A systematic review on the definition of rhabdomyolysis
ConclusionAt present, we recommend a clinical syndrome of acute muscle weakness, myalgia, and muscle swelling combined with a CK cut-off value of>  1000 IU/L/ or CK >  5 × ULN for the standard definition of a mild RML. Additionally measured myoglobinuria and AKI indicate a severe type of RML. Exclusion criteria as well as the chronological sequence need to be considered for a conclusive RML definition. (Source: Journal of Neurology)
Source: Journal of Neurology - January 7, 2019 Category: Neurology Source Type: research

Outcomes after stenting for symptomatic intracranial arterial stenosis: a systematic review and meta-analysis
ConclusionThis systematic review provided the worldwide profile of short- and long-term outcomes of stenting for symptomatic ICAS. The generally acceptable outcomes indicate that stenting may still be feasible in selected patients. Regional disparity calls for more cautious decisions and future studies. (Source: Journal of Neurology)
Source: Journal of Neurology - January 5, 2019 Category: Neurology Source Type: research

Progressive multifocal leukoencephalopathy in Finland: a cross-sectional registry study
ConclusionsPML most often occurs in patients with malignancies and patients with HIV or CTD cover a third. PML incidence in Finland is lower than in Sweden and shows no temporal trend despite increasing use of predisposing drugs. Mortality after PML varies according to the predisposing condition. (Source: Journal of Neurology)
Source: Journal of Neurology - January 5, 2019 Category: Neurology Source Type: research

Impact of virtual reality-based rehabilitation on functional outcomes in patients with acute stroke: a retrospective case-matched study
AbstractBackground and objectivesTo date, the efficacy of the virtual reality (VR) application for acute stroke compared with conventional therapy (CT) remains unclear. This retrospective study aims to assess the impact of adjuvant VR technology on multidimensional therapy for patients with acute-stage stroke.Methods100 acute ischemic stroke patients with onset within 7 days who underwent combined adjuvant VR-based rehabilitation program and CT (intervention group –VR + CT) were compared to an equal number of cross-matched patients who received CT alone. While the intervention group received 40-min CT p...
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Long-term follow-up of multiple sclerosis studies and outcomes from early treatment of clinically isolated syndrome in the BENEFIT 11 study
AbstractMultiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with a diverse disease course involving inflammation and degeneration of neurons and axons. Multiple sclerosis results from a complex interaction of genetic and environmental factors and clinically several disease subtypes with marked variation in symptoms can be discerned. Disease-modifying therapies (DMTs) impact disease activity and outcome. Long-term follow-up studies of DMTs in MS have generally shown that the short-term effects in clinical trials are maintained for up to 21 years, e.g. in the case of interferon beta-1b. Howev...
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Determining factors of better leptomeningeal collaterals: a study of 857 consecutive acute ischemic stroke patients
AbstractBackgroundIn acute ischemic stroke (AIS) collaterals correlate with infarct size, recanalization rate and clinical outcome. We aimed to identify factors associated with better collateral status in a large series of AIS patients with middle cerebral artery (MCA) occlusion.MethodsIn the Acute STroke Registry and Analysis of Lausanne (ASTRAL) from 2003 to 2016, we identified all consecutive AIS with proximal MCA occlusion on CT-angiography performed  
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Differential long-term evolution after surgery or pharmacotherapy of Rasmussen encephalopathy in adult patients
(Source: Journal of Neurology)
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Correction to: Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody
The original version of this article unfortunately contained a mistake. (Source: Journal of Neurology)
Source: Journal of Neurology - January 4, 2019 Category: Neurology Source Type: research

Usefulness of MOG-antibody titres at first episode to predict the future clinical course in adults
AbstractObjectiveTo analyze whether myelin oligodendrocyte glycoprotein antibody (MOG-Ab) titres at onset of the disease were different according to the clinical phenotype at presentation, and to investigate whether the titres were associated with risk of further relapses or predicted clinical outcome in adult patients. Finally, we assessed an alternative method to the classical measurement of MOG-Ab levels by serial dilutions.MethodsThis is a retrospective study including 79 MOG-Ab-positive adult patients, whose samples were obtained at first episode. MOG-Ab were tested by cell-based assay. HEK293 cells were transfected (...
Source: Journal of Neurology - January 3, 2019 Category: Neurology Source Type: research

Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson ’s disease
AbstractExcessive daytime sleepiness (EDS) may represent a disabling non-motor symptom in patients affected by Parkinson ’s disease (PD). This is a secondary analysis of a previous study documenting the improvement of nocturnal sleep in PD patients treated by rotigotine vs placebo. Here we tested the supposition that EDS may represent a distinct PD non-motor symptom occurring independently of other sleep-wake disor ders; moreover, we verified whether EDS can be influenced by the improvement of nocturnal sleep in PD. In the present study, we evaluated the daytime sleepiness of PD patients treated with nocturnal a...
Source: Journal of Neurology - January 3, 2019 Category: Neurology Source Type: research

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study
AbstractThe aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer ’s disease (AD). For this purpose, we followed up 263 patients (154 SCD; 109 MCI) for a mean time of 7 years. CR was assessed by the Test di Intelligenza Breve (TIB), functionally equivalent to the National Adult Reading Test. High CR resulted as a protective factor for progression from SCD to MC I. Age at conversion to MCI was delayed 9 years on average in SCD with high CR with respect to SCD with low CR. On the contrary,...
Source: Journal of Neurology - January 2, 2019 Category: Neurology Source Type: research

Clinical and demographic correlates of apathy in Parkinson ’s disease
AbstractObjectiveTo better understand the demographic, neuropsychiatric, cognitive, and motor predictors of apathy in Parkinson ’s disease (PD).Method112 participants (Mage = 68.53 years;Mdisease duration = 6.17  years) were administered the Apathy Scale (AS), Beck Depression Inventory-II (BDI-II), Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Trail Making Test (TMT), Wechsler Adult Intelligence Scale-IV Matrix Reasoning subtest, letter (F-A-S) and category (Animals) flu ency, and Hopkins Verbal Learning Test-Revised. Psychosis was assessed. A stepwise logistic regression ...
Source: Journal of Neurology - January 2, 2019 Category: Neurology Source Type: research

Limb girdle muscular dystrophy D3 HNRNPDL related in a Chinese family with distal muscle weakness caused by a mutation in the prion-like domain
AbstractLimb-girdle muscular dystrophies (LGMD) are a group of clinically and genetically heterogeneous diseases characterized by weakness and wasting of the pelvic and shoulder girdle muscles. Twenty-four recessive LGMD (types R1 –R24) and five dominant LGMD (types D1-D5) have been identified with characterization of mutations in various genes. To date, LGMD D3 (previously known as LGMD1G) has been characterized in only two families with Brazilian or Uruguayan origin. Each was caused by a distinct mutation at codon 378 in the prion-like domain ofHNRNPDL encoding heterogeneous nuclear ribonucleoprotein D like (HNRNPD...
Source: Journal of Neurology - January 2, 2019 Category: Neurology Source Type: research

Christiaan Eijkman (1856 –1930)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 26, 2018 Category: Neurology Source Type: research

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study
AbstractBackgroundPersons who develop multiple sclerosis (MS) at a young age may bear a higher genetic risk load than persons who develop MS later in life; however, the contribution of familial influence to the risk of MS, in relation to onset age, has not been established.ObjectiveTo investigate the familial risk of MS at two extremes of the spectrum of MS onset age: early onset (first MS symptom
Source: Journal of Neurology - December 21, 2018 Category: Neurology Source Type: research

Predictors and outcome of status epilepticus in cerebral venous thrombosis
We report the clinico-radiological characteristics of SE in the patients with cerebral venous thrombosis (CVT), and compare the relative risk of SE in determining death and disability compared with those patients with and without self-limiting seizures. Consecutive patients with magnetic resonance venography (MRV) confirmed CVT, admitted during 2006 –2017, were included. Their clinical details, risk factors, and magnetic resonance imaging and MRV findings were noted. Duration of SE, Status Epilepticus Severity Score (STESS), Glasgow Coma Scale score, and response to antiepileptic drugs were noted. 6-month outcomes we...
Source: Journal of Neurology - December 19, 2018 Category: Neurology Source Type: research

