Endovascular treatment versus intravenous thrombolysis alone in isolated M2 occlusion: a meta-analysis
ConclusionsIVT alone provides similar clinical benefit compared to MT with/without IVT in cases of M2 occlusion. MT quadruplicates rates of good recanalization, but triplicates risk of sICH. Further trials are needed to define if MT confers any advantage over IVT for M2 occlusion. (Source: Neurological Sciences)
Source: Neurological Sciences - September 17, 2021 Category: Neurology Source Type: research

Can diplopia complaint be reduced by telerehabilitation in multiple sclerosis patient during the pandemic?: A case report
In this study, we aimed to show the effect of Cawthorne-Cooksey exercises to be applied through telerehabilitation on eye movements, vision, and quality of life in a patient suffering from diplopia due to multiple sclerosis (MS). It has been found that Cawthorne-Cooksey exercises improve the quality of life and reduce the complaints of diplopia in MS patients with diplopia. In addition, the patient verbally stated that his balance increased after Cawthorne-Cooksey exercises. As a result, Cawthorne-Cooksey exercises are a rehabilitation method that gives positive results in the treatment of diplopia and it is recommended to...
Source: Neurological Sciences - September 17, 2021 Category: Neurology Source Type: research

Depressive symptoms in patients with epilepsy and clinically associated features in a single tertiary center
AbstractAlthough depressive symptoms are the most common psychiatric comorbidity in epilepsy, they remain underestimated and untreated in a large proportion of patients. The purpose of this study was to evaluate depression severity and related clinical features in people with epilepsy using a well-reliable self-report index of mood, the Beck Depression Inventory-II (BDI-II). One-hundred seventeen adult patients with epilepsy were recruited from a tertiary epilepsy center and completed the BDI-II. A single-item analysis of the 21 questions of the BDI-II was computed and differences between women and men in each depressive s...
Source: Neurological Sciences - September 15, 2021 Category: Neurology Source Type: research

Long-term neurological manifestations of COVID-19: prevalence and predictive factors
ConclusionsPremorbid vulnerability and severity of SARS-CoV-2 infection impact on prevalence and severity of long-term neurological manifestations. (Source: Neurological Sciences)
Source: Neurological Sciences - September 15, 2021 Category: Neurology Source Type: research

Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice
ConclusionsThe multidimensional evaluation revealed that higher levels of anxiety and depression are associated with worse quality of life in real clinical practice in patients with epilepsy, especially in females and drug-resistant epilepsy. In addition, sleep disturbances are associated with particular aspects of the quality of life. Further studies with longitudinal follow-up would be useful to adequately manage these comorbidities in patients with epilepsy. (Source: Neurological Sciences)
Source: Neurological Sciences - September 15, 2021 Category: Neurology Source Type: research

Spontaneous thrombosis of cerebral arteriovenous malformation post COVID-19
(Source: Neurological Sciences)
Source: Neurological Sciences - September 15, 2021 Category: Neurology Source Type: research

Rate-dependent depression is impaired in amyotrophic lateral sclerosis
ConclusionWe report a loss of RDD in patients with ALS. The strong correlation detected between the RDD deficit and increased MUP suggests that RDD is a sensitive indicator of underlying spinal disinhibition in ALS.Trial registrationChiCTR2000038848, 10/7/2020 (retrospectively registered),http://www.chictr.org.cn/. (Source: Neurological Sciences)
Source: Neurological Sciences - September 13, 2021 Category: Neurology Source Type: research

A case series of two post-infectious acute cerebellitis an insidious path to the diagnosis and therapy
(Source: Neurological Sciences)
Source: Neurological Sciences - September 13, 2021 Category: Neurology Source Type: research

Multi-auxiliary domain transfer learning for diagnosis of MCI conversion
AbstractIn the early stage of Alzheimer ’s disease (AD), mild cognitive impairment (MCI) has a higher risk of progression to AD, so the prediction of whether an MCI subject will progress to AD (known as progressive MCI, PMCI) or not (known as stable MCI, SMCI) within a certain period is particularly important in practice. It is known th at such a task could benefit from jointly learning-related auxiliary tasks such as differentiating AD from PMCI or PMCI from normal control (NC) in order to take full advantage of their shared commonality. However, few existing methods along this line fully consider the correlations b...
Source: Neurological Sciences - September 12, 2021 Category: Neurology Source Type: research

