Expanding the importance of HMERF titinopathy: new mutations and clinical aspects
ConclusionsOur collection of 12 new families expands mutational spectrum with two new mutations identified. HMERF is not that rare and can be found worldwide, but maybe underdiagnosed. Diagnostic process seems to be complex as this study shows with mostly single patients without clear dominant family history. (Source: Journal of Neurology)
Source: Journal of Neurology - January 21, 2019 Category: Neurology Source Type: research

Comparative efficacy and safety of therapy for the behavioral and psychological symptoms of dementia: a systemic review and Bayesian network meta-analysis
ConclusionPharmacological therapies should be the first choice for BPSD. Aripiprazole, haloperidol, quetiapine, and risperidone of antipsychotics showed the significant efficacy, while memantine, galantine, and donepezil may provide the modest effectiveness. The safety of all was thought to be acceptable. (Source: Journal of Neurology)
Source: Journal of Neurology - January 21, 2019 Category: Neurology Source Type: research

Treatment with alemtuzumab or rituximab after fingolimod withdrawal in relapsing –remitting multiple sclerosis is effective and safe
AbstractBackgroundIt has been described that treating relapsing –remitting multiple sclerosis (RRMS) patients with alemtuzumab following fingolimod could be less effective due to the different dynamics of lymphocyte repopulation. Effectiveness and safety of alemtuzumab compared to rituximab after fingolimod withdrawal were analyzed.Patients and methodsA follow-up of a cohort of RRMS patients treated with alemtuzumab or rituximab after fingolimod withdrawal was accomplished. Effectiveness, measured by the percentage of patients with no evidence of disease activity (NEDA), and the presence of side effects (SE) were reg...
Source: Journal of Neurology - January 19, 2019 Category: Neurology Source Type: research

Sensor-based algorithmic dosing suggestions for oral administration of levodopa/carbidopa microtablets for Parkinson ’s disease: a first experience
ConclusionThis study shows that it is possible to use algorithmic sensor-based dosing adjustments to optimize treatment with oral medication for  PD patients. (Source: Journal of Neurology)
Source: Journal of Neurology - January 18, 2019 Category: Neurology Source Type: research

Deep brain stimulation for monogenic Parkinson ’s disease: a systematic review
AbstractDeep brain stimulation (DBS) is an effective treatment for Parkinson ’s disease (PD) patients with motor fluctuations and dyskinesias. The key DBS efficacy studies were performed in PD patients with unknown genotypes; however, given the estimated monogenic mutation prevalence of approximately 5–10%, most commonlyLRRK2, PRKN, PINK1 andSNCA, and risk-increasing genetic factors such asGBA, proper characterization is becoming increasingly relevant. We performed a systematic review of 46 studies that reported DBS effects in 221 genetic PD patients. The results suggest that monogenic PD patients have variable...
Source: Journal of Neurology - January 18, 2019 Category: Neurology Source Type: research

Factors interfering with parenthood decision-making in an Italian sample of people with multiple sclerosis: an exploratory online survey
ConclusionMS diagnosis impacted dramatically on the life project of 7% of pwMS that decided not to have children because of the disease and in pro-parenthood pwMS impacted especially on having the second child. Only a minority was counseled to plan pregnancy. A worse disease course driving to a progressive phenotype at survey time might have negatively impacted on parenthood desire. (Source: Journal of Neurology)
Source: Journal of Neurology - January 16, 2019 Category: Neurology Source Type: research

High efficacy of rituximab for myasthenia gravis: a comprehensive nationwide study in Austria
ConclusionIn this retrospective study on RTX for MG, the largest to date, RTX appeared safe, efficacious and fast acting. Benefit from RTX was greatest in MuSK ab  + MG. (Source: Journal of Neurology)
Source: Journal of Neurology - January 16, 2019 Category: Neurology Source Type: research