Neurological update: MOG antibody  disease
AbstractMyelin oligodendrocyte glycoprotein  (MOG) antibody disease (MOG-AD) is now recognised as a nosological entity with specific clinical and paraclinical features to aid early diagnosis. Although no age group is exempt, median age of onset is within the fourth decade of life, with optic neuritis being the most frequent presenting pheno type. Disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. Residual disability develops in 50–80% of patients, with transverse myelitis at onset being the most significant predictor of long-term outcome. ...
Source: Journal of Neurology - December 19, 2018 Category: Neurology Source Type: research

Moyamoya angiopathy: long-term follow-up study in a Finnish population
ConclusionsFinnish MMA patients have a benign and stable course with a ~3.5  % annual stroke risk. We found no differences in the clinical outcomes between the operated and conservative groups, however, the psychosocial well-being requires more attention in MMA patients. (Source: Journal of Neurology)
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Patient characteristics and outcome associations in AMPA receptor encephalitis
We present findings from two cases of AMPAR encephalitis that exemplify variability in the disease spectrum, and summarize findings in published cases derived from a systematic literature review. When all patients are considered together, the presence of psychiatric symptoms at presentation portended a poor outcome and was associated with the presence of a tumor. Furthermore, we provide evidence to suggest that the topography of magnetic resonance imaging abnormalities in reported cases mirrors the distribution of AMPARs in the human brain. The potential for neurological improvement following immunomodulatory therapy toget...
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Clinical and economic comparison of an individualised immunoglobulin protocol vs. standard dosing for chronic inflammatory demyelinating polyneuropathy
AbstractBackgroundThe clinical and economic implications of an individualised intravenous immunoglobulin (IVIg) protocol for chronic inflammatory demyelinating polyneuropathy (CIDP) are unknown. Comparison with standard dosing regimens has not been performed.MethodsWe retrospectively studied 47 IVIg-treated subjects with CIDP over 4  years with an individualised, outcome-measured, dose-modifying protocol. We evaluated responder and remission rates, clinical improvement levels and dose requirements. We compared clinical benefits and costs with those reported with standard dosing at 1 g/kg every 3 weeks.Result...
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody
AbstractTo define the prevalence and characteristics of single ocular motor nerve palsy (OMNP) associated with positive serum anti-GQ1b antibody. We performed a prospective multicenter study that recruited 82 patients with single OMNP without identifiable causes from the history and neuroimaging in six neurology clinics of university hospitals. We measured serum anti-GQ1b antibody in all participants. Twelve patients with multiple OMNP and 30 with identifiable causes served as the controls. Overall, the prevalence of anti-GQ1b antibody syndrome was 10% (8/82) in patients with single OMNP and 6% (5/78) in those with single ...
Source: Journal of Neurology - December 17, 2018 Category: Neurology Source Type: research

Cannabis use in myotonic dystrophy patients in Germany and USA: a pilot survey
(Source: Journal of Neurology)
Source: Journal of Neurology - December 15, 2018 Category: Neurology Source Type: research

Nerve echogenicity and intranerve CSA variability in high-resolution nerve ultrasound (HRUS) in chronic inflammatory demyelinating polyneuropathy (CIDP)
ConclusionEchogenicity of the arm nerves in CIDP may be used as a prognostic marker, but not as a follow-up tool for evaluating clinical changes. Further studies in a larger cohort are needed to confirm these results. (Source: Journal of Neurology)
Source: Journal of Neurology - December 15, 2018 Category: Neurology Source Type: research

Prophylactic treatment of migraine with and without aura with acetyl- dl -leucine: a case series
(Source: Journal of Neurology)
Source: Journal of Neurology - December 13, 2018 Category: Neurology Source Type: research

