A novel missense mutation in the ABCD1 gene of a Chinese boy diagnosed with X-linked adrenoleukodystrophy: case report
(Source: Neurological Sciences)
Source: Neurological Sciences - October 20, 2018 Category: Neurology Source Type: research

Stroke or Stramonium? A novel stroke mimic
(Source: Neurological Sciences)
Source: Neurological Sciences - October 19, 2018 Category: Neurology Source Type: research

Coxsackievirus B1 resulting acute flaccid myelitis with entire spinal cord lesion: a case report
(Source: Neurological Sciences)
Source: Neurological Sciences - October 19, 2018 Category: Neurology Source Type: research

Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson ’s disease
(Source: Neurological Sciences)
Source: Neurological Sciences - October 18, 2018 Category: Neurology Source Type: research

Pseudo-orthostatic tremor in idiopathic Parkinson ’s disease: could it be re-emergent tremor?
(Source: Neurological Sciences)
Source: Neurological Sciences - October 18, 2018 Category: Neurology Source Type: research

Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease
(Source: Neurological Sciences)
Source: Neurological Sciences - October 18, 2018 Category: Neurology Source Type: research

The relationship among neutrophil to lymphocyte ratio, stroke territory, and 3-month mortality in patients with acute ischemic stroke
ConclusionNLR is significantly correlated with ACS infarct volume, but not with PCS infarct volume in AIS. Also, NLR was an independent predictor of 3-month mortality in AIS patient. (Source: Neurological Sciences)
Source: Neurological Sciences - October 17, 2018 Category: Neurology Source Type: research

Boosting and consolidating the proprioceptive cortical aftereffect by combining tendon vibration and repetitive TMS over primary motor cortex
AbstractTendon vibration of a limb elicits illusory movements in the direction that the vibrated muscle would be stretched, followed by a transient perception of movement in the opposite direction, that was demonstrated to correspond to a “cortical” aftereffect (Goodwin et al. Science 175:1382–1384, 1972). Primary motor cortex (M1) excitability of the non-vibrated antagonist muscle of the vibrated muscle increased during vibration and decreased thereafter. The cortical aftereffect is of interest when considering the possibility to use tendon vibration in rehabilitation for restoring unbalance activity bet...
Source: Neurological Sciences - October 16, 2018 Category: Neurology Source Type: research

Decreasing 123 I-ioflupane SPECT accumulation and 123 I-MIBG myocardial scintigraphy uptake in a patient with a novel homozygous mutation in the ZFYVE26 gene
(Source: Neurological Sciences)
Source: Neurological Sciences - October 16, 2018 Category: Neurology Source Type: research

Anti-vascular endothelial growth factor in glioblastoma: a systematic review and meta-analysis
In conclusion, anti-VEGF agents can improve the PFS but not OS in glioblastoma patients. The current evidence is not satisfactory to declare a new therapeutic line. Further RCTs with sharply determined outcomes and assessment methods are required. (Source: Neurological Sciences)
Source: Neurological Sciences - October 16, 2018 Category: Neurology Source Type: research

Was the subject portrayed in “A Man” by Cornelis Anthonisz around 1530 really affected by progressive supranuclear palsy?
(Source: Neurological Sciences)
Source: Neurological Sciences - October 15, 2018 Category: Neurology Source Type: research

Highlights of the issue 11, 2018
(Source: Neurological Sciences)
Source: Neurological Sciences - October 15, 2018 Category: Neurology Source Type: research

Movement disorders in emergency settings: a prospective study
AbstractIntroductionAcute movement disorders (MD) are etiologically heterogeneous entities. Since studies on the relative frequency of different MD and their underlying diseases are limited, we performed a prospective study to investigate the spectrum of various MD and their causes in patients presenting with acute MD in an emergency room (ER) setting.ObjectiveTo describe the spectrum and outcomes of acute MD in a prospective cohort and to guide its management.MethodsWe investigated acute MD in 96 consecutive patients admitted to ERs between 2013 and 2017. Time of disease onset, type of MD according to published criteria, ...
Source: Neurological Sciences - October 15, 2018 Category: Neurology Source Type: research

