Dysregulation of multisensory processing stands out from an early stage of migraine: a study in pediatric patients
AbstractResting state (RS) functional connectivity (FC) abnormalities of brain networks involved in pain- and multisensory processing have been disclosed in adult-migraine patients. We explored RS FC of large-scale brain networks in pediatric-migraine patients and their correlation with patients ’ clinical characteristics. RS functional MRI data was acquired from 13 pediatric-migraine patients and 14 age- and sex-matched controls. Intra- and inter-network RS FC differences between patients and controls were evaluated. Correlations between RS FC abnormalities and patients’ clinical chara cteristics were also ass...
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Exit strategies for “needle fatigue” in multiple sclerosis: a propensity score-matched comparison study
AbstractPatients with multiple sclerosis on long-term injectable therapies may suffer from the so-called “needle fatigue”, i.e., a waning commitment to continue with the prescribed injectable treatment. Therefore, alternative treatment strategies to enhance patients’ adherence are warranted. In this independent, multicentre post-marketing study, we sought to directly compare switching to either t eriflunomide (TFN), dimethyl fumarate (DMF), or pegylated interferon (PEG) on treatment persistence and time to first relapse over a 12-month follow-up. We analyzed a total of 621 patients who were free of relaps...
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy
In this study, we investigated whether myelopathy in ALD is associated with retinal neurodegeneration on optical coherence tomography (OCT), which could serve as a surrogate outcome measure.MethodsSixty-two patients (29 men and 33 women) and 70 age-matched and sex-matched controls (33 men and 37 women) were included in this cross-sectional study. We compared retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness between ALD patients and controls. In addition, we correlated these OCT measurements with clinical parameters of severity of myelopathy.ResultsPati...
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Using personalized medicine in gliomas: a genomic approach to diagnosis and overcoming treatment resistance in a case with pleomorphic xanthoastrocytoma
ConclusionThis is the first report of a PXA patient receiving therapy with BRAF MEKi and an autophagy inhibitor with prolonged stable disease. This patient highlights the importance of a molecular interrogation in gliomas to provide an integrated diagnosis and effective treatment. This may be useful in up to 3% of glioma patients withBRAF mutations. Molecular testing in neuro-oncology is providing new avenues of diagnosis and treatment, and detailed molecular interrogation should be considered routine. (Source: Journal of Neurology)
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Classic ataxia-telangiectasia: the phenotype of long-term survivors
ConclusionsPaucity of descriptions in the literature, and withdrawal from medical care complicate the acquisition of follow-up data on the natural history of long-term survivors. Irrespective of these limitations, we have obtained impression of the many problems that these patients face when surviving beyond 30  years of age. Awareness of these problems is needed to guide follow-up, counselling, and (palliative) care; decisions about life-prolonging treatments should be well considered. (Source: Journal of Neurology)
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Intravenous cyclophosphamide monthly pulses in refractory myasthenia gravis
ConclusionsCYC was effective in all patients with refractory MG for a mean of 9  months, with worsening thereafter, which could be associated with low cumulative dose. The symptomatic improvement with CYC was noted within the 1st month. We conclude that CYC is effective as an induction to remission therapy, although our data suggest it is not effective as a long-term therapy. (Source: Journal of Neurology)
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit
This study aimed to investigate the effects of rTPA in WUS patients during every day clinical scenarios, by measuring ischemic lesion volume and functional outcomes compared to non-treated WUS patients.MethodsWe retrospectively analyzed clinical and imaging data of 149 (75  rTPA; 74 non-rTPA) patients with acute ischemic WUS. Ischemic volume was calculated on follow-up CT and functional outcomes were the NIHSS and mRS comparing rTPA and non-rTPA WUS. Patients were selected using ASPECTS >  6 on CT and/or ischemic penumbra >  50% of hypoperfused tissue on CTP.ResultsA reduced volu...
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Cerebrospinal fluid total protein in Guillain –Barré syndrome variants: correlations with clinical category, severity, and electrophysiology
AbstractThe discriminative value of CSF total protein (CSF-TP) in subtypes of Guillain –Barré syndrome has not been well documented in North-American patients. We reviewed 173 cases from a single institution, comprising the following clinical categories of neuropathy: 134 Sensorimotor (SM) GBS, 13 Motor (M) GBS, 8 Localized (L) GBS, and 18 Miller Fisher syndrome (MFS). We grouped t he electrophysiological interpretation in primarily demyelinating, primarily axonal and normal / equivocal categories. Mean CSF-TP were substantially higher for SM and L-GBS, as well as cases classified as Acute-onset chronic inflam...
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis
ConclusionAtrophied T2-LV is associated with disability accrual in MS, and to several multimodal markers of disease evolution. (Source: Journal of Neurology)
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Ji ří Procháska (1749–1820)
(Source: Journal of Neurology)
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Evolution of the vestibular function during head impulses in spinocerebellar ataxia type 6
This study aimed to determine temporal evolution in the findings of head impulse tests (HITs) in SCA type 6 (SCA6). We serially evaluated HITs in 12 patients with SCA6 using video-oculography for 3  months to 5 years [median = 12 months, interquartile range (IQR) = 9–50] at two university hospitals in South Korea. Patients (8/12, 67%) usually showed abnormal responses at least for one semicircular canal during video-HITs. The gains of the vestibulo-ocular reflex (VOR) for the ante rior canals (ACs) were larger than those for the posterior canals (PCs,p = 0.005)...
Source: Journal of Neurology - February 17, 2020 Category: Neurology Source Type: research

