Negative symptoms in Huntington ’s disease
ConclusionsNegative symptoms are pervasive in HD but more severe in stage 2. The associations of SANS with MMSE and SAPS suggest impaired cognition and thinking as important in generating negative symptoms. SANS appears useful for revealing a wide range of negative symptoms in HD. (Source: Neurological Sciences)
Source: Neurological Sciences - January 24, 2022 Category: Neurology Source Type: research

Low online search interest in teleneurology before and during COVID-19 pandemic: an infodemiological study
ConclusionThere was an increase in the SVI of telehealth and telemedicine, possibly implying an increase in the general awareness of these virtual methods of health care, as catalyzed by the pandemic. However, the stable SVI of teleneurology may signify that the public awareness regarding it remained unchanged despite the increase in application in clinics and hospitals. (Source: Neurological Sciences)
Source: Neurological Sciences - January 24, 2022 Category: Neurology Source Type: research

Impact of COVID-19 lockdown on progressive multiple sclerosis patients
ConclusionThese results highlight the adverse impact, on pMS patients, of the public health measures implemented for the containment of the pandemic. (Source: Neurological Sciences)
Source: Neurological Sciences - January 24, 2022 Category: Neurology Source Type: research

Very low peroneal nerve compound muscle action potential amplitude predicts poor outcome in patients with Guillain-Barr é syndrome: a prospective cohort
AbstractIntroductionTwenty percent of patients with Guillain-Barr é syndrome (GBS) have poor outcomes despite proper management. The aim of the study was to characterize electrophysiological factors related to poor outcome in patients with GBS.MethodsWe conducted an observational study from a prospective cohort of 91 patients with GBS in a tertiary healthcare center in Mexico, from 2017 to 2019. Demographics and nerve conduction studies were performed on admission, and a 3-month follow-up for GBS disability score was ensued, allocating patients in good (GBS disability score  ≤ 2) and poor outcome (G...
Source: Neurological Sciences - January 24, 2022 Category: Neurology Source Type: research

EEG changes in intensive care patients diagnosed with COVID-19: a prospective clinical study
AbstractIntroductionCoronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was declared a pandemic on March 11th, 2020, by the World Health Organization (WHO). There has been a substantial increase in the epileptic seizures and status epilepticus reported in the pandemic period. In this context, it is aimed with this study to identify the electroencephalography (EEG) features of patients admitted to the intensive care unit with the diagnosis of COVID-19 and to look for any specific patterns in these features.Material and methodThe mate...
Source: Neurological Sciences - January 23, 2022 Category: Neurology Source Type: research

A case of spastic paraplegia type 11 mimicking a GM2-gangliosidosis
ConclusionsWe describe for the first time pathological hallmarks of SPG11 in enteric neuron from a rectal mucosa biopsy. The report illustrates the possible overlap between SPG11 and GM2-gangliosidosis, especially in the first disease phases and helps to improve our knowledge about SPG11 physiopathology. (Source: Neurological Sciences)
Source: Neurological Sciences - January 23, 2022 Category: Neurology Source Type: research

Genetic causes of acute encephalopathy in adults: beyond inherited metabolic and epileptic disorders
AbstractAcute encephalopathy is a widely used term, implying a rapidly progressive multifocal or diffuse brain dysfunction, caused by acute structural disturbance or a myriad of metabolic, toxic, epileptic, or infection-related factors. Apart from the more common acquired causes, a broad range of rare inherited disorders may produce spells of encephalopathy in adulthood, posing diagnostic challenges to clinicians. Among the latter, neurometabolic disorders and epileptic syndromes constitute typical examples. Interestingly, certain genetic entities have the potential to provoke episodic changes of cognition, via alternative...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