Clinical analysis of 103 cases of tuberculous meningitis complicated with hyponatremia in adults
ConclusionTBM with hyponatremia was dominated by moderate hyponatremia, which often manifested as SIADH. The more severe hyponatremia was, the longer the correction time of hyponatremia, which will affect the prognosis of TBM patients. (Source: Neurological Sciences)
Source: Neurological Sciences - September 12, 2021 Category: Neurology Source Type: research

Validation of the Italian version of the Myasthenia Gravis Impairment Index (MGII)
ConclusionsThe MGII score was cross-culturally validated in an Italian cohort of MG patients. We confirmed its lower floor effect and the correlations with other MG measures including INCB-MG that was not evaluated in previous studies. (Source: Neurological Sciences)
Source: Neurological Sciences - September 9, 2021 Category: Neurology Source Type: research

Risk factors of asymptomatic reduction of motor conduction velocity of the ulnar nerve across the elbow
DiscussionRisk factors for A-UNE are different from UNE. The prevalence of right side in A-UNE was not due to particular elbow postures. Diabetes is a risk factor, probably because MCV reduction of the ulnar nerve across the elbow was an early manifestation of asymptomatic polyneuropathy in diabetes. A-UNE is associated with narrow CGW as already demonstrated in UNE, even if the OR was higher in UNE than in A-UNE. Only future longitudinal studies will be able to check whether the A-UNE subjects develop symptoms and signs of true mononeuropathy with time. (Source: Neurological Sciences)
Source: Neurological Sciences - September 9, 2021 Category: Neurology Source Type: research

Short- and long-term motor outcome of  STN-DBS in Parkinson’s Disease: focus on sex differences
ConclusionOur data suggest that there are no major differences on the motor effect of STN-DBS between males and females. However, there may be some slight differences that should be specifically investigated in the future and that may influence therapeutic decisions in the chronic follow-up. (Source: Neurological Sciences)
Source: Neurological Sciences - September 9, 2021 Category: Neurology Source Type: research

Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus
AbstractBackgroundProgressive supranuclear palsy (PSP) patients can show ventricular enlargement mimicking normal pressure hydrocephalus (NPH). The aim of this study was to distinguish PSP patients with marked ventricular dilatation (PSP-vd) from those with normal ventricular system and to evaluate the coexistence of NPH in PSP-vd patients.MethodsOne hundred three probable PSP patients, 18 definite NPH patients, and 41 control subjects were enrolled in the study. Evans index (EI)  >  0.32 associated with callosal angle (CA) 
Source: Neurological Sciences - September 9, 2021 Category: Neurology Source Type: research

Patterns of prophylactic anticonvulsant use in spontaneous intracerebral and subarachnoid hemorrhage: results of a practitioner survey
ConclusionThe use of ASMs for seizure prophylaxis after sICH and aSAH remains widespread despite the lack of any specific evidence-based guideline to support the practice. A large-scale randomized controlled trial is needed to add clarity to the practice of prophylactic ASM use in patients with spontaneous intracranial hemorrhage. (Source: Neurological Sciences)
Source: Neurological Sciences - September 8, 2021 Category: Neurology Source Type: research

Epidemiology, management and outcome of status epilepticus in adults: single-center Italian survey
In this study, we aimed at evaluating (a) the frequency of SE in our hospital adopting the new ILAE 2015 SE diagnostic criteria and NCSE Salzburg Consensus Criteria, (b) the frequency of adherence to current treatment guidelines for SE and their relationship with patients ’ outcome, and (c) reliability of standardized prognostic scales (Status Epilepticus Severity Score—STESS—and modified STESS) for short-term outcome prediction in the setting of the newest diagnostic criteria for SE and NCSE. Detailed clinical and electrophysiological data collected in a 1-yea r retrospective hospital-based single-center...
Source: Neurological Sciences - September 6, 2021 Category: Neurology Source Type: research