Correction to: Jean Baptiste Octave Landry (1826 –1865)
The original version of this article unfortunately contained a mistake. Title was incorrect. The corrected title is given below. (Source: Journal of Neurology)
Source: Journal of Neurology - December 13, 2018 Category: Neurology Source Type: research

Imaging in the diagnosis of progressive supranuclear palsy
(Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2018 Category: Neurology Source Type: research

Characteristics and relative factors of headache caused by cervicocerebral artery dissection
ConclusionThe headache and neck pain caused by CAD is a moderate to severe pain occurring suddenly. The pain nature may be diverse but mostly like throbbing and pulsating. When the dissected artery is located in the posterior circulation, the pain is mostly in the occipital region, and mostly in the temporal region when the dissected artery is located in the anterior circulation. The pain can occur in ipsilateral, bilateral, or contralateral of the dissection. In addition, several factors might contribute to the occurrence of headache and neck pain. (Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2018 Category: Neurology Source Type: research

Pretreatment cerebral microbleeds and symptomatic intracerebral hemorrhage post-thrombolysis: a systematic review and meta-analysis
ConclusionsThe pretreatment CMBs were associated with increased incidence of sICH and PFO in acute ischemic stroke patients receiving IVT. However, it was not convincing enough to set the presence of CMBs as contraindication to IVT. (Source: Journal of Neurology)
Source: Journal of Neurology - December 12, 2018 Category: Neurology Source Type: research

Guillain –Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity
AbstractObjectivesTo describe the epidemiology and clinical heterogeneity of Guillain –Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).MethodsThe incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish Nat...
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research

Metronidazole-induced encephalopathy: a systematic review
ConclusionMetronidazole-induced encephalopathy should be considered in patients presenting with neurological symptoms in relation to newly initiated or prolonged metronidazole treatment. MRI changes are highly characteristic and specific. Patients with liver disease are at increased risk. Prognosis is good if recognized early. (Source: Journal of Neurology)
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research

Pioneers in neurology: Michel Jouvet (1925 –2017)
(Source: Journal of Neurology)
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research

Clinical feasibility of 1-min ultrafast brain MRI compared with routine brain MRI using synthetic MRI: a single center pilot study
ConclusionsAlthough the overall image quality and anatomical delineation of the 1-min ultrafast MRI were inferior to those of the routine brain MRI protocol, the ultrafast protocol showed at least sufficient image quality. Therefore, this protocol may be an option in specific clinical situations involving non-cooperative, restless, or pediatric patients, or patients with time-critical disease such as stroke. Further study is required to validate our findings. (Source: Journal of Neurology)
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research

Gait festination in parkinsonism: introduction of two phenotypes
AbstractGait festination is one of the most characteristic gait disturbances in patients with Parkinson ’s disease or atypical parkinsonism. Although festination is common and disabling, it has received little attention in the literature, and different definitions exist. Here, we argue that there are actually two phenotypes of festination. The first phenotype entails a primary locomotion disturbance , due to the so-called sequence effect: a progressive shortening of step length, accompanied by a compensatory increase in cadence. This phenotype strongly relates to freezing of gait with alternating trembling of the leg...
Source: Journal of Neurology - December 7, 2018 Category: Neurology Source Type: research

Vibrotactile feedback improves balance and mobility in patients with severe bilateral vestibular loss
AbstractThe impact of vibrotactile feedback of the gravity vector, provided by a “balance” belt worn around the waist, was evaluated in 39 patients with a severe bilateral vestibular loss, confirmed by extensive laboratory testing and suffering from a low quality of life, mainly due to imbalance. The mobility and balance score (MBS) of all patients prior to the use of the be lt was equal or less than 5 out of a scale of 10. Thirty-one out of the 39 patients experienced the effect of the belt on their balance and mobility as positive in a preselection trial of 2 h in the hospital. The 31 positive responders...
Source: Journal of Neurology - December 5, 2018 Category: Neurology Source Type: research

