Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination
We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Clinical, biochemical and instrumental work-up demonstrated Graves' disease and autoimmune diabetes mellitus. The occurrence of these disorders could be explained through different mechanism such as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), mRNA "self-adjuvant" effect, molecular mimicry between human and viral proteins and ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Armando Patrizio Silvia Martina Ferrari Alessandro Antonelli Poupak Fallahi Source Type: research

Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network
J Autoimmun. 2021 Oct 9:102730. doi: 10.1016/j.jaut.2021.102730. Online ahead of print.ABSTRACTOBJECTIVES: To determine the severity and outcome of COVID-19 among individuals with lupus as compared to controls. The secondary objective was to identify the risk association of sex, race, presence of nephritis, and use of various immunomodulators with COVID-19 outcomes.METHODS: Retrospective data of individuals with lupus with and without COVID-19 between January 2020 to May 2021 was retrieved from the TriNetX. A one-to-one matched COVID-19 positive control was selected using propensity score(PS) matching. We assessed several ...
Source: Journal of Autoimmunity - October 15, 2021 Category: Allergy & Immunology Authors: Rahul Raiker Haig Pakhchanian Charles DeYoung Latika Gupta Sinan Karde ş Sakir Ahmed Chengappa Kavadichanda Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Nov;124:102727. doi: 10.1016/j.jaut.2021.102727. Epub 2021 Oct 1.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously published in the...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis
J Autoimmun. 2021 Sep 30;124:102727. doi: 10.1016/j.jaut.2021.102727. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis involving the skin and internal organs. The etiology of SSc remains quite obscure; it may encompass multiple host genetic and environmental -infectious/chemical-factors. The present review focused on the potential role of environmental agents in the etiopathogenesis of SSc based on epidemiological, clinical, and laboratory investigations previously publish...
Source: Journal of Autoimmunity - October 3, 2021 Category: Allergy & Immunology Authors: Clodoveo Ferri Maria-Cristina Arcangeletti Elisabetta Caselli Krystyna Zakrzewska Clara Maccari Adriana Calderaro Maria D'Accolti Irene Soffritti Rosaria Arvia Gianluca Sighinolfi Erica Artoni Dilia Giuggioli Source Type: research

Durable renal response and safety with add-on belimumab in patients with lupus nephritis in real-life setting (BeRLiSS-LN). Results from a large, nationwide, multicentric cohort
J Autoimmun. 2021 Sep 30;124:102729. doi: 10.1016/j.jaut.2021.102729. Online ahead of print.ABSTRACTBACKGROUND: Belimumab was recently approved for treatment of lupus glomerulonephritis (LN).AIM: To evaluate renal response and its predictors in LN patients receiving belimumab in real-life.PATIENTS AND METHODS: We considered all patients fulfilling the SLEDAI-2K renal items and/or having estimated glomerular filtration rate (eGFR)≤60 ml/min/1.73 m2, with positive anti-dsDNA and/or low C3/C4 enrolled in the multicentre Italian lupus cohort BeRLiSS (BElimumab in Real LIfe Setting Study), treated with monthly IV Belimumab 1...
Source: Journal of Autoimmunity - October 2, 2021 Category: Allergy & Immunology Authors: Mariele Gatto Francesca Saccon Laura Andreoli Elena Bartoloni Francesco Benvenuti Alessandra Bortoluzzi Enrica Bozzolo Enrico Brunetta Valentina Canti Paolo Cardinaletti Fulvia Ceccarelli Francesco Ciccia Fabrizio Conti Ginevra De Marchi Amato de Paulis S Source Type: research

Durable renal response and safety with add-on belimumab in patients with lupus nephritis in real-life setting (BeRLiSS-LN). Results from a large, nationwide, multicentric cohort
J Autoimmun. 2021 Sep 29;124:102729. doi: 10.1016/j.jaut.2021.102729. Online ahead of print.ABSTRACTBACKGROUND: Belimumab was recently approved for treatment of lupus glomerulonephritis (LN).AIM: To evaluate renal response and its predictors in LN patients receiving belimumab in real-life.PATIENTS AND METHODS: We considered all patients fulfilling the SLEDAI-2K renal items and/or having estimated glomerular filtration rate (eGFR)≤60 ml/min/1.73 m2, with positive anti-dsDNA and/or low C3/C4 enrolled in the multicentre Italian lupus cohort BeRLiSS (BElimumab in Real LIfe Setting Study), treated with monthly IV Belimumab 1...
Source: Journal of Autoimmunity - October 2, 2021 Category: Allergy & Immunology Authors: Mariele Gatto Francesca Saccon Laura Andreoli Elena Bartoloni Francesco Benvenuti Alessandra Bortoluzzi Enrica Bozzolo Enrico Brunetta Valentina Canti Paolo Cardinaletti Fulvia Ceccarelli Francesco Ciccia Fabrizio Conti Ginevra De Marchi Amato de Paulis S Source Type: research

