Diagnosing chronic inflammatory demyelinating polyradiculoneuropathy with triple stimulation technique
ConclusionTST can detect CBs located between the root emergence and the Erb point. TST is useful for early diagnosis of CIDP. (Source: Journal of Neurology)
Source: Journal of Neurology - June 20, 2018 Category: Neurology Source Type: research

W ładysław Sterling (1877–1943)
(Source: Journal of Neurology)
Source: Journal of Neurology - June 20, 2018 Category: Neurology Source Type: research

Use of anti-Parkinson medication during pregnancy: a case series
ConclusionResults in our case series suggest that levodopa, rasagiline, pramipexole, and ropinirole alone or in combination with each other may be considered relatively safe during pregnancy. Expected benefits and risks should be considered when prescribing anti-PD medication in pregnant women. (Source: Journal of Neurology)
Source: Journal of Neurology - June 20, 2018 Category: Neurology Source Type: research

A strategy for managing flu-like symptoms after botulinum toxin injections
(Source: Journal of Neurology)
Source: Journal of Neurology - June 20, 2018 Category: Neurology Source Type: research

Time window and “tissue window”: two approaches to assist decision-making in strokes
AbstractIntravenous alteplase given in an appropriate time window has been recommended in guidelines and effects are on the decline over time. In general, the clinical decision is primarily based on whether ischemic stroke patients are sent to hospitals within the time window. However, some patients sent to the hospital over time limitations are eligible to receive intervention for recanalization due to good collateral circulation. In this dilemma, “tissue window” can be more reliable, which means using the penumbra as a major criterion for patient recruitment. Hence, we herein aim to address how could “t...
Source: Journal of Neurology - June 19, 2018 Category: Neurology Source Type: research

Sarcoidosis of the central nervous system: clinical features, imaging, and CSF results
ConclusionsThis prospective study of neurosarcoidosis increases our understanding of the pathophysiology of the disease. A reclassification of the clinical and imaging features of the disease allows an understanding of its pathophysiology and correlation with CSF indices allows an early identification of those with a more destructive disease will help to define treatment and may thereby improve outcome. (Source: Journal of Neurology)
Source: Journal of Neurology - June 19, 2018 Category: Neurology Source Type: research

Depressive symptoms in stroke patients treated and non-treated with intravenous thrombolytic therapy: a 1-year follow-up study
Conclusions(1) Thrombolysed and non-thrombolysed stroke survivors had similar frequency of depressive symptoms although the thrombolysed patients had more severe neurological deficits in the acute phase. It can be assumed that if thrombolysis had not been used, depressive symptoms would have been more frequent. (2) Lack of the rt-PA treatment was associated with three-time greater odds of screening for PSD at 3  months post-stroke, after adjustment for other PSD correlates. (3) Therefore, thrombolytic therapy seems to have a positive, but indirect, effect on patients’ mood, especially in the first months after s...
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research

Carotid endarterectomy in patients with recurrent symptoms associated with an ipsilateral carotid artery near occlusion with full collapse
ConclusionIn patients with RSNOFC, CEA may be considered a potential treatment option. Although procedural risks in this small subgroup may be higher as compared to patients with low-to-moderate risk anatomy, this risk may outbalance the natural course. (Source: Journal of Neurology)
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research

Subthalamic deep brain stimulation and levodopa in Parkinson ’s disease: a meta-analysis of combined effects
ConclusionSubthalamic nucleus deep brain stimulation and levodopa independently lessened motor severity in PD to a similar magnitude, but their combined effect was greater than either treatment alone, suggesting therapeutic synergism. (Source: Journal of Neurology)
Source: Journal of Neurology - June 16, 2018 Category: Neurology Source Type: research

Comparison of CT black hole sign and other CT features in predicting hematoma expansion in patients with ICH
In this study, we aimed to compare the black hole sign with other computed tomography (CT) features to predict the HE and the outcome in patients with intracerebral hemorrhage (ICH).MethodsPatients were enrolled within 12  h after stroke attack in the emergency department of Henan Provincial People’s Hospital between January 2012 and June 2016. The clinical characters and CT features including the initial CT and the follow-up CT within 48 h were recorded. The outcome was assessed by using the modified Rankin Scal e on discharge. Logistic regression analyses were used to investigate whether the factors were ...
Source: Journal of Neurology - June 15, 2018 Category: Neurology Source Type: research

Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML
We report a 76-year-old MS patient, treated with DMF for 3  years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloqui ne, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF. (Source...
Source: Journal of Neurology - June 15, 2018 Category: Neurology Source Type: research

