New treatments in Alzheimer ’s disease
(Source: Journal of Neurology)
Source: Journal of Neurology - August 21, 2018 Category: Neurology Source Type: research

Initiating anticoagulant therapy after ICH is associated with patient characteristics and treatment recommendations
AbstractBackgroundThe proportion of patients with intracerebral hemorrhage (ICH) and concomitant indication for oral anticoagulant (OAC) therapy is increasing. Although recent studies documented a favorable risk –benefit profile of OAC initiation, deciding whether, when, and which OAC should be started remains controversial. We investigated (1) OAC recommendations, its implementation, and adherence and (2) factors associated with OAC initiation after ICH.MethodsThis prospective observational study analyzed consecutive ICH patients (n = 246) treated at the neurological and neurosurgical department of the...
Source: Journal of Neurology - August 20, 2018 Category: Neurology Source Type: research

Stroke recurrence and mortality in northeastern Greece: the Evros Stroke Registry
AbstractUp to date there is no population-based study from Greece providing long-term data on incidence of both all-cause mortality and stroke recurrence for patients with first ever stroke (FES). Adult patients with FES were registered during a 24-month period (2010 –2012) and followed-up for 12 months. We calculated cumulative incidences of stroke mortality and recurrence. Univariable and multivariable Cox proportional hazards regression analyses were used to identify independent determinants of 1-year mortality and 1-year stroke recurrence. We prospectivel y documented 703 first ever stroke cases (mean age 75...
Source: Journal of Neurology - August 20, 2018 Category: Neurology Source Type: research

Mitochondrial DNA mutations in late-onset Leigh syndrome
AbstractLeigh syndrome (LS) is an early onset progressive neurodegenerative disorder with considerable clinical and genetic heterogeneities. Late-onset Leigh syndrome, i.e., onset after age of 2 years, is considered rare and often presents with atypical clinical features. We review the clinical features and imaging studies in a cohort of late-onset Leigh syndrome caused by mtDNA mutations. A total of 16 patients, 6 males and 10 females, were enrolled. The age at presentation was between 2 and 27  years of age. The first three clinical presentations found in our case series were ataxia, bulbar palsy, and pyramidal trac...
Source: Journal of Neurology - August 20, 2018 Category: Neurology Source Type: research

Aspirin plus clopidogrel may reduce the risk of early neurologic deterioration in ischemic stroke patients carrying CYP2C19 * 2 reduced-function alleles
ConclusionsDual therapy with clopidogrel and aspirin may be adequate for prevention of END in carriers ofCYP2C19 reduced-function alleles, but not for noncarriers. Our findings may be useful to guide precise antiplatelet therapy, and decrease the risk of END. (Source: Journal of Neurology)
Source: Journal of Neurology - August 20, 2018 Category: Neurology Source Type: research

Subacute encephalopathy with seizures in alcoholics (SESA) syndrome: further evidence supporting that may lie on the ictal-interictal continuum
(Source: Journal of Neurology)
Source: Journal of Neurology - August 18, 2018 Category: Neurology Source Type: research

Magnetic resonance imaging in Alzheimer ’s disease and mild cognitive impairment
AbstractResearch utilizing magnetic resonance imaging (MRI) has been crucial to the understanding of the neuropathological mechanisms behind and clinical identification of Alzheimer ’s disease (AD) and mild cognitive impairment (MCI). MRI modalities show patterns of brain damage that discriminate AD from other brain illnesses and brain abnormalities that are associated with risk of conversion to AD from MCI and other behavioural outcomes. This review discusses the application of various MRI techniques to and their clinical usefulness in AD and MCI. MRI modalities covered include structural MRI, diffusion tensor imagi...
Source: Journal of Neurology - August 17, 2018 Category: Neurology Source Type: research

Cluster headache: pathophysiology, diagnosis and treatment
AbstractCluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15 –180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal congestion, rhinorrhea, forehead and facial sweating, miosis, ptosis and/or eyelid edema, and/or with restlessness or agitation. The understandin g of the pathophysiological mechanisms behind CH is far from complete, but CH is considered to be a neurovascular and chronobiologic headache disord...
Source: Journal of Neurology - August 17, 2018 Category: Neurology Source Type: research