FLAIR vascular hyperintensity predicts early neurological deterioration in patients with acute ischemic stroke receiving endovascular thrombectomy
AbstractFluid-attenuated inversion recovery vascular hyperintensity (FVH) is frequently observed in patients with acute ischemic stroke (AIS). FVH is associated with functional outcome at 3  months in AIS patients receiving endovascular thrombectomy. In the present study, we assessed whether FVH predicted early neurological deterioration (END) and hemorrhagic transformation (HT) within 72 h in AIS patients receiving endovascular thrombectomy. We retrospectively analyzed 104 patients with acute internal-carotid-artery or proximal middle-cerebral-artery occlusion within 16 h after symptom onset. Before thrombe...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Neurological involvement associated with COVID-19 disease: a study on psychosocial factors
ConclusionAfter 3  months from hospital discharge, patients with more severe COVID-19 and mild neurological involvement experienced more psychosocial alterations than patients with unspecific or no neurological involvement. Both COVID-19 and neurological manifestations’ severity should be considered in the clinica l settings to plain tailored interventions for patients recovering from COVID-19. (Source: Neurological Sciences)
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Correction to: Genetic analysis in Chinese patients with familial or young ‑onset amyotrophic lateral sclerosis
(Source: Neurological Sciences)
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Acute telestroke evaluations during the COVID-19 pandemic
This study is a retrospective database review of all telestroke requests at one academic vascular neurology center telestroke network with seven remote sites in the USA between March 15 and April 30, 2020. Data were compared with historical cohort spanning same time frame in 2019 using parametric or nonparametric methods as appropriate. Among telestroke requests, characteristics of age, gender, race/ethnicity, National Institutes of Health Stroke Scale (NIHSS), primary diagnosis of AIS or transient ischemic attack (TIA), and number of patients receiving intravenous alteplase (IV-rtPA) and endovascular therapy (ET) were rec...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

In-hospital and out-of-hospital stroke in patients with COVID-19: two different diseases?
ConclusionsPatients with stroke and COVID-19 had higher mortality compared to patients without COVID-19. Among patients with COVID-19 those with out-of-hospital stroke had better outcome and fewer blood test abnormalities compared to patients with in-hospital stroke. (Source: Neurological Sciences)
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Task-switching abilities in episodic and chronic migraine
AbstractMigraineurs show impaired cognitive functions interictally, mainly involving information processing speed, basic attention, and executive functions. We aimed to assess executive impairment in migraine patients with different attack frequencies through a task-switching protocol designed to assess different sub-processes of executive functioning. We enrolled 42 migraine patients and divided them into three groups based on the attack frequency: 13 subjects had episodic migraine with a low frequency (LFEM, 4 –7 migraine days per month), 14 subjects had high-frequency episodic migraine (HFEM, 8–14 days)...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Addiction-induced plasticity in underlying neural circuits
AbstractSynaptic plasticity, the substrate for learning, has been established in neural reward circuits and might involve in the learning of addictive behaviors. Long-term exposure to addictive drugs caused long-lasting memories of the drug experience. The main clinical problem that involves the persistence of addiction is a relapse that is resulted from the exposure to cues of the drug experience. Persistent forms of synaptic plasticity are associated with some of the behavioral effects of addictive drugs. Here, we present the underlying mechanisms of plasticity induced by different brain reward circuitry. Therefore, we f...
Source: Neurological Sciences - January 22, 2022 Category: Neurology Source Type: research

Chronic fatigue syndrome and cognitive deficit are associated with acute-phase neuropsychiatric manifestations of COVID-19: A 9-month follow-up study
AbstractThe preva lence of long-COVID symptoms is rising but it is not still possible to predict which patients will present them, and which types of symptoms they will present. We followed up 95 patients with confirmed COVID-19 for 9  months to identify and characterize long-COVID symptoms. Easy fatigability was the most common symptom (51.04%), followed by anxiety (38.54%), dyspnea (38.54%), and new-onset headache (38.54%). There was no association between COVID-19 severity in the acute phase and the number of long-COVID sympt oms (F(1,93)  = 0.75,p = 0.45), and cognitive function (MoCA...
Source: Neurological Sciences - January 21, 2022 Category: Neurology Source Type: research

The role of efferocytosis in neuro-degenerative diseases
This study is a review of the efferocytosis molecular pathways and their role in neuro-degenerative diseases in order to discover a new treatment option to cure patients. (Source: Neurological Sciences)
Source: Neurological Sciences - January 21, 2022 Category: Neurology Source Type: research