Physical activity in myotonic dystrophy type 1
The objective of this study is to assess physical activity and predictors of physical activity in individuals with DM1.MethodsSixty-seven adults with DM1 and 39 healthy adults were recruited. Physical activity was monitored by accelerometry and assessed using the International Physical Activity Questionnaire. Age, marital status, education, apathy, cognition, fatigue, and muscle strength were assessed as predictors of physical activity in DM1.ResultsThe individuals with DM1 were on average − 187 min (p 
Source: Journal of Neurology - February 17, 2020 Category: Neurology Source Type: research

Pallidal lead placement in dystonia: leads of non-responders are contained within an anatomical range defined by responders
AbstractBackgroundDeep brain stimulation (DBS) within the pallidum represents an effective and well-established treatment for isolated dystonia. However, clinical outcome after surgery may be variable with limited response in 10 –25% of patients. The effect of lead location on clinical improvement is still under debate.ObjectiveTo identify stimulated brain regions associated with the most beneficial clinical outcome in dystonia patients.Methods18 patients with cervical and generalized dystonia with chronic DBS of the internal pallidum were investigated. Patients were grouped according to their clinical improvement in...
Source: Journal of Neurology - February 17, 2020 Category: Neurology Source Type: research

Outcome of patients with large vessel occlusion in the anterior circulation and low NIHSS score
ConclusionsOur data indicate that primary IVT and/or EVT may be better than primary conservative therapy in patients with LVO in the anterior circulation and low NIHSS score. Furthermore, primary EVT was better than secondary EVT in case of neurological deterioration. There is an unmet need for RCTs to find the optimal therapy for this patient group. (Source: Journal of Neurology)
Source: Journal of Neurology - February 15, 2020 Category: Neurology Source Type: research

A study of susceptibility-weighted imaging in patients with Wilson disease during the treatment of metal chelator
ConclusionsTherapy with DMPS and DMSA improves neurological symptoms of WD patients more quickly and leads to less aggravation, compared with therapy with DPA. The metal content in the brain of WD patients was at a low level after 3  years of treatment. DMPS and DMSA can remove metal from brain tissue faster than DPA. (Source: Journal of Neurology)
Source: Journal of Neurology - February 14, 2020 Category: Neurology Source Type: research

MOG encephalomyelitis: distinct clinical, MRI and CSF features in patients with longitudinal extensive transverse myelitis as first clinical presentation
ConclusionsWe identify common pathological findings in patients with LETM as first clinical presentation of MOG-EM which distinguishes it from other forms of LETM and should lead to testing for MOG-IgG in these cases. (Source: Journal of Neurology)
Source: Journal of Neurology - February 13, 2020 Category: Neurology Source Type: research

Long-term effects of bilateral pallidal deep brain stimulation in dystonia: a follow-up between 8 and 16  years
ConclusionsPallidal DBS is a safe and efficacious long-term treatment for dystonia with sustained effects on motor impairment and disability, accompanied by a robust improvement in mood and quality of life. (Source: Journal of Neurology)
Source: Journal of Neurology - February 13, 2020 Category: Neurology Source Type: research

Prognostic role of slow vital capacity in amyotrophic lateral sclerosis
AbstractObjectivesTo compare the prognostic role of FVC and SVC at diagnosis in amyotrophic lateral sclerosis (ALS) patients.MethodsWe included all patients from the Piemonte and Valle D ’Aosta ALS register (PARALS) who had been diagnosed with ALS between 1995 and 2015 and underwent spirometry at diagnosis. Survival was considered as time to death/tracheostomy; to assess the prognostic value in typical trial timeframes, survival at 12 and 18 months was calculated too. Cox proport ional hazard regression models adjusted by sex, age at diagnosis, diagnostic delay, onset site, and ALSFRS-R total score at the moment...
Source: Journal of Neurology - February 12, 2020 Category: Neurology Source Type: research