Windmill nystagmus in a patient with subacute visual loss
(Source: Journal of Neurology)
Source: Journal of Neurology - August 17, 2018 Category: Neurology Source Type: research

Moyamoya angiopathy: early postoperative course within 3 months after STA –MCA–bypass surgery in Europe—a retrospective analysis of 64 procedures
ConclusionRevasculating surgery is a safe procedure in Caucasian patients with Moyamoya angiopathy. The observed complications have a good prognosis. (Source: Journal of Neurology)
Source: Journal of Neurology - August 17, 2018 Category: Neurology Source Type: research

Correction to: Effectiveness of Rotigotine plus intensive and goal ‑based rehabilitation versus Rotigotine alone in “de‑novo” Parkinsonian subjects: a randomized controlled trial with 18‑month follow‑up
The original version of this article unfortunately contained a mistake. The funding information was incorrect. The corrected funding information is given below. (Source: Journal of Neurology)
Source: Journal of Neurology - August 17, 2018 Category: Neurology Source Type: research

Paradoxical elevation of plasma dabigatran after reversal with idarucizumab in stroke thrombolysis
(Source: Journal of Neurology)
Source: Journal of Neurology - August 16, 2018 Category: Neurology Source Type: research

Vertebral artery hypoplasia: an innocent lamb or a disguise?
In this study, we correlated extra- and intra-cranial vertebral artery ultrasound findings with brain CT/MRI and clinical outcome.Materials and methodsWe recruited all consecutive first-ever stroke patients with a documented acute ischemic brain lesion and a complete extra-intracranial ultrasound evaluation. Those with previous stroke, or with anterior and posterior strokes were excluded. The prevalence of VAH diagnosed by ultrasound was recorded both in anterior circulation and posterior circulation infarctions. In the latter group, we compared the risk profile, topographic and neuroradiological lesion features, etiology ...
Source: Journal of Neurology - August 16, 2018 Category: Neurology Source Type: research

Does normal substantia nigra echogenicity make a difference in Parkinson ’s disease diagnosis? A real clinical practice follow-up study
AbstractObjectivesSubstantia nigra hyperechogenicity (SN+) detected by transcranial ultrasound (TUS) is useful for Parkinson ’s disease (PD) diagnosis. Approximately 15% false negative results of unknown significance are reported. However, most TUS studies are transversal, and diagnosis of PD may change during follow-up.MethodsAnalysis of our prospective registry of TUS in clinical practice, selecting patients with sufficient bone window, to whom TUS was performed because of suspected PD, and a minimum of 3-year follow-up. Subjects were classified regarding SN echogenicity (SN+/SN −).Results172 patients (122 SN...
Source: Journal of Neurology - August 16, 2018 Category: Neurology Source Type: research

Diagnostic and prognostic power of CSF Tau in amyotrophic lateral sclerosis
This study aims to evaluate the diagnostic and prognostic potential of CSF total Tau (t-Tau), phospho-Tau (p-Tau) and p-Tau/t-Tau ratio in ALS patients using CSF neurofilament light (NFL) as the reference biomarker.MethodsEighty-five incident ALS, 30 ALS-mimicking (AM) diseases and 51 other non-neurodegenerative diseases (ONND) were included in the study.ResultsALS patients had higher levels of CSF t-Tau and lower p-Tau/t-Tau ratio than AM (p = 0.005 andp = 0.006) and ONND (p 
Source: Journal of Neurology - August 16, 2018 Category: Neurology Source Type: research

Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis
ConclusionsCerebrovascular events may be the first manifestation of neurosarcoidosis, and have a prognosis impact in such patients, leading to death and permanent neurological impairment. (Source: Journal of Neurology)
Source: Journal of Neurology - August 14, 2018 Category: Neurology Source Type: research