Vinpocetine regulates levels of circulating TLRs in Parkinson ’s disease patients
ConclusionVinpocetine treatment may exhibit anti-inflammatory activity and alleviate cognitive impairment. (Source: Neurological Sciences)
Source: Neurological Sciences - October 12, 2018 Category: Neurology Source Type: research

Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache
ConclusionThis systematic review shows that the delays in the diagnosis of CH are a widespread problem, the time to diagnosis still vary from country to country and both patients and physicians are responsible for the delays in diagnosis. (Source: Neurological Sciences)
Source: Neurological Sciences - October 10, 2018 Category: Neurology Source Type: research

Dramatic improvement by levodopa treatment in a patient with vascular parkinsonism
(Source: Neurological Sciences)
Source: Neurological Sciences - October 9, 2018 Category: Neurology Source Type: research

Self-assessment reliability in multiple sclerosis: the role of socio-demographic, clinical, and quality of life aspects
DiscussionResults seem to suggest that higher education and worse clinical and QoL conditions could engage the patient in developing more disease awareness and realistic self-perception and self-evaluation. (Source: Neurological Sciences)
Source: Neurological Sciences - October 5, 2018 Category: Neurology Source Type: research

Early and rapidly progressing respiratory failure in a patient with amyotrophic lateral sclerosis: when FVC% is misleading
(Source: Neurological Sciences)
Source: Neurological Sciences - October 4, 2018 Category: Neurology Source Type: research

A case of primary angiitis of the central nervous system presenting with diffuse cerebral microbleeds and recurrent intracranial hemorrhage
(Source: Neurological Sciences)
Source: Neurological Sciences - October 4, 2018 Category: Neurology Source Type: research

Auditory brainstem response to speech in children with high functional autism spectrum disorder
AbstractAuditory brainstem response (ABR) provides useful information about the auditory brainstem pathway. However, there is little known about the subcortical speech processing in individuals with autism spectrum disorder (ASD). The aim of the present study was to investigate the subcortical speech processing in children with high functioning ASD. Twenty-eight children with ASD, with a mean age of 14.36  ± 1.86, and 28 typically developing (TD) children, with a mean age of 14.99 ± 1.92, were selected from Rofeydeh Rehabilitation Hospital (Tehran, Iran), and speech ABR (sABR) with...
Source: Neurological Sciences - October 4, 2018 Category: Neurology Source Type: research

Early and rapidly progressing respiratory failure in a patient with amyotrophic lateral sclerosis: when FVC% is misleading
(Source: Neurological Sciences)
Source: Neurological Sciences - October 4, 2018 Category: Neurology Source Type: research

A case of primary angiitis of the central nervous system presenting with diffuse cerebral microbleeds and recurrent intracranial hemorrhage
(Source: Neurological Sciences)
Source: Neurological Sciences - October 4, 2018 Category: Neurology Source Type: research

Auditory brainstem response to speech in children with high functional autism spectrum disorder
AbstractAuditory brainstem response (ABR) provides useful information about the auditory brainstem pathway. However, there is little known about the subcortical speech processing in individuals with autism spectrum disorder (ASD). The aim of the present study was to investigate the subcortical speech processing in children with high functioning ASD. Twenty-eight children with ASD, with a mean age of 14.36  ± 1.86, and 28 typically developing (TD) children, with a mean age of 14.99 ± 1.92, were selected from Rofeydeh Rehabilitation Hospital (Tehran, Iran), and speech ABR (sABR) with...
Source: Neurological Sciences - October 4, 2018 Category: Neurology Source Type: research

Hirayama disease: analysis of cases in Russia
AbstractThe fourteen cases of Hirayama disease (HD) are presented in this article. HD is seldom disease characterized by juvenile muscular atrophy of upper extremities and benign course. All cases were diagnosed in the Research Center of Neurology (Moscow, Russia) during the year 2015 –2017. Such methods as MRI (magnetic resonance imaging), EMG (electromyography), and NCS (nerve conduction studies) have been used to confirm diagnosis of HD. Transcranial magnetic stimulation was used to exclude upper motor neuron involvement in two cases. The original scale of neurological distu rbances in HD has been proposed by auth...
Source: Neurological Sciences - October 3, 2018 Category: Neurology Source Type: research