Neuroimaging findings in leukoencephalopathy with calcifications and cysts: case report and review of the literature
AbstractLeukoencephalopathy with cerebral calcifications and cysts (LCC) is a neurological disorder characterized by the radiological triad of white matter abnormalities, intracranial calcifications and cystic lesions variable in size resulting from a diffuse cerebral microangiopathy. Typically, progressive focal neurological deficits and seizures are the first clinical manifestation, but the severity of symptoms can vary according to the size and location of the cystic lesions holding compressive effects on the surrounding brain tissue. The most common histopathological finding is diffuse microangiopathy, which might be a...
Source: Neurological Sciences - September 5, 2021 Category: Neurology Source Type: research

Sudden onset hearing loss as initial presentation of Susac syndrome: a rare case report and brief review
In this study, we aimed to raise awareness of Susac syndrome among physicians and facilitate recognition of its manifestation, especially in those patients presenting with hearing loss alone. Identifying Susac syndrome that presents as sudden sensorineural hearing loss can be challenging but a number of case reviews have been reported in recent years and treatment guidelines are available. (Source: Neurological Sciences)
Source: Neurological Sciences - September 4, 2021 Category: Neurology Source Type: research

Early reversible leukoencephalopathy and unilateral sixth cranial nerve palsy in mild COVID-19 infection
We describe a patient with mild COVID-19 associated with diplopia from right sixth cranial nerve palsy and early diffuse leukoencephalopathy, successfully treated with intravenous methylprednisolone.MethodsThe patient was evaluated for diplopia that occurred 1  day after the onset of fever, myalgia, and headache. A complete neurological workup, including neurological examination, cerebrospinal fluid (CSF) analysis with viral polymerase chain reaction (PCR), serum autoimmune encephalitis, and anti-nerve antibodies and brain magnetic resonance imaging (MRI ), was performed.ResultsClinical examination revealed incomplete...
Source: Neurological Sciences - September 4, 2021 Category: Neurology Source Type: research

Critical illness neuropathy in severe COVID-19: a case series
AbstractIntroductionNeurological complications of SARS-CoV-2 disease have received growing attention, but only few studies have described to date clinical and neurophysiological findings in COVID patients during their stay in intensive care units (ICUs). Here, we neurophysiologically assessed the presence of either critical illness neuropathy (CIP) or myopathy (CIM) in ICU patients.Materials and MethodsPatients underwent a neurophysiological assessment, including bilateral examination of the median, ulnar, deep peroneal and tibial motor nerves and of the median, ulnar, radial and sural sensory nerves. Needle electromyograp...
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research

A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson ’s disease
AbstractParkinson ’s disease (PD) is a chronic and progressive neurodegenerative disorder that affects 1% of the population worldwide. Etiology of PD is likely to be multi-factorial such as protein misfolding, mitochondrial dysfunction, oxidative stress, and neuroinflammation that contributes to the pathology of Pa rkinson’s disease (PD), numerous studies have shown that mitochondrial dysfunction may play a key role in the dopaminergic neuronal loss. In multiple ways, the two most important are the activation of neuroinflammation and mitochondrial dysfunction, while mitochondrial dysfunction could cause neur oi...
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research

Thrombolytic DNT and fatality and disability rates in acute ischemic stroke: a study from Bigdata Observatory Platform for Stroke of China
ConclusionsThe results did not show that shorter DNT for tPA administration was significantly associated with better 1-year outcomes. (Source: Neurological Sciences)
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research

Reperfusion therapy in a patient with early recurrence of ischemic stroke
We report a case addressing this issue.Case presentationWe present a patient who was successfully treated by mechanical thrombectomy (MT) for middle cerebral artery occlusion. Due to an early stroke recurrence, within 72  h after the first MT, he received systemic thrombolysis and repeated MT was performed with excellent clinical outcome.DiscussionWe discuss the aspects of reperfusion therapy for patients experiencing early stroke recurrence. Consideration was given to stroke etiology and off-label use of thrombolytic therapy. Also, effectiveness of repeated MT for early re-occlusion of initially reanalyzed vessel was...
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research

