Proteomic analyses of plasma-derived exosomes in immunoglobulin (Ig) G4-related disease and their potential roles in B cell differentiation and tissue damage
CONCLUSION: Proteomic profiling revealed that plasma exosome proteins may participate in the pathogenesis of IgG4-RD through complement activation and may be involved in B cell differentiation and activation of the B cell auto-oxidative damage pathway.PMID:34107438 | DOI:10.1016/j.jaut.2021.102650 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - June 9, 2021 Category: Allergy & Immunology Authors: Panpan Zhang Yusheng Zhang Meng Pan Zheng Liu Jieqiong Li Linyi Peng Jiaxin Zhou Chaojun Hu Shengyun Liu Xiaofeng Zeng Wei Ge Wen Zhang Source Type: research

Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk
J Autoimmun. 2021 Jun 5;122:102675. doi: 10.1016/j.jaut.2021.102675. Online ahead of print.ABSTRACTΒ2-Glycoprotein I (β2GPI) is an important anti-thrombotic protein and is the major auto-antigen in the antiphospholipid syndrome (APS). The clinical relevance of nitrosative stress in post translational modification of β2GPI was examined.The effects of nitrated (n)β2GPI on its anti-thrombotic properties and its plasma levels in primary and secondary APS were determined with appropriate clinical control groups. β2-glycoprotein I was nitrated at tyrosines 218, 275 and 309. β2-glycoprotein I binds t...
Source: Journal of Autoimmunity - June 7, 2021 Category: Allergy & Immunology Authors: M Krilis M Qi Y Ioannou J Y Zhang Z Ahmadi J W H Wong P G Vlachoyiannopoulos H M Moutsopoulos T Koike A D Sturgess B H Chong S A Krilis B Giannakopoulos Source Type: research

Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk
J Autoimmun. 2021 Jun 4;122:102675. doi: 10.1016/j.jaut.2021.102675. Online ahead of print.ABSTRACTΒ2-Glycoprotein I (β2GPI) is an important anti-thrombotic protein and is the major auto-antigen in the antiphospholipid syndrome (APS). The clinical relevance of nitrosative stress in post translational modification of β2GPI was examined.The effects of nitrated (n)β2GPI on its anti-thrombotic properties and its plasma levels in primary and secondary APS were determined with appropriate clinical control groups. β2-glycoprotein I was nitrated at tyrosines 218, 275 and 309. β2-glycoprotein I binds t...
Source: Journal of Autoimmunity - June 7, 2021 Category: Allergy & Immunology Authors: M Krilis M Qi Y Ioannou J Y Zhang Z Ahmadi J W H Wong P G Vlachoyiannopoulos H M Moutsopoulos T Koike A D Sturgess B H Chong S A Krilis B Giannakopoulos Source Type: research

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629]
J Autoimmun. 2021 Jul;121:102665. doi: 10.1016/j.jaut.2021.102665. Epub 2021 May 28.NO ABSTRACTPMID:34058602 | DOI:10.1016/j.jaut.2021.102665 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 31, 2021 Category: Allergy & Immunology Authors: Elisa McEachern Allison M Carroll Miguel Fribourg Thomas D Schiano Susan Hartzell Sofia Bin Paolo Cravedi Josh Levitsky Source Type: research

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629]
J Autoimmun. 2021 Jul;121:102665. doi: 10.1016/j.jaut.2021.102665. Epub 2021 May 28.NO ABSTRACTPMID:34058602 | DOI:10.1016/j.jaut.2021.102665 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 31, 2021 Category: Allergy & Immunology Authors: Elisa McEachern Allison M Carroll Miguel Fribourg Thomas D Schiano Susan Hartzell Sofia Bin Paolo Cravedi Josh Levitsky Source Type: research

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629]
J Autoimmun. 2021 May 28;121:102665. doi: 10.1016/j.jaut.2021.102665. Online ahead of print.NO ABSTRACTPMID:34058602 | DOI:10.1016/j.jaut.2021.102665 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 31, 2021 Category: Allergy & Immunology Authors: Elisa McEachern Allison M Carroll Miguel Fribourg Thomas D Schiano Susan Hartzell Sofia Bin Paolo Cravedi Josh Levitsky Source Type: research

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629]
J Autoimmun. 2021 May 28;121:102665. doi: 10.1016/j.jaut.2021.102665. Online ahead of print.NO ABSTRACTPMID:34058602 | DOI:10.1016/j.jaut.2021.102665 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 31, 2021 Category: Allergy & Immunology Authors: Elisa McEachern Allison M Carroll Miguel Fribourg Thomas D Schiano Susan Hartzell Sofia Bin Paolo Cravedi Josh Levitsky Source Type: research

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629]
J Autoimmun. 2021 May 28;121:102665. doi: 10.1016/j.jaut.2021.102665. Online ahead of print.NO ABSTRACTPMID:34058602 | DOI:10.1016/j.jaut.2021.102665 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 31, 2021 Category: Allergy & Immunology Authors: Elisa McEachern Allison M Carroll Miguel Fribourg Thomas D Schiano Susan Hartzell Sofia Bin Paolo Cravedi Josh Levitsky Source Type: research

