Conjugate torsional pendular nystagmus and palatal tremor after unilateral internuclear ophthalmoplegia
(Source: Journal of Neurology)
Source: Journal of Neurology - January 1, 2024 Category: Neurology Source Type: research
Correction to: Predicting neurologic recovery after severe acute brain injury using resting-state networks
(Source: Journal of Neurology)
Source: Journal of Neurology - January 1, 2024 Category: Neurology Source Type: research
Correction to: Acute vestibular migraine: a ghost diagnosis in patients with acute vertigo
(Source: Journal of Neurology)
Source: Journal of Neurology - January 1, 2024 Category: Neurology Source Type: research
Correction to: Synergistic effects of vagus nerve stimulation and antiseizure medication
(Source: Journal of Neurology)
Source: Journal of Neurology - January 1, 2024 Category: Neurology Source Type: research
An exploratory study on the association between blood-based biomarkers and subacute neurometabolic changes following mild traumatic brain injury
ConclusionThis study demonstrates potential associations between the intensity of the inflammatory response in the acute phase post-mTBI and neurometabolic perturbations in the subacute phase. Future studies should assess the longitudinal dynamics of blood-based and imaging biomarkers after injury. (Source: Journal of Neurology)
Source: Journal of Neurology - December 29, 2023 Category: Neurology Source Type: research
Cerebrospinal fluid NPTX2 changes and relationship with regional brain metabolism metrics across mild cognitive impairment due to Alzheimer's disease
ConclusionsHigher CSF NPTX2 in EMCI compared to controls and LMCI suggests compensatory synaptic responses to initial AD pathology. Disease progression sees these mechanisms overwhelmed, lowering CSF NPTX2 approaching dementia. Positive CSF NPTX2 correlation with precuneus glucose metabolism links to AD-related metabolic changes across MCI course. These findings posit CSF NPTX2 as a promising biomarker for both AD staging and progression risk stratification. (Source: Journal of Neurology)
Source: Journal of Neurology - December 29, 2023 Category: Neurology Source Type: research
Tumefactive demyelinating lesions: a challenging first manifestation of multiple sclerosis
(Source: Journal of Neurology)
Source: Journal of Neurology - December 28, 2023 Category: Neurology Source Type: research
Impact of demographics and comorbid conditions on plasma biomarkers concentrations and their diagnostic accuracy in a memory clinic cohort
In conclusion, in a memory clinic cohort, a ge, sex, eGFR, BMI, BV and CCI slightly modified plasma p-tau181, GFAP and NfL concentrations but their impact on the diagnostic accuracy of plasma biomarkers for Aβ status discrimination was minimal. (Source: Journal of Neurology)
Source: Journal of Neurology - December 27, 2023 Category: Neurology Source Type: research
Clinical features and neurobiochemical mechanisms of olfactory dysfunction in patients with Parkinson disease
This study aimed to investigate clinical features, influencing factors and neurobiochemical mechanisms of olfactory dysfunction (OD) in Parkinson disease (PD). Total 39 patients were divided into the PD with OD (PD–OD) and PD with no OD (PD–nOD) groups according to overall olfactory function, including threshold, discrimination and identification, assessed by Sniffin’ Sticks test. Motor function and non-motor symptoms were rated by multiple scales. Dopamine, acetylcholine, norepinephrin e and 5-hydroxytryptamine levels in cerebrospinal fluid (CSF) were measured. We found that the PD–OD group showed significantl...
Source: Journal of Neurology - December 27, 2023 Category: Neurology Source Type: research
Correction to: Neurological update: non-motor symptoms in atypical parkinsonian syndromes
(Source: Journal of Neurology)
Source: Journal of Neurology - December 27, 2023 Category: Neurology Source Type: research
Progressive multifocal leukoencephalopathy in patients with chronic liver disease successfully treated with pembrolizumab
(Source: Journal of Neurology)
Source: Journal of Neurology - December 24, 2023 Category: Neurology Source Type: research
Immune checkpoint inhibitor-related myositis and myocarditis: diagnostic pitfalls and imaging contribution in a real-world, institutional case series
ConclusionMyositis is a potentially severe irAE. Despite its heterogeneous presentation, some highly suggestive clinical symptoms, such as ocular involvement, or radiological signs should raise physicians ’ attention to avoid misdiagnosis. We thus recommend a multidisciplinary assessment (including complete neuromuscular evaluation) even in case of isolated myocarditis. Our series underlines the importance of an early diagnosis, since suspension of ICI and adequate treatment are usually associated with good functional outcome. (Source: Journal of Neurology)
Source: Journal of Neurology - December 23, 2023 Category: Neurology Source Type: research
Prognostic and relapsing factors of primary autoimmune cerebellar ataxia: a prospective cohort study
ConclusionThis study identified younger onset age, presence of peripheral neuropathy/radiculopathy and elevated CSF protein concentration as relapsing factors, and absence of peripheral neuropathy/radiculopathy and responsiveness to first-line immunotherapy as independent factors for favorable prognosis in PACA patients. These findings may guide individualized treatment strategies and potentially improve patient outcomes. (Source: Journal of Neurology)
Source: Journal of Neurology - December 23, 2023 Category: Neurology Source Type: research
Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry
ConclusionsMore than 50% of RMS switched therapy due to disease activity. HE DMTs, especially anti-CD20 drugs, significantly reduce the risk of treatment switch. (Source: Journal of Neurology)
Source: Journal of Neurology - December 22, 2023 Category: Neurology Source Type: research
Predicting disease severity in multiple sclerosis using multimodal data and machine learning
ConclusionCombining clinical, imaging and omics data with machine learning helps identify MS patients at risk of disability worsening. (Source: Journal of Neurology)
Source: Journal of Neurology - December 22, 2023 Category: Neurology Source Type: research
