Neurology Authors: Jowita Adamczyk-Zostawa Adam Wyl ęgała Martyna Lis Jacek Zostawa Rafa ł Fiolka Edward Wyl ęgała Monika Adamczyk-Sowa Zenon Czuba Source Type: research
Epidemiological, Clinical, and Therapeutic Profile of Uveitis in Multiple Sclerosis: A Multicenter Study
CONCLUSION: MS-associated uveitis occurs most frequently before the diagnosis of relapsing-remitting MS in the form of panuveitis or intermediate uveitis, which is mildly inflammatory and whose main complications are macular edema, cataract and venous vasculitis. Despite their chronicity, these uveitis cases have a good visual prognosis and teriflunomide appears to have a positive effect on progression.PMID:38602890 | DOI:10.1080/09273948.2024.2337839 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 11, 2024 Category: Allergy & Immunology Authors: R Fitoussi P Gascon D Denis T Mathis N Tieul é C Schneider-Rouhaud R Attia T David N Stolowy Source Type: research
Iraqi experts consensus on the management of relapsing remitting multiple sclerosis in adults
This study aimed to develop consensus recommendations regarding the diagnosis and management of MS in Iraq, specifically focusing on treatment-naïve patients, suboptimal responders, and women of childbearing age during preconception, pregnancy planning, and lactation. A survey was conducted to collect feedback from a panel of ten key opinion leaders (KOLs), who evaluated and discussed the statements to determine agreement levels. The mini-Delphi method was employed to establish a consensus on the management recommendations, and a meeting was held to analyze the responses and ensure that the recommendations were based on c...
Source: Current Medical Research and Opinion - April 11, 2024 Category: Research Authors: Hayder K Hassoun Anmar Oday Hatem Akram Al-Mahdawi Sarwer Jamal Al-Bajalan Ali Kadim Karim Sarmad Abdulrasool Al-Mashta Saif Mohammed Tawfeeq Majeed Salih Hamad Nawfal M Sheaheed Samer Mohammed Ridha Murad Al-Naqshbandi Hasan Aziz Al-Hamadani Source Type: research
Geographical variation in medication and health resource use in multiple sclerosis
Can J Neurol Sci. 2024 Apr 11:1-21. doi: 10.1017/cjn.2024.54. Online ahead of print.NO ABSTRACTPMID:38600770 | DOI:10.1017/cjn.2024.54 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - April 11, 2024 Category: Neurology Authors: Erin F Balcom Jennifer A McCombe Mahesh Kate Khanh Vu Karen Jb Martins Sylvia Aponte-Hao Huong Luu Lawrence Richer Tyler Williamson Scott W Klarenbach Penelope Smyth Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
The level of cytokines in tears as a novel indicator of demyelinating diseases
CONCLUSIONS: Our results show that MS and other demyelination diseases lead to decrease in the overall level of cytokines in tears. Further research is needed to determine the role of tear fluid in the assessment of demyelinating disorders like MS.PMID:38602307 | DOI:10.1080/01616412.2024.2337502 (Source: Neurological Research)
Source: Neurological Research - April 11, 2024 Category: Neurology Authors: Jowita Adamczyk-Zostawa Adam Wyl ęgała Martyna Lis Jacek Zostawa Rafa ł Fiolka Edward Wyl ęgała Monika Adamczyk-Sowa Zenon Czuba Source Type: research
Epidemiological, Clinical, and Therapeutic Profile of Uveitis in Multiple Sclerosis: A Multicenter Study
CONCLUSION: MS-associated uveitis occurs most frequently before the diagnosis of relapsing-remitting MS in the form of panuveitis or intermediate uveitis, which is mildly inflammatory and whose main complications are macular edema, cataract and venous vasculitis. Despite their chronicity, these uveitis cases have a good visual prognosis and teriflunomide appears to have a positive effect on progression.PMID:38602890 | DOI:10.1080/09273948.2024.2337839 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 11, 2024 Category: Allergy & Immunology Authors: R Fitoussi P Gascon D Denis T Mathis N Tieul é C Schneider-Rouhaud R Attia T David N Stolowy Source Type: research
Iraqi experts consensus on the management of relapsing remitting multiple sclerosis in adults
This study aimed to develop consensus recommendations regarding the diagnosis and management of MS in Iraq, specifically focusing on treatment-naïve patients, suboptimal responders, and women of childbearing age during preconception, pregnancy planning, and lactation. A survey was conducted to collect feedback from a panel of ten key opinion leaders (KOLs), who evaluated and discussed the statements to determine agreement levels. The mini-Delphi method was employed to establish a consensus on the management recommendations, and a meeting was held to analyze the responses and ensure that the recommendations were based on c...
Source: Current Medical Research and Opinion - April 11, 2024 Category: Research Authors: Hayder K Hassoun Anmar Oday Hatem Akram Al-Mahdawi Sarwer Jamal Al-Bajalan Ali Kadim Karim Sarmad Abdulrasool Al-Mashta Saif Mohammed Tawfeeq Majeed Salih Hamad Nawfal M Sheaheed Samer Mohammed Ridha Murad Al-Naqshbandi Hasan Aziz Al-Hamadani Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