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629]
J Autoimmun. 2021 May 28;121:102665. doi: 10.1016/j.jaut.2021.102665. Online ahead of print.NO ABSTRACTPMID:34058602 | DOI:10.1016/j.jaut.2021.102665 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 31, 2021 Category: Allergy & Immunology Authors: Elisa McEachern Allison M Carroll Miguel Fribourg Thomas D Schiano Susan Hartzell Sofia Bin Paolo Cravedi Josh Levitsky Source Type: research

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection
J Autoimmun. 2021 May 19;121:102662. doi: 10.1016/j.jaut.2021.102662. Online ahead of print.ABSTRACTHerein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA release (RNAaemia) contributes to innate immune coagulation cascade activation, with both pulmonary and systemic immunothrombosis - including venous territory strokes. However, anti-SARS-CoV-2 adenoviral-vectored-DNA vaccines -initially shown for the ChAdOx1 vaccine-may rarely exhibit autoimmunity with autoantibodies to Platelet Factor-4 (PF4) that is termed ...
Source: Journal of Autoimmunity - May 29, 2021 Category: Allergy & Immunology Authors: Dennis McGonagle Gabriele De Marco Charles Bridgewood Source Type: research

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection
J Autoimmun. 2021 May 19;121:102662. doi: 10.1016/j.jaut.2021.102662. Online ahead of print.ABSTRACTHerein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA release (RNAaemia) contributes to innate immune coagulation cascade activation, with both pulmonary and systemic immunothrombosis - including venous territory strokes. However, anti-SARS-CoV-2 adenoviral-vectored-DNA vaccines -initially shown for the ChAdOx1 vaccine-may rarely exhibit autoimmunity with autoantibodies to Platelet Factor-4 (PF4) that is termed ...
Source: Journal of Autoimmunity - May 29, 2021 Category: Allergy & Immunology Authors: Dennis McGonagle Gabriele De Marco Charles Bridgewood Source Type: research

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection
J Autoimmun. 2021 May 19;121:102662. doi: 10.1016/j.jaut.2021.102662. Online ahead of print.ABSTRACTHerein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA release (RNAaemia) contributes to innate immune coagulation cascade activation, with both pulmonary and systemic immunothrombosis - including venous territory strokes. However, anti-SARS-CoV-2 adenoviral-vectored-DNA vaccines -initially shown for the ChAdOx1 vaccine-may rarely exhibit autoimmunity with autoantibodies to Platelet Factor-4 (PF4) that is termed ...
Source: Journal of Autoimmunity - May 29, 2021 Category: Allergy & Immunology Authors: Dennis McGonagle Gabriele De Marco Charles Bridgewood Source Type: research

Long-term (16-26 years) follow-up outcome of steroid therapy in refractory autoimmune sensorineural hearing loss
J Autoimmun. 2021 May 25;121:102664. doi: 10.1016/j.jaut.2021.102664. Online ahead of print.ABSTRACTAutoimmune sensorineural hearing loss (ASHL) is a rare disease of uncertain etiology, with no established treatment strategy. The duration of morbidity is increased in refractory cases; and therefore, the preservation of hearing and the prevention of adverse effects with steroid therapy are serious long term issues to consider. Long-term follow up of patients treated for ASHL was performed retrospectively in order to elucidate the pathogenesis of ASHL, evaluate the consequences of steroid therapy, and determine a promising t...
Source: Journal of Autoimmunity - May 28, 2021 Category: Allergy & Immunology Authors: Tadashi Nishimura Tadao Okayasu Hiroshi Hosoi Tadashi Kitahara Source Type: research

Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease
J Autoimmun. 2021 May 23;121:102661. doi: 10.1016/j.jaut.2021.102661. Online ahead of print.ABSTRACTInterstitial lung disease (ILD) sometimes becomes a life-threatening complication of systemic autoimmune diseases; however, little is known about the immune response in lung lesions. We aimed to investigate humoural immunity in ILD associated with rheumatoid arthritis (RA), sjögren's syndrome (SjS), and mixed connective tissue disease (MCTD), using bronchoalveolar fluid (BALF) and serum samples from 15 patients with autoimmune disease associated-ILD. We first showed that BALF contained higher titers of disease-related a...
Source: Journal of Autoimmunity - May 25, 2021 Category: Allergy & Immunology Authors: Masaru Takeshita Katsuya Suzuki Maho Nakazawa Hirofumi Kamata Makoto Ishii Yoshitaka Oyamada Hisaji Oshima Tsutomu Takeuchi Source Type: research

Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease
J Autoimmun. 2021 May 22;121:102661. doi: 10.1016/j.jaut.2021.102661. Online ahead of print.ABSTRACTInterstitial lung disease (ILD) sometimes becomes a life-threatening complication of systemic autoimmune diseases; however, little is known about the immune response in lung lesions. We aimed to investigate humoural immunity in ILD associated with rheumatoid arthritis (RA), sjögren's syndrome (SjS), and mixed connective tissue disease (MCTD), using bronchoalveolar fluid (BALF) and serum samples from 15 patients with autoimmune disease associated-ILD. We first showed that BALF contained higher titers of disease-related a...
Source: Journal of Autoimmunity - May 25, 2021 Category: Allergy & Immunology Authors: Masaru Takeshita Katsuya Suzuki Maho Nakazawa Hirofumi Kamata Makoto Ishii Yoshitaka Oyamada Hisaji Oshima Tsutomu Takeuchi Source Type: research

Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease
J Autoimmun. 2021 May 22;121:102661. doi: 10.1016/j.jaut.2021.102661. Online ahead of print.ABSTRACTInterstitial lung disease (ILD) sometimes becomes a life-threatening complication of systemic autoimmune diseases; however, little is known about the immune response in lung lesions. We aimed to investigate humoural immunity in ILD associated with rheumatoid arthritis (RA), sjögren's syndrome (SjS), and mixed connective tissue disease (MCTD), using bronchoalveolar fluid (BALF) and serum samples from 15 patients with autoimmune disease associated-ILD. We first showed that BALF contained higher titers of disease-related a...
Source: Journal of Autoimmunity - May 25, 2021 Category: Allergy & Immunology Authors: Masaru Takeshita Katsuya Suzuki Maho Nakazawa Hirofumi Kamata Makoto Ishii Yoshitaka Oyamada Hisaji Oshima Tsutomu Takeuchi Source Type: research

A biomarker for lymphoma development in Sjogren's syndrome: Salivary gland focus score
J Autoimmun. 2021 May 21;121:102648. doi: 10.1016/j.jaut.2021.102648. Online ahead of print.ABSTRACTThe aim of this study is to explore the role of labial minor salivary gland (LMSG) focus score (FS) in stratifying Sjögren's Syndrome (SS) patients, lymphoma development prediction and to facilitate early lymphoma diagnosis. Ιn an integrated cohort of 1997 patients, 618 patients with FS ≥ 1 and at least one-year elapsing time interval from SS diagnosis to lymphoma diagnosis or last follow up were identified. Clinical, laboratory and serological features were recorded. A data driven logistic regression model was ...
Source: Journal of Autoimmunity - May 24, 2021 Category: Allergy & Immunology Authors: Loukas Chatzis Andreas V Goules Vasilis Pezoulas Chiara Baldini Saviana Gandolfo Fotini N Skopouli Themis P Exarchos Efstathia K Kapsogeorgou Valentina Donati Paraskevi V Voulgari Clio P Mavragani Vasilis Gorgoulis Salvatore De Vita Dimitrios Fotiadis Mic Source Type: research

A biomarker for lymphoma development in Sjogren's syndrome: Salivary gland focus score
J Autoimmun. 2021 May 21;121:102648. doi: 10.1016/j.jaut.2021.102648. Online ahead of print.ABSTRACTThe aim of this study is to explore the role of labial minor salivary gland (LMSG) focus score (FS) in stratifying Sjögren's Syndrome (SS) patients, lymphoma development prediction and to facilitate early lymphoma diagnosis. Ιn an integrated cohort of 1997 patients, 618 patients with FS ≥ 1 and at least one-year elapsing time interval from SS diagnosis to lymphoma diagnosis or last follow up were identified. Clinical, laboratory and serological features were recorded. A data driven logistic regression model was ...
Source: Journal of Autoimmunity - May 24, 2021 Category: Allergy & Immunology Authors: Loukas Chatzis Andreas V Goules Vasilis Pezoulas Chiara Baldini Saviana Gandolfo Fotini N Skopouli Themis P Exarchos Efstathia K Kapsogeorgou Valentina Donati Paraskevi V Voulgari Clio P Mavragani Vasilis Gorgoulis Salvatore De Vita Dimitrios Fotiadis Mic Source Type: research

Transcriptome landscape of double negative T cells by single-cell RNA sequencing
In conclusion, we provide a map of the heterogeneity in naïve and active DNT cells, addresses the controversy about DNT cells, and provides potential transcription signatures of DNT cells. The landscape approach herein will eventually become more feasible through newer high throughput methods and will enable clustering data to be fed into a systems analysis approach. Thus the approach should become the "backdrop" of similar studies in the myriad murine models of autoimmunity, potentially highlighting the importance of DNT cells and other minor lineage of cells in immune homeostasis. The clear characterizatio...
Source: Journal of Autoimmunity - May 22, 2021 Category: Allergy & Immunology Authors: Lu Yang Yanbing Zhu Dan Tian Song Wang Jincheng Guo Guangyong Sun Hua Jin Chunpan Zhang Wen Shi M Eric Gershwin Zhongtao Zhang Yi Zhao Dong Zhang Source Type: research

Transcriptome landscape of double negative T cells by single-cell RNA sequencing
In conclusion, we provide a map of the heterogeneity in naïve and active DNT cells, addresses the controversy about DNT cells, and provides potential transcription signatures of DNT cells. The landscape approach herein will eventually become more feasible through newer high throughput methods and will enable clustering data to be fed into a systems analysis approach. Thus the approach should become the "backdrop" of similar studies in the myriad murine models of autoimmunity, potentially highlighting the importance of DNT cells and other minor lineage of cells in immune homeostasis. The clear characterizatio...
Source: Journal of Autoimmunity - May 22, 2021 Category: Allergy & Immunology Authors: Lu Yang Yanbing Zhu Dan Tian Song Wang Jincheng Guo Guangyong Sun Hua Jin Chunpan Zhang Wen Shi M Eric Gershwin Zhongtao Zhang Yi Zhao Dong Zhang Source Type: research