The effects of concurrent M1 anodal tDCS and physical therapy interventions on function of ankle muscles in patients with stroke: a randomized, double-blinded sham-controlled trial study
AbstractOne of the most common symptoms in stroke patients is spasticity. The aims were to investigate the effects of anodal trans-cranial direct current stimulation (a-tDCS) over the affected primary motor cortex (M1) on ankle plantar flexor spasticity and dorsiflexor muscle activity in stroke patients. The design of this study was a randomized sham-controlled clinical trial. Thirty-two participants with stroke were randomly assigned to three groups (experimental, sham, control groups). Participants in the experimental and sham groups received 10-session 20-min M1 a-tDCS concurrent with physical therapy (PT), while the co...
Source: Neurological Sciences - September 2, 2021 Category: Neurology Source Type: research

Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?
AbstractObjectiveEpilepsy treatment during pregnancy is still challenging. The study is aimed at comparing the efficacy and safety of carbamazepine (CBZ), lamotrigine (LTG) and levetiracetam (LEV) monotherapies during pregnancy in women with focal (FE) or generalized (GE) epilepsy.MethodsA multicentre retrospective study was conducted to evaluate seizures frequency and seizure freedom (SF) rate during 3  months before pregnancy, each trimester of gestation and post-partum period in women on monotherapy with CBZ, LTG and LEV.ResultsFifty-seven pregnancies (45 FE, 12 GE) on monotherapy (29 CBZ, 11 LTG, 17 LEV) were incl...
Source: Neurological Sciences - September 1, 2021 Category: Neurology Source Type: research

Deep brain stimulation in Huntington ’s disease: a literature review
ConclusionsHD patients with predominant choreic symptoms may be the best candidates for surgery, but the role of other clinical features and of disease progression should be elucidated. For this reason, there is a need for more reliable criteria that may guide the selection of HD patients suitable for DBS. Accordingly, further studies including functional outcomes as primary endpoints are needed. (Source: Neurological Sciences)
Source: Neurological Sciences - September 1, 2021 Category: Neurology Source Type: research

How does semantic pain and words condition pain perception? A short communication
ConclusionsThere may be a link between language and pain, both at the behavioral and neural level. The processing of semantic information associated with pain influences the pain perception. (Source: Neurological Sciences)
Source: Neurological Sciences - August 30, 2021 Category: Neurology Source Type: research

Serum levels of lipocalin-2 in patients with Parkinson ’s disease
ConclusionsOverall, our study suggests that serum LCN2 levels may not be a biomarker for PD. (Source: Neurological Sciences)
Source: Neurological Sciences - August 29, 2021 Category: Neurology Source Type: research

Effect of ketogenic diet for drug-resistant epilepsy on immunological cells
ConclusionKD has no effect on neutrophil and lymphocytic counts as well as the number of adaptive and immune cells; nevertheless, it causes a reduction in phagocytic index in DRE. Accordingly, further detailed study for the full immunological profile and function is needed to ensure the safety of this therapeutic line and correlate it with the clinical history. (Source: Neurological Sciences)
Source: Neurological Sciences - August 27, 2021 Category: Neurology Source Type: research

Zonisamide in Parkinson ’s disease: a current update
AbstractParkinson ’s disease (PD) is a progressive neurodegenerative disease due to the depletion of the neurotransmitter dopamine in basal ganglia. There is a scarcity of available therapies for motor and non-motor symptoms of PD. Zonisamide (ZNS) may be one such potential candidate to alleviate PD symptoms. It wa s serendipitously found to be useful for PD in a patient with both epilepsy and PD. Since then, there have been many clinical trials, case series, observational studies, and case reports published supporting the efficacy of ZNS in PD. This review focuses on the efficacy and usefulness of ZNS in vari ous mo...
Source: Neurological Sciences - August 27, 2021 Category: Neurology Source Type: research