Anti-JC virus antibody index changes in rituximab-treated multiple sclerosis patients
AbstractRituximab, a monoclonal antibody to CD20, is an effective treatment for relapsing remitting multiple sclerosis (MS) reducing relapse rate by at least 50% over time. Although the mechanism for this clinical benefit is unclear, rituximab depletes circulating B cells, which can perform antigen presentation and stimulation of T cells. Another anti-CD20 drug, ocrelizumab, has recently been FDA approved to treat both relapsing remitting and progressive forms of MS. While long-term effects of ocrelizumab use are essentially unknown, long-term use of rituximab has been associated with the development of progressive multifo...
Source: Journal of Neurology - August 14, 2018 Category: Neurology Source Type: research

Impaired brain response to odors in patients with varied severity of olfactory loss after traumatic brain injury
AbstractTraumatic brain injury (TBI) as a major public health problem may lead to olfactory dysfunction. However, little is known about brain responses to odors in TBI olfactory loss patients. Nineteen healthy controls and forty TBI olfactory dysfunctional patients (19 with hyposmia and 21 with anosmia) underwent a functional magnetic resonance imaging scan when two odors (peach and coffee) were presented intranasally using a computerized olfactometer. Olfactory performance was measured using the “Sniffin’ Sticks” test. TBI patients with hyposmia or anosmia showed decreased odor-induced brain activations ...
Source: Journal of Neurology - August 14, 2018 Category: Neurology Source Type: research

Fatigue in patients with myasthenia gravis
ConclusionFatigue in MG is highly prevalent, mainly physical, and influenced by depressive symptoms, disease severity, female sex and sleep debt. Cognitive fatigue in MG may not be a direct disease manifestation, but secondary to depression. The FSS and FIS represent reliable and validated tools, appropriate to discern meaningful clinical aspects of fatigue in MG. Clinical recognition of the complexity of fatigue may foster individualized treatment approaches for affected MG patients. (Source: Journal of Neurology)
Source: Journal of Neurology - August 11, 2018 Category: Neurology Source Type: research

Pierre Mollaret (1898 –1987)
(Source: Journal of Neurology)
Source: Journal of Neurology - August 10, 2018 Category: Neurology Source Type: research

The video head impulse test: a right –left imbalance
(Source: Journal of Neurology)
Source: Journal of Neurology - August 6, 2018 Category: Neurology Source Type: research

Compromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis
ConclusionAbsence of post-training tDCS-induced facilitation of consolidation in patients with MS suggests that the interaction of tDCS with the motor consolidation network is inefficient. Identification of the underlying disease-related mechanisms will have important implications for the design of studies aiming to promote motor recovery in MS by non-invasive brain stimulation. (Source: Journal of Neurology)
Source: Journal of Neurology - August 6, 2018 Category: Neurology Source Type: research

Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson’s disease dementia, dementia with Lewy bodies and Alzheimer’s disease
This study aims to c ompare the neuropsychiatric and CSF α-Syn profiles in these conditions, and to investigate the possible association between CSF α-Syn levels and neuropsychiatric symptoms.MethodsWe conducted a prospective cross-sectional study, between January 2013 and January 2015, with 16 PDD, 28 DLB and 19 AD patients. All participants underwent a detailed clinical, neuropsychological, neuropsychiatric [Neuropsychiatric Inventory (NPI)] and CSF α-Syn analysis.ResultsSignificantly greater NPI Hallucinations Subitem score was found in the PDD and DLB groups compared to AD (bothp 
Source: Journal of Neurology - August 6, 2018 Category: Neurology Source Type: research

Management of Pisa syndrome with lateralized subthalamic stimulation
(Source: Journal of Neurology)
Source: Journal of Neurology - August 3, 2018 Category: Neurology Source Type: research

Discriminative power of intra-retinal layers in early multiple sclerosis using 3D OCT imaging
AbstractObjectiveTo evaluate volumetric changes and discriminative power of intra-retinal layers in early-stage multiple sclerosis (MS) using a 3D optical coherence tomography (OCT) imaging method based on an in-house segmentation algorithm.Methods3D analysis of intra-retinal layers was performed in 71 patients with early-stage MS (mean disease duration 2.2  ± 3.5 years) at baseline and 40 healthy controls (HCs). All patients underwent a follow-up OCT scan within 23 ± 9 months. Patients with a clinical episode of optic neuritis (ON) more than 6 months prior to study ...
Source: Journal of Neurology - August 2, 2018 Category: Neurology Source Type: research

