A multimodal clinical diagnostic approach using MRI and 18F-FDG-PET for antemortem diagnosis of TDP-43 in cases with low –intermediate Alzheimer’s disease neuropathologic changes and primary age-related tauopathy
ConclusionVisual inspection of the medial temporal lobe on MRI and FDG-PET may help to predict TDP-43 status in the context of low –intermediate ADNC and PART. (Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis
ConclusionsPECAM-1 in combination with D-Dimer should be used to improve the diagnostic accuracy of acute CSVT and sPECAM-1 may predict long-term outcome of CSVT. Confirmatory results are needed in other settings in order to show their value in the management concept of CSVT patients. (Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Inter-laboratory comparison of routine autoantibody detection methods for autoimmune neuropathies and myasthenia gravis
AbstractSerological tests are important to detect autoantibodies (autoAbs) in patients with autoimmune neuropathies (AN) and myasthenia gravis (MG) as they are biomarkers for diagnosis, stratification, treatment selection, and monitoring. However, tests to detect autoAbs frequently lack proper standardization and results differ across diagnostic laboratories. We compared results for tests routinely performed in Spanish diagnostic laboratories to detect AN and MG autoAbs. In the Spanish Society of Immunology Autoimmunity Group national workshop, serum samples from 13 patients with AN or MG were tested for anti-ganglioside, ...
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Ticagrelor versus clopidogrel in dual antiplatelet therapy after minor stroke or transient ischemic attack: an updated network meta-analysis
ConclusionsDAPTs were superior to aspirin in preventing recurrence or ischemic stroke. Although no significant difference was observed between DAPTs, ticagrelor plus aspirin may be related to worse major bleeding results, including intracranial bleeding. Ticagrelor plus aspirin is a considerable option for patients after a minor stroke or TIA. (Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management
(Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Keeping prior anticoagulation treatment in the acute phase of ischaemic stroke: the REKOALA study
ConclusionContinuation of anticoagulation in patients with acute ischaemic stroke and cardioembolic source did not increase the risk of intracranial haemorrhage and may be associated with better functional outcomes. (Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Correction to: Implementation of a 7T Epilepsy Task Force consensus imaging protocol for routine presurgical epilepsy work-up: effect on diagnostic yield and lesion delineation
(Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Risk of hepatitis B virus reactivation in people with multiple sclerosis treated with ocrelizumab: an observational study from Turkey
ConclusionThis study highlights a 14% anti-HBc positivity, indicating a potential risk for HBV reactivation in people with MS receiving ocrelizumab. This suggests the importance of vigilant monitoring and the implementation of prophylactic measures. Our recommendation emphasizes antiviral prophylaxis, particularly for patients with low anti-HBs, and a pre-emptive strategy for others. (Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
Prevalence and epidemiology of stroke in patients with multiple sclerosis: a systematic review and meta-analysis
ConclusionThe findings of the present meta-analysis indicate that MS is associated with an increased risk for ischaemic and haemorrhagic stroke. Future well-designed epidemiological studies are warranted to corroborate the robustness of the present findings in the MS population. (Source: Journal of Neurology)
Source: Journal of Neurology - April 4, 2024 Category: Neurology Source Type: research
Pallidal deep brain stimulation for patients with myoclonus-dystonia without SGCE mutations
ConclusionsGPi-DBS is effective for treating myoclonus-dystonia in patients with and withoutSGCE mutations. GPi-DBS should be considered as a treatment option for myoclonus-dystonia withoutSGCE mutations. (Source: Journal of Neurology)
Source: Journal of Neurology - April 4, 2024 Category: Neurology Source Type: research
Takotsubo cardiomyopathy in Guillain –Barré syndrome
ConclusionsTCM occurred at a relatively early phase of GBS. The characteristics of GBS-TCM were the elder, lower cranial nerve involvements, severe limb weakness, and respiratory failure. (Source: Journal of Neurology)
Source: Journal of Neurology - April 4, 2024 Category: Neurology Source Type: research
ChatGPT vs. neurologists: a cross-sectional study investigating preference, satisfaction ratings and perceived empathy in responses among people living with multiple sclerosis
ConclusionsChatGPT-authored responses provided higher empathy than neurologists. Although AI holds potential, physicians should prepare to interact with increasingly digitized patients and guide them on responsible AI use. Future development should consider tailoring AIs ’ responses to individual characteristics. Within the progressive digitalization of the population, ChatGPT could emerge as a helpful support in healthcare management rather than an alternative. (Source: Journal of Neurology)
Source: Journal of Neurology - April 3, 2024 Category: Neurology Source Type: research
Pregnancy effect on disease activity in women with multiple sclerosis treated with cladribine
DiscussionOur findings suggest that pregnancy does not appear to influence disease activity and disability in women previously treated with cladribine; further studies with larger numbers and longer follow-up are needed to confirm this finding. (Source: Journal of Neurology)
Source: Journal of Neurology - April 3, 2024 Category: Neurology Source Type: research
Acute recanalization therapy for ischemic stroke during pregnancy and puerperium
ConclusionsIn this small nationwide cohort of maternal ISs, the complications of recanalization therapy were rare, and the outcomes were similar in IVT-treated maternal IS patients and controls. Maternal ISs should not be excluded from recanalization therapy in otherwise eligible situations. (Source: Journal of Neurology)
Source: Journal of Neurology - April 3, 2024 Category: Neurology Source Type: research
The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
ConclusionsYounger children with RIS may be at continued risk for misdiagnosis and misclassification of MS risk. Consensus guidelines are needed. (Source: Journal of Neurology)
Source: Journal of Neurology - April 2, 2024 Category: Neurology Source Type: research