Can we predict cognitive decline after initial diagnosis of multiple sclerosis? Results from the German National early MS cohort (KKNMS)
ConclusionsIdentification of risk factors for short-term cognitive change in newly diagnosed MS or CIS is insufficient using only demographic, clinical and conventional MRI data. Change-sensitive, re-test reliable cognitive tests and more sophisticated predictors need to be employed in future clinical trials and cohort studies of early-stage MS to improve prediction. (Source: Journal of Neurology)
Source: Journal of Neurology - December 4, 2018 Category: Neurology Source Type: research

ANO10 mutational screening in recessive ataxia: genetic findings and refinement of the clinical phenotype
AbstractAutosomal recessive cerebellar ataxia type 3 (ARCA3) is a rare inherited disorder caused by mutations in theANO10 gene. The disease is characterized by slowly progressive spastic ataxia variably associated with motor neuron involvement, epilepsy, and cognitive decline. We performed mutational screening in 80 patients with sporadic or autosomal recessive adult-onset ataxia. We identified 11ANO10 gene variants in 10 patients from 8 families (10%): 4 mutations were previously described and 7 were novel. Age at onset ranged between 27 and 53  years. All patients presented ataxia, pyramidal signs and cerebellar atr...
Source: Journal of Neurology - December 4, 2018 Category: Neurology Source Type: research

Discontinuation of teriflunomide and dimethyl fumarate in a large Italian multicentre population: a 24-month real-world experience
ConclusionsIn a real-world setting, pwRRMS on TRF and DMF had similar discontinuation rates over 24 months. Male pwRRMS on DMF with a previous history of therapeutic failure are at more risk of discontinuation therapy. (Source: Journal of Neurology)
Source: Journal of Neurology - December 4, 2018 Category: Neurology Source Type: research

Recessive PYROXD1 mutations cause adult-onset limb-girdle-type muscular dystrophy
ConclusionPYROXD1 variants can cause an adult-onset slowly progressive LGMD-type phenotype. (Source: Journal of Neurology)
Source: Journal of Neurology - December 4, 2018 Category: Neurology Source Type: research

Treatment escalation leads to fewer relapses compared with switching to another moderately effective therapy
AbstractBackgroundPatients with multiple sclerosis who experience disease breakthrough often switch disease-modifying therapy (DMT).ObjectiveTo compare treatment effectiveness of switch to highly effective DMT (heDMT) with switch to moderately effective DMT (meDMT) for patients who switch due to disease breakthrough defined as at least one relapse within 12  months of their treatment switch.MethodsWe retrieved data from The Danish Multiple Sclerosis Registry on all relapsing-remitting MS patients with expanded disability status scale (EDSS) less than 6 who experienced disease breakthrough. We used propensity score mat...
Source: Journal of Neurology - December 4, 2018 Category: Neurology Source Type: research

A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy
ConclusionsViral loads in the cerebrospinal fluid, a controlled inflammatory response mediated by CD4- and CD8-positive T cells, and plasma cells are associated with PML prognosis. Our findings further indicate that regulatory plasma cells may regulate inflammatory T-cell activity via a PD-1/PD-L1 immuno-checkpoint pathway, thereby protecting the uninfected brain from excessive immune-mediated damage during an active JC virus infection. (Source: Journal of Neurology)
Source: Journal of Neurology - December 3, 2018 Category: Neurology Source Type: research