Machine learning in neurology: what neurologists can learn from machines and vice versa
This article discusses whether these methods are ready to make their entrance into clinical practice. The underlying principles of classification will be explored, as well as the potential pitfalls. Strengths of machine learning methods are that they are unbiased and very sensitive to patterns emerging from small changes spread across a large number of variables. Potential pitfalls are that building reliable classifiers requires large amounts of well-selected data and extensive validation. Currently, machine learning classifiers offer neurologists a new diagnostic tool which can aid in the diagnosis of cases with a high de...
Source: Journal of Neurology - August 2, 2018 Category: Neurology Source Type: research

A novel real-space navigation paradigm reveals age- and gender-dependent changes of navigational strategies and hippocampal activation
ConclusionReal-space navigation testing was a feasible and sensitive method to depict age-related changes in navigation performance and strategy. Normalized error rates, total mean durations per item and total number of saccades were the most sensitive and practical parameters to indicate deterioration of allocentric navigation strategies and right hippocampal function in age irrespective of gender. (Source: Journal of Neurology)
Source: Journal of Neurology - August 2, 2018 Category: Neurology Source Type: research

Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet
AbstractBackground and aimPeripheral neuropathy is a common extraintestinal manifestation of gluten sensitivity (gluten neuropathy). We aimed to establish the prevalence of neuropathic pain in patients with otherwise idiopathic PN and gluten sensitivity (positive antigliadin, endomysial, and/or transglutaminase antibodies, with or without enteropathy) and to describe any contributory factors.MethodsAll consecutive patients with gluten neuropathy (GN) attending a specialist gluten/neurology clinic were invited to participate. Pain was assessed via the DN4 questionnaire and the visual analog scale. Overall Neuropathy Limitat...
Source: Journal of Neurology - July 21, 2018 Category: Neurology Source Type: research

Care-related quality of life in caregivers of children with drug-resistant epilepsy
AbstractBackgroundEpilepsy in children negatively impacts on caregiver quality of life (QOL). The study aimed to evaluate the relationships between patient factors [demographics, clinical factors, health-related quality of life (HRQL)], contextual factors (socio-economic factors), caregiver mood, and caregiver QOL, and whether family factors mediate the relationship between patient HRQL and caregiver QOL.MethodsChildren aged 4 –18 years with medically intractable epilepsy were enrolled. Patient demographics, clinical data, patient HRQL [measured using Quality of Life in Childhood Epilepsy Questionnaire (QOLCE)],...
Source: Journal of Neurology - July 20, 2018 Category: Neurology Source Type: research

Bringing order to higher order motor disorders
AbstractMajority of movements in everyday situations are complex and involve volition, planning of the movement and selection of the motor programme, all occurring before movement execution. Higher order motor disorders may be defined as abnormal motor behaviours resulting from disruption of any of the cortical processes that precede execution of the motor act. They are common in patients with neurodegenerative disorders, psychiatric diseases and structural brain lesions. These abnormal behaviours may be overlooked in the clinic, unless specifically evoked by the examiner. We discuss clinical and pathophysiological aspects...
Source: Journal of Neurology - July 19, 2018 Category: Neurology Source Type: research

Patient delay in TIA: a systematic review
ConclusionsMore than a third of patients experiencing a TIA delays medical attention for more than a day, thus critically extending the initiation of stroke preventive treatment. There still seems to be insufficient awareness among lay people that symptoms suggestive of TIA should be considered as an emergency. Additional data and multivariable analyses are needed to define main determinants of patient delay. (Source: Journal of Neurology)
Source: Journal of Neurology - July 19, 2018 Category: Neurology Source Type: research

Early transient asymptomatic neutropenia associated with alemtuzumab treatment in multiple sclerosis: a case report
(Source: Journal of Neurology)
Source: Journal of Neurology - July 17, 2018 Category: Neurology Source Type: research

