Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case –control study
ConclusionThis study identified clinically relevant associations of MIG/TAC and CRPS not explained by chance. Further longitudinal investigations exploring potentially mutual pathomechanisms may improve the clinical management of both CRPS and primary headache disorders.Trial registrationGerman Clinical Trials Register (DRKS00022961). (Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
The impact of metformin use on the outcomes of relapse-remitting multiple sclerosis patients receiving interferon beta 1a: an exploratory prospective phase II open-label randomized controlled trial
ConclusionAdding metformin to IFN β-1a demonstrated a potential effect on an oxidative stress marker (MDA). However, there is no statistically significant effect on immunological, MRI and clinical outcomes. We recommend larger scale studies to confirm or negate these findings.Trial registrationClinicalTrials.gov number: NCT05298670, 28/3/2022. (Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
Myelitis as a side effect of tofersen therapy in SOD1-associated ALS
(Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
Subacute transverse myelitis of possible vasculitic origin after SARS-CoV2 and Varicella-Zoster virus infections: a case report
(Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
Reduced tear fluid production in neurological diseases: a cohort study in 708 patients
ConclusionWL was altered in many neurological diseases compared to healthy controls. Most importantly, we observed a reduction of WL in NDDs, independent of age or sex. This study highlights the potential of WL as an easily obtainable parameter and suggests functional alterations in the autonomic innervation in various neurological disorders. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
Frataxin analysis using triple quadrupole mass spectrometry: application to a large heterogeneous clinical cohort
ConclusionThe present data show that assay of FXN-M and FXN-E levels in blood provides an appropriate biofluid for assessing their repletion in particular clinical contexts. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
Relationship between plasma NFL and disease progression in Parkinson ’s disease: a prospective cohort study
ConclusionsPlasma NFL exhibits a tendency to increase with disease progression, and elevated baseline plasma NFL can serve as a predictor for accelerated motor deterioration and cognitive decline in PD. However, plasma NFL does not have high accuracy to distinguish individuals with early-stage PD from HC. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
Evaluation and management of insomnia in the clinical practice in Italy: a 2023 update from the Insomnia Expert Consensus Group
ConclusionsOur findings suggest that symptoms of insomnia must be assessed in the Italian clinical practice by evaluating nocturnal and daytime symptoms, comorbid conditions, and lifestyle. Cognitive behavioral therapy for insomnia should be the first option according to availability. The choice of the drug should be based on different factors including type of insomnia, age, comorbidities, and potential side effects. If the choice would be a Z-drug or a short-acting benzodiazepine (in subjects < 65 years old), the use should be in the short term (≤ 4 weeks). Indeed, eszopiclone, as a new option in Italy, ma...
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
The brief repeatable battery of neuropsychological tests (BRB-N) version a: update of Italian normative data from the Italian Neuroimaging Network Initiative (INNI)
This study provides updated normative data for the BRB-N version A in the Italian population. The use of a regression-based method and scaled scores ensures consistency with other neuropsychological batteries commonly used in Italy, namely MACFIMS and BICAMS. The availability of updated normative data increases reliability of neuropsychological assessment of cognitive function in Italian PwMS and other clinical populations using BRB-N version A, providing valuable insights for both clinical and research applications. (Source: Journal of Neurology)
Source: Journal of Neurology - December 7, 2023 Category: Neurology Source Type: research
The DeMyers: Marian (1922 –2012) and William (1924–2008)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 7, 2023 Category: Neurology Source Type: research
A retrospective study of accuracy and usefulness of electrophysiological exercise tests
ConclusionsElectrophysiological exercise test is not optimal to exclude skeletal muscle channelopathy. It may be useful if a skeletal muscle channelopathy is suspected and genetic testing is negative or indeterminate and further evidence is required. Slightly abnormal exercise test results are possible in various conditions and result from different aetiologies. There is a demand for neurophysiological studies with higher sensitivity to detect skeletal muscle channelopathies. (Source: Journal of Neurology)
Source: Journal of Neurology - December 6, 2023 Category: Neurology Source Type: research
Long-term safety and efficacy of cipaglucosidase alfa plus miglustat in individuals living with Pompe disease: an open-label phase I/II study (ATB200-02)
We report data from the Phase I/II ATB200-02 study for up to 48 months of treatment. Four adult cohorts, including one non-ambulatory ERT-experienced (n = 6) and three ambulatory cohorts, (two enzyme replacement therapy [ERT]-experienced cohorts [2–6 years (n = 11) and ≥ 7 years (n = 6)]), one ERT-naïve cohort (n = 6), received 20 mg/kg intravenous-infused cipa plus 260 mg oral mig biweekly. Change from baseline (CFBL) for multiple efficacy endpoints at 12, 24, 36, and 48 months, pharmacodynamics, pharmacokinetics, safety, and immunogenicity data were assessed. Six-minute walking distance (% predi...
Source: Journal of Neurology - December 6, 2023 Category: Neurology Source Type: research
Ernest de Massary (1866 –1955)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 6, 2023 Category: Neurology Source Type: research
Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study
(Source: Journal of Neurology)
Source: Journal of Neurology - December 6, 2023 Category: Neurology Source Type: research
Neurological toxicities of targeted therapies in melanoma: a multicenter national observational study of the French Group of Skin Cancers (Groupe de Canc érologie Cutanée, GCC)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 6, 2023 Category: Neurology Source Type: research
