Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic
DiscussionThis multicentre retrospective analysis demonstrates a decline in the number of patients treated for viral and pneumococcal meningitis as well as otolaryngological infections in 2020 compared to previous years. Since the latter often precedes pneumococcal meningitis, this may point to the significance of the direct spread of pneumococci from an otolaryngological focus such as mastoiditis to the brain as one important pathophysiological route in the development of pneumococcal meningitis. (Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Quantifying test-retest reliability of repeated objective attentional measures in Lewy body dementia
This study examined the reliability of these attentional measures at short-term and longer-term follow-up stages. LBD patients (n = 36) completed computerised attentional tasks [simple and choice reaction time, and digit vigilance (SRT, CRT, DV)] at short-term (Day 0–Day 5) and longer-term (4 and 12 weeks) follow-up. Intra-class correlations (ICCs) were calculated to assess test–retest reliability. At short-term, the reciprocal SRT, CRT and DV mean reaction time to correct answers, the reciprocal DV coefficient of variation, and reciprocal power of attention (PoA) all showed excellent levels of reliability (all IC...
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Herpetic encephalitis: which treatment for which body weight?
ConclusionThese results suggest to modify acyclovir management in herpetic encephalitis, for low-weight patients (<  79 kg) with a minimum dosage of 2550 mg/day (850 mg/ 8 h), when possible. (Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Measuring the functional impact of cognitive impairment in Huntington ’s disease
ConclusionsThese findings support the utility of the HD-CFRS as a brief and reliable instrument to measure functional defects associated with cognitive impairment in HD. We believe this questionnaire could be a useful tool both for clinical practice and research. (Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Familial British dementia: a clinical and multi-modal imaging case study
(Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

A role for the Epstein –Barr virus in multiple sclerosis aetiology?
(Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Correction to: The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis
(Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Correction to: Nystagmus only with fixation in the light: a rare central sign due to cerebellar malfunction
The original version of this article unfortunately contained a mistake. (Source: Journal of Neurology)
Source: Journal of Neurology - June 22, 2022 Category: Neurology Source Type: research

Autism spectrum disorder in the fragile X premutation state: possible mechanisms and implications
AbstractThere is increasing recognition of the heterogeneity of origin of cases of autism spectrum disorder (ASD) with multiple forms of ASD having been identified over the decades. Among these, a genetic etiology can be identified in 20 –40% of cases when a full genetic work-up is completed. The Fragile X premutation state (characterized by the presence of 55–200 CGG repeats in theFMR1 gene) is a relatively newly identified disease state that has since been associated with several disorders including fragile X-associated tremor ataxia syndrome (FXTAS), fragile X-associated primary ovarian insufficiency (FXPOI) and mos...
Source: Journal of Neurology - June 20, 2022 Category: Neurology Source Type: research

Correlation between clinical severity and extent of autonomic cardiovascular impairment in the acute phase of subarachnoid hemorrhage
ConclusionWithin the acute phase, spontaneous SAH induces a decrease in sympathetic and total autonomic cardiovascular modulation. Higher H&H-scores were associated with increasing autonomic dysfunction and may therefore augment the risk of cardiovascular complications and poor clinical outcome. (Source: Journal of Neurology)
Source: Journal of Neurology - June 20, 2022 Category: Neurology Source Type: research

Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B)
ConclusionIn our study, NMDAR1-abs seropositivity did not affect CF over 3  years after a first mild to moderate ischemic stroke. CF differed according to NMDAR1-abs serum titer, with patients with high NMDAR1-abs titers having a less favorable cognitive outcome compared to seronegative patients. (Source: Journal of Neurology)
Source: Journal of Neurology - June 19, 2022 Category: Neurology Source Type: research

Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis
This study provides initial evidence of strong, selective associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with TA as a biomarker for MS-related neurodegeneration. Such data support TA as a moderator of the association among aerobic fitness, cognitive processing speed, and walking endurance in persons with MS. Future research should carefully consider the role of TA when designing trials of aerobic exercise, cognition, and mobility in MS. (Source: Journal of Neurology)
Source: Journal of Neurology - June 19, 2022 Category: Neurology Source Type: research

Brainstem stroke presenting with uncontrollable laughter: be alert when nobody else is laughing
(Source: Journal of Neurology)
Source: Journal of Neurology - June 19, 2022 Category: Neurology Source Type: research

Carotid web: the challenging diagnosis of an under-recognized entity
ConclusionKnowledge of CW and differentiating it from atheroma plaques is essential, as medical management seems to be insufficient in many cases. Revascularization, which has been shown to be safe and effective, might be the best treatment modality. (Source: Journal of Neurology)
Source: Journal of Neurology - June 17, 2022 Category: Neurology Source Type: research

Progressive medial temporal degeneration with TDP-43 pathology is associated with upper limb and bulbar onset types of amyotrophic lateral sclerosis
ConclusionMedial temporal atrophy in ALS is associated with bulbar and upper limb onset subtypes. This progression may be related to the extent of TDP-43 pathology. (Source: Journal of Neurology)
Source: Journal of Neurology - June 16, 2022 Category: Neurology Source Type: research