GCH1 mutations in dopa-responsive dystonia and Parkinson ’s disease
AbstractGuanosine triphosphate cyclohydrolase I (GCH1) mutations are associated with increased risk for dopa-responsive dystonia (DRD) and Parkinson ’s disease (PD). Herein, we investigated the frequency ofGCH1 mutations and clinical symptoms in patients with clinically diagnosed PD and DRD. We used the Sanger method to screen entire exons in 268 patients with PD and 26 patients with DRD, with the examinations of brain magnetic resonance imaging scans, striatal dopamine transporter scans, and [123I] metaiodobenzylguanidine (MIBG) myocardiac scintigraphy scans. We identified 15 patients with heterozygousGCH1 mutations...
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research

Two-year real-life efficacy, tolerability and safety of dimethyl fumarate in an Italian multicentre study
ConclusionOur post-market study corroborated that DMF is a safe and effective drug. Additionally, the study suggested that na ïve patients strongly benefit from DMF and that DMF improved ARR also in patients who were horizontally switched from injectable therapies due to tolerability and efficacy issues. (Source: Journal of Neurology)
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research

Application value of serum biomarkers for choosing memantine therapy for moderate AD
This study suggests that the logistic regression model (LRM) and the ROC curve based on patients’ serum levels of VEGF, BDNF, IL-6 and IL-1β is a promising research for diagnosing and choosing the best course of treatment for moderate AD. (Source: Journal of Neurology)
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research

Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
ConclusionsAlthough data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially  in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients. (Source: Journal of Neurology)
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research

Transmissible amyloid protein: evidence from iatrogenic CJD
(Source: Journal of Neurology)
Source: Journal of Neurology - June 13, 2018 Category: Neurology Source Type: research

Brain imaging in pregnant women with acute headache
ConclusionBrain imaging may reveal a secondary headache etiology in more than 25% of pregnant women presenting with acute headache. In particular, when the acute headache is of severe intensity, and the headache is accompanied by seizures or a change in consciousness, brain imaging is required. (Source: Journal of Neurology)
Source: Journal of Neurology - June 11, 2018 Category: Neurology Source Type: research

Neuromyelitis optica: suicide risk and psychiatric comorbidities
(Source: Journal of Neurology)
Source: Journal of Neurology - June 8, 2018 Category: Neurology Source Type: research

The clinical significance of 10-m walk test standardizations in Parkinson ’s disease
ConclusionsDifferent 10MWT standardizations yield very similar results, suggesting that there is no practical need for an acceleration distance or repeated trials when conducting this test in mild PD. (Source: Journal of Neurology)
Source: Journal of Neurology - June 6, 2018 Category: Neurology Source Type: research

Distorted own-body representations in patients with dizziness and during caloric vestibular stimulation
AbstractThere is increasing evidence that vestibular disorders evoke deficits reaching far beyond imbalance, oscillopsia and spatial cognition. Yet, how vestibular disorders affect own-body representations, in particular the perceived body shape and size, has been overlooked. Here, we explored vestibular contributions to own-body representations using two approaches. Study 1 measured the occurrence and severity of distorted own-body representations in 60 patients with dizziness and 60 healthy controls using six items from the Cambridge Depersonalization Scale. 12% of the patients have experienced distorted own-body represe...
Source: Journal of Neurology - June 6, 2018 Category: Neurology Source Type: research

Globus pallidus internus stimulation in spino-cerebellar ataxia type 3
(Source: Journal of Neurology)
Source: Journal of Neurology - June 6, 2018 Category: Neurology Source Type: research

The functional head impulse test: preliminary data
AbstractThe functional head impulse test is a new test of vestibular function based on the ability to recognize the orientation of a Landolt C optotype that briefly appears on a computer screen during passive head impulses imposed by the examiner over a range of head accelerations. Here, we compare its results with those of the video head impulse test on a population of vestibular neuritis patients recorded acutely and after 3  months from symptoms onset. The preliminary results presented here show that while both tests are able to identify the affected labyrinth and to show a recovery of vestibular functionality at 3...
Source: Journal of Neurology - June 4, 2018 Category: Neurology Source Type: research

Primary lateral sclerosis and the amyotrophic lateral sclerosis –frontotemporal dementia spectrum
AbstractAimTo investigate whether primary lateral sclerosis (PLS) represents part of the amyotrophic lateral sclerosis –frontotemporal dementia (ALS–FTD) spectrum of diseases.MethodsComprehensive assessment was taken on 21 patients with PLS and results were compared to patients diagnosed with pure motor ALS (n = 27) and ALS–FTD (n = 12). Clinical features, Addenbrooke’s Cognitive Examination (ACE) scores, Motor Neuron Disease Behaviour (Mind-B) scores, motor disability on the ALS functional rating scale (ALSFRS) and survival times were documented. Motor cortex excitabilit...
Source: Journal of Neurology - June 4, 2018 Category: Neurology Source Type: research