Effects of quarantine applied during the COVID-19 pandemic on mental health and quality of life in patients with multiple sclerosis and healthy controls
AbstractBackgroundThe coronavirus outbreak, which emerged in Wuhan, China, in late 2019 and spread to the world, has changed each of our lives.ObjectiveTo investigate the effects of quarantine on depression, anxiety, sleep quality, fatigue, and SF-36 of multiple sclerosis (MS) patients during the COVID-19 outbreak and differences between healthy controls (HC).MethodsEighty-six MS patients and 65 HC patients were included in the study. Participants filled out the various scales through face-to-face interviews for mental health assessment from January 15 to February 15, 2021.ResultsWhen both groups were compared in terms of ...
Source: Neurological Sciences - January 21, 2022 Category: Neurology Source Type: research

Nerve ultrasound may help predicting response to immune treatment in chronic inflammatory demyelinating polyradiculoneuropathy
ConclusionsNerve ultrasonography could help guide treatment strategies in patients with CIDP. Patients with normal or moderately enlarged CSA may respond better to steroids than to IVIG. The decrease in CSA after treatment may also indicate better prognosis. (Source: Neurological Sciences)
Source: Neurological Sciences - January 21, 2022 Category: Neurology Source Type: research

Frequency and clinical correlates of anti-nerve antibodies in a large population of CIDP patients included in the Italian database
ConclusionsAnti-paranodal and anti-ganglioside antibodies are infrequent in patients with CIDP but are associated with some typical clinical association supporting the hypothesis that CIDP might be a pathogenically heterogeneous syndrome possibly explaining the different clinical presentations. (Source: Neurological Sciences)
Source: Neurological Sciences - January 20, 2022 Category: Neurology Source Type: research

SARS-CoV-2 vaccine-related neurological complications
ConclusionsA variety of symptoms, including thunderclap headache, focal deficits and movement disorders, can occur after SARS-CoV-2 vaccination, and an activation or reactivation of the immune system is suggested as most likely cause. However, one should be careful about claiming a direct correlation. It remains important to exclude other causes, such as structural lesions, infections or subarachnoid hemorrhage, and future research is required to understand possible pathophysiological mechanisms and associations with the SARS-CoV-2 vaccine. (Source: Neurological Sciences)
Source: Neurological Sciences - January 20, 2022 Category: Neurology Source Type: research

Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis
AbstractPurposeTo explore the efficacy and safety of intravenous immunoglobulin (IVIG) in the treatment of severe Japanese encephalitis (JE).MethodsA retrospective study of 124 children diagnosed with the severe or very severe form of JE was undertaken. There were 62 cases in the IVIG group and control group. The efficacy, safety, and tolerability of IVIG were evaluated 3  days, as well as 1, 2, and 3 weeks after IVIG, respectively, and the prognosis was assessed at 6 months.ResultsCox regression survival analysis suggested that the IVIG group reached the criteria for efficacious treatment faster than that i...
Source: Neurological Sciences - January 19, 2022 Category: Neurology Source Type: research

Genetic screening in patients of Meige syndrome and blepharospasm
ConclusionsTOR1A rs1435566780 (c.*16G  >  C(G >  A)) andTHAP1 rs545930392 (c.192G  >  A[K64K]) may contribute to the etiology of MS and BSP. Other identified rare mutations predicted as deleterious probably damaging need further confirmation. Larger MS and BSP cohorts and functional studies will need to be performed further to elucidate the association between these genes and the diseases. (Source: Neurological Sciences)
Source: Neurological Sciences - January 19, 2022 Category: Neurology Source Type: research

Does erythropoietin affect the outcome  and complication rates of patient with traumatic brain injury? A pooled-analysis
ConclusionsFindings of the present meta-analysis suggest that the use of EPO could reduce mortality rate in patients with TBI, without increasing the incidence of AEs. EPO has potential research and application value in the treatment of TBI. (Source: Neurological Sciences)
Source: Neurological Sciences - January 19, 2022 Category: Neurology Source Type: research

Questionnaire-based survey on the prevalence of medication-overuse headache in Japanese one city —Itoigawa study
ConclusionsThis is the first study of MOH prevalence in Japan. Most MOH characteristics were similar to previous reports worldwide. Public awareness of proper headache treatment knowledge is still needed. Clustering results may be important for subtype grouping from a social perspective apart from existing clinical subtypes. (Source: Neurological Sciences)
Source: Neurological Sciences - January 19, 2022 Category: Neurology Source Type: research