Chemotherapy and peripheral neuropathy
AbstractChemotherapy-induced peripheral neurotoxicity (CIPN) is a major dose-limiting side effect of many anti-cancer agents, including taxanes, platinums, vinca alkaloids, proteasome inhibitors, immunomodulatory drugs, and antibody –drug conjugates. The resultant symptoms often persist post treatment completion and continue to impact on long-term function and quality of life for cancer survivors. At present, dose reduction remains the only strategy to prevent severe neuropathy, often leading clinicians to the difficult decis ion of balancing maximal treatment exposure and minimal long-lasting side effects. This revi...
Source: Neurological Sciences - August 26, 2021 Category: Neurology Source Type: research

Myasthenia gravis and telemedicine: a lesson from COVID-19 pandemic
AbstractCOVID-19 pandemic has induced an urgent reorganization of the healthcare system to ensure continuity of care for patients affected by chronic neurological diseases including myasthenia gravis (MG). Due to the fluctuating nature of the disease, early detection of disease worsening, adverse events, and possibly life-threatening complications is mandatory. This work analyzes the main unresolved issues in the management of the myasthenic patient, the possibilities offered so far by digital technologies, and proposes an online evaluation protocol based on 4 simple tests to improve MG management. Telemedicine and Digital...
Source: Neurological Sciences - August 26, 2021 Category: Neurology Source Type: research

“Glu/GABA-Gln” metabolic loop abnormalities in iminodipropionitrile (IDPN)-induced dyskinetic syndrome
This study explored the mechanism of glutamate (Glu)/ γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic circuit in rat dyskinetic syndrome and the possible regulation mechanism of “tiapride (Tia).”MethodsMale Wistar rats were assigned to the control group, dyskinetic syndrome group, and Tia group. Dyskinetic syndrome was induced by injecting with 3,3 ′-iminodipropionitrile for 7 days. Tia group was treated with tiapride, while the control and dyskinetic syndrome groups were gavaged with saline. Eventually the Glu, GABA, and Gln concentrations in striatum were detected using UPLC-3QMS, additi...
Source: Neurological Sciences - August 25, 2021 Category: Neurology Source Type: research

Focal neurological deficits from multiple thromboembolic stroke complicating COVID-19 and limitations of stroke management during outbreak in Korea
(Source: Neurological Sciences)
Source: Neurological Sciences - August 25, 2021 Category: Neurology Source Type: research

SARS-CoV-2 infection after alemtuzumab in a multiple sclerosis patient: milder disease symptoms in comparison with coinfected relatives: a case report and review of the literature
We report the case of a 30-year-old female MS patient infected by SARS-CoV-2 virus 4 months after alemtuzumab II cycle, while she was still leukopenic and lymphopenic. She had no complications and also presented milder COVID-related signs and symptoms as compared to her coinfected relatives (father, mother and her partner). Anti-S1 and S2 SARS-CoV-2 antibodies, tested 1 month and a half after the infection, resulted positive. We review all cases reported in literature of SARS-CoV-2 infection in MS patients treated with alemtuzumab. None of them had complications or severe disease. (Source: Neurological Sciences)
Source: Neurological Sciences - August 24, 2021 Category: Neurology Source Type: research

Postural tremor in L-2-hydroxyglutaric aciduria is associated with cerebellar atrophy
ConclusionsLow-amplitude postural tremor is common in L2HGA. It is related with cerebellar atrophy. Although the neuroimaging shows no overt lesions at the brainstem, there is a functional inhibition at this level. (Source: Neurological Sciences)
Source: Neurological Sciences - August 24, 2021 Category: Neurology Source Type: research