Rheumatoid arthritis significantly increased recurrence risk after ischemic stroke/transient ischemic attack
This study provides the first evidence that RA significantly increased recurrence IS/TIA risk. The changes of TG/HDL-C ratio may play some roles in the recurrence IS/TIA risk in RA patients. In addition, our results suggest that smoking increases the risk of recurrent IS/TIA in RA patients and reinforces the need for aggressive smoking cessation efforts in RA patients. (Source: Journal of Neurology)
Source: Journal of Neurology - June 2, 2018 Category: Neurology Source Type: research

Fatigue, not self-rated motor symptom severity, affects quality of life in functional motor disorders
AbstractWhile fatigue is found to be an impairing symptom in functional motor disorders (FMD) in clinical practice, scientific evidence is lacking. We investigated fatigue severity and subtypes in FMD compared to organic neurological disease. Furthermore, the role of fatigue within FMD and its impact on quality of life and self-rated health were investigated. Data from 181 patients participating in theself-help on the internet for functional motor disorders, randomised Trial were included. Data from 217 neurological controls with neuromuscular disorders (NMD) originated from a historical cohort. Fatigue was measured using ...
Source: Journal of Neurology - June 2, 2018 Category: Neurology Source Type: research

The nystagmus of vestibular paroxysmia
(Source: Journal of Neurology)
Source: Journal of Neurology - May 31, 2018 Category: Neurology Source Type: research

Serving performance in a suprapostural visual signal detection task: context-dependent and direction-specific control of body sway with fingertip light touch
(Source: Journal of Neurology)
Source: Journal of Neurology - May 30, 2018 Category: Neurology Source Type: research

Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study
AbstractProton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal-appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the ...
Source: Journal of Neurology - May 30, 2018 Category: Neurology Source Type: research

Anti-NMDA receptor encephalitis triggered by epilepsy surgery
(Source: Journal of Neurology)
Source: Journal of Neurology - May 30, 2018 Category: Neurology Source Type: research

The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study
ConclusionBoth early-onset and late-onset seizures do not influence long-term mortality after ischemic stroke. (Source: Journal of Neurology)
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

Infectious agents and amyotrophic lateral sclerosis: another piece of the puzzle of motor neuron degeneration
AbstractAmyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons (MN). This fatal disease is characterized by progressive muscle wasting and lacks an effective treatment. ALS pathogenesis has not been elucidated yet. In a small proportion of ALS patients, the disease has a familial origin, related to mutations in specific genes, which directly result in MN degeneration. By contrast, the vast majority of cases are though to be sporadic, in which genes and environment interact leading to disease in genetically predisposed individuals. Lately, the role of the environment has gai...
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

Neuronal network-based mathematical modeling of perceived verticality in acute unilateral vestibular lesions: from nerve to thalamus and cortex
AbstractAcute unilateral lesions of vestibular graviceptive pathways from the otolith organs and semicircular canals via vestibular nuclei and the thalamus to the parieto-insular vestibular cortex regularly cause deviations of perceived verticality in the frontal roll plane. These tilts are ipsilateral in peripheral and in ponto-medullary lesions and contralateral in ponto-mesencephalic lesions. Unilateral lesions of the vestibular thalamus or cortex cause smaller tilts of the perceived vertical, which may be either ipsilateral or contralateral. Using a neural network model, we previously explained why unilateral vestibula...
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

The motor and cognitive features of Parkinson ’s disease in patients with concurrent Gaucher disease over 2 years: a case series
We report the cognitive features and progression of Parkinson ’s disease (PD) in five patients with concurrent Gaucher disease. The patients presented at an earlier age than patients with sporadic PD, as previously noted by others; but in contrast to many previous reports, our patients followed a variable clinical course. While two patients developed early c ognitive deficits and dementia, three others remained cognitively intact over the follow-up period. Thus, in this small case series, PD in the context of GD more closely resembles idiopathic PD in terms of its clinical heterogeneity in contrast to PD associated w...
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

Autoimmune hepatitis induced by a single injection of interferon- β 1a in a patient with multiple sclerosis
(Source: Journal of Neurology)
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

Cognitive impairments that everybody has
(Source: Journal of Neurology)
Source: Journal of Neurology - May 29, 2018 Category: Neurology Source Type: research