Transcriptome landscape of double negative T cells by single-cell RNA sequencing
In conclusion, we provide a map of the heterogeneity in naïve and active DNT cells, addresses the controversy about DNT cells, and provides potential transcription signatures of DNT cells. The landscape approach herein will eventually become more feasible through newer high throughput methods and will enable clustering data to be fed into a systems analysis approach. Thus the approach should become the "backdrop" of similar studies in the myriad murine models of autoimmunity, potentially highlighting the importance of DNT cells and other minor lineage of cells in immune homeostasis. The clear characterizatio...
Source: Journal of Autoimmunity - May 22, 2021 Category: Allergy & Immunology Authors: Lu Yang Yanbing Zhu Dan Tian Song Wang Jincheng Guo Guangyong Sun Hua Jin Chunpan Zhang Wen Shi M Eric Gershwin Zhongtao Zhang Yi Zhao Dong Zhang Source Type: research

T helper cell immunity in pregnancy and influence on autoimmune disease progression
J Autoimmun. 2021 May 18;121:102651. doi: 10.1016/j.jaut.2021.102651. Online ahead of print.ABSTRACTPregnancy presents the maternal immune system with a unique immunological challenge since it has to defend against pathogens while tolerating paternal allo-antigens expressed by fetal tissues. T helper (Th) cells play a central role in modulating immune responses and recent advances have defined distinct contributions of various Th cell subsets throughout each phase of human pregnancy, while dysregulation in Th responses show association with multiple obstetrical complications. In addition to localized decidual mechanisms, m...
Source: Journal of Autoimmunity - May 21, 2021 Category: Allergy & Immunology Authors: Jonathon J Graham Maria Serena Longhi Michael A Heneghan Source Type: research

Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p
J Autoimmun. 2021 May 19;121:102660. doi: 10.1016/j.jaut.2021.102660. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a potentially lethal disease with no curative treatment. Mesenchymal stromal cells (MSCs) have proved efficacy in SSc but no data is available on MSC-derived extracellular vesicles (EVs) in this multi-organ fibrosis disease. Small size (ssEVs) and large size EVs (lsEVs) were isolated from murine MSCs or human adipose tissue-derived MSCs (ASCs). Control antagomiR (Ct) or antagomiR-29a-3p (A29a) were transfected in MSCs and ASCs before EV production. EVs were injected in the HOCl-induced SSc model a...
Source: Journal of Autoimmunity - May 21, 2021 Category: Allergy & Immunology Authors: Pauline Rozier Marie Maumus Alexandre Thibault Jacques Maria Karine Toupet Jos éphine Lai-Kee-Him Christian Jorgensen Philippe Guilpain Dani èle Noël Source Type: research

Perspectives on vaccine induced thrombotic thrombocytopenia
J Autoimmun. 2021 May 18;121:102663. doi: 10.1016/j.jaut.2021.102663. Online ahead of print.ABSTRACTAs the novel SARS-CoV-2 continues to infect numerous individuals worldwide, one of the leading approaches in dealing with the global health crisis is vaccination against the COVID-19. Due to recent reports, vaccination with ChAdOx1 nCov-19 (developed by Oxford and AstraZeneca) may result in a vaccine-induced catastrophic thrombotic thrombocytopenia disorder. Thus, as of March 16 of 2021, vaccination programs in 18 countries had been suspended until further examination, including Sweden, Germany and France. This disorder pres...
Source: Journal of Autoimmunity - May 21, 2021 Category: Allergy & Immunology Authors: Arad Dotan Yehuda Shoenfeld Source Type: research

Mucosal-associated invariant T cells in Giant Cell Arteritis
This study aimed to assess the implication of mucosal-associated invariant T (MAIT) cells in GCA. Blood samples were obtained from 34 GCA patients (before and after 3 months of treatment with glucocorticoids (GC) alone) and compared with 20 controls aged>50 years. MAIT cells, defined by a CD3+CD4-TCRγδ-TCRVα7.2+CD161+ phenotype, were analyzed by flow cytometry. After sorting, we assessed the ability of MAIT cells to proliferate and produce cytokines after stimulation with anti CD3/CD28 microbeads or IL-12 and IL-18. MAIT were stained in temporal artery biopsies (TAB) by confocal microscopy. MAIT cells ...
Source: Journal of Autoimmunity - May 17, 2021 Category: Allergy & Immunology Authors: Thibault Ghesqui ère Marion Ciudad Andr é Ramon H élène Greigert Claire Gerard Claudie Cladi ère Marine Th ébault Coraline Genet Herv é Devilliers Fran çois Maurier Paul Ornetti Val érie Quipourt Pierre-Henry Gabrielle Catherine Creuzot-Garcher G Source Type: research

Mucosal-associated invariant T cells in Giant Cell Arteritis
This study aimed to assess the implication of mucosal-associated invariant T (MAIT) cells in GCA. Blood samples were obtained from 34 GCA patients (before and after 3 months of treatment with glucocorticoids (GC) alone) and compared with 20 controls aged>50 years. MAIT cells, defined by a CD3+CD4-TCRγδ-TCRVα7.2+CD161+ phenotype, were analyzed by flow cytometry. After sorting, we assessed the ability of MAIT cells to proliferate and produce cytokines after stimulation with anti CD3/CD28 microbeads or IL-12 and IL-18. MAIT were stained in temporal artery biopsies (TAB) by confocal microscopy. MAIT cells ...
Source: Journal of Autoimmunity - May 17, 2021 Category: Allergy & Immunology Authors: Thibault Ghesqui ère Marion Ciudad Andr é Ramon H élène Greigert Claire Gerard Claudie Cladi ère Marine Th ébault Coraline Genet Herv é Devilliers Fran çois Maurier Paul Ornetti Val érie Quipourt Pierre-Henry Gabrielle Catherine Creuzot-Garcher G Source Type: research