Painful legs and moving toes syndrome evaluated through brain single photon emission computed tomography: a case series
AbstractPainful legs and moving toes (PLMT) syndrome is a clinical entity characterized by persistent pain in the feet or legs and involuntary movements of one or more toes. The precise patho-mechanisms of PLMT still remain unknown. Herein, we examined ten patients clinically identified with PLMT syndrome. All patients first presented persistent pain prior to the onset of motor symptoms. Each patient was examined by neurological investigation, neuro-imaging methods including brain magnetic resonance imaging (MRI) and electrophysiological methods. The brain single photon emission computed tomography (SPECT) images of eight ...
Source: Journal of Neurology - January 14, 2019 Category: Neurology Source Type: research

Peripheral neuropathy in hereditary spastic paraplegia caused by REEP1 variants
The objective of this study was to characterize patients with pathogenicREEP1 variants and neurophysiologically assess the extent of peripheral nerve involvement in this patient group. Thirty-eight index cases were molecular-genetically tested, yielding two previously reported pathogenicREEP1 variants and a novel missense variant, in a total of four index patients. Three of four probands and five additional family members underwent nerve conduction studies, electromyography, quantitative sensory testing, and examination of the autonomic nervous system. None of the examined patients had completely unremarkable results of pe...
Source: Journal of Neurology - January 12, 2019 Category: Neurology Source Type: research

Long-term tolerability, safety and efficacy of rituximab in neuromyelitis optica spectrum disorder: a prospective study
AbstractBackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a B-cell-mediated disease with autoimmunity towards the astrocyte water channel aquaporin-4 (AQP-4) in the central nervous system.ObjectiveTo assess the long-term safety and efficacy in NMOSD patients receiving maintenance therapy with B-cell-depleting agent rituximab for more than 2  years.MethodNMOSD patients were included prospectively from 2014 to 2018 and received continuous cycles of rituximab infusions biannually. Incidence of adverse events (AE), serious AEs (SAE), and infusion-related AEs were evaluated through monthly phone calls and neurolo...
Source: Journal of Neurology - January 11, 2019 Category: Neurology Source Type: research

Subjective cognitive decline and progression to dementia in Parkinson ’s disease: a long-term follow-up study
ConclusionsThe present investigation is the first to conduct a long-term follow-up study of PD-SCD and its relationship with the development of dementia. The results provide relevant data about the characterization of SCD in PD patients and show that PD-SCD is a risk factor for progression to dementia. (Source: Journal of Neurology)
Source: Journal of Neurology - January 11, 2019 Category: Neurology Source Type: research

Mills ’ syndrome revisited
We describe three cases that have been under review for a minimum of 11 years (range 11–19). In all patients, symptoms started in a leg, with a mean age of onset of 59 years (range 53–63). The only abnormality on laborator y investigations was a mildly elevated CSF protein in one case. MRI demonstrated focal T2 hyper-intensity located eccentrically in the cervical cord ipsilateral to the symptomatic side. No cerebral abnormality was demonstrated. Whilst visual and somatosensory evoked potentials were unremarkable, mot or evoked potentials were abnormal in all patients: central motor conduction times w...
Source: Journal of Neurology - January 10, 2019 Category: Neurology Source Type: research

Long-lasting diagonistic dyspraxia suppressed by rTMS applied to the right motor cortex
We describe the case of a 58-year-old patient with complete callosal agenesis, who developed after a stroke a long lasting and distressing diagonistic dyspraxia. We found two original treatments to relieve the patient from his left limb conflicting movements. Reinforcing left arm sensory input minimized dyspraxic movements but was difficult to apply daily and was found unsatisfactory by the patient. As left anarchic, unwished movements of diagonistic dyspraxia have been attributed to the lack of inhibition exerted by supplementary motor area on right motor cortex, we applied sham-controlled rTMS to the right motor cortex. ...
Source: Journal of Neurology - January 10, 2019 Category: Neurology Source Type: research

Incidence and mechanism of early neurological deterioration after endovascular thrombectomy
ConclusionNeurological deterioration frequently occurs after endovascular thrombectomy, and the risk factors of END differ according to the mechanism of END. (Source: Journal of Neurology)
Source: Journal of Neurology - January 10, 2019 Category: Neurology Source Type: research

Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage
ConclusionsCerebellar-ICH patients frequently show supratentorial CMBs. The mixed-CMBs pattern appears to be the most common. Our radiological and pathological results suggest that the majority of cerebellar-ICH patients harbor HTN-SVD as dominant microangiopathy. (Source: Journal of Neurology)
Source: Journal of Neurology - January 8, 2019 Category: Neurology Source Type: research

Clinical effect of successful reperfusion in patients presenting with NIHSS   & lt;  8: data from the BEYOND-SWIFT registry
AbstractBackground and purposeIf patients presenting with large vessel occlusions (LVO) and mild symptoms should be treated with endvoascular treatment (EVT) remains unclear. Aims of this study were (1) assessing the safety and technical efficacy of EVT in patients with NIHSS  
Source: Journal of Neurology - January 8, 2019 Category: Neurology Source Type: research

Adult CSF total protein upper reference limits should be age-partitioned and significantly higher than 0.45  g/L: a systematic review
ConclusionsThere is concordance in available literature to recommend increasing CSF total protein upper reference limits, and to consider implementing age-adjusted values above 0.60  g/L starting at age 50. This information merits worldwide dissemination, to reduce the risk of over-diagnosis. (Source: Journal of Neurology)
Source: Journal of Neurology - January 8, 2019 Category: Neurology Source Type: research

Patient MW: transient visual hemi-agnosia
AbstractThe concept of functional modularity in human visual processing was proposed 25 years ago with the distinction between a ventral pathway for object recognition and a dorsal pathway for action processing. Lesions along these pathways yield selective deficits. A 15-year-old patient (MW) presented with a seizure due to a lesion in the left occipitotemporal cortex. Surgical resection of the lesion was performed with sparing of the classic language areas and visual fields. Postoperatively MW had great difficulty reading and had a specific agnosia for more complex visual stimuli in the right hemifield. No deficit was see...
Source: Journal of Neurology - January 7, 2019 Category: Neurology Source Type: research

Continuous subcutaneous apomorphine in advanced Parkinson ’s disease patients treated with deep brain stimulation
We describe our experience with continuous subcutaneous apomorphine infusion (APO) in patients with DBS.MethodsWe undertook a retrospective analysis of all patients treated with DBS and APO at our centre over 12  years. Subjects were allocated to four groups: (1) APO temporarily before DBS, (2) APO after DBS complications before a new DBS, (3) APO after definitive DBS removal, and (4) APO in patients with DBS and declining response. Motor state and other parameters were analysed and compared for the differ ent treatments.ResultsData for 71 patients were evaluated. Group 1: (n = 18) patients improved thei...
Source: Journal of Neurology - January 7, 2019 Category: Neurology Source Type: research

Atypical parkinsonism with severely reduced striatal dopamine uptake associated with a 16p11.2 duplication syndrome
(Source: Journal of Neurology)
Source: Journal of Neurology - January 7, 2019 Category: Neurology Source Type: research

A systematic review on the definition of rhabdomyolysis
ConclusionAt present, we recommend a clinical syndrome of acute muscle weakness, myalgia, and muscle swelling combined with a CK cut-off value of>  1000 IU/L/ or CK >  5 × ULN for the standard definition of a mild RML. Additionally measured myoglobinuria and AKI indicate a severe type of RML. Exclusion criteria as well as the chronological sequence need to be considered for a conclusive RML definition. (Source: Journal of Neurology)
Source: Journal of Neurology - January 7, 2019 Category: Neurology Source Type: research

Outcomes after stenting for symptomatic intracranial arterial stenosis: a systematic review and meta-analysis
ConclusionThis systematic review provided the worldwide profile of short- and long-term outcomes of stenting for symptomatic ICAS. The generally acceptable outcomes indicate that stenting may still be feasible in selected patients. Regional disparity calls for more cautious decisions and future studies. (Source: Journal of Neurology)
Source: Journal of Neurology - January 5, 2019 Category: Neurology Source Type: research

Progressive multifocal leukoencephalopathy in Finland: a cross-sectional registry study
ConclusionsPML most often occurs in patients with malignancies and patients with HIV or CTD cover a third. PML incidence in Finland is lower than in Sweden and shows no temporal trend despite increasing use of predisposing drugs. Mortality after PML varies according to the predisposing condition. (Source: Journal of Neurology)
Source: Journal of Neurology - January 5, 2019 Category: Neurology Source Type: research

