The effect of melatonin supplementation on liver indices in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials.
Abstract Several randomized clinical trials (RCTs) evaluated the effect of melatonin supplementation on liver enzymes in patients with non-alcoholic fatty liver disease (NAFLD) and reported conflicting results. To meet these discrepancies, a meta-analysis was conducted to evaluate the eff ;ect of melatonin on liver indices in patients with NAFLD. To collect the required data, a thorough search was conducted through Web of science, Pubmed, Cochrane database, Embase, Google Scholar, ProQuest, and Scopus databases. The aim was to find clinical trials over the effect of melatonin supplementation on liver indices up t...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Mansoori A, Salimi Z, Hosseini SA, Hormoznejad R, Jafarirad S, Bahrami M, Asadi M Tags: Complement Ther Med Source Type: research

Treatment expectations seem to affect bowel health when using acupuncture during radiotherapy for cancer: Secondary outcomes from a clinical randomized sham-controlled trial.
CONCLUSION: Penetrating acupuncture was not effective for frequent stools or for infrequent stools and did not improve capacity in daily activities or QoL in patients undergoing pelvic-abdominal irradiation for cancer more than non-penetrating acupuncture. Since patients with low acupuncture treatment expectations were more likely to experience frequent stools compared to other patients, non-specific treatment effects warrant further studies. PMID: 32951698 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Efverman A Tags: Complement Ther Med Source Type: research

Comparison of child report and parent-proxy report using PROMIS-25 in the chiropractic care for children.
PMID: 32951699 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Alcantara J, Whetten A, Alcantara J Tags: Complement Ther Med Source Type: research

The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-analysis.
Abstract Cardiovascular disease (CVD) is the leading causes of mortality across the world. Some earlier studies have revealed the beneficial effects of fenugreek on the risk factors for CVDs. However, a systematic review and meta-analysis is needed to clarify its effectiveness. Accordingly, the purpose of this study was to assess the impacts of fenugreek on several cardiometabolic risk factors in adult populations. Four electronic databases including PubMed/Medline, Scopus, Embase and Cochrane Library were searched from 2000 to 31 July 2019 to identify studies with English language. Controlled clinical trials on f...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Khodamoradi K, Khosropanah MH, Ayati Z, Chang D, Nasli-Esfahani E, Ayati MH, Namazi N Tags: Complement Ther Med Source Type: research

Beliefs and Attitudes of Graduate Gerontology Students about Medical Marijuana Use for Alzheimer's and Parkinson's Disease.
CONCLUSIONS: The study findings show the need for students' MMJ education in order to provide future gerontology service providers with the necessary knowledge and ability to address clients' questions about MMJ use. Efforts to develop curricula and training programs need to be promoted. PMID: 32951701 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Edelstein OE, Wacht O, Isralowitz R, Reznik A, Bachner YG Tags: Complement Ther Med Source Type: research

Why are we hiding? A qualitative exploration of New Zealand acupuncturists views on interprofessional care.
CONCLUSIONS: This research contributes to the body of knowledge concerning communication and collaboration between GPs and acupuncturists, and suggests that by facilitating communication and collaboration, acupuncture can provide a significant component of integrated care packages. This research provides context within a New Zealand health care setting, and also provides insight through the disaggregation of specific provider groups for analysis, rather than a grouping together of CAM as a whole. PMID: 32951702 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Roberts K, Betts D, Dowell T, Nie JB Tags: Complement Ther Med Source Type: research

Impact of Yoga on cognition and mental health among elderly: A systematic review.
CONCLUSION: The present review indicates that Yoga-based interventions have some positive evidence in improving attention, executive functions and memory of cognition, while depression in mental health compared to active control among the elderly. However, methodological limitations and small number of studies preclude confirming the potential benefits of Yoga-based interventions on cognition and mental health among the elderly. Further, this review strongly recommends more randomized control trials with standard study methodology, use of validated modules of Yoga intervention, and long term follow up to have definite conc...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Chobe S, Chobe M, Metri K, Patra SK, Nagaratna R Tags: Complement Ther Med Source Type: research