Mucosal-associated invariant T cells in Giant Cell Arteritis
This study aimed to assess the implication of mucosal-associated invariant T (MAIT) cells in GCA. Blood samples were obtained from 34 GCA patients (before and after 3 months of treatment with glucocorticoids (GC) alone) and compared with 20 controls aged>50 years. MAIT cells, defined by a CD3+CD4-TCRγδ-TCRVα7.2+CD161+ phenotype, were analyzed by flow cytometry. After sorting, we assessed the ability of MAIT cells to proliferate and produce cytokines after stimulation with anti CD3/CD28 microbeads or IL-12 and IL-18. MAIT were stained in temporal artery biopsies (TAB) by confocal microscopy. MAIT cells ...
Source: Journal of Autoimmunity - May 17, 2021 Category: Allergy & Immunology Authors: Thibault Ghesqui ère Marion Ciudad Andr é Ramon H élène Greigert Claire Gerard Claudie Cladi ère Marine Th ébault Coraline Genet Herv é Devilliers Fran çois Maurier Paul Ornetti Val érie Quipourt Pierre-Henry Gabrielle Catherine Creuzot-Garcher G Source Type: research

Mucosal-associated invariant T cells in Giant Cell Arteritis
This study aimed to assess the implication of mucosal-associated invariant T (MAIT) cells in GCA. Blood samples were obtained from 34 GCA patients (before and after 3 months of treatment with glucocorticoids (GC) alone) and compared with 20 controls aged>50 years. MAIT cells, defined by a CD3+CD4-TCRγδ-TCRVα7.2+CD161+ phenotype, were analyzed by flow cytometry. After sorting, we assessed the ability of MAIT cells to proliferate and produce cytokines after stimulation with anti CD3/CD28 microbeads or IL-12 and IL-18. MAIT were stained in temporal artery biopsies (TAB) by confocal microscopy. MAIT cells ...
Source: Journal of Autoimmunity - May 17, 2021 Category: Allergy & Immunology Authors: Thibault Ghesqui ère Marion Ciudad Andr é Ramon H élène Greigert Claire Gerard Claudie Cladi ère Marine Th ébault Coraline Genet Herv é Devilliers Fran çois Maurier Paul Ornetti Val érie Quipourt Pierre-Henry Gabrielle Catherine Creuzot-Garcher G Source Type: research

Population-based study on the association between autoimmune disease and lymphoma: National Health Insurance Service-National Sample Cohort 2002-2015 in Korea
J Autoimmun. 2021 May 12;121:102647. doi: 10.1016/j.jaut.2021.102647. Online ahead of print.ABSTRACTBACKGROUND: We aimed to evaluate the association between autoimmune disease (AID) and lymphoma incidence in the Korean population. We also aimed to compare the overall survival (OS) in patients with AID-associated lymphoma (AAL) with that in patients with lymphoma without AID.MATERIAL AND METHODS: We used National Sample Cohort 2002-2015 provided by National Health Insurance Service. Among 1,011,638 patients, 994,496 were recruited for the final cohort: 130,987 patients (13.2%) in the AID group and 863,509 (86.8%) in control...
Source: Journal of Autoimmunity - May 15, 2021 Category: Allergy & Immunology Authors: Jae Sik Kim Il Han Kim Ja Min Byun Ji Hyun Chang Source Type: research

Population-based study on the association between autoimmune disease and lymphoma: National Health Insurance Service-National Sample Cohort 2002-2015 in Korea
J Autoimmun. 2021 May 12;121:102647. doi: 10.1016/j.jaut.2021.102647. Online ahead of print.ABSTRACTBACKGROUND: We aimed to evaluate the association between autoimmune disease (AID) and lymphoma incidence in the Korean population. We also aimed to compare the overall survival (OS) in patients with AID-associated lymphoma (AAL) with that in patients with lymphoma without AID.MATERIAL AND METHODS: We used National Sample Cohort 2002-2015 provided by National Health Insurance Service. Among 1,011,638 patients, 994,496 were recruited for the final cohort: 130,987 patients (13.2%) in the AID group and 863,509 (86.8%) in control...
Source: Journal of Autoimmunity - May 15, 2021 Category: Allergy & Immunology Authors: Jae Sik Kim Il Han Kim Ja Min Byun Ji Hyun Chang Source Type: research

A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine
J Autoimmun. 2021 May 1;121:102649. doi: 10.1016/j.jaut.2021.102649. Online ahead of print.ABSTRACTAutoimmune and autoinflammatory rheumatic disorders (ARD) are treated with antimetabolites, calcineurin inhibitors and biologic agents either neutralizing cytokines [Tumor Necrosis Factor (TNF), Interleukin (IL)-1, IL-6, IL-17, B-cell activating factor] or being directed against B-cells (anti-CD-20), costimulatory molecules or JAK kinases. Similarly for the influenza or pneumococcal vaccines, there is limited data on the effectiveness of vaccination against SARS-CoV-2 infection and COVID-19 prevention for this susceptible pat...
Source: Journal of Autoimmunity - May 13, 2021 Category: Allergy & Immunology Authors: Haralampos M Moutsopoulos Source Type: research