Do neuropsychiatric fluctuations temporally match motor fluctuations in Parkinson ’s disease?
ConclusionNeuropsychiatric fluctuations temporarily matched the OFF MFs only in the OFF condition. These findings are useful to better manage OFF NMSs and support the need to further investigate associations between non-motor and motor symptoms in PD patients. (Source: Neurological Sciences)
Source: Neurological Sciences - January 19, 2022 Category: Neurology Source Type: research

Volumetric changes within hippocampal subfields in Alzheimer ’s disease continuum
AbstractNeurodegeneration in Alzheimer ’s disease continuum (ADC) starts from the transentorhinal cortex and progresses within hippocampal circuitry following the connectivity of its subfields transsynaptically. We aimed to track volumetric changes of the hippocampal subfields by comparing three stages of the ADC. MRI data of 15 patien ts diagnosed with Alzheimer’s disease dementia (ADD), 15 patients with amnestic mild cognitive impairment (MCI), and 15 individuals with subjective cognitive impairment (SCI) were analyzed. The hippocampal formation was subdivided into CA1, CA3, subiculum (SUB), and dentate gyrus...
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Serum NfL associated with anti-NMDA receptor encephalitis
AbstractIntroductionNeurofilament light chains (NfL) have been reported as potential markers for neuronal-axonal injury in neuroinflammatory diseases. In the current study, we describe serum NfL levels as a prognostic marker for anti-N-methyl-D-aspartate receptor encephalitis (NMDARE).MethodsSerum levels of NfL of 64 patients with anti-NMDARE and 84 healthy controls were measured by Simoa. The anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score, Modified Rankin Scale (mRS) scores, and clinical and cerebrospinal fluid parameters were evaluated in patients with anti-NMDARE. Meanwhile, we performed a receiver-oper...
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Less is not necessarily more: low-dose corticosteroid therapy and long-term prognosis in generalized myasthenia gravis after thymectomy
ConclusionLow-dose initiation, slowly incrementing PSL therapy is feasible for generalized MG patients after thymectomy. Early response to low-dose PSL therapy may predict better long-term outcomes. (Source: Neurological Sciences)
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Neurological emergency at the COVID-19 pandemic: report from a referral hospital in Eastern Piedmont, Italy
We described how the flow of neurological emergencies was affected by the pandemic impact.MethodsWe analyzed accesses to the Emergency Department (ED) of the “Maggiore della Carità” Hospital, Piedmont, Italy, during a period of 8 months (COVID time; March to May 2020 and October 2020 to February 2021) and analyzed the admissions to the Neurology Unit and the underlying diagnosis. We also evaluated potential changes in the treatment of acute ischemi c stroke in the same period. These variables were compared with two equivalent periods of time (2019–2020; 2018–2019).ResultsDuring the COVID...
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Comparison of the mass and amount of intramuscular non-contractile tissue of the trunk and lower extremity muscles between patients with Parkinson ’s disease and community-dwelling older adults
ConclusionsOur results revealed lower masses of the gluteus maximus and tibialis anterior muscles, higher mass of the short head of the biceps femoris muscle, and higher amounts of intramuscular non-contractile tissue of the gluteus maximus muscle in patients with PD. (Source: Neurological Sciences)
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Myasthenia gravis exacerbation and myasthenic crisis associated with COVID-19: case series and literature review
We report 8 cases of MG exacerbation or myasthenic crisis associated with COVID-19 and discuss prognosis and treatment based on a literature review.ResultsMost patients were female (7/8), with an average age of 47.1  years. Treatment was immunoglobulin (IVIG) in 3 patients, plasma exchange (PLEX) in 2 patients, and adjustment of baseline drugs in 3. In-hospital mortality was 25% and 37.5% in 2-month follow-up.DiscussionThis is the largest case series of MG exacerbation or myasthenic crisis due to COVID-19 to this date. Mortality was considerably higher than in myasthenic crisis of other etiologies. Previous treatment ...
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Neurological manifestation of 22q11.2 deletion syndrome
This article reviews the different neurological manifestations of 22q11.2 deletion syndrome. The syndrome is associated with neurological disorders such as epilepsy and movement disorders. Patients with 22q11.2 DS have an increased incidence of provoked and unprovoked seizures. Provoked seizures include, amongst others, seizures due to hypocalcemia, surgery, perioperative hypoxia, antipsychotic medication, and fever. Both focal seizures, myoclonus and generalized tonic –clonic seizures occur in 22q11.2 DS. Generalized epilepsy occurs more often than in the background population. Furthermore, 22q11.2 DS is associated ...
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Whole-exome sequencing analysis to identify novel potential pathogenetic NPC1 mutations in two Chinese families with Niemann –Pick disease type C
ConclusionOur study identified three novel mutations and one known mutation inNPC1 and evaluated their pathogenicity, enriching theNPC1 mutation and phenotype spectrum and providing a new basis for the genetic and prenatal diagnosis of this disease. (Source: Neurological Sciences)
Source: Neurological Sciences - January 17, 2022 Category: Neurology Source Type: research