Cognitive performance in multiple sclerosis: the contribution of intellectual enrichment and brain MRI measures
In conclusion, the findings suggested that CR seems to mitigate cognitive dysfunction in MS patients and can reduce the negative impact of brain atrophy on inhibitory control, relevant for integrity of instrumental activities of daily living. (Source: Journal of Neurology)
Source: Journal of Neurology - May 26, 2018 Category: Neurology Source Type: research

Cutaneous somatic and autonomic nerve TDP-43 deposition in amyotrophic lateral sclerosis
AbstractObjectiveTo evaluate the involvement of the sensory and autonomic nervous system in amyotrophic lateral sclerosis (ALS) and to determine whether TDP-43/pTDP-43 deposits in skin nerve fibers signify a valuable biomarker for ALS.MethodsEighteen patients with ALS and 18 age- and sex-matched control subjects underwent physical examinations, in addition to donating skin biopsies from the distal leg. The density of epidermal, Meissner ’s corpuscle (MC), sudomotor, and pilomotor nerve fibers were measured. Confocal microscopy was used to determine the cutaneous somatic and autonomic nerve fiber density and TDP-43/pT...
Source: Journal of Neurology - May 26, 2018 Category: Neurology Source Type: research

Correlation among olfactory function, motors ’ symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson’s disease
In conclusion, our results reported changes in apathy and motor disability as significant predictors in alterations of odor identification, discrimination and TDI score. Furthermore, these data suggest that olfactory dysfunction might progress in tight relation with motor impairment UPDRS but also with non-motor symptoms such as apathy. (Source: Journal of Neurology)
Source: Journal of Neurology - May 26, 2018 Category: Neurology Source Type: research

Non-invasive vagus nerve stimulation significantly improves quality of life in patients with persistent postural-perceptual dizziness
AbstractPersistent postural-perceptual dizziness (PPPD) is one of the most common causes of chronic vestibular disorders, with a substantial portion of the affected patients showing no significant improvement to standard therapies (i.e., pharmacotherapy, behavioral psychotherapy). Patients with PPPD have been shown to have a significant comorbidity with anxiety disorders and depression. Further, these patients show an activation of the autonomic nervous system resulting in symptoms such as nausea, increase of heart rate, and sweating. Based on the comorbidities and the activation of the autonomic nervous system, we address...
Source: Journal of Neurology - May 21, 2018 Category: Neurology Source Type: research

Efficacy and safety of rituximab in relapsing and progressive multiple sclerosis: a hospital-based study
AbstractIntroductionRituximab is considered as a potential therapeutic option in relapsing-remitting (RRMS) and progressive forms (PMS) of multiple sclerosis (MS).ObjectiveTo investigate the effectiveness and safety of rituximab in MS.Patients and methodsObservational study of effectiveness (clinical and radiological) and safety of rituximab in RRMS and PMS.ResultsA total of 90 rituximab-treated patients were collected: 31 RRMS and 59 PMS All patients had an active disease despite standard treatment. The annualized relapse rate (ARR) the year before rituximab was 0.86, 53.3% of patients had gadolinium enhanced lesion, and ...
Source: Journal of Neurology - May 21, 2018 Category: Neurology Source Type: research

A 9-year follow-up study of quantitative muscle strength changes in myotonic dystrophy type 1
AbstractMyotonic dystrophy type 1 (DM1) is a neuromuscular disorder presenting with major muscle impairments. However, few studies have addressed muscle strength progression using quantitative methods. The aims of this study were to document muscle strength changes in eight muscle groups among adults with DM1 over a 9-year period, and to compare this progression between phenotypes (adult and late-onset) and sex. Patients with a genetic diagnosis of DM1 with the late-onset or the adult phenotype were recruited at baseline through the clinical registry of the Saguenay Neuromuscular Clinic. The maximum isometric muscle streng...
Source: Journal of Neurology - May 21, 2018 Category: Neurology Source Type: research

Tremor induced by Calcineurin inhibitor immunosuppression: a single-centre observational study in kidney transplanted patients
ConclusionsNon-Calcineurin inhibitors such as Sirolimus have the lowest propensity to induce tremor and with a milder severity, while Calcineurin inhibitors, especially Tacrolimus, the highest, and regardless of the formulation. Plasmatic concentration of Tacrolimus was higher in tremulous patients; further research needs to validate the role of cholesterol plasmatic concentration in predicting the occurrence of tremor in patients on Tacrolimus. (Source: Journal of Neurology)
Source: Journal of Neurology - May 18, 2018 Category: Neurology Source Type: research