Impact of virtual reality-based rehabilitation on functional outcomes in patients with acute stroke: a retrospective case-matched study
AbstractBackground and objectivesTo date, the efficacy of the virtual reality (VR) application for acute stroke compared with conventional therapy (CT) remains unclear. This retrospective study aims to assess the impact of adjuvant VR technology on multidimensional therapy for patients with acute-stage stroke.Methods100 acute ischemic stroke patients with onset within 7 days who underwent combined adjuvant VR-based rehabilitation program and CT (intervention group –VR + CT) were compared to an equal number of cross-matched patients who received CT alone. While the intervention group received 40-min CT p...
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Long-term follow-up of multiple sclerosis studies and outcomes from early treatment of clinically isolated syndrome in the BENEFIT 11 study
AbstractMultiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with a diverse disease course involving inflammation and degeneration of neurons and axons. Multiple sclerosis results from a complex interaction of genetic and environmental factors and clinically several disease subtypes with marked variation in symptoms can be discerned. Disease-modifying therapies (DMTs) impact disease activity and outcome. Long-term follow-up studies of DMTs in MS have generally shown that the short-term effects in clinical trials are maintained for up to 21 years, e.g. in the case of interferon beta-1b. Howev...
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Determining factors of better leptomeningeal collaterals: a study of 857 consecutive acute ischemic stroke patients
AbstractBackgroundIn acute ischemic stroke (AIS) collaterals correlate with infarct size, recanalization rate and clinical outcome. We aimed to identify factors associated with better collateral status in a large series of AIS patients with middle cerebral artery (MCA) occlusion.MethodsIn the Acute STroke Registry and Analysis of Lausanne (ASTRAL) from 2003 to 2016, we identified all consecutive AIS with proximal MCA occlusion on CT-angiography performed  
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Differential long-term evolution after surgery or pharmacotherapy of Rasmussen encephalopathy in adult patients
(Source: Journal of Neurology)
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Correction to: Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody
The original version of this article unfortunately contained a mistake. (Source: Journal of Neurology)
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Usefulness of MOG-antibody titres at first episode to predict the future clinical course in adults
AbstractObjectiveTo analyze whether myelin oligodendrocyte glycoprotein antibody (MOG-Ab) titres at onset of the disease were different according to the clinical phenotype at presentation, and to investigate whether the titres were associated with risk of further relapses or predicted clinical outcome in adult patients. Finally, we assessed an alternative method to the classical measurement of MOG-Ab levels by serial dilutions.MethodsThis is a retrospective study including 79 MOG-Ab-positive adult patients, whose samples were obtained at first episode. MOG-Ab were tested by cell-based assay. HEK293 cells were transfected (...
Source: Journal of Neurology - January 3, 2019 Category: Neurology Source Type: research

Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson ’s disease
AbstractExcessive daytime sleepiness (EDS) may represent a disabling non-motor symptom in patients affected by Parkinson ’s disease (PD). This is a secondary analysis of a previous study documenting the improvement of nocturnal sleep in PD patients treated by rotigotine vs placebo. Here we tested the supposition that EDS may represent a distinct PD non-motor symptom occurring independently of other sleep-wake disor ders; moreover, we verified whether EDS can be influenced by the improvement of nocturnal sleep in PD. In the present study, we evaluated the daytime sleepiness of PD patients treated with nocturnal a...
Source: Journal of Neurology - January 3, 2019 Category: Neurology Source Type: research

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study
AbstractThe aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer ’s disease (AD). For this purpose, we followed up 263 patients (154 SCD; 109 MCI) for a mean time of 7 years. CR was assessed by the Test di Intelligenza Breve (TIB), functionally equivalent to the National Adult Reading Test. High CR resulted as a protective factor for progression from SCD to MC I. Age at conversion to MCI was delayed 9 years on average in SCD with high CR with respect to SCD with low CR. On the contrary,...
Source: Journal of Neurology - January 2, 2019 Category: Neurology Source Type: research