A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine
J Autoimmun. 2021 May 1;121:102649. doi: 10.1016/j.jaut.2021.102649. Online ahead of print.ABSTRACTAutoimmune and autoinflammatory rheumatic disorders (ARD) are treated with antimetabolites, calcineurin inhibitors and biologic agents either neutralizing cytokines [Tumor Necrosis Factor (TNF), Interleukin (IL)-1, IL-6, IL-17, B-cell activating factor] or being directed against B-cells (anti-CD-20), costimulatory molecules or JAK kinases. Similarly for the influenza or pneumococcal vaccines, there is limited data on the effectiveness of vaccination against SARS-CoV-2 infection and COVID-19 prevention for this susceptible pat...
Source: Journal of Autoimmunity - May 13, 2021 Category: Allergy & Immunology Authors: Haralampos M Moutsopoulos Source Type: research

A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine
J Autoimmun. 2021 May 1;121:102649. doi: 10.1016/j.jaut.2021.102649. Online ahead of print.ABSTRACTAutoimmune and autoinflammatory rheumatic disorders (ARD) are treated with antimetabolites, calcineurin inhibitors and biologic agents either neutralizing cytokines [Tumor Necrosis Factor (TNF), Interleukin (IL)-1, IL-6, IL-17, B-cell activating factor] or being directed against B-cells (anti-CD-20), costimulatory molecules or JAK kinases. Similarly for the influenza or pneumococcal vaccines, there is limited data on the effectiveness of vaccination against SARS-CoV-2 infection and COVID-19 prevention for this susceptible pat...
Source: Journal of Autoimmunity - May 13, 2021 Category: Allergy & Immunology Authors: Haralampos M Moutsopoulos Source Type: research

An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19
This study provides a large list of autoantigens as well as new targets for future investigation, e.g., UBA1, UCHL1, USP7, CDK11A, PRKDC, PLD3, PSAT1, RAB1A, SLC2A1, platelet activating factor acetylhydrolase, and mitochondrial ribosomal proteins. This study illustrates how viral infection can modify host cellular proteins extensively, yield diverse autoantigens, and trigger a myriad of autoimmune sequelae. Our work provides a rich resource for studies into "long COVID" and related autoimmune sequelae.PMID:33971585 | PMC:PMC8075847 | DOI:10.1016/j.jaut.2021.102644 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 10, 2021 Category: Allergy & Immunology Authors: Julia Y Wang Wei Zhang Michael W Roehrl Victor B Roehrl Michael H Roehrl Source Type: research

An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19
This study provides a large list of autoantigens as well as new targets for future investigation, e.g., UBA1, UCHL1, USP7, CDK11A, PRKDC, PLD3, PSAT1, RAB1A, SLC2A1, platelet activating factor acetylhydrolase, and mitochondrial ribosomal proteins. This study illustrates how viral infection can modify host cellular proteins extensively, yield diverse autoantigens, and trigger a myriad of autoimmune sequelae. Our work provides a rich resource for studies into "long COVID" and related autoimmune sequelae.PMID:33971585 | PMC:PMC8075847 | DOI:10.1016/j.jaut.2021.102644 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 10, 2021 Category: Allergy & Immunology Authors: Julia Y Wang Wei Zhang Michael W Roehrl Victor B Roehrl Michael H Roehrl Source Type: research

An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19
This study provides a large list of autoantigens as well as new targets for future investigation, e.g., UBA1, UCHL1, USP7, CDK11A, PRKDC, PLD3, PSAT1, RAB1A, SLC2A1, platelet activating factor acetylhydrolase, and mitochondrial ribosomal proteins. This study illustrates how viral infection can modify host cellular proteins extensively, yield diverse autoantigens, and trigger a myriad of autoimmune sequelae. Our work provides a rich resource for studies into "long COVID" and related autoimmune sequelae.PMID:33971585 | DOI:10.1016/j.jaut.2021.102644 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 10, 2021 Category: Allergy & Immunology Authors: Julia Y Wang Wei Zhang Michael W Roehrl Victor B Roehrl Michael H Roehrl Source Type: research

Corrigendum to "Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19" [J. Autoimmun. 117C (2020) 102595]
J Autoimmun. 2021 Apr 30;120:102646. doi: 10.1016/j.jaut.2021.102646. Online ahead of print.NO ABSTRACTPMID:33940483 | PMC:PMC8086412 | DOI:10.1016/j.jaut.2021.102646 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 3, 2021 Category: Allergy & Immunology Authors: Luca Valenti Samantha Griffini Giuseppe Lamorte Elena Grovetti Sara Colonia Uceda Renteria Francesco Malvestiti Luigia Scudeller Alessandra Bandera Flora Peyvandi Daniele Prati Pierluigi Meroni Massimo Cugno Source Type: research

Corrigendum to "Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19" [J. Autoimmun. 117C (2020) 102595]
J Autoimmun. 2021 Apr 30;120:102646. doi: 10.1016/j.jaut.2021.102646. Online ahead of print.NO ABSTRACTPMID:33940483 | PMC:PMC8086412 | DOI:10.1016/j.jaut.2021.102646 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 3, 2021 Category: Allergy & Immunology Authors: Luca Valenti Samantha Griffini Giuseppe Lamorte Elena Grovetti Sara Colonia Uceda Renteria Francesco Malvestiti Luigia Scudeller Alessandra Bandera Flora Peyvandi Daniele Prati Pierluigi Meroni Massimo Cugno Source Type: research