Cognitive profiles discriminate between genetic variants of behavioral frontotemporal dementia
This study shows gene-specific cognitive profiles in bvFTD, which underlines the value of neuropsychological tests as outcome measures in upcoming trials for genetic bvFTD. (Source: Journal of Neurology)
Source: Journal of Neurology - February 12, 2020 Category: Neurology Source Type: research

Reversal of spontaneous nystagmus during visual fixation in dorsal medullary infarction
(Source: Journal of Neurology)
Source: Journal of Neurology - February 12, 2020 Category: Neurology Source Type: research

Comment on: “Multiple acyl‑CoA dehydrogenase deficiency in elderly carriers”
(Source: Journal of Neurology)
Source: Journal of Neurology - February 12, 2020 Category: Neurology Source Type: research

Gait variability as digital biomarker of disease severity in Huntington ’s disease
ConclusionsSensor-based gait variability parameters were identified as clinically most relevant digital biomarker for gait impairment in HD. Altered gait variability represents characteristic irregularity of gait in HD and reflects disease severity. (Source: Journal of Neurology)
Source: Journal of Neurology - February 11, 2020 Category: Neurology Source Type: research

Volume loss in the deep gray matter and thalamic subnuclei: a longitudinal study on disability progression in multiple sclerosis
ConclusionThese results highlight the relevance of volume loss in the thalamus as a key metric for predicting disability worsening as assessed by EDSS (in RRMS). Moreover, the volume loss in specific nuclei such as the ventral lateral nucleus seems to play a role in disability worsening. (Source: Journal of Neurology)
Source: Journal of Neurology - February 10, 2020 Category: Neurology Source Type: research

Effects of disease-modifying therapy on peripheral leukocytes in patients with multiple sclerosis
AbstractModern disease-modifying therapies (DMTs) in multiple sclerosis (MS) have variable modes of action and selectively suppress or modulate the immune system. In this review, we summarize the predicted and intended as well as unwanted adverse effects on leukocytes in peripheral blood as a result of treatment with DMTs for MS. We link changes in laboratory tests to the possible therapeutic risks that include secondary autoimmunity, infections, and impaired response to vaccinations. Profound knowledge of the intended effects on leukocyte counts, in particular lymphocytes, explained by the mode of action, and adverse effe...
Source: Journal of Neurology - February 8, 2020 Category: Neurology Source Type: research

Utility of the Parkinson ’s disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington’s disease
DiscussionThe PD-CRS is a valid and reliable instrument to assess global cognition in HD in routine clinical care and clinical trials. (Source: Journal of Neurology)
Source: Journal of Neurology - February 7, 2020 Category: Neurology Source Type: research

Clonidine GH stimulation test to differentiate MSA from idiopathic late onset cerebellar ataxia: a prospective, controlled study
AbstractIntroductionDespite the consensus criteria for multiple system atrophy (MSA), the diagnosis of MSA of cerebellar type (MSA-C) may be difficult in the early stage of the disease. There are several differential diagnoses including idiopathic late-onset cerebellar ataxias (ILOCA) and it is often necessary to wait for clinical worsening so that the criteria can be met. Our aim was to assess the efficacy of clonidine growth hormone test (CGH test) to distinguish MSA-C from ILOCA in the early stage of the disease.MethodsWithin our cohort of late-onset sporadic, progressive cerebellar ataxia, the group of patients meeti...
Source: Journal of Neurology - February 7, 2020 Category: Neurology Source Type: research

Subjects at risk of Parkinson ’s disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study
AbstractIntroductionThe present study aimed to survey the prevalence of prodromal symptoms of Parkinson ’s disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects.MethodsWe conducted a questionnaire survey of annual health checkup examinees without neurological symptoms using the following self-reported questionnaires: Japanese version of the Scale for Outcomes in Parkinson ’s disease for Autonomic Symptoms (SCOPA-AUT); Self-administered Odor Question (SAOQ); REM Sleep Behavior Disorder Screening Scale (RBDSQ); Beck Depression Inventory-Second Edition (BDI-II); Epworth Sleepiness Sca...
Source: Journal of Neurology - February 7, 2020 Category: Neurology Source Type: research

Correction to: Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis
The original version of this article unfortunately contained a mistake. (Source: Journal of Neurology)
Source: Journal of Neurology - February 7, 2020 Category: Neurology Source Type: research