The prevalence of osteoporosis/osteopenia in patients with multiple sclerosis (MS): a systematic review and meta-analysis
Abstract   BackgroundThe prevalence of osteoporosis is reported differently. We designed this systematic review and meta-analysis to estimate pooled prevalence of osteoporosis and osteopenia in patients with MS.MethodsIndependently, two researchers searched PubMed, Scopus, EMBASE, Web of Science, and google scholar along with gray literature (conference abstracts and references of the references) up to March 2021. We collected data regarding first author, country of origin, number of enrolled patients, number cases with osteoporosis/ osteopenia, mean age, F/M ratio, mean EDSS, and mean duration of the disease.Res...
Source: Neurological Sciences - January 17, 2022 Category: Neurology Source Type: research

Effects of stroke etiology on angiographic success in patients undergoing mechanical thrombectomy
ConclusionRecanalization success and clinical outcomes did not differ significantly in patients with LVAD and those with cardioembolic etiology. However, mortality rate was higher in patients with atherosclerotic etiology, due to the complexity of the procedure and the high rate of reocclusion. (Source: Neurological Sciences)
Source: Neurological Sciences - January 17, 2022 Category: Neurology Source Type: research

Determinants of hyponatremia following a traumatic brain injury
The objectives of this study are to characterize hyponatremia in TBI patients and find its main risk factors.MethodsAll patients admitted with a diagnosis of acute TBI over a 1-year period were included, except patients with known chronic hyponatremia, those who died within 72  h, and those receiving hyperosmolar therapy to treat their intracranial hypertension. Sodium levels throughout hospitalization were collected. Post-traumatic hyponatremia was defined as follows: borderline (1–2 points below normal and 1–2 days duration) and significant (more than 2 points bel ow normal and/or more than 2 d...
Source: Neurological Sciences - January 17, 2022 Category: Neurology Source Type: research

Focal and asymmetric triceps brachii weakness: a rare but possible myasthenia gravis presentation
(Source: Neurological Sciences)
Source: Neurological Sciences - January 17, 2022 Category: Neurology Source Type: research

A case of neurodegenerative disorder caused by PLA2G6 compound heterozygous pathogenic variant and SCA17 pathogenic variant
(Source: Neurological Sciences)
Source: Neurological Sciences - January 17, 2022 Category: Neurology Source Type: research

Electroclinical spectrum of generalized paroxysmal fast activity in adults without epileptic encephalopathy
ConclusionIn this study, GPFA had a wide diagnostic range from focal to generalized epilepsy. The association of GPFA with other electroclinical features was of importance mostly for sleep outcomes; this finding might lead to a better understanding of epileptogenesis. (Source: Neurological Sciences)
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research

The second family affected with a PRDM8-related disease
ConclusionsThe current study increases the number ofPRDM8-related cases and expands the phenotypic spectrum of mutations in thePRDM8 gene. Both reportedPRDM8-related families presented intra and inter-familial heterogeneity and they have originated from the Middle East. Thus, it seems thePRDM8 mutations should be considered not only in LD but also in other neurodegenerative disorders such as a complicated HSP-like phenotype, especially in this region. (Source: Neurological Sciences)
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research

Structural and functional connections between the autonomic nervous system, hypothalamic –pituitary–adrenal axis, and the immune system: a context and time dependent stress response network
This article reviews the brain circuitry, peripheral connections, and chemical messengers that enable communication between the ANS, HPA axis, and immune system. We describe findings of in vitro and animal studies that challenge the immune system with lipopolysaccharide. Next, neuroimmune connections in animal m odels of chronic inflammatory disease are reviewed. Finally, we discuss how a greater understanding of the ANS-HPA-immune network may lead to the development of novel therapeutic strategies that are focused on modulation of the sympathetic and parasympathetic nervous system. (Source: Neurological Sciences)
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research