Consumption of complement in a 26-year-old woman with severe thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination
J Autoimmun. 2021 Sep 27;124:102728. doi: 10.1016/j.jaut.2021.102728. Online ahead of print.ABSTRACTExtremely rare reactions characterized by thrombosis and thrombocytopenia have been described in subjects that received ChAdOx1 nCoV-19 vaccination 5-16 days earlier. Although patients with vaccine-induced thrombotic thrombocytopenia (VITT) have high levels of antibodies to platelet factor 4 (PF4)-polyanion complexes, the exact mechanism of the development of thrombosis is still unknown. Here we reported serum studies as well as proteomics and genomics analyses demonstrating a massive complement activation potentially linked...
Source: Journal of Autoimmunity - September 30, 2021 Category: Allergy & Immunology Authors: Massimo Cugno Paolo Macor Mara Giordano Marcello Manfredi Samantha Griffini Elena Grovetti Luca De Maso Simona Mellone Luca Valenti Daniele Prati Sara Bonato Giacomo Comi Andrea Artoni Pier Luigi Meroni Flora Peyvandi Source Type: research

Consumption of complement in a 26-year-old woman with severe thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination
J Autoimmun. 2021 Sep 27;124:102728. doi: 10.1016/j.jaut.2021.102728. Online ahead of print.ABSTRACTExtremely rare reactions characterized by thrombosis and thrombocytopenia have been described in subjects that received ChAdOx1 nCoV-19 vaccination 5-16 days earlier. Although patients with vaccine-induced thrombotic thrombocytopenia (VITT) have high levels of antibodies to platelet factor 4 (PF4)-polyanion complexes, the exact mechanism of the development of thrombosis is still unknown. Here we reported serum studies as well as proteomics and genomics analyses demonstrating a massive complement activation potentially linked...
Source: Journal of Autoimmunity - September 30, 2021 Category: Allergy & Immunology Authors: Massimo Cugno Paolo Macor Mara Giordano Marcello Manfredi Samantha Griffini Elena Grovetti Luca De Maso Simona Mellone Luca Valenti Daniele Prati Sara Bonato Giacomo Comi Andrea Artoni Pier Luigi Meroni Flora Peyvandi Source Type: research

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis
J Autoimmun. 2021 Sep 21;124:102726. doi: 10.1016/j.jaut.2021.102726. Online ahead of print.ABSTRACTThe ability of regulatory T (Treg) cells to migrate into inflammatory sites is reduced in autoimmune diseases, including rheumatoid arthritis (RA). The reasons for impaired Treg cell migration remain largely unknown. We performed multiplex human kinase activity arrays to explore possible differences in the post-translational phosphorylation status of kinase related proteins that could account for altered Treg cell migration in RA. Results were verified by migration assays and Western blot analysis of CD4+ T cells from RA pat...
Source: Journal of Autoimmunity - September 23, 2021 Category: Allergy & Immunology Authors: Anja Meyer Shuaifeng Yan Viktoria Golumba-Nagy Ruth L Esser Verena Barbarino Stuart J Blakemore Lisa Rusyn Anastasia Nikiforov Tamina Seeger-Nukpezah Holger Gr üll Christian P Pallasch David M Kofler Source Type: research

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis
J Autoimmun. 2021 Sep 20;124:102726. doi: 10.1016/j.jaut.2021.102726. Online ahead of print.ABSTRACTThe ability of regulatory T (Treg) cells to migrate into inflammatory sites is reduced in autoimmune diseases, including rheumatoid arthritis (RA). The reasons for impaired Treg cell migration remain largely unknown. We performed multiplex human kinase activity arrays to explore possible differences in the post-translational phosphorylation status of kinase related proteins that could account for altered Treg cell migration in RA. Results were verified by migration assays and Western blot analysis of CD4+ T cells from RA pat...
Source: Journal of Autoimmunity - September 23, 2021 Category: Allergy & Immunology Authors: Anja Meyer Shuaifeng Yan Viktoria Golumba-Nagy Ruth L Esser Verena Barbarino Stuart J Blakemore Lisa Rusyn Anastasia Nikiforov Tamina Seeger-Nukpezah Holger Gr üll Christian P Pallasch David M Kofler Source Type: research