Autoimmune and limbic encephalitis: case series with some atypical variables in clinical practice
AbstractAutoimmune and limbic encephalitides are still rare diseases characterized by rapid diagnostics and treatment development in recent years. The incidence of anti-N-methyl-D- aspartate receptor [NMDAR] encephalitis is about 1.5 per million person per year, and the incidence of paraneoplastic neurological syndromes [PNS] including limbic encephalitis [LE] is about 1.22 per 100  000 person per year (Vogrig et al. J Neurol 267:26–35,1; Dalmau et al. Ann Neurol 61:25 –36,2). The diagnostic criteria of anti-NMDAR encephalitis are already well established (Zuliani et al. Neurol Sci 40:2017 –2030,10)....
Source: Neurological Sciences - August 24, 2021 Category: Neurology Source Type: research

Myasthenia Gravis Lambert-Eaton overlap syndrome induced by nivolumab in a metastatic melanoma patient
ConclusionWe describe the first case of MG-LE overlap syndrome diagnosed after anti-PD1 immunotherapy for metastatic  melanoma, which appeared after radiation therapy and then relapsed after brain radiation necrosis. We hypothesized a role for brain inflammation as a trigger for MG-LE onset. Neuro-muscular junctions disease induced or revealed by checkpoint inhibitors can be challenging and requires long-term f ollow-up. (Source: Neurological Sciences)
Source: Neurological Sciences - August 24, 2021 Category: Neurology Source Type: research

Characterization and management of neurological adverse events during immune-checkpoint inhibitors treatment: an Italian multicentric experience
ConclusionsNeurological irAEs are rare but potentially fatal. They primarily affect neuromuscular structures but encompass a broad range of presentations. A prompt recognition is mandatory to timely withheld immunotherapy and administrate glucocorticoids. In corticoresistant or severely affected patients, second-line treatments with IVIg or plasmapheresis may result in additional benefit. (Source: Neurological Sciences)
Source: Neurological Sciences - August 23, 2021 Category: Neurology Source Type: research

Neurological manifestations of COVID-19 in patients: from path physiology to therapy
AbstractCoronavirus is a family of ARN positive single-stranded belonging to the family of Coronaviridae. There are several families of coronavirus that transmit more or less serious diseases. However, the so-called coronavirus-19 (SARS-CoV2) is the one that is currently causing most of the problems; in fact, biological dysfunctions that this virus causes provoke damage in various organs, from the lung to the heart, the kidney, the circulatory system, and even the brain. The neurological manifestations caused by viral infection, as well as the hypercoagulopathy and systemic inflammation, have been reported in several studi...
Source: Neurological Sciences - August 21, 2021 Category: Neurology Source Type: research

The Frontal Assessment Battery 20  years later: normative data for a shortened version (FAB15)
AbstractObjectiveThe Frontal Assessment Battery (FAB) is a neuropsychological tool largely used to assess executive functions. Prior studies found a marked ceiling effect for the prehension behavior subtest (PBT) in healthy and clinical populations. Aims of the present study were (i) to examine the psychometric properties of the FAB without the contribution of PBT and (ii) to provide normative data for a revised version of the FAB after exclusion of PBT (FAB15).MethodsThe normative sample included 1,187 healthy participants. PBT had near-zero variance, poor content validity, and no discrimination power. Internal consistenc...
Source: Neurological Sciences - August 19, 2021 Category: Neurology Source Type: research

Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinson ’s disease
ConclusionsThis study shows that serum UA levels were correlated with the nonmotor symptoms of dysphagia, anxiety, depression, apathy, and cognitive dysfunction and the whole-brain gray matter volume. That is the first report examining the relationships between serum UA and clinical manifestations and imaging features in PD patients. (Source: Neurological Sciences)
Source: Neurological Sciences - August 18, 2021 Category: Neurology Source Type: research

The cognitive impact of guard shifts in physicians: a before-after study
AbstractObjectiveWe intend to evaluate the change of different cognitive functions after a guard shift in physicians.MethodsA descriptive observational study was performed. The study population included Spanish physicians who were asked to complete before and immediately after their guard shift the following tests: Digit Span, TMT-A, TMT-B, Symbol Digit, Stroop, Free and Cued Selective Reminding, creep and formal fluency, Visual Orientation and Space Perception tests, and the Leeds Sleep Questionnaire.ResultsThirty subjects were included in the study among which 43.3% were female. The mean subjective impression of the guar...
Source: Neurological Sciences - August 18, 2021 Category: Neurology Source Type: research

Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy
This study aimed to explore cognitive impairment and to determine the potential clinical, radiological, and quantitative electroencephalography markers for cognitive impairment in temporal lobe epilepsy patients versus extra-temporal lobe epilepsy.MethodsForty-five patients with temporal lobe epilepsy and forty-five patients with extra-temporal lobe epilepsy were recruited for an administered digit span test, verbal fluency test, mini-mental state examination, digital symbol test, and Montreal cognitive assessment. Also, they were subjected to magnetic resonance imaging assessment for hippocampal atrophy and a quantitative...
Source: Neurological Sciences - August 18, 2021 Category: Neurology Source Type: research

Early implementation of intended exercise improves quality of life in Parkinson ’s disease patients
This study aims to investigate how intended exercise impacts motor and non-movement symptoms of PD.MethodsEighty-eight patients were randomly assigned to an early exercise group (E-EG), late exercise group (L-EG), or a control group (CG) using a randomized delayed-start design. The E-EG carried out a rigorous, formal exercise program for 1  h, twice per week, for 18 months (May 2018–November 2019). The L-EG took part in the exercise program in the final 6–12 months of the study. We assessed outcomes using the Unified Parkinson’s Disease Rating Scale (UPDRS), PDQ-39 Questionnaire, Line A tes...
Source: Neurological Sciences - August 18, 2021 Category: Neurology Source Type: research

Brain network modulation in transradial amputee with finger perception restored through biomimetic intraneural stimulation
DiscussionDelta increases (less orderly network) while Beta 1 decreases (more ordered network). It could be seen as a sign of higher attention and concentration of subjects to understand the perception and this monolateral modulation is similar to the bilateral attention given to the mathematical task difficulty ’s increment. (Source: Neurological Sciences)
Source: Neurological Sciences - August 18, 2021 Category: Neurology Source Type: research

Effectiveness of dual migraine therapy with CGRP inhibitors and onabotulinumtoxinA injections: case series
AbstractAimsClinical trials for calcitonin gene-related peptide (CGRP) inhibitors excluded the concomitant use of onabotulinumtoxinA; thus, there is a lack of efficacy and safety data of the combined therapies. Our study aims to examine the effectiveness of CGRP inhibitors with onabotulinumtoxinA by evaluating migraine reductions in headache days and severity.MethodsSeventeen patients with chronic migraines were identified who had a partial or poor response to onabotulinumtoxinA, and were placed on dual therapy with a CGRP inhibitor. Patients ’ initial headache days and severity ratings were compared to final values ...
Source: Neurological Sciences - August 18, 2021 Category: Neurology Source Type: research

Ten years evaluation of epidemiology- and mortality-related factors in adults and children with Guillain-Barr é syndrome in the north of Iran
In this study, the hospital information system (HIS) was used to access each patient ’s information. The final 174 cases were examined in terms of age, sex, place of residence, the year of referral, the month of referral, the season of referral, client city, accompanying background disease, and the type of GBS.ResultsThe mean incidence rate in Guilan province was about 0.69 in 100,000 persons, and the case fatality rate was 10.34%. The most reported type of GBS was AIDP (33.90%), and the most common symptom was upper and lower limbs paresis in 65 cases (37%). Respiratory distress (P =  
Source: Neurological Sciences - August 17, 2021 Category: Neurology Source Type: research

Cognitive impairment in young COVID-19 patients: the tip of the iceberg?
(Source: Neurological Sciences)
Source: Neurological Sciences - August 17, 2021 Category: Neurology Source Type: research

Effects of repetitive transcranial magnetic stimulation on cerebral glucose metabolism
ConclusionsThese results suggest for the first time that improved glucose metabolism is associated with improved motor function after a combination of rTMS and intensive rehabilitation. (Source: Neurological Sciences)
Source: Neurological Sciences - August 16, 2021 Category: Neurology Source Type: research