Neurological toll of COVID-19
AbstractThe first case of coronavirus illness was discovered in Wuhan, China, in January 2020 and quickly spread worldwide within the next couple of months. The condition was initially only linked with respiratory disorders. After the evolution of various variants of the SARS-CoV-2, the critical impact of the virus spread to multiple organs and soon, neurological disorder manifestations started to appear in the infected patients. The review is focused on the manifestation of various neurological disorders linked with both the central nervous system and peripheral nervous system. Disorders such as cytokine release syndrome,...
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research

An invisible cause of disability: stigma in migraine and epilepsy
AbstractObjectiveOur purpose was to identify the ratio and severity of stigmatization in patients with migraine and epilepsy. We also collected demographic and clinical data to search for possible facilitators.MethodsIn total, 196 patients with migraine and 60 patients with epilepsy were enrolled. Neuro-QoL Stigma Scale was applied in an office setting by a neurologist in 3 different centers. Stigma scores were calculated as standardizedT scores (total, enacted, and internalized). Demographics, clinical characteristics, and treatment status of the patients were also compared in terms of stigma scores. Kruskal –Wallis...
Source: Neurological Sciences - January 15, 2022 Category: Neurology Source Type: research

Evaluation of rest tremor in different positions in Parkinson ’s disease and essential tremor plus
This study aimed to compare the RT electrophysiological features across different positions in tremor-dominant Parkinson ’s disease (PD) and essential tremor plus (ET with RT, rET).MethodsWe consecutively enrolled 90 tremor-dominant PD and 24 rET patients. The RT presence was evaluated in three positions: with the patient seated, the arm flexed at 90 °, the forearm supported against gravity, and the hand hanging down from the chair armrest (hand-hanging position), in lying down supine and in standing position. RT electrophysiological features (amplitude, frequency, burst duration, pattern) were compared between t...
Source: Neurological Sciences - January 15, 2022 Category: Neurology Source Type: research

Stroke and kidney stones: common predisposing factors in viewpoint of Persian medicine
(Source: Neurological Sciences)
Source: Neurological Sciences - January 15, 2022 Category: Neurology Source Type: research

ALS2-related disorders in Spanish children: a severely affected case of infantile ascending spastic paraplegia due to homozygous R704X mutation
(Source: Neurological Sciences)
Source: Neurological Sciences - January 15, 2022 Category: Neurology Source Type: research

The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence
AbstractFibromyalgia (FM) is a condition characterized by chronic widespread pain whose pathogenesis is still not fully defined. Evidence based on structural and functional neuroimaging methods, electrophysiological, and morphological – skin biopsy – features demonstrated a central and peripheral nervous system involvement. A dysfunction in nociceptive inputs processing at the central level was highlighted as the primary cause of FM, but other data coming from different laboratories contributed to emphasize again the peripher al origin of FM. In fact, small fibers neuropathy (SFN) was observed in a large number...
Source: Neurological Sciences - January 14, 2022 Category: Neurology Source Type: research

Freezing of gait: overview on etiology, treatment, and future directions
ConclusionsFurther studies focusing on the potential genetic role in FOG may increase the knowledge on the FOG etiology and pathophysiology, allowing further individualized treatment strategies for this very disabling phenomenon. (Source: Neurological Sciences)
Source: Neurological Sciences - January 14, 2022 Category: Neurology Source Type: research

Visual evoked potential and nerve conduction study findings in patients recovered from COVID-19
ConclusionsWe detected subclinical afferent visual pathway abnormality evaluated by VEP analysis. In addition, we found subtle electrophysiological features in the NCS of the patients presented with COVID-19 pneumonia. However, our findings did not fortify the diagnosis of peripheral neuropathy or optic neuropathy. Further studies are needed to determine the characteristics of COVID-19-related peripheral neuropathy/optic neuropathy whether it has distinct clinical features and disease course. (Source: Neurological Sciences)
Source: Neurological Sciences - January 14, 2022 Category: Neurology Source Type: research

A novel homozygous mutation in TBK1 gene causing ALS-FTD
(Source: Neurological Sciences)
Source: Neurological Sciences - January 14, 2022 Category: Neurology Source Type: research