Efficacy of pregabalin in post-traumatic peripheral neuropathic pain: a randomized, double-blind, placebo-controlled phase 3 trial
AbstractThe growing need for symptomatic treatment of post-traumatic neuropathic pain (PTNP) continues  to be unmet. Studies evaluating the efficacy of pregabalin for reducing neuropathic pain following trauma and surgery yielded positive results over ≤ 8-week treatment. To assess the efficacy and tolerability of pregabalin over 3 months in patients with PTNP, a randomized, double-blind, placebo -controlled, parallel-group trial evaluated patients with PTNP at 101 centers in 11 countries—the longest, largest such trial. Adults diagnosed with PTNP were randomly assigned (1:1) to 15 weeks of pregabalin (...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Risk factors for self-harm in people with epilepsy
ConclusionPeople with epilepsy have elevated self-harm risk, especially in the first year following diagnosis. Clinicians should adequately monitor these individuals and be especially vigilant to self-harm risk in people with epilepsy and comorbid mental illness, frequent healthcare service contact, those taking multiple AEDs and during treatment augmentation. (Source: Journal of Neurology)
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Relation between functional connectivity and disability in multiple sclerosis: a non-linear model
AbstractObjectiveTo characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms.MethodsHundred-and-nineteen patients with no-to-severe disability and 42 healthy subjects were studied via 3T resting state functional MRI. Out of 116 regions extracted from Automated Anatomical Labeling atlas, pairs of regions whose functional connectivity correlated with Expanded Disability Status Score were identified. In patients, ...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Structural signature in SCA1: clinical correlates, determinants and natural history
AbstractSpinocerebellar ataxia type 1 is an autosomal dominant disorder caused by a CAG repeat expansion inATXN1, characterized by progressive cerebellar and extracerebellar symptoms. MRI-based studies in SCA1 focused in the cerebellum and connections, but there are few data about supratentorial/spinal damage and its clinical relevance. We have thus designed this multimodal MRI study to uncover the structural signature of SCA1. To accomplish that, a group of 33 patients and 33 age-and gender-matched healthy controls underwent MRI on a 3T scanner. All patients underwent a comprehensive neurological and neuropsychological ev...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Elevated C-reactive protein and white blood cell count at admission predict functional outcome after non-aneurysmal subarachnoid hemorrhage
ConclusionElevated C-reactive protein and WBC count at admission were associated with unfavorable outcome after non-aneurysmal SAH. (Source: Journal of Neurology)
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Nerve sheath tumours
(Source: Journal of Neurology)
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status
AbstractIntroductionThe progression of amyotrophic lateral sclerosis (ALS) leads to a decline of the nutritional status that represents an independent prognostic factor for survival. Recent studies recognize the muscle tissue as an endocrine organ able to release several molecules, called myokines. Among them, irisin seems to be involved in the regulation of metabolism, body weight and development and function of the nervous system.Objectives(1) To evaluate irisin serum levels in patients with ALS, with comparison to healthy subjects; (2) to assess the possible association of circulating irisin levels of ALS patients with ...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Multifocal motor neuropathy in Austria: a nationwide survey of clinical features and response to treatment
The objective of this study was to evaluate epidemiological, clinical, and laboratory features of MMN patients and their response to treatment in Austria and to compare these data with those from the literature.MethodsAnonymized demographic and clinical data about MMN patients until 31.12.2017 were collected from registered Austrian neurologists. Exploratory statistics on clinical and laboratory features as well as treatment regimens and responses were performed.Results57 Patients with MMN were identified, resulting in a prevalence of 0.65/100.000. Mean age of onset was 44.1  ± 13.1 years, the diagnost...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Perfusion-CT imaging in epileptic seizures
ConclusionIn patients with acute epileptic seizures, regional hyperperfusion on PCT may suggest an ongoing or recently resolved SE, whereas hypoperfusion may be due to post-ictal state or simultaneous AIS. These observations might help attributing focal deficits to epileptic seizures rather than stroke, allowing for targeted therapy. (Source: Journal of Neurology)
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

Early MRI-negative posterior circulation stroke presenting as acute dizziness
AbstractThe aim of this study was to determine the frequency, clinical and radiological features, and efficacy of clinical evaluation and perfusion-weighted imaging (PWI) for the prediction of final stroke in patients with DWI/MRI-negative posterior circulation stroke (PCS) presenting acute dizziness/vertigo. From our comprehensive prospective stroke registry of acute ischemic stroke during a 7-year period, we identified 1846 consecutive patients with PCS, 850 of whom presented with acute dizziness/vertigo. Of these 850 patients, initial DWI-MRI was negative in 35 (4.1%). In these 35 patients, dizziness/vertigo was acute p...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research