Do professionals change their communication behaviours following a training in hypnosis-derived communication? A feasibility study in pediatric oncology.
CONCLUSION: A 4-day training in hypnotic communication techniques translated into the use of HCTech by nurses practicing in pediatric oncology when comparing the same dyads at baseline, post-training and follow-up. Results support further refinement and suggest nurses could be trained to prevent pain and distress with hypnosis-derived communication strategies. PMID: 32951704 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Aramideh J, Ogez D, Mizrahi T, Charest MC, Plante C, Duval M, Sultan S Tags: Complement Ther Med Source Type: research

Long-term use of combined conventional medicine and Chinese herbal medicine decreases the mortality risk of patients with lung cancer.
CONCLUSION: CHM users had significantly lower mortality than CHM nonusers. The longer the CHM use, the more the mortality HR declined. Glehnia littoralisF. Schmidt ex Miq., Polyporus umbellatus(Pers.) Fries and Trichosanthes kirilowii Maxim. possess a highly substantial anticancer activity compared with other herbs. PMID: 32951705 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Yeh MH, Wu HC, Lin NW, Hsieh JJ, Yeh JW, Chiu HP, Wu MC, Tsai TY, Yeh CC, Li TM Tags: Complement Ther Med Source Type: research

Progressive muscle-strength protocol for the functionality of upper limbs and quality of life in individuals with Parkinson's disease: Pilot study.
Abstract The effects of physical-therapy intervention on the motor function of upper limbs and the quality of life in patients with Parkinson's disease (PD) are not fully understood. We evaluated the effects of a progressive muscle-strengthening protocol for upper limbs on the functionality and quality of life. Patients were divided into two groups: Intervention (n = 6) and Control (n = 7). Assessment tools used were: Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire, Nine-Hole Peg Test (9HPT), Test d'Évaluation des Membres Supérieurs de Personnes Âg&ea...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Correa TV, da Silva Rocha Paz T, Allodi S, de Britto VLS, Correa CL Tags: Complement Ther Med Source Type: research

The reporting quality and risk of bias of randomized controlled trials of acupuncture for migraine: Methodological study based on STRICTA and RoB 2.0.
CONCLUSIONS: The reporting quality and risk of bias of RCTs of acupuncture for migraine remain suboptimal. Therefore, all stakeholders should make a contribution to improve the quality of RCTs of acupuncture for migraine using STRICTA and RoB 2.0, while not limiting this approach solely to studies on migraine, using STRICTA and RoB 2.0 tools. PMID: 32951707 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Lu T, Lu C, Li H, Xing X, Deng X, Li X, Wang Y, Niu J, Liu Y, Yang K Tags: Complement Ther Med Source Type: research

The effects of eugenol nanoemulsion on pain caused by arteriovenous fistula cannulation in hemodialysis patients: A randomized double-blinded controlled cross-over trial.
CONCLUSIONS: It seems that topical application of eugenol nanoemulsion may significantly decrease AVF cannulation related pain intensity score in patients undergoing HD. However, further studies with larger sample size and longer intervention period should be done for better judgment on its efficiency and safety. PMID: 32951708 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Maghbool M, Khosravi T, Vojdani S, Chaijan MR, Esmaeili F, Amani A, Rezayat F, Nasimi Doost Azgomi R, Mehraban SS, Hashempur MH Tags: Complement Ther Med Source Type: research

The relationship between health sciences students' perceptions of health news and their attitudes to using complementary and alternative medicine.
Abstract PURPOSE: Written-visual and social media play a significant role in accessing knowledge about health issues. Media coverage of complementary and alternative medicine (CAM) can affect the beliefs, attitudes, behaviors and decisions to use of CAM the individuals. The research was planned as a descriptive, cross-sectional study was to evaluate the relationship between the health sciences students' perceptions of health news and their attitude towards using CAM. METHOD: The sample included 736 students studying in a Department of Nursing, Physiotherapy and Rehabilitation, and Nutrition and Dietetics prog...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Yilmaz DU, Dereli F, Tuncali SH, Karatekin D Tags: Complement Ther Med Source Type: research

