Effect of siponimod on lymphocyte subsets in active secondary progressive multiple sclerosis and clinical implications
ConclusionsPatients treated with siponimod showed a T and B lymphocyte reduction, especially CD4+, CD3+CD20+ and na ïve regulatory T cells and memory regulatory B cells. Disability progression while on siponimod treatment was associated with a less pronounced effect on B and CD3+CD20+ lymphocytes. (Source: Journal of Neurology)
Source: Journal of Neurology - April 17, 2024 Category: Neurology Source Type: research
Frontal hypometabolism in the diagnosis of progressive supranuclear palsy clinical variants
ConclusionsFrontal hypometabolism is a common finding in PSP, although it varies in severity and pattern across PSP variants and will likely be the most diagnostically useful in PSP-SL and PSP-CBS. (Source: Journal of Neurology)
Source: Journal of Neurology - April 17, 2024 Category: Neurology Source Type: research
Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings
ConclusionsOur findings indicate that 18.3% of NMOSD patients developed APS during the follow-up period, with most patients fulfilling criteria for severe APS. The inflammatory activity decreased after the onset of APS compared to the previous year. (Source: Journal of Neurology)
Source: Journal of Neurology - April 17, 2024 Category: Neurology Source Type: research
TMS of the left primary motor cortex improves tremor intensity and postural control in primary orthostatic tremor
In conclusion, non-invasive neuromodulation particularly of the M1 area can improve postural control and tremor intensity in primary orthostatic tremor by interference with the tremor network. (Source: Journal of Neurology)
Source: Journal of Neurology - April 16, 2024 Category: Neurology Source Type: research
Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis
ConclusionsCertain DMTs have the potential to positively impact QoL of PwMS, and the assessment and reporting of QoL is suboptimal with a multitude of diverse instruments being used. There is an urgent need that design and reporting of clinical trials reflect the critical importance of QoL for PwMS. (Source: Journal of Neurology)
Source: Journal of Neurology - April 16, 2024 Category: Neurology Source Type: research
Genetic diagnosis and detection rates using C9orf72 repeat expansion and a multi-gene panel in amyotrophic lateral sclerosis
AbstractAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. It is mostly sporadic, with theC9orf72 repeat expansion being the most common genetic cause. While the prevalence ofC9orf72-ALS in patients from different populations has been studied, data regarding the yield ofC9orf72 compared to an ALS gene panel testing is limited.We aimed to explore the application ofC9orf72 versus a gene panel in the general Israeli population. A total of 140 ALS patients attended our Neurogenetics Clinic throughout 2018 –2023. Disease onset was between ages 60 and 69 years for most patients (34%); however, a ...
Source: Journal of Neurology - April 16, 2024 Category: Neurology Source Type: research
Applying the 2022 optic neuritis criteria to noninflammatory optic neuropathies with optic nerve T2-hyperintensity: an observational study
DiscussionThe application of the 2022 optic neuritis diagnostic criteria in patients with noninflammatory optic neuropathy and ON-T2-hyperintensity in at least one ON resulted in misdiagnosis of optic neuritis in only 4 patients because of ON head enhancement, all with nonarteritic anterior ischemic optic neuropathy. Neuro-ophthalmologic evaluation and exclusion of the ON head as a location in the MRI criteria would have prevented optic neuritis misdiagnosis in our study. (Source: Journal of Neurology)
Source: Journal of Neurology - April 15, 2024 Category: Neurology Source Type: research
Which parameters influence cognitive, psychiatric and long-term seizure outcome in mesial temporal lobe epilepsy after selective amygdalohippocampectomy?