Clinical and demographic correlates of apathy in Parkinson ’s disease
AbstractObjectiveTo better understand the demographic, neuropsychiatric, cognitive, and motor predictors of apathy in Parkinson ’s disease (PD).Method112 participants (Mage = 68.53 years;Mdisease duration = 6.17  years) were administered the Apathy Scale (AS), Beck Depression Inventory-II (BDI-II), Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Trail Making Test (TMT), Wechsler Adult Intelligence Scale-IV Matrix Reasoning subtest, letter (F-A-S) and category (Animals) flu ency, and Hopkins Verbal Learning Test-Revised. Psychosis was assessed. A stepwise logistic regression ...
Source: Journal of Neurology - January 2, 2019 Category: Neurology Source Type: research

Limb girdle muscular dystrophy D3 HNRNPDL related in a Chinese family with distal muscle weakness caused by a mutation in the prion-like domain
AbstractLimb-girdle muscular dystrophies (LGMD) are a group of clinically and genetically heterogeneous diseases characterized by weakness and wasting of the pelvic and shoulder girdle muscles. Twenty-four recessive LGMD (types R1 –R24) and five dominant LGMD (types D1-D5) have been identified with characterization of mutations in various genes. To date, LGMD D3 (previously known as LGMD1G) has been characterized in only two families with Brazilian or Uruguayan origin. Each was caused by a distinct mutation at codon 378 in the prion-like domain ofHNRNPDL encoding heterogeneous nuclear ribonucleoprotein D like (HNRNPD...
Source: Journal of Neurology - January 2, 2019 Category: Neurology Source Type: research

Christiaan Eijkman (1856 –1930)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 26, 2018 Category: Neurology Source Type: research

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study
AbstractBackgroundPersons who develop multiple sclerosis (MS) at a young age may bear a higher genetic risk load than persons who develop MS later in life; however, the contribution of familial influence to the risk of MS, in relation to onset age, has not been established.ObjectiveTo investigate the familial risk of MS at two extremes of the spectrum of MS onset age: early onset (first MS symptom
Source: Journal of Neurology - December 21, 2018 Category: Neurology Source Type: research

Predictors and outcome of status epilepticus in cerebral venous thrombosis
We report the clinico-radiological characteristics of SE in the patients with cerebral venous thrombosis (CVT), and compare the relative risk of SE in determining death and disability compared with those patients with and without self-limiting seizures. Consecutive patients with magnetic resonance venography (MRV) confirmed CVT, admitted during 2006 –2017, were included. Their clinical details, risk factors, and magnetic resonance imaging and MRV findings were noted. Duration of SE, Status Epilepticus Severity Score (STESS), Glasgow Coma Scale score, and response to antiepileptic drugs were noted. 6-month outcomes we...
Source: Journal of Neurology - December 19, 2018 Category: Neurology Source Type: research

Neurological update: MOG antibody  disease
AbstractMyelin oligodendrocyte glycoprotein  (MOG) antibody disease (MOG-AD) is now recognised as a nosological entity with specific clinical and paraclinical features to aid early diagnosis. Although no age group is exempt, median age of onset is within the fourth decade of life, with optic neuritis being the most frequent presenting pheno type. Disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. Residual disability develops in 50–80% of patients, with transverse myelitis at onset being the most significant predictor of long-term outcome. ...
Source: Journal of Neurology - December 19, 2018 Category: Neurology Source Type: research

