A case of concurrent anti-myelin oligodendrocyte glycoprotein antibody-associated myelitis and subacute combined degeneration
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

New MAPT variant in a FTD patient with Alzheimer ’s disease phenotype at onset
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Microcytic abnormalities of the inner retina in a patient with myelin oligodendrocyte glycoprotein (MOG) antibody –associated optic neuritis
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

A case of paraneoplastic optic neuropathy in pancreatic adenocarcinoma
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Factors affecting the behavior of children with ASD during the first outbreak of the COVID-19 pandemic
ConclusionPotentially modifiable psychosocial factors affecting children ’s behavior should be considered in a possible second outbreak. (Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Erenumab during pregnancy: a case report in a patient with chronic migraine
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Cranial multineuropathy with hypoglossal nerve involvement in a patient with anti-Ku autoantibodies
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Focal cortical atrophy following transient meningeal enhancement in a progressive multiple sclerosis
We report a spontaneously remitting meningeal uptake in a patient suffering from SP MS. No cortical lesion was visible on FLAIR or DIR sequences, but the rate of cortical atrophy was higher in this area. This case suggests that conventional 3-T MRI, by contrary to white matter lesions, may be amnesic with regard to the potential burden of previous regressive meningeal lesions. Moreover, T1-enhanced sequences underscore the real inflammatory activity. LME could be more than passive markers of SP MS, but is also directly responsible for focal cortical atrophy and could be an early manifestation of cortical lesions. (Source: ...
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Clonal evolution and supratentorial dissemination of a spinal cord glioma
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Long-term follow-up of a child with anti-AMPA receptor encephalitis
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Wolfgang Grisold, Riccardo Soffietti, Stefan Oberndorfer, Guido Cavaletti (eds): Effects of cancer treatment on the nervous system
(Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Correction to: Efficacy and acceptability of the S1P receptor in the treatment of multiple sclerosis: a meta-analysis
A Correction to this paper has been published:https://doi.org/10.1007/s10072-021-05137-x (Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2021 Category: Neurology Source Type: research

Cognitive and behavioral manifestations in SARS-CoV-2 infection: not specific or distinctive features?
We examined both hypotheses, reporting opposite points of view, with the aim to stimulate discussion and raise awareness of the topic. (Source: Neurological Sciences)
Source: Neurological Sciences - April 12, 2021 Category: Neurology Source Type: research

The effect of ketogenic diet on thyroid functions in children with drug-resistant epilepsy
ConclusionIt appears that KD therapy does not impair thyroid functions in children with drug-resistant epilepsy. KD can be used safely along with L-thyroxine replacement even in children with pre-existing subclinical hypothyroidism. (Source: Neurological Sciences)
Source: Neurological Sciences - April 12, 2021 Category: Neurology Source Type: research

Nanoparticles approaches in neurodegenerative diseases diagnosis and treatment
AbstractThe World Health Organization (WHO) has declared that neurodegenerative diseases will be the biggest health issues of the twenty-first century. Among these, Alzheimer ’s and Parkinson’s diseases can be considered as the most acute incurable neurological diseases. Researchers are studying and developing a new treatment approach that uses nanotechnology to diagnosis and treatment neurodegenerative diseases. This treatment strategy will be used to regress neurod egenerative diseases such as Alzheimer’s disease. Alzheimer’s disease (AD) is one of the most common forms of reduced brain function, ...
Source: Neurological Sciences - April 12, 2021 Category: Neurology Source Type: research

Association of gender and age at onset with glucocerebrosidase associated Parkinson ’s disease: a systematic review and meta-analysis
AbstractGlucocerebrosidase (GBA) gene has been proved to be a risk factor for the development of Parkinson ’s disease (PD). However, the gender effect in the prevalence of GBA-associated PD (GBA-PD) is still controversial. And there is no conclusion whether the age at onset (AAO) of PD is different between carriers and non-carriers of GBA. To clarify the association between gender and AAO in GBA-PD, we conducted a systematic review and meta-analysis. PubMed, Web of Science, and Embase were retrieved to obtain potentially related studies. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to dete...
Source: Neurological Sciences - April 10, 2021 Category: Neurology Source Type: research

