Thalamic nuclei volume partially mediates the effects of aerobic capacity on fatigue in people with multiple sclerosis
ConclusionsHigher VO2peak is associated with lower fatigue in pwMS, likely acting on Dor thalamic cluster volume integrity. Such an effect might be different according to the type of fatigue (cognitive or physical). (Source: Journal of Neurology)
Source: Journal of Neurology - March 20, 2024 Category: Neurology Source Type: research
Follow-up infarct volume on fluid attenuated inversion recovery (FLAIR) imaging in distal medium vessel occlusions: the role of cerebral blood volume index
ConclusionOur findings underscore the CBV index as an independent association with FIV in DMVOs, which highlights the critical role of collateral circulation in determining stroke outcomes in this patient population. In addition, our study confirms a negative association of ASPECTS with FLAIR FIV and identifies diabetes as independent factor associated with larger FIV. These insights pave the way for further large-scale, prospective studies to corroborate these findings, thereby refining the strategies for stroke prognostication and management. (Source: Journal of Neurology)
Source: Journal of Neurology - March 20, 2024 Category: Neurology Source Type: research
Predictors of early neurological deterioration in patients with intracerebral hemorrhage: a systematic review and meta-analysis
ConclusionsThis meta-analysis revealed a pooled prevalence of early neurological deterioration of 23% in patients with intracerebral hemorrhage. The initial NIHSS score, hematoma volume, intraventricular hemorrhage, intraventricular expansion, hematoma expansion, and spot sign enhanced the probability of early neurological deterioration. These findings provide healthcare providers with an evidence-based basis for detecting and managing early neurological deterioration in patients with intracerebral hemorrhage. (Source: Journal of Neurology)
Source: Journal of Neurology - March 20, 2024 Category: Neurology Source Type: research
Efficacy and safety of selumetinib in patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas: a systematic review and meta-analysis
ConclusionOur study demonstrates that selumetinib is effective in patients with NF1 and PN, significantly improving the serious complications associated with PN as well as having tolerable toxicities. Our findings help to increase clinicians' confidence in applying selumetinib and promote the clinical adoption and benefit of the new drug. (Source: Journal of Neurology)
Source: Journal of Neurology - March 19, 2024 Category: Neurology Source Type: research
Radiologically isolated syndromes: to treat or not to treat?
AbstractThe widespread use of magnetic resonance imaging (MRI) has led to increased detection of individuals exhibiting asymptomatic brain and spinal cord lesions suggestive of multiple sclerosis (MS), defined as “radiologically isolated syndrome” (RIS). Specific criteria have been proposed and updated over time to identify individuals with RIS. Moreover, a younger age, the presence of infratentorial, spinal cord or gadolinium-enhancing lesions, as well as of cerebrospinal fluid-specific oligoclonal band s have been recognized as relevant risk factors for the occurrence of a first clinical event. Recent randomized cont...
Source: Journal of Neurology - March 19, 2024 Category: Neurology Source Type: research
Genetics of ischemic stroke functional outcome
AbstractIschemic stroke, which accounts for 87% of cerebrovascular accidents, is responsible for massive global burden both in terms of economic cost and personal hardship. Many stroke survivors face long-term disability —a phenotype associated with an increasing number of genetic variants. While clinical variables such as stroke severity greatly impact recovery, genetic polymorphisms linked to functional outcome may offer physicians a unique opportunity to deliver personalized care based on their patient’s gene tic makeup, leading to improved outcomes. A comprehensive catalogue of the variants at play is required for ...
Source: Journal of Neurology - March 19, 2024 Category: Neurology Source Type: research
Corneal nerves and amyotrophic lateral sclerosis: an in vivo corneal confocal imaging study
ConclusionsThe present study does not support the use of in vivo corneal confocal microscopy as an early diagnostic or prognostic tool for ALS. Further research, especially longitudinal investigations, is needed to understand any potential corneal innervation changes as ALS progresses. (Source: Journal of Neurology)
Source: Journal of Neurology - March 18, 2024 Category: Neurology Source Type: research
Correction to: The impact of metformin use on the outcomes of relapse ‑remitting multiple sclerosis patients receiving interferon beta 1a: an exploratory prospective phase II open‑label randomized controlled trial
(Source: Journal of Neurology)
Source: Journal of Neurology - March 18, 2024 Category: Neurology Source Type: research
Dysautonomia in anti-Hu paraneoplastic neurological syndromes
We describe anti-Hu patients with dysautonomia, estimate its frequency, and compare them to patients without dysautonomia.MethodsPatients with anti-Hu antibodies diagnosed in the study centre (1990 –2022) were retrospectively reviewed; those with autonomic signs and symptoms were identified.ResultsAmong 477 anti-Hu patients, 126 (26%) had dysautonomia (the only PNS manifestation in 7/126, 6%); gastrointestinal (82/126, 65%), cardiovascular (64/126, 51%), urogenital (24/126, 19%), pupillomotor/secretomotor (each, 11/126, 9%), and central hypoventilation (10/126, 8%). Patients with isolated CNS involvement less frequently ...
Source: Journal of Neurology - March 17, 2024 Category: Neurology Source Type: research
Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study
ConclusionsIn high-risk population, sex modifies the association of HDL cholesterol on stroke incidence, and the association of overweight on stroke recurrence. Our findings highlight the importance of sex-specific secondary prevention. (Source: Journal of Neurology)
Source: Journal of Neurology - March 16, 2024 Category: Neurology Source Type: research
A biological characterization of patients with postmenopausal Parkinson ’s disease
In conclusion, menopause-related hormonal chang es might differentially contribute to clinical-pathological trajectories of PD, accounting for the peculiar vulnerability to the disease. (Source: Journal of Neurology)
Source: Journal of Neurology - March 16, 2024 Category: Neurology Source Type: research
Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials
AbstractMultiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsonism and/or ce rebellar...
Source: Journal of Neurology - March 14, 2024 Category: Neurology Source Type: research
Moyamoya disease in Southeast Asians: genetic and autopsy data, new cases, systematic review, and meta-analysis of all patients from the literature
ConclusionClinical and histopathological manifestations of MMD in Southeast Asians are similar to those in Caucasian Europeans. The genotype of MMD in Southeast Asians differs from that of most East Asian patients. (Source: Journal of Neurology)
Source: Journal of Neurology - March 13, 2024 Category: Neurology Source Type: research
Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area
ConclusionThe recent increase in recreational N2O use has led to a rise in the incidence of severe NI-NDs, particularly in young adults with low socioeconomic status for whom NI-NDs strongly outweigh similar neurological disorders. (Source: Journal of Neurology)
Source: Journal of Neurology - March 13, 2024 Category: Neurology Source Type: research
Progressive leukoencephalopathy as a manifestation of primary angiitis of the central nervous system: case report and review of the literature
We describe a 51-year-old man with a case of PACNS manifesting as akinetic mutism with progressive leukoencephalopathy.DiscussionProgressive leukoencephalopathy has not been well defined as a manifestation of PACNS. We review a small number of cases with comparable features, providing additional context on this PACNS manifestation with consideration of clinical subtypes. (Source: Journal of Neurology)
Source: Journal of Neurology - March 13, 2024 Category: Neurology Source Type: research
