Basilar artery occlusion: drip-and-ship versus direct-to-center for mechanical thrombectomy within the Neurovascular Network of Southwest Bavaria (NEVAS)
ConclusionWe show for the first time that patients with BAO in rural areas benefit from a structured telemedicine network such as NEVAS, regarding both on-site processing and drip-and-ship for MT. Clinical outcomes are comparable among DS and DC patients. (Source: Journal of Neurology)
Source: Journal of Neurology - December 14, 2023 Category: Neurology Source Type: research
Cavernomas: to treat or not to treat?
(Source: Journal of Neurology)
Source: Journal of Neurology - December 14, 2023 Category: Neurology Source Type: research
Routine outcomes and evaluation of an 8-week outpatient multidisciplinary rehabilitative therapy program for functional neurological disorder
We report routinely collected outcome data from an 8-week outpatient rehabilitative therapy program. The aims of the intervention were to (1) reduce symptom severity and (2) improve functional mobility in adults with functional neurological disorder (FND).MethodsThe program delivered individual physiotherapy, cognitive behavioral therapy (CBT) and self-management sessions, group physiotherapy, and psychoeducation. Outcome measures included the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II), Work and Social Adjustment Scale (WSAS), 10-Meter Walk Test (10MWT), Timed Up and Go (TUG), and Berg Balance Scale (...
Source: Journal of Neurology - December 13, 2023 Category: Neurology Source Type: research
Peering further into the mind ’s eye: combining visual evoked potential and optical coherence tomography measures enhances insight into the variance in cognitive functioning in multiple sclerosis
ConclusionApproaches that combine the use of OCT and VEP measures can enhance insight into underlying factors that contribute to variance in cognitive functioning in PwMS. (Source: Journal of Neurology)
Source: Journal of Neurology - December 13, 2023 Category: Neurology Source Type: research
Baseline serum neurofilament light chain levels differentiate aggressive from benign forms of relapsing –remitting multiple sclerosis: a 20-year follow-up cohort
DiscussionThis proof-of-concept study comparing benign and aggressive RRMS groups reinforces the potential role of baseline NfL serum levels as a promising long-term disability prognostic marker. In contrast, serum GFAP, total tau, and CHI3L1 levels demonstrated a lower or no ability to differentiate between the long-term outcomes of RRMS. (Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2023 Category: Neurology Source Type: research
William Cumberland Cruikshank (1745 –1800)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2023 Category: Neurology Source Type: research
Disease-modifying therapies used to treat multiple sclerosis and the gut microbiome: a systematic review
DiscussionWhile DMT use (versus no use) was not associated with gut microbiota diversity differences, taxa-level differences were observed. Further work is warranted, as most studies were cross-sectional, few examined functionality, and DMTs were combined. (Source: Journal of Neurology)
Source: Journal of Neurology - December 11, 2023 Category: Neurology Source Type: research
Expanding clinical profiles and prognostic markers in stiff person syndrome spectrum disorders
ConclusionsWe present the expanding phenotypic variability of this rare spectrum of disorders and highlight potential predictors of future disability. (Source: Journal of Neurology)
Source: Journal of Neurology - December 11, 2023 Category: Neurology Source Type: research
Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case –control study
ConclusionThis study identified clinically relevant associations of MIG/TAC and CRPS not explained by chance. Further longitudinal investigations exploring potentially mutual pathomechanisms may improve the clinical management of both CRPS and primary headache disorders.Trial registrationGerman Clinical Trials Register (DRKS00022961). (Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
The impact of metformin use on the outcomes of relapse-remitting multiple sclerosis patients receiving interferon beta 1a: an exploratory prospective phase II open-label randomized controlled trial
ConclusionAdding metformin to IFN β-1a demonstrated a potential effect on an oxidative stress marker (MDA). However, there is no statistically significant effect on immunological, MRI and clinical outcomes. We recommend larger scale studies to confirm or negate these findings.Trial registrationClinicalTrials.gov number: NCT05298670, 28/3/2022. (Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
Myelitis as a side effect of tofersen therapy in SOD1-associated ALS
(Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
Subacute transverse myelitis of possible vasculitic origin after SARS-CoV2 and Varicella-Zoster virus infections: a case report
(Source: Journal of Neurology)
Source: Journal of Neurology - December 9, 2023 Category: Neurology Source Type: research
Reduced tear fluid production in neurological diseases: a cohort study in 708 patients
ConclusionWL was altered in many neurological diseases compared to healthy controls. Most importantly, we observed a reduction of WL in NDDs, independent of age or sex. This study highlights the potential of WL as an easily obtainable parameter and suggests functional alterations in the autonomic innervation in various neurological disorders. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
Frataxin analysis using triple quadrupole mass spectrometry: application to a large heterogeneous clinical cohort
ConclusionThe present data show that assay of FXN-M and FXN-E levels in blood provides an appropriate biofluid for assessing their repletion in particular clinical contexts. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
Relationship between plasma NFL and disease progression in Parkinson ’s disease: a prospective cohort study
ConclusionsPlasma NFL exhibits a tendency to increase with disease progression, and elevated baseline plasma NFL can serve as a predictor for accelerated motor deterioration and cognitive decline in PD. However, plasma NFL does not have high accuracy to distinguish individuals with early-stage PD from HC. (Source: Journal of Neurology)
Source: Journal of Neurology - December 8, 2023 Category: Neurology Source Type: research