Effects of virtual reality in post-stroke aphasia: a systematic review and meta-analysis
ConclusionThis review demonstrated a borderline positive clinical effect of VR for the severity of language impairment when compared with conventional rehabilitation therapy. Conversely, VR had no effect on functional communication, word finding, and repetition. Further research is warranted to reach more definite conclusions. (Source: Neurological Sciences)
Source: Neurological Sciences - April 9, 2021 Category: Neurology Source Type: research

Mosaic ring chromosome 18 in a Chinese child with epilepsy: a case report and review of the literature
We report herein the case of a 12-year-old Chinese girl who presented with typical facial dysmorphisms, developmental delay, cognitive disability, hyperactivity, and epilepsy and discuss the clinical features of r(18) syndromes through comparison with previously described cases worldwide.ResultsWe describe the characteristics of all seizures that have been reported in these cases and propose that the appearance of epilepsy in r(18) patients may be associated with the abnormality of chromosome karyotypes. Further studies are warranted to confirm this. (Source: Neurological Sciences)
Source: Neurological Sciences - April 8, 2021 Category: Neurology Source Type: research

Disability progression in multiple sclerosis is associated with plasma neuroactive steroid profile
ConclusionsRRMS and CIS patients exhibited differing concentrations of both NASs and AAs in plasma while both THDOC and pregnanolone might serve as biomarkers of disability worsening. (Source: Neurological Sciences)
Source: Neurological Sciences - April 8, 2021 Category: Neurology Source Type: research

Correction to: Virtual visits for chronic neurologic disorders during COVID-19 pandemic
A Correction to this paper has been published:https://doi.org/10.1007/s10072-021-05229-8 (Source: Neurological Sciences)
Source: Neurological Sciences - April 7, 2021 Category: Neurology Source Type: research

Robotic rehabilitation for end-effector device and botulinum toxin in upper limb rehabilitation in chronic post-stroke patients: an integrated rehabilitative approach
ConclusionOur results suggest, in line with the literature, a good efficacy in the reduction of spasticity and in the improvement of the function of the UL, with the reduction of pain, adopting a rehabilitation protocol integrated with BoTN, robot-assisted training, and traditional physiotherapy. (Source: Neurological Sciences)
Source: Neurological Sciences - April 7, 2021 Category: Neurology Source Type: research

A rare triad of morning glory disc anomaly, moyamoya vasculopathy, and transsphenoidal cephalocele: pathophysiological considerations and surgical management
AbstractMorning glory disc anomaly is a congenital abnormality of the optic disc and peripapillary retina reported as an isolated condition or associated with various anomalies, including basal encephaloceles and moyamoya vasculopathy. However, the co-occurrence of these three entities is extremely rare and the pathogenesis is still poorly understood. Moreover, data on the surgical management and long-term follow-up of the intracranial anomalies are scarce. Here, we describe the case of a 11-year-old boy with morning glory disc anomaly, transsphenoidal cephalocele, and moyamoya vasculopathy, who underwent bilateral indirec...
Source: Neurological Sciences - April 6, 2021 Category: Neurology Source Type: research

Characteristics of pupil palsy in miller-fisher syndrome: case reports and review of the literature
We report cases of four MFS patients with bilateral pupil palsy and specify pupil characteristics of light-near dissociation (LND), cholinergic super-sensitivity, vermiform movements, and prognosis. We conducted a literature review to compare with our cases and investigate common findings of pupil palsy in MFS patients. We suggest that the acute generalized pupil palsy without vermiform movements can serve as a key finding for the diagnosis of pupil palsy associated with MFS. However, the presence of LND and cholinergic super-sensitivity was not distinctive clinical findings in MFS patients who had pupil palsy and did not ...
Source: Neurological Sciences - April 6, 2021 Category: Neurology Source Type: research

High-resolution ultrasound changes of the vagus nerve in idiopathic Parkinson ’s disease (IPD): a possible additional index of disease
AbstractBackground and rationaleHistopathological studies revealed degeneration of the dorsal motor nucleus of the vagus nerve (VN) early in the course of idiopathic Parkinson ’s disease (IPD). Degeneration of VN axons should be detectable by high-resolution ultrasound (HRUS) as a thinning of the nerve trunk. In order to establish if the VN exhibits sonographic signs of atrophy in IPD, we examined patients with IPD compared with age-matched controls.Material and methodsWe measured the caliber (cross-sectional area, CSA) and perimeter of the VN in 20 outpatients with IPD (8 females and 12 males; mean age 73.0+ 8.6 yea...
Source: Neurological Sciences - April 5, 2021 Category: Neurology Source Type: research