Crossed aphasia following cerebral infarction in a right-handed patient with atypical cerebral language dominance
ConclusionThe findings suggest that the patient has right-sided cerebral language dominance, or that both hemispheres have linguistic functions. Not all patients show linguistic capabilities on the side opposite hand preference. The language dominance should be predicted by a combination of clinical manifestations and functional imaging techniques. (Source: Journal of Neurology)
Source: Journal of Neurology - May 18, 2018 Category: Neurology Source Type: research

The silver effect of admission glucose level on excellent outcome in thrombolysed stroke patients
AbstractHigher admission glucose levels (AGL) are associated with less favorable outcome in thrombolysis. But, could AGL ’s impact on outcome vary by onset-to-treatment (OTT) time? Is hyperglycemia associated with a shorter therapeutic time window for excellent outcome for thrombolysed stroke patients? We assessed predictive values of AGL, baseline NIHSS, age, and OTT time quartiles on excellent outcome (3-month mod ified Rankin score of 0–1) in 773 patients treated by rt-Pa. We added the AGL × OTT time quartile interaction in the model and separately analyzed the predictive values of AGL, a...
Source: Journal of Neurology - May 18, 2018 Category: Neurology Source Type: research

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction
In conclusion, we demonstrate that smell dysfunction is clearly a key element of both TLE and TLR, impacting odor identification, detection, and discrimination/memory. Whether our novel finding of significant post-operative increases in the volume of brain structures contralateral to the resection side reflects plasticity and co mpensatory processes requires further study. (Source: Journal of Neurology)
Source: Journal of Neurology - May 16, 2018 Category: Neurology Source Type: research

Multifocal motor neuropathy following treatment with adalimumab for ulcerative colitis
(Source: Journal of Neurology)
Source: Journal of Neurology - May 16, 2018 Category: Neurology Source Type: research

Proprioceptive muscle tendon stimulation reduces symptoms in primary orthostatic tremor
AbstractIntroductionPrimary orthostatic tremor (OT) is characterized by high-frequency lower limb muscle contractions and a disabling sense of unsteadiness while standing. To date, therapeutic options for OT are limited. Here, we examined the effects of proprioceptive leg muscle stimulation via muscle tendon vibration (MTV) on tremor and balance control in patients with primary OT.MethodsTremor in nine patients with primary OT was examined during four conditions: standing (1), standing with MTV on the bilateral soleus muscles (2), lying (3), and lying with MTV (4). Tremor characteristics were assessed by frequency domain a...
Source: Journal of Neurology - May 16, 2018 Category: Neurology Source Type: research

Obstructive sleep apnea and cerebral white matter change: a systematic review and meta-analysis
AbstractObstructive sleep apnea (OSA) can cause sleep fragmentation and intermittent hypoxemia, which are linked to oxidative stress. White matter changes (WMCs) representing cerebrovascular burden and are at risk factor for oxidative ischemic injury. The current study explores the mutual relationships between OSA and WMCs. We performed a systematic review of electronic databases for clinical studies investigating OSA and WMCs. Random-effects models were used for pooled estimates calculation. A total of 22 studies were included in the meta-analysis. The results revealed a significantly higher prevalence rate of WMCs [odds ...
Source: Journal of Neurology - May 15, 2018 Category: Neurology Source Type: research

A startling acoustic stimulus facilitates voluntary lower extremity movements and automatic postural responses in people with chronic stroke
AbstractA startling acoustic stimulus (SAS) involuntary releases prepared movements at accelerated latencies, known as the StartReact effect. Previous work has demonstrated intact StartReact in paretic upper extremity movements in people after stroke, suggesting preserved motor preparation. The question remains whether motor preparation of lower extremity movements is also unaffected after stroke. Here, we investigated StartReact effects on ballistic lower extremity movements and on automatic postural responses (APRs) following perturbations to standing balance. These APRs are particularly interesting as they are critical ...
Source: Journal of Neurology - May 14, 2018 Category: Neurology Source Type: research

Severe neurologic complications of immune checkpoint inhibitors: a single-center review
ConclusionIn this clinical practice study, the incidence of neurologic IRAEs from ICIs was 0.95%. Although rare, neurologic IRAEs can be highly variable and severe, and patients with combination immunotherapy appeared to suffer more severe IRAEs. Neurologists play an important role in the early identification and management of IRAEs to reduce long-term morbidity and mortality. (Source: Journal of Neurology)
Source: Journal of Neurology - May 14, 2018 Category: Neurology Source Type: research