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis
J Autoimmun. 2021 Sep 20;124:102726. doi: 10.1016/j.jaut.2021.102726. Online ahead of print.ABSTRACTThe ability of regulatory T (Treg) cells to migrate into inflammatory sites is reduced in autoimmune diseases, including rheumatoid arthritis (RA). The reasons for impaired Treg cell migration remain largely unknown. We performed multiplex human kinase activity arrays to explore possible differences in the post-translational phosphorylation status of kinase related proteins that could account for altered Treg cell migration in RA. Results were verified by migration assays and Western blot analysis of CD4+ T cells from RA pat...
Source: Journal of Autoimmunity - September 23, 2021 Category: Allergy & Immunology Authors: Anja Meyer Shuaifeng Yan Viktoria Golumba-Nagy Ruth L Esser Verena Barbarino Stuart J Blakemore Lisa Rusyn Anastasia Nikiforov Tamina Seeger-Nukpezah Holger Gr üll Christian P Pallasch David M Kofler Source Type: research

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis
J Autoimmun. 2021 Sep 20;124:102726. doi: 10.1016/j.jaut.2021.102726. Online ahead of print.ABSTRACTThe ability of regulatory T (Treg) cells to migrate into inflammatory sites is reduced in autoimmune diseases, including rheumatoid arthritis (RA). The reasons for impaired Treg cell migration remain largely unknown. We performed multiplex human kinase activity arrays to explore possible differences in the post-translational phosphorylation status of kinase related proteins that could account for altered Treg cell migration in RA. Results were verified by migration assays and Western blot analysis of CD4+ T cells from RA pat...
Source: Journal of Autoimmunity - September 23, 2021 Category: Allergy & Immunology Authors: Anja Meyer Shuaifeng Yan Viktoria Golumba-Nagy Ruth L Esser Verena Barbarino Stuart J Blakemore Lisa Rusyn Anastasia Nikiforov Tamina Seeger-Nukpezah Holger Gr üll Christian P Pallasch David M Kofler Source Type: research

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis
J Autoimmun. 2021 Sep 20;124:102726. doi: 10.1016/j.jaut.2021.102726. Online ahead of print.ABSTRACTThe ability of regulatory T (Treg) cells to migrate into inflammatory sites is reduced in autoimmune diseases, including rheumatoid arthritis (RA). The reasons for impaired Treg cell migration remain largely unknown. We performed multiplex human kinase activity arrays to explore possible differences in the post-translational phosphorylation status of kinase related proteins that could account for altered Treg cell migration in RA. Results were verified by migration assays and Western blot analysis of CD4+ T cells from RA pat...
Source: Journal of Autoimmunity - September 23, 2021 Category: Allergy & Immunology Authors: Anja Meyer Shuaifeng Yan Viktoria Golumba-Nagy Ruth L Esser Verena Barbarino Stuart J Blakemore Lisa Rusyn Anastasia Nikiforov Tamina Seeger-Nukpezah Holger Gr üll Christian P Pallasch David M Kofler Source Type: research

IgG anti-Pentraxin 3 antibodies are a novel biomarker of ANCA-associated vasculitis and better identify patients with eosinophilic granulomatosis with polyangiitis
J Autoimmun. 2021 Sep 14;124:102725. doi: 10.1016/j.jaut.2021.102725. Online ahead of print.ABSTRACTOBJECTIVE: To investigate prevalence of anti-Pentraxin 3 (PTX3) antibodies in sera of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.METHODS: Anti-PTX3 and PTX3 levels were analysed by enzyme-linked immunosorbent assays in sera from unselected patients with AAV and compared with patients with systemic lupus erythematosus (SLE, n = 130), other connective tissue diseases (CTDs, n = 97) and matched healthy controls (n = 97). Optical density (OD) cut-off for positive anti-PTX3 antibodies was d...
Source: Journal of Autoimmunity - September 17, 2021 Category: Allergy & Immunology Authors: Roberto Padoan Mariele Gatto Anna Ghirardello Marta Tonello Chiara Franco Mara Felicetti Franco Schiavon Andrea Doria Source Type: research

IgG anti-Pentraxin 3 antibodies are a novel biomarker of ANCA-associated vasculitis and better identify patients with eosinophilic granulomatosis with polyangiitis
J Autoimmun. 2021 Sep 14;124:102725. doi: 10.1016/j.jaut.2021.102725. Online ahead of print.ABSTRACTOBJECTIVE: To investigate prevalence of anti-Pentraxin 3 (PTX3) antibodies in sera of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.METHODS: Anti-PTX3 and PTX3 levels were analysed by enzyme-linked immunosorbent assays in sera from unselected patients with AAV and compared with patients with systemic lupus erythematosus (SLE, n = 130), other connective tissue diseases (CTDs, n = 97) and matched healthy controls (n = 97). Optical density (OD) cut-off for positive anti-PTX3 antibodies was d...
Source: Journal of Autoimmunity - September 17, 2021 Category: Allergy & Immunology Authors: Roberto Padoan Mariele Gatto Anna Ghirardello Marta Tonello Chiara Franco Mara Felicetti Franco Schiavon Andrea Doria Source Type: research