Can we now say that commonalities between restless leg syndrome and migraine exist?
AbstractThe recent manuscript by Xinglong Yang and colleagues provided the first relatively reliable estimate of restless leg syndrome (RLS) prevalence among migraine sufferers, which was estimated at 19% (95% CI 14 –24%). The implications of the association between the two conditions are wide, and call for further action aimed to address common disease mechanism-associated conditions such as sleep-related ones and associated burden. (Source: Neurological Sciences)
Source: Neurological Sciences - October 2, 2018 Category: Neurology Source Type: research

Olfactory bulb atrophy in migraine patients
AbstractObjectiveOsmophobia and headache triggered by odors are commonly seen in migraine, and these are symptoms that differentiate migraine from other primary headaches. Since these odor-related symptoms are disease-specific, we aimed to measure the volume of olfactory bulb and depth of olfactory sulcus in migraine patients.Patients and methodA total of 93 subjects, consisting of 62 episodic migraine (32 with osmophobia, 30 without osmophobia) patients and 31 healthy controls, were included in this study. Diagnosis and classification of migraine were performed according to the beta version criteria of International Class...
Source: Neurological Sciences - October 2, 2018 Category: Neurology Source Type: research

Hyperresponsivity in migraine: a network dysfunction or an analytic cognitive style-connected feature?
(Source: Neurological Sciences)
Source: Neurological Sciences - October 2, 2018 Category: Neurology Source Type: research

Can we now say that commonalities between restless leg syndrome and migraine exist?
AbstractThe recent manuscript by Xinglong Yang and colleagues provided the first relatively reliable estimate of restless leg syndrome (RLS) prevalence among migraine sufferers, which was estimated at 19% (95% CI 14 –24%). The implications of the association between the two conditions are wide, and call for further action aimed to address common disease mechanism-associated conditions such as sleep-related ones and associated burden. (Source: Neurological Sciences)
Source: Neurological Sciences - October 2, 2018 Category: Neurology Source Type: research

Olfactory bulb atrophy in migraine patients
AbstractObjectiveOsmophobia and headache triggered by odors are commonly seen in migraine, and these are symptoms that differentiate migraine from other primary headaches. Since these odor-related symptoms are disease-specific, we aimed to measure the volume of olfactory bulb and depth of olfactory sulcus in migraine patients.Patients and methodA total of 93 subjects, consisting of 62 episodic migraine (32 with osmophobia, 30 without osmophobia) patients and 31 healthy controls, were included in this study. Diagnosis and classification of migraine were performed according to the beta version criteria of International Class...
Source: Neurological Sciences - October 2, 2018 Category: Neurology Source Type: research

Hyperresponsivity in migraine: a network dysfunction or an analytic cognitive style-connected feature?
(Source: Neurological Sciences)
Source: Neurological Sciences - October 2, 2018 Category: Neurology Source Type: research

Early detection of memory impairments in older adults: standardization of a short version of the verbal and nonverbal Recognition Memory Test
AbstractIn several neurological conditions, in elderly and cognitively impaired subjects, memory functioning must be evaluated to early detect the cognitive deterioration processes. In particular, recognition memory assessment is an essential step in the clinical and neuropsychological evaluation of early memory impairments. The Recognition Memory Test (RMT) developed by Smirni et al. (G Ital Psicol XXXVII(1):325 –343,2010) is an effective instrument to assess verbal and nonverbal recognition memory in the Italian population. The current study provides a new, brief, and reliable RMT format to evaluate recognition mem...
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