Use of l-3-n-Butylphthalide within 24 h after intravenous thrombolysis for acute cerebral infarction.
CONCLUSION: Use of NBP within 24 h after IT can reduce the prevalence of reocclusion of blood vessels without increasing the risk of cerebral hemorrhage. PMID: 32951710 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Wang M, Feng Y, Yuan Y, Gui L, Wang J, Gao P, Qin B, Sima D, Wang Q, Pan W Tags: Complement Ther Med Source Type: research

Feasibility analysis of external application of Xiao-Shuan-San in preventing PICC-related thrombosis.
Abstract PURPOSE: We aim to analyze the feasibility of external application of Xiao-Shuan-Santo prevent peripherally inserted central catheter (PICC) -related thrombosis. METHODS: A total of 218 patients with PICC catheterization were randomly divided into a control group (n = 103) and a treatment group (n = 115). Patients in the treatment group received additional external application of Xiao-Shuan-San. The changes of coagulation index, the incidence of PICC-related thrombosis and other complications, and the maximum blood flow rate (Vmax) of axillary vein were observed at 1 day before catheterizatio...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Li JP, Jiang WW, Bi WK, Jiang CH, Li ZK, Zou Y, Zhang SB, Bi MJ, Li Q Tags: Complement Ther Med Source Type: research

Vacuum myofascial therapy device for non-specific neck pain. A single blind randomized clinical trial.
This study aimed to investigate the efficacy of a vacuum myofascial therapy device (VT) for improving pressure pain thresholds (PPTs), range of motion (ROM), neck pain-related disability, pain, and quality of life in patients with non-specific neck pain. METHODS: A randomized controlled trial in which thirty-eight participants with non-specific neck pain (NP) were randomly assigned to either an experimental (VT) or a comparison physical therapy program (PTP) group. The VT group (n = 19) received five sessions of treatment with a vacuum myofascial therapy device while the PTP group (n = 19) received five sessio...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Rodríguez-Huguet M, Rodríguez-Huguet P, Lomas-Vega R, Ibáñez-Vera AJ, Rodríguez-Almagro D Tags: Complement Ther Med Source Type: research

The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials.
CONCLUSION: The present meta-analysis demonstrated that supplementing with tocotrienols does not decrease the concentrations of LDL-C, TC and TG. However, tocotrienol supplementation was considered a candidate for increasing HDL-C levels. PMID: 32951713 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Zuo S, Wang G, Han Q, Xiao H, O Santos H, Avelar Rodriguez D, Khani V, Tang J Tags: Complement Ther Med Source Type: research

Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis.
Abstract OBJECTIVE: Several trials have examined the effect of Garcinia cambogia supplement on the weight and body composition, but their results are conflicting. This systematic review and dose-response meta-analysis was designed to determine the effect of Garcinia cambogia supplement on the obesity indices in human randomized controlled trials (RCTs). METHODS: PubMed/Medline, Scopus, Cochrane library, and Web of Science databases were searched up to 1th January, 2020, to screen relevant trials. The mean changes in the weight, body mass index (BMI), percentage of fat mass (PFM), and waist circumference (WC) ...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Golzarand M, Omidian M, Toolabi K Tags: Complement Ther Med Source Type: research

The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial.
CONCLUSIONS: Administration of 6 mg/day melatonin had improvement effect on many factors related to NAFLD such as liver enzymes, hs-CRP, anthropometric measurements, blood pressure, leptin serum levels and the grade of fatty liver. PMID: 32951715 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Bahrami M, Cheraghpour M, Jafarirad S, Alavinejad P, Asadi F, Hekmatdoost A, Mohammadi M, Yari Z Tags: Complement Ther Med Source Type: research