Corrigendum to "Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19" [J. Autoimmun. 117C (2020) 102595]
J Autoimmun. 2021 Apr 30;120:102646. doi: 10.1016/j.jaut.2021.102646. Online ahead of print.NO ABSTRACTPMID:33940483 | PMC:PMC8086412 | DOI:10.1016/j.jaut.2021.102646 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 3, 2021 Category: Allergy & Immunology Authors: Luca Valenti Samantha Griffini Giuseppe Lamorte Elena Grovetti Sara Colonia Uceda Renteria Francesco Malvestiti Luigia Scudeller Alessandra Bandera Flora Peyvandi Daniele Prati Pierluigi Meroni Massimo Cugno Source Type: research

Corrigendum to "Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19" [J. Autoimmun. 117C (2020) 102595]
J Autoimmun. 2021 Apr 30;120:102646. doi: 10.1016/j.jaut.2021.102646. Online ahead of print.NO ABSTRACTPMID:33940483 | PMC:PMC8086412 | DOI:10.1016/j.jaut.2021.102646 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 3, 2021 Category: Allergy & Immunology Authors: Luca Valenti Samantha Griffini Giuseppe Lamorte Elena Grovetti Sara Colonia Uceda Renteria Francesco Malvestiti Luigia Scudeller Alessandra Bandera Flora Peyvandi Daniele Prati Pierluigi Meroni Massimo Cugno Source Type: research

Corrigendum to "Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19" [J. Autoimmun. 117C (2020) 102595]
J Autoimmun. 2021 Apr 30;120:102646. doi: 10.1016/j.jaut.2021.102646. Online ahead of print.NO ABSTRACTPMID:33940483 | PMC:PMC8086412 | DOI:10.1016/j.jaut.2021.102646 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 3, 2021 Category: Allergy & Immunology Authors: Luca Valenti Samantha Griffini Giuseppe Lamorte Elena Grovetti Sara Colonia Uceda Renteria Francesco Malvestiti Luigia Scudeller Alessandra Bandera Flora Peyvandi Daniele Prati Pierluigi Meroni Massimo Cugno Source Type: research

Corrigendum to "Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19" [J. Autoimmun. 117C (2020) 102595]
J Autoimmun. 2021 Apr 30;120:102646. doi: 10.1016/j.jaut.2021.102646. Online ahead of print.NO ABSTRACTPMID:33940483 | DOI:10.1016/j.jaut.2021.102646 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 3, 2021 Category: Allergy & Immunology Authors: Luca Valenti Samantha Griffini Giuseppe Lamorte Elena Grovetti Sara Colonia Uceda Renteria Francesco Malvestiti Luigia Scudeller Alessandra Bandera Flora Peyvandi Daniele Prati Pierluigi Meroni Massimo Cugno Source Type: research

Implication of a lysosomal antigen in the pathogenesis of lupus erythematosus
J Autoimmun. 2021 Apr 28;120:102633. doi: 10.1016/j.jaut.2021.102633. Online ahead of print.ABSTRACTNaturally-occurring autoantibodies to certain components of autophagy processes have been described in a few autoimmune diseases, but their fine specificity, their relationships with clinical phenotypes, and their potential pathogenic functions remain elusive. Here, we explored IgG autoantibodies reacting with a panel of cytoplasmic endosomal/lysosomal antigens and individual heat-shock proteins, all of which share links to autophagy. Sera from autoimmune patients and from MRL/lpr and NZB/W lupus-prone mice reacted with the ...
Source: Journal of Autoimmunity - May 1, 2021 Category: Allergy & Immunology Authors: Maud Wilhelm Srinivasa Reddy Bonam Nicolas Schall Mykolas Bendorius Anne-Sophie Korganow Catherine Lumbroso Sylviane Muller Source Type: research

Implication of a lysosomal antigen in the pathogenesis of lupus erythematosus
J Autoimmun. 2021 Apr 28;120:102633. doi: 10.1016/j.jaut.2021.102633. Online ahead of print.ABSTRACTNaturally-occurring autoantibodies to certain components of autophagy processes have been described in a few autoimmune diseases, but their fine specificity, their relationships with clinical phenotypes, and their potential pathogenic functions remain elusive. Here, we explored IgG autoantibodies reacting with a panel of cytoplasmic endosomal/lysosomal antigens and individual heat-shock proteins, all of which share links to autophagy. Sera from autoimmune patients and from MRL/lpr and NZB/W lupus-prone mice reacted with the ...
Source: Journal of Autoimmunity - May 1, 2021 Category: Allergy & Immunology Authors: Maud Wilhelm Srinivasa Reddy Bonam Nicolas Schall Mykolas Bendorius Anne-Sophie Korganow Catherine Lumbroso Sylviane Muller Source Type: research