Step length predicts executive dysfunction in Parkinson ’s disease: a 3-year prospective study
AbstractCognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict subsequent cognitive impairment in Parkinson ’s disease (PD). We evaluated cognition and gait in 39 Parkinsonian patients at an initial assessment and after 3 years. Cognitive performance was evaluated with a neuropsychological battery designed to assess memory, executive/attention, and vis...
Source: Journal of Neurology - July 16, 2018 Category: Neurology Source Type: research

The intraventricular-spot sign: prevalence, significance, and relation to hematoma expansion and outcomes
AbstractBackgroundThe presence of the spot sign on computed tomography angiogram (CTA) is considered a sign of active bleeding, and studies have shown it can predict hematoma expansion in intraparenchymal hemorrhage (IPH). The spot sign in intraventricular hemorrhage (IVH) has not been explored yet. The purpose of this study is to estimate the prevalence of the intraventricular-spot sign, and its prediction of hematoma expansion and clinical outcomes.MethodsWe retrieved data of hemorrhagic stroke patients seen at our medical center from January 2013 to January 2018. A total of 321 subjects were filtered for the prevalence ...
Source: Journal of Neurology - July 16, 2018 Category: Neurology Source Type: research

Kennedy ’s disease (spinal and bulbar muscular atrophy): a clinically oriented review of a rare disease
AbstractSpinal and bulbar muscular atrophy (SBMA), also known as Kennedy ’s disease, is a rare, X-linked hereditary lower motor neuron disease, characterized by progressive muscular weakness. An expanded trinucleotide repeat (CAG >  37) in the androgen receptor gene (AR), encoding glutamine, is the mutation responsible for Kennedy’s disease. Toxicity of this mutant protein affects both motor neurons and muscles. In this review, we provide a comprehensive, clinically oriented overview of the current literature regarding Ken nedy’s disease, highlighting gaps in our knowledge that remain to ...
Source: Journal of Neurology - July 13, 2018 Category: Neurology Source Type: research

Primary progressive freezing gait with impressive response to laser light visual cueing: a video case report
(Source: Journal of Neurology)
Source: Journal of Neurology - July 13, 2018 Category: Neurology Source Type: research

Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies
AbstractObjectiveThe aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor.MethodsRetrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors.ResultsSixty patients (23.8%) had an associated tumor and 15 (6%) were malignant. No particular neurological symptom was observed in these patients. Ovarian...
Source: Journal of Neurology - July 12, 2018 Category: Neurology Source Type: research

Cognitive and fatigue side effects of anti-epileptic drugs: an analysis of phase III add-on trials
AbstractWe aimed to investigate the terms used to refer to cognitive and fatigue related side effects and their prevalence in phase III add-on clinical trials of anti-epileptic drugs (AEDs). We extracted data from publicly available FDA documents as well as the published literature. Target drug doses were then calculated as drug loads and divided into three categories (low, average, high). The odds ratio of developing the side effects was calculated for each drug load, and the presence of a dose –response effect was also assessed. We found that the cognitive terms used across trials were very variable, and data on di...
Source: Journal of Neurology - July 12, 2018 Category: Neurology Source Type: research

Telomere length as a modifier of age-at-onset in Huntington disease: a two-sample Mendelian randomization study
(Source: Journal of Neurology)
Source: Journal of Neurology - July 12, 2018 Category: Neurology Source Type: research

Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study
AbstractIntroductionExtrapyramidal deficits are poorly characterised in amyotrophic lateral sclerosis (ALS) despite their contribution to functional disability, increased fall risk and their quality-of-life implications. Given the concomitant pyramidal and cerebellar degeneration in ALS, the clinical assessment of extrapyramidal features is particularly challenging.ObjectiveThe comprehensive characterisation  of postural instability in ALS using standardised clinical assessments, gait analyses and computational neuroimaging tools in a prospective study design.MethodsParameters of gait initiation in the anticipatory po...
Source: Journal of Neurology - July 11, 2018 Category: Neurology Source Type: research

Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis
ConclusionLeft precuneus volume was the best predictor of memory in relapsing MS patients with low disability and mild deficits in EM. (Source: Journal of Neurology)
Source: Journal of Neurology - July 11, 2018 Category: Neurology Source Type: research