Results of a mindfulness intervention feasibility study among elder African American women: A qualitative analysis.
CONCLUSION: . Tailoring classes to older African American women should consider integrating biblical teachings, African American instructors who understand socio-historical contexts of older black women's stressors and strengths, and time for group-reflection to support community building. PMID: 32951716 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Proulx J, Croff R, Hebert M, Oken B Tags: Complement Ther Med Source Type: research

Clinical observation on the effect of Chinese medicine-"TCM formula" intervention on recurrence and metastasis of triple negative breast cancer.
CONCLUSION: 1. In the exposed group, the two-year rate of invasive disease-free survival increased by 6.2 % compared with the non-exposed group(P>0.05). 2. According to K-M survival analysis, TNBC patients with age ≤35 years and regional lymph node metastasis to N1 may be potential beneficiaries of "TCM formula". 3. "TCM Formula" is safe and tolerable to most patients. PMID: 32951717 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Wang Y, Li JW, Qin YN, Sun CP, Chen JJ, Ruan YY, Chen LX, Liu S, Liu GY Tags: Complement Ther Med Source Type: research

Ginseng integrative supplementation for seasonal acute upper respiratory infections: A systematic review and meta-analysis.
Abstract BACKGROUND: The aim of the review was to assess whether ginseng can be a useful supplementation for seasonal acute upper respiratory infections (SAURIs). METHODS: All clinical studies investigating ginseng efficacy for the treatment or prevention of SAURIs were included in the review. Medline, EMBASE, Web of Science, Scopus, Cochrane Library, Google Scholar were systematically screened for relevant articles up to May 26th, 2020. The risk of bias was assessed with the Cochrane tool (RoB 2). RESULTS: Nine articles (describing ten trials about P. ginseng or P. quinquefolius) were included in the re...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Antonelli M, Donelli D, Firenzuoli F Tags: Complement Ther Med Source Type: research

The safety and effectiveness of mind body interventions for women with pregnancy induced hypertension and or preeclampsia: A systematic review and meta-analysis.
CONCLUSION: Few high quality trials have examined the effectiveness and safety of mind body interventions to manage HDP. Relaxation, yoga, guided imagery and music may have some potential benefit. Safety issues are completely unclear and thus the risk-benefit ratio of all interventions could not be determined. Further research is recommended. PMID: 32951719 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Smith CA, Tuson A, Thornton C, Dahlen HG Tags: Complement Ther Med Source Type: research

A Pragmatic Controlled Trial of a Brief Yoga and Mindfulness-Based Program for Psychological and Occupational Health in Education Professionals.
CONCLUSIONS: The yoga mindfulness program was associated with improvements in educators' psychological and occupational wellbeing immediately following and 2-months following the program. Future research with a larger sample size is needed to confirm these results. PMID: 32951720 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Dyer NL, Borden S, Dusek JA, Khalsa SBS Tags: Complement Ther Med Source Type: research

Special issue on aromatherapy: A low cost, low risk, complementary environmental therapy.
PMID: 32951721 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Kemper KJ Tags: Complement Ther Med Source Type: research

Systematic review and meta-analysis of Chinese herbal medicine as adjuvant treatment in advanced non-small cell lung cancer patients.
CONCLUSIONS: Our study found that higher ORR, DCR, QOL, mST and 1-year OS rate were associated with CHM use as an adjuvant to chemotherapy. Although these results require further confirmation, CHMs apparently have potential therapeutic value for patients with advanced NSCLC. PMID: 32951722 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Wang LC, Chang YY, Lee IC, Kuo HC, Tsai MY Tags: Complement Ther Med Source Type: research

