Meningeal Lymphatics in Central Nervous System Diseases
Annu Rev Neurosci. 2024 Apr 22. doi: 10.1146/annurev-neuro-113023-103045. Online ahead of print.ABSTRACTSince its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment, including brain tumors, inflammatory diseases such as multiple sclerosis, CNS injuries, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review...
Source: Annual Review of Neuroscience - April 22, 2024 Category: Neurology Authors: Andrea Francesca M Salvador Nora Abduljawad Jonathan Kipnis Source Type: research
Development of the Binocular Circuit
We present new views on the specification of ipsi- and contralateral RGC subpopulations and factors implementing their organization in the optic tract and termination in subregions of their targets. Lastly, we describe the functional and behavioral aspects of binocular vision, focusing on the mouse, and discuss recent discoveries on the evolution of the binocular circuit.PMID:38635868 | DOI:10.1146/annurev-neuro-111020-093230 (Source: Annual Review of Neuroscience)
Source: Annual Review of Neuroscience - April 18, 2024 Category: Neurology Authors: Elo ísa Herrera Alain Ch édotal Carol Mason Source Type: research
From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology
Annu Rev Neurosci. 2024 Apr 12. doi: 10.1146/annurev-neuro-111020-090208. Online ahead of print.ABSTRACTThe intricate network of the brain's neurons and synapses poses unparalleled challenges for research, distinct from other biological studies. This is particularly true when dissecting how neurons and their functional units work at a cell biological level. While traditional microscopy has been foundational, it was unable to reveal the deeper complexities of neural interactions. However, an imaging renaissance has transformed our capabilities. Advancements in light and electron microscopy, combined with correlative imaging...
Source: Annual Review of Neuroscience - April 12, 2024 Category: Neurology Authors: Kirby R Campbell Liam P Hallada Yu-Shan Huang David J Solecki Source Type: research
From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology
Annu Rev Neurosci. 2024 Apr 12. doi: 10.1146/annurev-neuro-111020-090208. Online ahead of print.ABSTRACTThe intricate network of the brain's neurons and synapses poses unparalleled challenges for research, distinct from other biological studies. This is particularly true when dissecting how neurons and their functional units work at a cell biological level. While traditional microscopy has been foundational, it was unable to reveal the deeper complexities of neural interactions. However, an imaging renaissance has transformed our capabilities. Advancements in light and electron microscopy, combined with correlative imaging...
Source: Annual Review of Neuroscience - April 12, 2024 Category: Neurology Authors: Kirby R Campbell Liam P Hallada Yu-Shan Huang David J Solecki Source Type: research
From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology
Annu Rev Neurosci. 2024 Apr 12. doi: 10.1146/annurev-neuro-111020-090208. Online ahead of print.ABSTRACTThe intricate network of the brain's neurons and synapses poses unparalleled challenges for research, distinct from other biological studies. This is particularly true when dissecting how neurons and their functional units work at a cell biological level. While traditional microscopy has been foundational, it was unable to reveal the deeper complexities of neural interactions. However, an imaging renaissance has transformed our capabilities. Advancements in light and electron microscopy, combined with correlative imaging...
Source: Annual Review of Neuroscience - April 12, 2024 Category: Neurology Authors: Kirby R Campbell Liam P Hallada Yu-Shan Huang David J Solecki Source Type: research
From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology
Annu Rev Neurosci. 2024 Apr 12. doi: 10.1146/annurev-neuro-111020-090208. Online ahead of print.ABSTRACTThe intricate network of the brain's neurons and synapses poses unparalleled challenges for research, distinct from other biological studies. This is particularly true when dissecting how neurons and their functional units work at a cell biological level. While traditional microscopy has been foundational, it was unable to reveal the deeper complexities of neural interactions. However, an imaging renaissance has transformed our capabilities. Advancements in light and electron microscopy, combined with correlative imaging...