Myelin oligodendrocyte glycoprotein antibody-associated disease: characterising clinical disease
(Source: Journal of Neurology)
Source: Journal of Neurology - July 10, 2018 Category: Neurology Source Type: research

The accuracy of the clinical diagnosis of Parkinson disease. The HUNT study
AbstractDiagnostic accuracy is crucial not only for prognostic and therapeutic reasons, but also for epidemiologic studies. We aimed to study the accuracy of the clinical diagnosis of Parkinson disease (PD) for participants in The Nord-Tr øndelag Health Study (HUNT), a health survey, containing data from approximately 126,000 individuals and biological material from 80,000 individuals. We included 980 participants from the HUNT study diagnosed with PD or secondary parkinsonism/related parkinsonian disorders. The participants had bee n diagnosed in conjunction with admission to hospitals in Trøndelag or throug...
Source: Journal of Neurology - July 10, 2018 Category: Neurology Source Type: research

The discriminative value of blood gas analysis parameters in the differential diagnosis of transient disorders of consciousness
AbstractAimThe differentiation between epileptic and non-epileptic episodes can be challenging. Our aim was to compare lactate, anion gap (AG), bicarbonate and the Denver Seizure Score (DSS) as point-of-care test (POCT) markers for episodes of transient alterations of consciousness.MethodsThe blood serum parameters were drawn at arrival in the emergency department (ED) within 2  h of the episode. After calculating AG and DSS values, the four parameters were compared retrospectively between patients with generalized tonic–clonic seizures (GTCS) (n = 165) and patients with other disorders of consciou...
Source: Journal of Neurology - July 9, 2018 Category: Neurology Source Type: research

Botulinum toxin therapy of hemifacial spasm: bilateral injections can reduce facial asymmetry
AbstractBotulinum toxin (BT) is the treatment of choice for hemifacial spasm (HFS). When BT is injected into the affected side, patients may experience increased facial asymmetry. We wanted to evaluate in a prospective, randomised, placebo-controlled study whether bilateral BT injections may reduce this facial asymmetry. For this, we treated 19 HFS patients with unilateral and 24 with bilateral BT therapy using CBTX-A (Lanzhou Biological Products Institute, Lanzhou, China). BT doses on the affected side were standard doses, on the non-affected side they were one-third of those. Facial asymmetry was studied with the Sunnybr...
Source: Journal of Neurology - July 9, 2018 Category: Neurology Source Type: research

Low specificity of voltage-gated calcium channel antibodies in Lambert –Eaton myasthenic syndrome: a call for caution
AbstractAs testing for neuronal antibodies become more readily available, the spectrum of conditions potentially associated with these autoantibodies has been widening. Voltage-gated calcium channel antibodies (VGCC-Ab) are no exception to this trend. The significance of an elevated VGCC-Ab titer beyond its original clinicopathological correlate, Lambert –Eaton myasthenic syndrome (LEMS) remains undetermined. We sought to determine the diagnostic significance of an elevated serum VGCC-Ab titer in a large single-center cohort of 100 patients. The majority of patients (58%) with elevated VGCC-Ab levels lacked an inflam...
Source: Journal of Neurology - July 9, 2018 Category: Neurology Source Type: research

Prevalence of motion sickness in various vestibular disorders: a study on 749 patients
(Source: Journal of Neurology)
Source: Journal of Neurology - July 7, 2018 Category: Neurology Source Type: research

Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study
(Source: Journal of Neurology)
Source: Journal of Neurology - July 6, 2018 Category: Neurology Source Type: research

Dysfunctional inhibitory control in Parkinson ’s disease patients with levodopa-induced dyskinesias
ConclusionInhibitory control is compromised in dyskinetic patients in parallel with increased impulsivity, revealing an impairment of motor and behavioral inhibitory control in Parkinson ’s disease patients with levodopa-induced dyskinesias. (Source: Journal of Neurology)
Source: Journal of Neurology - July 6, 2018 Category: Neurology Source Type: research

Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy
ConclusionsDecreased FA values in the anterior corpus callosum showed a significant correlation with cognitive impairment in MSA. (Source: Journal of Neurology)
Source: Journal of Neurology - July 5, 2018 Category: Neurology Source Type: research