Association between subjective autonomic dysfunction and fatigue in Parkinson ’s disease in southern Chinese
In this study, 602 PD patients were recruited. All patients were evaluated by Scales for Outcomes in Parkinson ’s Disease-Autonomic questionnaire (SCOPA-AUT), Hamilton anxiety rating scale and Hamilton depression rating scale, non-motor symptoms scale (NMSS), and fatigue severity scale (FSS).ResultsTotal score and gastrointestinal subpart, urinary subpart, and cardiovascular subpart of NMSS and SCOPA-AUT were associated with FSS scores (NMSS: total score:p
Source: Neurological Sciences - April 5, 2021 Category: Neurology Source Type: research

Medico-legal aspects of functional neurological disorders: time for an interdisciplinary dialogue
(Source: Neurological Sciences)
Source: Neurological Sciences - April 3, 2021 Category: Neurology Source Type: research

The surgical treatment of epilepsy
The objective of this contribution is drawing up a methodological framework within which to integrate the experiences of each group in this complex and dynamic sector of the neurosciences. (Source: Neurological Sciences)
Source: Neurological Sciences - April 2, 2021 Category: Neurology Source Type: research

Two novel missense variants in SPTBN2 likely associated with spinocerebellar ataxia type 5
ConclusionWe identified two novel heterozygous variants ofSPTBN2 resulting in severe ataxia which further delineated the correlation between the genotype and phenotype of SCA5, and pathogenesis of variants inSPTBN2 should be further researched. (Source: Neurological Sciences)
Source: Neurological Sciences - April 2, 2021 Category: Neurology Source Type: research

Primary central nervous system lymphomatoid granulomatosis: a case report
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Parkinsonism-like features following reconstructive cranioplasty
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Postpartum reversible cerebral vasoconstriction syndrome confined to the bilateral cervical vertebral arteries
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Perfusion-computed tomography for simultaneous bilateral middle cerebral artery occlusion
We describe a case of bilateral middle cerebral artery occlusion in which perfusion-computed tomography was crucial both for addressing to endovascular procedure and planning the sequence treatment of mechanical thrombectomies. (Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Pipeline embolization for recurrent vertebral artery thromboembolic events secondary to a misplaced pedicle screw
ConclusionsTo our knowledge, this is the first published case of a chronic vertebral artery abnormality secondary to a misplaced pedicle screw that was treated with flow diversion. This is likely a safe and effective treatment for this rare complication of pedicle screw placement. (Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Spinocerebellar ataxia type 48: last but not least
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

A serial SPECT-CT study in a celiac disease patient with cerebellar ataxia and psychiatric symptoms
AbstractCeliac disease (CD) is an immune-mediated systemic disorder triggered by gluten and related prolamins in genetically predisposed individuals. Here, we described a case of a 31-year-old Caucasian woman who exhibited cerebellar and psychiatric dysfunctions. The patient underwent single-photon emission computed tomography (SPECT-CT) before and after a gluten-free diet (GFD). There was an improvement in cerebellar perfusion accompanied by a remission of cerebellar manifestations. The maintenance of the psychiatric manifestations was related to the persistence of the hypoperfusion in the frontal lobes. The patient &rsqu...
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Post-stroke hyperkinetic movement disorders: a brain network issue
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Tetraparesis and sensorimotor axonal polyneuropathy due to co-occurrence of Pompe disease and hereditary ATTR amyloidosis
This study highlights the importance of searching for co-occurrence of rare monogenetic neuromuscular diseases, especially in cases in which all clinical features can be readily explained by a single gene defect. (Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Focus on progressive myoclonic epilepsy in Berardinelli-Seip syndrome
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Correction to: Perampanel treatment in early-onset epileptic encephalopathy with infantile movement disorders associated with a de novo GRIN1 gene mutation: a 3-year follow-up
A Correction to this paper has been published:https://doi.org/10.1007/s10072-021-05084-7 (Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Spontaneous resolution of ruptured dissecting superior cerebellar artery aneurysm
(Source: Neurological Sciences)
Source: Neurological Sciences - March 13, 2021 Category: Neurology Source Type: research

