Cerebral microbleeds and risk of symptomatic hemorrhagic transformation following mechanical thrombectomy for large vessel ischemic stroke
ConclusionCMB presence and burden is not associated with increased occurrence of sICH after EVT. This result incites not to exclude patients with CMBs from EVT. The risk of sICH after EVT in patients with more than10 CMBs will require further investigation.RegistrationRegistration-URL:http://www.clinicaltrials.gov; Unique identifier: NCT01062698. (Source: Journal of Neurology)
Source: Journal of Neurology - February 14, 2024 Category: Neurology Source Type: research
Midbrain lesion-induced disconjugate gaze: a unifying circuit mechanism of ocular alignment?
ConclusionA circumscribed region in the dorsal midbrain appears to be a key node for disconjugate eye movements in both vertical and horizontal planes. Lesioning this area produces a unique ocular motor syndrome mirroring hallmarks of developmental strabismus and nystagmus. Further circuit-level studies could offer pivotal insights into shared pathomechanisms of acquired and developmental disorders affecting eye alignment. (Source: Journal of Neurology)
Source: Journal of Neurology - February 14, 2024 Category: Neurology Source Type: research
The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis
ConclusionsMSA patients face a substantial burden of comorbidities, notably in the genitourinary system. This, coupled with increased polypharmacy and potential drug interactions, highlights the complexity of managing MSA patients. Clinicians should carefully consider these factors when devising treatment strategies for MSA patients. (Source: Journal of Neurology)
Source: Journal of Neurology - February 14, 2024 Category: Neurology Source Type: research
Correction to: Analysis of muscle magnetic resonance imaging of a large cohort of patient with VCP ‑mediated disease reveals characteristic features useful for diagnosis
(Source: Journal of Neurology)
Source: Journal of Neurology - February 13, 2024 Category: Neurology Source Type: research
Assessing the synergistic effectiveness of intermittent theta burst stimulation and the vestibular ocular reflex rehabilitation protocol in the treatment of Mal de Debarquement Syndrome: a randomised controlled trial
DiscussionThese findings support the effectiveness of the VOR rehabilitation protocol in reducing MdDS symptoms. Further research into iTBS is required to elucidate whether the treatment has a role in the management of MdDS. TRN: ACTRN12619001519145 (Date registered: 04 November 2019). (Source: Journal of Neurology)
Source: Journal of Neurology - February 12, 2024 Category: Neurology Source Type: research
Impact of multiple treatment cycles with anti-CGRP monoclonal antibodies on migraine course: focus on discontinuation periods. Insights from the multicenter, prospective, I-GRAINE study
DiscussionA second TrC with anti-CGRP mAbs demonstrated clinical improvements compared to the first one, as indicated by a milder migraine relapse at D2 compared to D1. Multiple TrCs with anti-CGRP mAbs could progressively modify migraine evolution by reducing CGRP-dependent neuroinflammatory nociceptive inputs to the brain. (Source: Journal of Neurology)
Source: Journal of Neurology - February 12, 2024 Category: Neurology Source Type: research
Evaluating the performance of optically pumped magnetometers (OPM) in the diagnosis and presurgical workup of focal epilepsy
(Source: Journal of Neurology)
Source: Journal of Neurology - February 12, 2024 Category: Neurology Source Type: research
Prodromal multiple sclerosis: considerations and future utility
AbstractA multiple sclerosis (MS) prodrome has recently been described and is characterised by increased rates of healthcare utilisation and an excess frequency of fatigue, bladder problems, sensory symptoms and pain, in the years leading up to clinical onset of disease. This important observation may have several potential applications including in the identification of risk factors for disease, the potential to delay or prevent disease onset and early opportunities to alter disease course. It may also offer possibilities for the use of risk stratification algorithms and effective population screening. If standardised, cl...
Source: Journal of Neurology - February 11, 2024 Category: Neurology Source Type: research
Hippocampal sclerosis is associated with celiac disease type immunity in patients with drug-resistant temporal lobe epilepsy
ConclusionsThis study provides further evidence linking TLE with HS and CD-type autoimmunity suggesting that CD-type immune response to gluten can be one potential mechanism as a disease modifier leading to DRE and HS. Understanding these immunological factors is imperative for developing immunomodulatory or dietary treatments for DRE potentially preventing HS progression. (Source: Journal of Neurology)
Source: Journal of Neurology - February 10, 2024 Category: Neurology Source Type: research
The impact of subthalamic deep-brain stimulation in restoring motor symmetry in Parkinson ’s disease patients: a prospective study
ConclusionsBoth STN-DBS and levodopa lead to a reduction in motor asymmetry. Motor symmetry is associated with improvements in certain QoL sub-scores. (Source: Journal of Neurology)
Source: Journal of Neurology - February 9, 2024 Category: Neurology Source Type: research
Progression rate of radiation-induced carotid stenosis in head and neck cancer survivors after statin treatment: a retrospective cohort study
ConclusionsStatin treatment was associated with a lower risk of RICS progression in patients with HNC after radiotherapy, regardless of baseline LDL-C level and baseline stenosis degrees. (Source: Journal of Neurology)
Source: Journal of Neurology - February 8, 2024 Category: Neurology Source Type: research
POLAR: prediction of prolonged mechanical ventilation in patients with myasthenic crisis
(Source: Journal of Neurology)
Source: Journal of Neurology - February 8, 2024 Category: Neurology Source Type: research
Inflammatory neuropathy with evidence of anti-GQ1b antibodies in angioimmunoblastic T cell lymphoma (AITL): a case report
(Source: Journal of Neurology)
Source: Journal of Neurology - February 8, 2024 Category: Neurology Source Type: research
Endovascular thrombectomy for DAWN- and DEFUSE-3 ineligible acute ischemic stroke patients: a systematic review and meta-analysis
ConclusionThis meta-analysis demonstrates equivalent rates of functional independence between DD and NDND patients. However, the high proportion of distal occlusions and higher rates of sICH and mortality in NDND patients suggest caution in offering mechanical thrombectomy to DAWN/DEFUSE-3 ineligible patients. A more flexible approach to EVT eligibility criteria could benefit select patients in real-world practice. Nonetheless, further research is needed to identify which patients would benefit from expanded EVT eligibility criteria. (Source: Journal of Neurology)
Source: Journal of Neurology - February 3, 2024 Category: Neurology Source Type: research
Disease survival and progression in TARDBP ALS patients from Sardinia, Italy
ConclusionsTARDBP patients have a better survival/prognosis than C9orf72-positive and nmALS patients. King ’s staging also suggested that the higher survival rate and the slower progression associated with the TARDBP mutation could mainly be attributed to the longer time elapsed between King’s stages 2B to 3. (Source: Journal of Neurology)
Source: Journal of Neurology - January 31, 2024 Category: Neurology Source Type: research