IgG anti-Pentraxin 3 antibodies are a novel biomarker of ANCA-associated vasculitis and better identify patients with eosinophilic granulomatosis with polyangiitis
J Autoimmun. 2021 Sep 14;124:102725. doi: 10.1016/j.jaut.2021.102725. Online ahead of print.ABSTRACTOBJECTIVE: To investigate prevalence of anti-Pentraxin 3 (PTX3) antibodies in sera of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.METHODS: Anti-PTX3 and PTX3 levels were analysed by enzyme-linked immunosorbent assays in sera from unselected patients with AAV and compared with patients with systemic lupus erythematosus (SLE, n = 130), other connective tissue diseases (CTDs, n = 97) and matched healthy controls (n = 97). Optical density (OD) cut-off for positive anti-PTX3 antibodies was d...
Source: Journal of Autoimmunity - September 17, 2021 Category: Allergy & Immunology Authors: Roberto Padoan Mariele Gatto Anna Ghirardello Marta Tonello Chiara Franco Mara Felicetti Franco Schiavon Andrea Doria Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
J Autoimmun. 2021 Sep 1;124:102723. doi: 10.1016/j.jaut.2021.102723. Online ahead of print.ABSTRACTThe initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly un...
Source: Journal of Autoimmunity - September 4, 2021 Category: Allergy & Immunology Authors: Jeroen F J Bogie Tim Vanmierlo Jasmine Vanmol Silke Timmermans Jo Mailleux Katherine Nelissen Erwin Wijnands Kristiaan Wouters Piet Stinissen Jan- Åke Gustafsson Knut R Steffensen Monique Mulder Noam Zelcer Jerome J A Hendriks Source Type: research

Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle
In conclusion, human dermal γδT-cells exert physiological stress-sentinel functions in human skin, where their excessive activity can promote autoimmunity towards stressed HFs that overexpress CD1d, CXCL12, and/or MICA.PMID:34479087 | DOI:10.1016/j.jaut.2021.102711 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 3, 2021 Category: Allergy & Immunology Authors: Youhei Uchida Jennifer Gherardini Karin Pappelbaum J érémy Chéret Andreas Schulte-Mecklenbeck Catharina C Gross Natasa Strbo Amos Gilhar Alfredo Rossi Wolfgang Funk Takuro Kanekura Lu ís Almeida Marta Bertolini Ralf Paus Source Type: research

Anti-Ro60 and anti-Ro52/TRIM21: Two distinct autoantibodies in systemic autoimmune diseases
J Autoimmun. 2021 Aug 28;124:102724. doi: 10.1016/j.jaut.2021.102724. Online ahead of print.ABSTRACTAs iconic and important diagnostic autoantibodies, anti-Ro60 and anti-Ro52/tri-partite motif-containing 21 (TRIM21) make a common appearance in a number of systemic autoimmune disorders such as systemic lupus erythematosus (SLE). These autoantibodies often co-exist together; yet despite their close relationship, there is no evidence that they are physically linked and probably reflect a convergence of separate processes of failed immunological tolerance. Confusingly, they are sometimes classed together as the "SSA"...
Source: Journal of Autoimmunity - August 31, 2021 Category: Allergy & Immunology Authors: Adrian Y S Lee Joanne H Reed Tom P Gordon Source Type: research

Chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination
CONCLUSION: Vaccine misapplication, potentially a genetic predisposition, and vaccine components contribute to SIRVA. The association with autoimmunity risk allele HLA-DRB1*04 needs to be further investigated. Despite transient autoimmunity, SIRVA was not associated with progression to autoimmune disease during two years of follow-up.PMID:34403915 | DOI:10.1016/j.jaut.2021.102714 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - August 17, 2021 Category: Allergy & Immunology Authors: Julia R Hirsiger Giorgio Tamborrini Dorothee Harder Glenn R Bantug Gideon Hoenger Mike Recher Christian Marx Quan-Zhen Li Ivan Martin Christoph Hess Arnaud Scherberich Thomas Daikeler Christoph T Berger Source Type: research

Chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination
CONCLUSION: Vaccine misapplication, potentially a genetic predisposition, and vaccine components contribute to SIRVA. The association with autoimmunity risk allele HLA-DRB1*04 needs to be further investigated. Despite transient autoimmunity, SIRVA was not associated with progression to autoimmune disease during two years of follow-up.PMID:34403915 | DOI:10.1016/j.jaut.2021.102714 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - August 17, 2021 Category: Allergy & Immunology Authors: Julia R Hirsiger Giorgio Tamborrini Dorothee Harder Glenn R Bantug Gideon Hoenger Mike Recher Christian Marx Quan-Zhen Li Ivan Martin Christoph Hess Arnaud Scherberich Thomas Daikeler Christoph T Berger Source Type: research