The combined therapy of a traditional Chinese medicine formula and Western medicine for a critically ill case infected with COVID-19.
CONCLUSIONS: Our case report suggests that collaborative treatments with traditional Chinese medicine prove beneficial in the management of COVID-19 in critically ill patients. In order to give optimal care for this COVID-19 crisis for the whole world, Chinese medicine practitioners and Western medical doctors should work together in frontline. PMID: 32951723 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Zhang K, Tian M, Zeng Y, Wang L, Luo S, Xia W, Zhang X, Zha Y Tags: Complement Ther Med Source Type: research

Argentine tango in the care of Parkinson's disease: A systematic review and analysis of the intervention.
CONCLUSIONS: Argentine tango is appropriately described in the studies investigating the applicability and efficacy of the intervention in participants with Idiopathic Parkinson Disease. However, the reporting could be ameliorated. PMID: 32951724 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Berti A, Pini M, Ferrarello F Tags: Complement Ther Med Source Type: research

Effects of the laying on of hands on anxiety, stress and autonomic response of employees in a hospital: A double-blind randomized controlled trial.
The objective of this study was to evaluate the anxiety, stress, depression, negative and positive affects, and hematological and autonomic responses of employees in a public hospital exposed to laying on of hands with (LHS) or without Spiritual connection (control-LHW). METHODOLOGY: Eighty-four employees with anxiety/stress were enrolled and randomly allocated into two groups of intervention LHS by Spiritist "passe" and control-LHW by volunteers with healing intent. Anxiety, stress and depression were evaluated by Depression Anxiety and Stress Scale (DASS21). Negative and positive affects by Subjective Well...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Carneiro ÉM, Oliveira LFA, da Silva DAA, Sousa JBF, Timóteo RP, Neto OB, Silva AP, Rodrigues Junior V, de Resende LAPR, Borges MF Tags: Complement Ther Med Source Type: research

Spraying rhubarb powder solution under gastroscope in the treatment of acute non-varicose upper gastrointestinal bleeding: A systematic review and meta-analysis of randomized controlled trials.
Abstract OBJECTIVE: Systematically assessing the safety and effectiveness of spraying rhubarb powder solution under gastroscope for the treatment of acute non-varicose upper gastrointestinal bleeding, and confirmation for further clinical research and application. METHODS: We searched the following databases up till November 2019: PubMed, the Cochrane Library, EMBASE, CNKI, WanFang Data, VIP and SinoMed. Randomized controlled trials (RCTs) were used to compare the curative effect of spraying rhubarb powder solution with other drugs under gastroscope for the treatment of acute non-varicose upper gastrointestin...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Liu JT, Wu J, Wang HR, Geng KX, Dong XK, Huang JW, Xi CC, Zhai SQ Tags: Complement Ther Med Source Type: research

Integrative oncology from a bibliometric point of view.
CONCLUSIONS: Integrative oncology has been established as a small, but distinct, research domain. There are several signs of specialization in integrative oncology, but also in its integration into general medical and oncological research. PMID: 32951727 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Danell JB Tags: Complement Ther Med Source Type: research

The effect of pomegranate (Punica granatum) supplementation on metabolic status in patients with type 2 diabetes: A systematic review and meta-analysis.
CONCLUSION: There were no significant favorable effects of pomegranate supplementation on metabolic parameters in patients with T2DM. Future well-designed, large scale RCTs, with longer duration are needed in this field. PMID: 32951728 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Jandari S, Hatami E, Ziaei R, Ghavami A, Yamchi AM Tags: Complement Ther Med Source Type: research

Effects of baru almond oil (Dipteryx alata Vog.) supplementation on body composition, inflammation, oxidative stress, lipid profile, and plasma fatty acids of hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial.
CONCLUSION: Baru almond oil supplementation decreased us-CRP concentration in patients with chronic kidney disease under hemodialysis treatment. PMID: 32951729 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Schincaglia RM, Cuppari L, Neri HFS, Cintra DE, Sant'Ana MR, Mota JF Tags: Complement Ther Med Source Type: research