An evaluation of predictors for success of two-duct ligation for drooling in neurodisabilities
ConclusionsAge, adequate posture, and a normal speech are predictors for treatment success, are easily determined pre-operatively, and help the clinician providing patient-specific probability of treatment success. There is a significant subjective and objective decrease of drooling after two-duct ligation. (Source: Journal of Neurology)
Source: Journal of Neurology - February 6, 2020 Category: Neurology Source Type: research

Chronic traumatic encephalopathy: quantifying risk and clarifying pathogenesis
(Source: Journal of Neurology)
Source: Journal of Neurology - February 6, 2020 Category: Neurology Source Type: research

Nonmotor symptoms of 820 Taiwanese patients with Parkinson ’s disease: an exploratory-comparative study
ConclusionAlthough they exhibited similar NMS prevalence, Taiwanese PD patients reported less intense NMSs compared with those reported by Western patients. Furthermore, the NMS items our patients emphasized and gender discrepancies were distinct from those in Western studies. (Source: Journal of Neurology)
Source: Journal of Neurology - February 5, 2020 Category: Neurology Source Type: research

Microbleeds in dementia with Lewy bodies
ConclusionThe presence of microbleeds in DLB is associated with higher blood pressure, but not with other measures of vascular disease or amyloid deposition. The relationship between microbleeds and clinical presentation remains unclear. (Source: Journal of Neurology)
Source: Journal of Neurology - February 4, 2020 Category: Neurology Source Type: research

Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke
ConclusionsCMBs were common, and age, male sex, hypertension, chronic kidney disease, and cerebral white matter diseases were related to CMBs in cryptogenic stroke. Aortic complicated lesions were associated with deep and diffuse CMBs, while prior anticoagulant therapy was related to lobar CMBs. (Source: Journal of Neurology)
Source: Journal of Neurology - February 3, 2020 Category: Neurology Source Type: research

Quantitative serological antibody testing for suspected neuroborreliosis
ConclusionData show that in addition to the clinical presentation of patients with symptoms suggesting central or peripheral nervous system manifestation, serum IgG- and IgM-titers help to identify LNB-patients. The results should guide physicians counseling patients with suspected LNB about further diagnostic steps and treatment. (Source: Journal of Neurology)
Source: Journal of Neurology - February 1, 2020 Category: Neurology Source Type: research

Clinical features of Lewy body dementia: insights into diagnosis and pathophysiology
ConclusionsClusters of specific core and supportive DLB features are identified, which together with the evaluated screening instruments evaluated, may inform improved strategies to diagnose DLB in clinical and research settings. (Source: Journal of Neurology)
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Patterns of regional brain volume loss in multiple sclerosis: a cluster analysis
ConclusionWe identified brain regions that exhibit different degree of atrophy in a background of global brain atrophy in MS. (Source: Journal of Neurology)
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Association between REM sleep behavior disorder and impulsive –compulsive behaviors in Parkinson’s disease: a systematic review and meta-analysis of observational studies
AbstractBackgroundBoth REM sleep behavior disorder (RBD) and impulsive –compulsive behaviors (ICBs) are well-recognized non-motor features in patients with Parkinson’s disease (PD). Studies have given contradictory results about the potential association between RBD and ICBs.MethodsPubMed, Embase (via Ovid), and the Cochrane Central Registry of Controlled Trials (CENTRAL) databases were systematically searched till August 20, 2019 to identify studies that explored the possible correlation between RBD and ICBs in patients with PD. Two authors independently screened records, extracted data and evaluated quality o...
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Predicting daytime sleepiness and fatigue: a 9-year prospective study in myotonic dystrophy type 1
This study aimed to determine factors that may influence levels of daytime sleepiness and fatigue in a large cohort of DM1 patients followed for 9 years.MethodsThis study included 115 patients with DM1 at baseline (Time 1,T1) and at Time 2 (T2) who were questioned for daytime sleepiness, fatigue, history of depression, psychological distress, pain, hypothyroidism, and sleep habits. Also, their muscular impairment and intellectual quotient were evaluated. Regression models were used to identify correlates of daytime sleepiness and fatigue while controlling for time effect.ResultsBoth daytime sleepiness and fatigue incr...
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Elevated blood glucose is associated with aggravated brain edema in acute stroke
AbstractBackground and purposeClinical outcome after endovascular thrombectomy in patients with acute ischemic stroke still varies significantly. Higher blood glucose levels (BGL) have been associated with worse clinical outcome, but the pathophysiological causes are not yet understood. We hypothesized that higher levels of BGL are associated with more pronounced ischemic brain edema and worse clinical outcome mediated by cerebral collateral circulation.Methods178 acute ischemic stroke patients who underwent mechanical thrombectomy were included. Early ischemic brain edema was determined using quantitative lesion water upt...
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