Fingolimod as first-line treatment in pediatric-onset multiple sclerosis: a case report
AbstractPediatric-onset multiple sclerosis (MS) has a highly active and aggressive course, which can have a devastating effect on the physical and cognitive functioning of a child if not treated appropriately with effective disease-modifying drugs. The optimal treatment strategy of pediatric MS is currently unknown and debate continues as to whether treatment escalation or initiation of a highly active therapy provides a better outcome. Here, we present the case of a 16-year-old female diagnosed with highly active relapsing-remitting MS (age at onset: 14 years) who received first-line treatment with fingolimod within 1 yea...
Source: Neurological Sciences - March 12, 2021 Category: Neurology Source Type: research

The interrelation of COVID-19 and neurological modalities
(Source: Neurological Sciences)
Source: Neurological Sciences - March 12, 2021 Category: Neurology Source Type: research

Fasciculation score: a sensitive biomarker in amyotrophic lateral sclerosis
AbstractObjectiveThe aim of our study was to elucidate the characteristic of fasciculation distributions in amyotrophic lateral sclerosis (ALS) using a fasciculation score (FS) of muscle ultrasound (MUS) and to compare the diagnostic values of three MUS fasciculation parameters in patients.MethodsThirty ALS patients, 16 ALS mimics, and 10 healthy subjects were involved. MUS of unilateral 10 muscles in each patient and needle electromyography (EMG) of total 204 muscles were performed to detect fasciculations and spontaneous activity respectively in ALS. Control groups underwent only MUS. Fasciculation was graded semiquantit...
Source: Neurological Sciences - March 11, 2021 Category: Neurology Source Type: research

Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability
ConclusionsOur results furtherexpand the phenotype/genotype correlations of the ADCY5-related disorders.Mutations of ADCY5 should be considered in pediatric patients with ID andinvoluntary movement. (Source: Neurological Sciences)
Source: Neurological Sciences - March 11, 2021 Category: Neurology Source Type: research

Correction to: Validity of the Italian multiple sclerosis neuropsychological screening questionnaire
A correction to this paper has been published:https://doi.org/10.1007/s10072-021-05168-4 (Source: Neurological Sciences)
Source: Neurological Sciences - March 11, 2021 Category: Neurology Source Type: research

Fulminant amyotrophic lateral sclerosis manifesting in a young woman during pregnancy
(Source: Neurological Sciences)
Source: Neurological Sciences - March 10, 2021 Category: Neurology Source Type: research

Long-term fingolimod treatment in two pediatric patients with multiple sclerosis
AbstractData suggest that patients with pediatric-onset multiple sclerosis (POMS) should initiate treatment with a disease-modifying therapy early to slow progression. The PARADIGMS trial demonstrated that oral fingolimod reduced the annual rate of relapse by 82% compared with intramuscular interferon beta-1a in children with POMS. The PARADIGMS study had a follow-up of 2 years, but no data are available about the safety and efficacy of fingolimod for longer periods in children with POMS. Here we present two cases of children with POMS who achieved sustained clinical benefit from treatment with fingolimod for more than 2 y...
Source: Neurological Sciences - March 10, 2021 Category: Neurology Source Type: research

Cardiovascular autonomic dysfunction after stroke
AbstractStrokes are the paradigmatic example of the sudden impairment of the cerebral regulation of cardiac autonomic regulation. Although several aspects of dysautonomic cardiovascular regulation post stroke remain unanswered, there has been a wealth of research in this area in the last decade. In this article, we present a state-of-the-art review on the anatomical and functional organization of cardiovascular autonomic regulation, and the pathophysiology, incidence, time course, diagnosis, clinical aspects, prognosis, and management of post-stroke cardiovascular autonomic dysfunction. (Source: Neurological Sciences)
Source: Neurological Sciences - March 9, 2021 Category: Neurology Source Type: research

Correction to: Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin ’s lymphoma
A correction to this paper has been published:https://doi.org/10.1007/s10072-021-05161-x (Source: Neurological Sciences)
Source: Neurological Sciences - March 8, 2021 Category: Neurology Source Type: research

Long-term comparative analysis of no evidence of disease activity (NEDA-3) status between multiple sclerosis patients treated with natalizumab and fingolimod for up to 4 years
ConclusionsAlthough both medications were effective in patients non-responding to first-line agents, natalizumab seems to be superior to fingolimod in RRMS in obtaining NEDA-3 status at 4 years. (Source: Neurological Sciences)
Source: Neurological Sciences - March 6, 2021 Category: Neurology Source Type: research