ConclusionsSAHE gives an improved chance of achieving good postoperative seizure, psychiatric and neuropsychological outcome in patients with in MTLE due to HS. Predictors of short-term outcome don ’t predict long-term outcome. (Source: Journal of Neurology)
Source: Journal of Neurology - April 15, 2024 Category: Neurology Source Type: research
Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption
AbstractMultiple sclerosis (MS) is characterized by progressive neuroinflammation and neurodegeneration from disease onset that, if left untreated, can result in the accumulation of irreversible neurological disability. Early intervention with high-efficacy therapies (HETs) is increasingly recognized as the best strategy to delay or mitigate disease progression from the earliest stages of the disease and to prevent long-term neurodegeneration. Although there is growing clinical and real-world evidence supporting early HET intervention, foregoing this strategy in favor of a traditional escalation approach prioritizing lower...
Source: Journal of Neurology - April 14, 2024 Category: Neurology Source Type: research
Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity —a potential diagnostic pitfall in patients with MOG-EM/MOGAD
ConclusionsIn some patients with MOG-EM/MOGAD, MOG-IgG is either exclusively or predominantly MOG-IgG3. Thus, the use of IgG1-specific assays might only partly overcome the current limitations of MOG-IgG testing and —just like H+L- and Fcγ-specific testing—might overlook some genuinely seropositive patients. This would have potentially significant consequences for the management of patients with MOG-EM/MOGAD. Given that IgG3 chiefly detects proteins and is a strong activator of complement and other effecto r mechanisms, MOG-IgG3 may be involved in the immunopathogenesis of MOG-EM/MOGAD. Studies on the frequency and dy...
Source: Journal of Neurology - April 13, 2024 Category: Neurology Source Type: research
Amyloid antibody therapy for early-stage Alzheimer ’s disease: a critical review of three recent trials
(Source: Journal of Neurology)
Source: Journal of Neurology - April 13, 2024 Category: Neurology Source Type: research
Healthy blood, healthy brain: a window into understanding and treating neurodegenerative diseases
AbstractOur limited understanding of complex neurodegenerative disorders has held us back on the development of efficient therapies. While several approaches are currently being considered, it is still unclear what will be most successful. Among the latest and more novel ideas, the concept of blood or plasma transfusion from young healthy donors to diseased patients is gaining momentum and attracting attention beyond the scientific arena. While young or healthy blood is enriched with protective and restorative components, blood from older subjects may accumulate neurotoxic agents or be impoverished of beneficial factors....
Source: Journal of Neurology - April 12, 2024 Category: Neurology Source Type: research
Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study
DiscussionThe high G23.1 PPV in inpatient data shows it is a useful tool for PSP case ascertainment, but death certificate coding is inaccurate. The PPV and sensitivity of existing ICD-10 codes for CBS are poor due to a lack of a specific code. (Source: Journal of Neurology)
Source: Journal of Neurology - April 12, 2024 Category: Neurology Source Type: research
The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia
AbstractThe neural mechanisms underlying language recovery after a stroke remain controversial. This review aimed to summarize the plasticity and reorganization mechanisms of the language network through neuroimaging studies. Initially, we discussed the involvement of right language homologues, perilesional tissue, and domain-general networks. Subsequently, we summarized the white matter functional mapping and remodeling mechanisms associated with language subskills. Finally, we explored how non-invasive brain stimulation (NIBS) promoted language recovery by inducing neural network plasticity. It was observed that the recr...
Source: Journal of Neurology - April 12, 2024 Category: Neurology Source Type: research
Exosomes for neurodegenerative diseases: diagnosis and targeted therapy
AbstractPurpose of ReviewNeurodegenerative diseases are still challenging clinical issues, with no curative interventions available and early, accurate diagnosis remaining difficult. Finding solutions to them is of great importance. In this review, we discuss possible exosomal diagnostic biomarkers and explore current explorations in exosome-targeted therapy for some common neurodegenerative diseases, offering insights into the clinical transformation of exosomes in this field.Recent FindingsThe burgeoning research on exosomes has shed light on their potential applications in disease diagnosis and treatment. As a type of e...
Source: Journal of Neurology - April 12, 2024 Category: Neurology Source Type: research