18 F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy
We examined the relationship between tau pathology (assessed via18F-AV1451 PET) and multimodal MRI imaging using GM volume, cortical thickness (CTh), and diffusion tensor imaging (DTI).MethodsTwenty-three people with clinically probable PSP-Richardson ’s syndrome (age 68.8 ± 5.8 years, 39% female) and 23 controls underwent structural 3 T brain MRI including DTI. Twenty-one patients also had18F-AV1451 PET imaging. Voxelwise volume-based morphometry, surface-based morphometry, and DTI correlations were performed with18F-AV1451 binding in typical PSP regions of interest (putamen, thalamus ...
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Central nervous system disorders after hematopoietic stem cell transplantation: a prospective study of the Infectious Diseases Working Party of EBMT
AbstractWe performed a prospective study to evaluate the types and characteristics of central nervous system (CNS) disorders in patients after hematopoietic stem cell transplantation. The study included 163 episodes of CNS disorders of which 58 (36%) were infections. Proven or probable infections were documented in 34 patients and included fungi (n = 10, 29%), viruses (n = 12, 35%),Toxoplasma spp. (n = 9, 27%) and bacteria (n = 3, 9%). Non-infectious neurological disorders (n = 105, 64%) frequently encompassed metabolic/drug-induced abnormalities (n&thin...
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Non-motor symptoms are relevant and possibly treatable in hereditary spastic paraplegia type 4 (SPG4)
AbstractHereditary spastic paraplegias (HSP) share as cardinal feature progressive spastic gait disorder. SPG4 accounts for about 25% of cases and is caused by mutations in theSPAST gene. Although HSP is an upper motor neuron disease, the relevance of non-motor symptoms is increasingly recognized because of the potential response to treatment. Our study sets out to evaluate non-motor symptoms and their relevance with regard to health-related quality of life. In 118 genetically confirmed SPG4 cases and age- and gender-matched controls, validated questionnaires were used to evaluate fatigue, depression, pain, and restless le...
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Cerebellum and cognition in Friedreich ataxia: a voxel-based morphometry and volumetric MRI study
ConclusionsWith two different image analysis techniques, we confirmed the presence of cerebellar volume loss in FRDA, mainly affecting the posterior lobe. In particular, Lobule IX atrophy correlated with worse visuo-spatial abilities, further expanding our knowledge about the physiopathology of cognitive impairment in FRDA. (Source: Journal of Neurology)
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Concomitant reversible cerebral vasoconstriction syndrome and transient global amnesia
ConclusionsRCVS and TGA can occur simultaneously, which suggests common mechanisms such as aberrant responses to physical or emotional stress and cerebral vasoconstriction. (Source: Journal of Neurology)
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Levels of 7alpha-hydroxycholesterol and/or 7alpha-hydroxy-4-cholest-3-one are the optimal biochemical markers for the evaluation of treatment of cerebrotendinous xanthomatosis
(Source: Journal of Neurology)
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Stefan Borowiecki (1881 –1937)
(Source: Journal of Neurology)
Source: Journal of Neurology - January 29, 2020 Category: Neurology Source Type: research

Menstrual migraine: what it is and does it matter?
AbstractThe diagnostic criteria of menstrual migraine (MM), migraine related to menstruation and pure menstrual migraine, are placed in the appendix of the International Classification of Headache Disorders and are still primarily considered as research criteria that need validation. Although there is a great wealth of knowledge about the neurobiological processes underlying MM and its symptoms, the mechanisms by which an attack starts during the menstrual cycle remain baffling, and the disease is still undertreated. In this narrative review, we aim to summarize recent data on pathophysiology, epidemiology, burden of disea...
Source: Journal of Neurology - January 28, 2020 Category: Neurology Source Type: research

Correction to: Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature
The original version of this article unfortunately contained a mistake. Oliver Hanemann name was incorrect in the in the acknowledgements section of this paper. (Source: Journal of Neurology)
Source: Journal of Neurology - January 28, 2020 Category: Neurology Source Type: research

Gastrointestinal dysfunction in Parkinson ’s disease
ConclusionsPD patients report more prevalent and severe GI dysfunction, although our cohort comprised of many later-stage participants. Earlier recognition of GI dysfunction in PD provides the opportunity to direct treatment for chronic pain and constipation, promote physical activity and rationalise PD therapies for optimal patient care. (Source: Journal of Neurology)
Source: Journal of Neurology - January 27, 2020 Category: Neurology Source Type: research

Bernard Sachs (1858 –1944)
(Source: Journal of Neurology)
Source: Journal of Neurology - January 25, 2020 Category: Neurology Source Type: research