Moyamoya angiopathy: long-term follow-up study in a Finnish population
ConclusionsFinnish MMA patients have a benign and stable course with a ~3.5  % annual stroke risk. We found no differences in the clinical outcomes between the operated and conservative groups, however, the psychosocial well-being requires more attention in MMA patients. (Source: Journal of Neurology)
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Patient characteristics and outcome associations in AMPA receptor encephalitis
We present findings from two cases of AMPAR encephalitis that exemplify variability in the disease spectrum, and summarize findings in published cases derived from a systematic literature review. When all patients are considered together, the presence of psychiatric symptoms at presentation portended a poor outcome and was associated with the presence of a tumor. Furthermore, we provide evidence to suggest that the topography of magnetic resonance imaging abnormalities in reported cases mirrors the distribution of AMPARs in the human brain. The potential for neurological improvement following immunomodulatory therapy toget...
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Clinical and economic comparison of an individualised immunoglobulin protocol vs. standard dosing for chronic inflammatory demyelinating polyneuropathy
AbstractBackgroundThe clinical and economic implications of an individualised intravenous immunoglobulin (IVIg) protocol for chronic inflammatory demyelinating polyneuropathy (CIDP) are unknown. Comparison with standard dosing regimens has not been performed.MethodsWe retrospectively studied 47 IVIg-treated subjects with CIDP over 4  years with an individualised, outcome-measured, dose-modifying protocol. We evaluated responder and remission rates, clinical improvement levels and dose requirements. We compared clinical benefits and costs with those reported with standard dosing at 1 g/kg every 3 weeks.Result...
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody
AbstractTo define the prevalence and characteristics of single ocular motor nerve palsy (OMNP) associated with positive serum anti-GQ1b antibody. We performed a prospective multicenter study that recruited 82 patients with single OMNP without identifiable causes from the history and neuroimaging in six neurology clinics of university hospitals. We measured serum anti-GQ1b antibody in all participants. Twelve patients with multiple OMNP and 30 with identifiable causes served as the controls. Overall, the prevalence of anti-GQ1b antibody syndrome was 10% (8/82) in patients with single OMNP and 6% (5/78) in those with single ...
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Cannabis use in myotonic dystrophy patients in Germany and USA: a pilot survey
(Source: Journal of Neurology)
Source: Journal of Neurology - December 15, 2018 Category: Neurology Source Type: research

Nerve echogenicity and intranerve CSA variability in high-resolution nerve ultrasound (HRUS) in chronic inflammatory demyelinating polyneuropathy (CIDP)
ConclusionEchogenicity of the arm nerves in CIDP may be used as a prognostic marker, but not as a follow-up tool for evaluating clinical changes. Further studies in a larger cohort are needed to confirm these results. (Source: Journal of Neurology)
Source: Journal of Neurology - December 15, 2018 Category: Neurology Source Type: research

Prophylactic treatment of migraine with and without aura with acetyl- dl -leucine: a case series
(Source: Journal of Neurology)
Source: Journal of Neurology - December 13, 2018 Category: Neurology Source Type: research

Correction to: Jean Baptiste Octave Landry (1826 –1865)
The original version of this article unfortunately contained a mistake. Title was incorrect. The corrected title is given below. (Source: Journal of Neurology)
Source: Journal of Neurology - December 13, 2018 Category: Neurology Source Type: research

Imaging in the diagnosis of progressive supranuclear palsy
(Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2018 Category: Neurology Source Type: research

Characteristics and relative factors of headache caused by cervicocerebral artery dissection
ConclusionThe headache and neck pain caused by CAD is a moderate to severe pain occurring suddenly. The pain nature may be diverse but mostly like throbbing and pulsating. When the dissected artery is located in the posterior circulation, the pain is mostly in the occipital region, and mostly in the temporal region when the dissected artery is located in the anterior circulation. The pain can occur in ipsilateral, bilateral, or contralateral of the dissection. In addition, several factors might contribute to the occurrence of headache and neck pain. (Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2018 Category: Neurology Source Type: research

Pretreatment cerebral microbleeds and symptomatic intracerebral hemorrhage post-thrombolysis: a systematic review and meta-analysis
ConclusionsThe pretreatment CMBs were associated with increased incidence of sICH and PFO in acute ischemic stroke patients receiving IVT. However, it was not convincing enough to set the presence of CMBs as contraindication to IVT. (Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2018 Category: Neurology Source Type: research

Guillain –Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity
AbstractObjectivesTo describe the epidemiology and clinical heterogeneity of Guillain –Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).MethodsThe incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish Nat...
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research

Metronidazole-induced encephalopathy: a systematic review
ConclusionMetronidazole-induced encephalopathy should be considered in patients presenting with neurological symptoms in relation to newly initiated or prolonged metronidazole treatment. MRI changes are highly characteristic and specific. Patients with liver disease are at increased risk. Prognosis is good if recognized early. (Source: Journal of Neurology)
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research