Virtual reality in psychiatric disorders: A systematic review of reviews.
CONCLUSION: This study provides evidence supporting the positive impact of VR therapy in psychiatric disorders. However, the impact is defined differently according to the studied area. Nevertheless, due to the continuous development of VR hardware and software, it is essential to conduct further research in the area of psychiatric disorders, especially as no review has concluded that VR does not work. PMID: 32951730 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Cieślik B, Mazurek J, Rutkowski S, Kiper P, Turolla A, Szczepańska-Gieracha J Tags: Complement Ther Med Source Type: research

Randomized phase 2 trial of Intravenous Gamma Globulin (IVIG) for the treatment of acute vaso-occlusive crisis in patients with sickle cell disease: Lessons learned from the midpoint analysis.
Abstract Sickle Cell Disease (SCD) is a chronic hemolytic disorder associated with frequent pain episodes, end organ damage and a shortened lifespan. Currently there exist no disease specific targeted therapies for the treatment of acute vaso-occlusive crisis (VOC) and management with analgesics and hydration is purely supportive. Improvement in understanding of disease pathophysiology has resulted in a great interest in disease modifying novel therapies and many are being evaluated in clinical trials. Here we report the results from the pre-specified mid-point analysis of the Phase 2 study of Intravenous Gamma Gl...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Manwani D, Xu C, Lee SK, Amatuni G, Cohen HW, Carullo V, Morrone K, Davila J, Shi PA, Ireland K, Keenan J, Frenette PS Tags: Complement Ther Med Source Type: research

Biochemical and therapeutic effects of Omega-3 fatty acids in sickle cell disease.
Abstract Sickle cell disease (SCD) is a hematologic disorder with complex pathophysiology that includes chronic hemolysis, vaso-occlusion and inflammation. Increased leukocyte-erythrocyte-endothelial interactions, due to upregulated expression of adhesion molecules and activated endothelium, are thought to play a primary role in initiation and progression of SCD vaso-occlusive crisis and end-organ damage. Several new pathophysiology-based therapeutic options for SCD are being developed, chiefly targeting the inflammatory pathways. Omega-3 fatty acids are polyunsaturated fatty acids that are known to have effects o...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Daak AA, Lopez-Toledano MA, Heeney MM Tags: Complement Ther Med Source Type: research

The effect of Achillea Millefolium L. on vulvovaginal candidiasis compared with clotrimazole: A randomized controlled trial.
Abstract INTRODUCTION: Vulvovaginal candidiasis is the second most common cause of vulvovaginal infections. The aim of this study is to evaluate the effectiveness of vaginal cream of Achillea millefolium extract in women with vulvovaginal candidiasis in comparison with vaginal clotrimazole. MATERIALS AND METHODS: This double-blind randomized clinical trial study was conducted on 80 women diagnosed with vulvovaginal candidiasis clinically and by laboratory test; 40 women received vaginal cream clotrimazole 1 % and 40 received vaginal cream containing the aqueous extract of A. millefolium for 7 days. Clinical a...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Zakeri S, Esmaeilzadeh S, Gorji N, Memariani Z, Moeini R, Bijani A Tags: Complement Ther Med Source Type: research

Effectiveness of yoga on arterial stiffness: A systematic review.
CONCLUSIONS: This review shows that yoga practice is effective in preventing or reducing the arterial stiffness in young healthy and obese, and elderly hypertensive patients. As the methodology of many studies is of low quality and safety measures were not reported, there is a need of quality randomized controlled trials of yoga effects on arterial stiffness among high risk individuals. PMID: 32951734 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Patil SG, Biradar MS, Khode V, Vadiraja HS, Patil NG, Raghavendra RM Tags: Complement Ther Med Source Type: research