Three distinct tolerogenic CD14 < sup > + < /sup > myeloid cell types to actively manage autoimmune disease: Opportunities and challenges
J Autoimmun. 2021 Apr 23;120:102645. doi: 10.1016/j.jaut.2021.102645. Online ahead of print.ABSTRACTCurrent treatment for patients with autoimmune disorders including rheumatoid arthritis, multiple sclerosis and type 1 diabetes, often consists of long-term drug regimens that broadly dampen immune responses. These non-specific treatments are frequently associated with severe side effects creating an urgent need for safer and more effective therapy to promote peripheral tolerance in autoimmune diseases. Cell-based immunotherapy may offer an encouraging alternative, where tolerogenic CD14+ myeloid cells are infused to inhibit...
Source: Journal of Autoimmunity - April 26, 2021 Category: Allergy & Immunology Authors: Glenn F van Wigcheren Daphne Roelofs Carl G Figdor Georgina Fl órez-Grau Source Type: research

Three distinct tolerogenic CD14 < sup > + < /sup > myeloid cell types to actively manage autoimmune disease: Opportunities and challenges
J Autoimmun. 2021 Apr 23;120:102645. doi: 10.1016/j.jaut.2021.102645. Online ahead of print.ABSTRACTCurrent treatment for patients with autoimmune disorders including rheumatoid arthritis, multiple sclerosis and type 1 diabetes, often consists of long-term drug regimens that broadly dampen immune responses. These non-specific treatments are frequently associated with severe side effects creating an urgent need for safer and more effective therapy to promote peripheral tolerance in autoimmune diseases. Cell-based immunotherapy may offer an encouraging alternative, where tolerogenic CD14+ myeloid cells are infused to inhibit...
Source: Journal of Autoimmunity - April 26, 2021 Category: Allergy & Immunology Authors: Glenn F van Wigcheren Daphne Roelofs Carl G Figdor Georgina Fl órez-Grau Source Type: research

Three distinct tolerogenic CD14 < sup > + < /sup > myeloid cell types to actively manage autoimmune disease: Opportunities and challenges
J Autoimmun. 2021 Apr 23;120:102645. doi: 10.1016/j.jaut.2021.102645. Online ahead of print.ABSTRACTCurrent treatment for patients with autoimmune disorders including rheumatoid arthritis, multiple sclerosis and type 1 diabetes, often consists of long-term drug regimens that broadly dampen immune responses. These non-specific treatments are frequently associated with severe side effects creating an urgent need for safer and more effective therapy to promote peripheral tolerance in autoimmune diseases. Cell-based immunotherapy may offer an encouraging alternative, where tolerogenic CD14+ myeloid cells are infused to inhibit...
Source: Journal of Autoimmunity - April 26, 2021 Category: Allergy & Immunology Authors: Glenn F van Wigcheren Daphne Roelofs Carl G Figdor Georgina Fl órez-Grau Source Type: research

Three distinct tolerogenic CD14 < sup > + < /sup > myeloid cell types to actively manage autoimmune disease: Opportunities and challenges
J Autoimmun. 2021 Apr 23;120:102645. doi: 10.1016/j.jaut.2021.102645. Online ahead of print.ABSTRACTCurrent treatment for patients with autoimmune disorders including rheumatoid arthritis, multiple sclerosis and type 1 diabetes, often consists of long-term drug regimens that broadly dampen immune responses. These non-specific treatments are frequently associated with severe side effects creating an urgent need for safer and more effective therapy to promote peripheral tolerance in autoimmune diseases. Cell-based immunotherapy may offer an encouraging alternative, where tolerogenic CD14+ myeloid cells are infused to inhibit...
Source: Journal of Autoimmunity - April 26, 2021 Category: Allergy & Immunology Authors: Glenn F van Wigcheren Daphne Roelofs Carl G Figdor Georgina Fl órez-Grau Source Type: research

Autoreactive T cells and their role in atopic dermatitis
J Autoimmun. 2021 Apr 20;120:102634. doi: 10.1016/j.jaut.2021.102634. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is an itchy, non-contagious relapsing and chronic inflammatory skin disease that usually develops in early childhood. This pathology is associated with food allergy, allergic asthma, allergic rhinitis and anaphylaxis which may persist in adulthood. The underlying mechanisms of AD (endotypes) are just beginning to be discovered and show a complex interaction of various pathways including skin barrier function and immune deviation. Immune reactions to self-proteins (autoantigens) of the skin have been id...
Source: Journal of Autoimmunity - April 23, 2021 Category: Allergy & Immunology Authors: Tina De Bruyn Carlier Fariza Mishaal Saiema Badloe Johannes Ring Jan Gutermuth Inge Kortekaas Krohn Source Type: research

Autoreactive T cells and their role in atopic dermatitis
J Autoimmun. 2021 Apr 20;120:102634. doi: 10.1016/j.jaut.2021.102634. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is an itchy, non-contagious relapsing and chronic inflammatory skin disease that usually develops in early childhood. This pathology is associated with food allergy, allergic asthma, allergic rhinitis and anaphylaxis which may persist in adulthood. The underlying mechanisms of AD (endotypes) are just beginning to be discovered and show a complex interaction of various pathways including skin barrier function and immune deviation. Immune reactions to self-proteins (autoantigens) of the skin have been id...
Source: Journal of Autoimmunity - April 23, 2021 Category: Allergy & Immunology Authors: Tina De Bruyn Carlier Fariza Mishaal Saiema Badloe Johannes Ring Jan Gutermuth Inge Kortekaas Krohn Source Type: research