Source: Annual Review of Neuroscience - April 12, 2024 Category: Neurology Authors: Kirby R Campbell Liam P Hallada Yu-Shan Huang David J Solecki Source Type: research
The Budding Neuroscience of Ant Social Behavior
Annu Rev Neurosci. 2024 Apr 11. doi: 10.1146/annurev-neuro-083023-102101. Online ahead of print.ABSTRACTAnt physiology has been fashioned by 100 million years of social evolution. Ants perform many sophisticated social and collective behaviors yet possess nervous systems similar in schematic and scale to that of the fruit fly Drosophila melanogaster, a popular solitary model organism. Ants are thus attractive complementary subjects to investigate adaptations pertaining to complex social behaviors that are absent in flies. Despite research interest in ant behavior and the neurobiological foundations of sociality more broadl...
Source: Annual Review of Neuroscience - April 11, 2024 Category: Neurology Authors: Dominic D Frank Daniel J C Kronauer Source Type: research
The Budding Neuroscience of Ant Social Behavior
Annu Rev Neurosci. 2024 Apr 11. doi: 10.1146/annurev-neuro-083023-102101. Online ahead of print.ABSTRACTAnt physiology has been fashioned by 100 million years of social evolution. Ants perform many sophisticated social and collective behaviors yet possess nervous systems similar in schematic and scale to that of the fruit fly Drosophila melanogaster, a popular solitary model organism. Ants are thus attractive complementary subjects to investigate adaptations pertaining to complex social behaviors that are absent in flies. Despite research interest in ant behavior and the neurobiological foundations of sociality more broadl...
Source: Annual Review of Neuroscience - April 11, 2024 Category: Neurology Authors: Dominic D Frank Daniel J C Kronauer Source Type: research
Toward Optogenetic Hearing Restoration
Annu Rev Neurosci. 2024 Apr 9. doi: 10.1146/annurev-neuro-070623-103247. Online ahead of print.ABSTRACTThe cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical stimulation of the auditory nerve, the broad spread of current from each electrode acts as a bottleneck that limits the transfer of sound frequency information. Hence, there remains a major unmet medical need for improving the quality of hearing with CIs. Recently, optogenetic stimulation of the cochlea has been suggested as an alter...
Source: Annual Review of Neuroscience - April 10, 2024 Category: Neurology Authors: Antoine Huet Thomas Mager Christian Gossler Tobias Moser Source Type: research
Toward Optogenetic Hearing Restoration
Annu Rev Neurosci. 2024 Apr 9. doi: 10.1146/annurev-neuro-070623-103247. Online ahead of print.ABSTRACTThe cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical stimulation of the auditory nerve, the broad spread of current from each electrode acts as a bottleneck that limits the transfer of sound frequency information. Hence, there remains a major unmet medical need for improving the quality of hearing with CIs. Recently, optogenetic stimulation of the cochlea has been suggested as an alter...
Source: Annual Review of Neuroscience - April 10, 2024 Category: Neurology Authors: Antoine Huet Thomas Mager Christian Gossler Tobias Moser Source Type: research
Predictive Processing: A Circuit Approach to Psychosis
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-100223-121214. Online ahead of print.ABSTRACTPredictive processing is a computational framework that aims to explain how the brain processes sensory information by making predictions about the environment and minimizing prediction errors. It can also be used to explain some of the key symptoms of psychotic disorders such as schizophrenia. In recent years, substantial advances have been made in our understanding of the neuronal circuitry that underlies predictive processing in cortex. In this review, we summarize these findings and how they might relate to psychosis...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Georg B Keller Philipp Sterzer Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Predictive Processing: A Circuit Approach to Psychosis
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-100223-121214. Online ahead of print.ABSTRACTPredictive processing is a computational framework that aims to explain how the brain processes sensory information by making predictions about the environment and minimizing prediction errors. It can also be used to explain some of the key symptoms of psychotic disorders such as schizophrenia. In recent years, substantial advances have been made in our understanding of the neuronal circuitry that underlies predictive processing in cortex. In this review, we summarize these findings and how they might relate to psychosis...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Georg B Keller Philipp Sterzer Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Predictive Processing: A Circuit Approach to Psychosis
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-100223-121214. Online ahead of print.ABSTRACTPredictive processing is a computational framework that aims to explain how the brain processes sensory information by making predictions about the environment and minimizing prediction errors. It can also be used to explain some of the key symptoms of psychotic disorders such as schizophrenia. In recent years, substantial advances have been made in our understanding of the neuronal circuitry that underlies predictive processing in cortex. In this review, we summarize these findings and how they might relate to psychosis...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Georg B Keller Philipp Sterzer Source Type: research