Educational intervention versus mindfulness-based intervention for ICU nurses with occupational burnout: A parallel, controlled trial.
CONCLUSION: Mindfulness-based intervention can effectively improve the level of mindfulness and decrease the level of experiential avoidance among ICU nurses, alleviating occupational burnout. PMID: 32951735 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Xie C, Zeng Y, Lv Y, Li X, Xiao J, Hu X Tags: Complement Ther Med Source Type: research

Impact of Finnish sauna bathing on circulating markers of inflammation in healthy middle-aged and older adults: A crossover study.
This study characterized the acute effect of Finnish sauna bathing on circulating markers of inflammation in healthy middle-aged and older adults. DESIGN: With the use of a crossover study design, 20 healthy middle-aged and older adults (9 men/11 women, 66 ± 6 years old) performed 3 interventions in random order: 1) 1 x 10 min of Finnish sauna bathing (80 °C, 20 % humidity); 2) 2 x 10 min of Finnish sauna bathing; 3) a time-control period during which participants sat outside of the sauna for 10 min. MAIN OUTCOMES: Venous blood samples were obtained before (≤15 min) and after (...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Behzadi P, Gravel H, Neagoe PE, Barry H, Sirois MG, Gagnon D Tags: Complement Ther Med Source Type: research

Movie watching during dialysis sessions reduces depression and anxiety and improves quality of life: A randomized clinical trial.
Abstract OBJECTIVE: Evaluate the effect of watching comedy movies as a complementary practice during dialysis on levels of anxiety, depression, quality of life, stress, laboratory findings and intra-dialysis complications. METHODS: A randomized clinical trial was conducted involving the practice of presenting comedy movies during dialysis. The primary outcome was depression. The secondary outcomes were anxiety, quality of life, stress, laboratory findings and intra-dialysis complications.ResultsTwenty-six patients were in the control group and 35 were in the experimental group. Significant intra-group differences [6.0 to 3.0 (p
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Morais EM, Moreira PR, Winkelmann ER Tags: Complement Ther Med Source Type: research

Dental students' knowledge of and attitudes towards complementary and alternative medicine in Australia - An exploratory study.
CONCLUSIONS: Despite approximately three out of four of dental students in this study having little to no knowledge on CAM, attitudes towards CAM therapies, and the need to integrate them into the dental curriculum, were generally positive. Future research into identifying specific knowledge gaps could help to redesign improved dental curricula. PMID: 32951738 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Park JS, Page A, Turner E, Li J, Tennant M, Kruger E Tags: Complement Ther Med Source Type: research

Acupuncture for treating diabetic retinopathy: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: Our results suggest the potential benefit of acupuncture in treating DR. Acupuncture in the form of combined therapy with standard medication or acupuncture alone may be more effective in the treatment of DR than standard medication alone. Further rigorous clinical trials are needed to confirm these findings. PMID: 32951739 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Ang L, Song E, Jun JH, Choi TY, Lee MS Tags: Complement Ther Med Source Type: research

The influence of maternal vitamin D supplementation on infant vitamin D status: A systematic review and meta-analyses.
CONCLUSIONS: The main results indicate a non-significant increase in infant vitamin D following maternal vitamin D supplementation. Additionally, vitamin D supplementation dosage ≥2000 IU/day and intervention duration ≥20 weeks significantly increased infant 25(OH) D. PMID: 32951740 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Zhong X, Xiong Y, Wei D, Wang S, Xiao Z, Liu M, Tan SC, Low TY, Khani V, Wang J Tags: Complement Ther Med Source Type: research

Letter to the Editor: Response to "What's a true change? - Interpreting change scores in measurement instruments of evidence-based practice: A comment".
Letter to the Editor: Response to "What's a true change? - Interpreting change scores in measurement instruments of evidence-based practice: A comment". Complement Ther Med. 2020 Aug;52:102492 Authors: Wong CHL, Chung VC PMID: 32951741 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Wong CHL, Chung VC Tags: Complement Ther Med Source Type: research

