Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Peripheral helper T cells in human diseases
J Autoimmun. 2024 Apr 3;145:103218. doi: 10.1016/j.jaut.2024.103218. Online ahead of print.ABSTRACTPeripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cyt...
Source: Journal of Autoimmunity - April 4, 2024 Category: Allergy & Immunology Authors: Xueyang Zou Feifei Huo Lulu Sun Jing Huang Source Type: research
Peripheral helper T cells in human diseases
J Autoimmun. 2024 Apr 3;145:103218. doi: 10.1016/j.jaut.2024.103218. Online ahead of print.ABSTRACTPeripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cyt...
Source: Journal of Autoimmunity - April 4, 2024 Category: Allergy & Immunology Authors: Xueyang Zou Feifei Huo Lulu Sun Jing Huang Source Type: research
Peripheral helper T cells in human diseases
J Autoimmun. 2024 Apr 3;145:103218. doi: 10.1016/j.jaut.2024.103218. Online ahead of print.ABSTRACTPeripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cyt...
Source: Journal of Autoimmunity - April 4, 2024 Category: Allergy & Immunology Authors: Xueyang Zou Feifei Huo Lulu Sun Jing Huang Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