Complementary, alternative, integrative and dietary therapies for children with Crohn's disease - A systematic review.
TJ Abstract Children with diagnosed inflammatory bowel diseases such as Crohn's disease are faced with the daunting prospect of living with a chronic disease. Besides psychological stress, children are suffering from therapy side-effects; in particular, corticosteroid therapies are problematic in the growth phase. This highlights that there is a need for less aggressive alternative therapies for children as well as adolescents living with such chronic conditions. Elemental diets are widely used and accepted therapy options. Several pediatric Crohn's disease patients also use complementary, alternative and integra...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Schwermer M, Fetz K, Längler A, Ostermann T, Zuzak TJ Tags: Complement Ther Med Source Type: research

Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
Abstract OBJECTIVE: The aim of this study was to examine the effects of delta-tocotrienol (δ-tocotrienol) supplementation on biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease (NAFLD). DESIGN: The study design was a two-group, randomized, double-blind, placebo-controlled trial. The patients with NAFLD were randomly assigned to receive δ-tocotrienol 300 mg twice daily or placebo for 24 weeks. ENDPOINTS: The primary endpoints were change from baseline in fatty liver index (FLI) and homeostasis model of insulin resistance (HOMA-IR) after ...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Pervez MA, Khan DA, Slehria AUR, Ijaz A Tags: Complement Ther Med Source Type: research

How adding the abdominal massage to polyethylene glycol can improve symptom and quality of life in patients with functional constipation in comparison with each one of the treatment modalities alone: A randomized clinical trial.
Abstract BACKGROUND: A variety of medical and non-medical treatments have been introduced for functional constipation relief. Here, we aimed to compare the efficacy of a combination of polyethylene glycol (PEG) and abdominal massage with each one of the treatments alone. MATERIALS AND METHODS: Patients with functional constipation based on Rome IV criteria were randomly assigned into the three treatment groups: group A (abdominal massage for 15 min daily), group B (PEG 20 g daily), and group C (PEG 20 g plus abdominal massage for 15 min daily) for 14 days. PAC-QOL questionnaire, Bristol stool scale we...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Mokhtare M, Karimi S, Bahardoust M, Sotoudeheian M, Ghazi A, Babaei-Ghazani A Tags: Complement Ther Med Source Type: research

Effects of Cynara scolymus L. on glycemic indices:A systematic review and meta-analysis of randomized clinical trials.
CONCLUSIONS: The supplementation of artichoke and artichoke products can significantly reduce the FBS concentrations in humans. Moreover, these outcomes suggested that just the supplementation of artichoke and artichoke products is more effective in the reduction of HOMA-IR levels than the co-supplementation form. However, additional clinical trials with longer study periods are necessitated to obtain a robust conclusion for producing new guidelines as part of a healthy diet. PMID: 32951745 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Jalili C, Moradi S, Babaei A, Boozari B, Asbaghi O, Lazaridi AV, Hojjati Kermani MA, Miraghajani M Tags: Complement Ther Med Source Type: research

The effect of Quercus (Oak Gal) vaginal cream versus metronidazole vaginal gel on bacterial vaginosis: A double ‑blind randomized controlled trial.
This study was aimed to compare the effect of an Oak Gall extract‑based cream and a metronidazole Gel on the bacterial vaginosis among women in reproductive age. MATERIAL AND METHODS: This was a double-blind, randomized controlled trial performed on 84 women with BV in reproductive age. Accordingly, the women were randomly assigned to the Oak Gall (n = 42) or metronidazole (n = 42) groups. Diagnosis of BV was confirmed when at least 3 of the 4 Amsel criteria were met by the participants (whitish-grey or thin homogeneous discharge, pH ≥ 4.5, the release of a fishy odor on the addition of 10 % KOH, and ...
Source: Complementary Therapies in Medicine - August 1, 2020 Category: Complementary Medicine Authors: Afzali E, Siahposh A, Haghighi-Zadeh MH, Farajzadeh A, Abbaspoor Z Tags: Complement Ther Med Source Type: research