A novel compound heterozygous mutation of the L2HGDH gene in a Chinese boy with L-2-hydroxyglutaric aciduria: case report and literature review
ConclusionThe results suggested that NGS could provide clues for identifying patients with abnormal neuroradiological findings in the subcortical white matter. (Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Ocular flutter, generalized myoclonus, and ataxia associated with anti-GM1, GD1a, and GD1b antibodies in a 6-year-old child
(Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Pimavanserin use in a movement disorders clinic: a single-center experience
AbstractBackgroundParkinson ’s disease psychosis (PDP) is a disabling non-motor symptom of Parkinson’s disease (PD) that is challenging to treat. Dopamine receptor blockers (DRB) are used to treat PDP, though these may be associated with adverse effects, including worsening of Parkinsonism. Pimavanserin, a selective 5-HT2A receptor inverse agonist, was recently FDA-approved for treatment of PDP; however, there is limited information on its long-term use in PDP patients.MethodsA retrospective chart review of patients prescribed pimavanserin was performed in August, 2017. Data on demographics, psychotic features,...
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Hyperhomocysteinemia influenced malnutrition in Parkinson ’s disease patients
AbstractIntroductionParkinson ’s disease (PD) is a neurodegenerative disease with many motor and non-motor symptoms. Hyperhomocysteinemia is reported in many PD patients. Homocysteine (Hcy) is reported to be a risk factor for some PD non-motor symptoms.AimThe aim was to analyze Hcy level and its correlation with physical activity and motor and some non-motor symptoms (depression and cognition) in PD patients.Patients and methodsPatients were surveyed for physical activity and demographic data. Blood samples were obtained for Hcy, vitamin B12, and folic acid determination. The Mini Nutritional Assessment (MNA), Unifie...
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Dual infectious brainstem encephalitis with Aspergillus flavus and Haemophilus influenza in an immunocompetent patient
(Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Sleep disorders in Cimarosa ’s “The Secret Marriage”
(Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Radiographic and microsurgical characteristics of proximal (A1) segment aneurysms of the anterior cerebral artery
ConclusionCompared to ICBIF aneurysms, proximal A1 aneurysms were smaller and directed posteriorly, with incorporating perforators. Because of these characteristics, it may be difficult to perform clipping with 360 ° view in microsurgical field. Therefore, when planning to treat proximal A1 aneurysms, different treatment strategies may be necessary, relative to those used for ICBIF aneurysms. (Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Highlights of Issue 10, 2018
(Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Acute-on-chronic subdural hematoma: the death of the famous XIX century soprano Maria Malibran —a study of the sources
AbstractMaria Malibran (1808 –1836) is one of the most famous sopranos of the nineteenth century. In 1825, along with her father, the renowned tenor Manuel Garcia, she introduced the Italian opera in America for the first time. The European debut in Paris (1828) definitively crowned her as a star. Thus, she was requested by t he most famous European theaters. In July 1836, during an equestrian excursion in London, she fell from her horse dashing her head against the ground, resulting in astate of insensibility. Since that accident, she had suffered fromcontinual headache and nervous attacks, but she continued to work...
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Brain volume loss is present in Japanese multiple sclerosis patients with no evidence of disease activity
AbstractNo evidence of disease activity-3 (NEDA-3), defined as absence of clinical relapse, disability progression, and brain magnetic resonance imaging (MRI) activity, has emerged as the therapeutic target of disease-modifying therapy for multiple sclerosis (MS). However, recent studies have revealed that NEDA-3 might not be sufficient to prevent cognitive deterioration and predict long-term disability. In addition to NEDA-3, brain atrophy has recently been recognized as a pivotal biomarker that is closely associated to disability in patients with MS. This retrospective observational study included 22 Japanese MS patients...
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Letter to the editor: lung metastasis in WHO grade I meningioma
(Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Early detection of memory impairments in older adults: standardization of a short version of the verbal and nonverbal Recognition Memory Test
AbstractIn several neurological conditions, in elderly and cognitively impaired subjects, memory functioning must be evaluated to early detect the cognitive deterioration processes. In particular, recognition memory assessment is an essential step in the clinical and neuropsychological evaluation of early memory impairments. The Recognition Memory Test (RMT) developed by Smirni et al. (G Ital Psicol XXXVII(1):325 –343,2010) is an effective instrument to assess verbal and nonverbal recognition memory in the Italian population. The current study provides a new, brief, and reliable RMT format to evaluate recognition mem...
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Language use at Italian medical congresses
(Source: Neurological Sciences)
Source: Neurological Sciences - October 1, 2018 Category: Neurology Source Type: research

Pimavanserin use in a movement disorders clinic: a single-center experience
AbstractBackgroundParkinson ’s disease psychosis (PDP) is a disabling non-motor symptom of Parkinson’s disease (PD) that is challenging to treat. Dopamine receptor blockers (DRB) are used to treat PDP, though these may be associated with adverse effects, including worsening of Parkinsonism. Pimavanserin, a selective 5-HT2A receptor inverse agonist, was recently FDA-approved for treatment of PDP; however, there is limited information on its long-term use in PDP patients.MethodsA retrospective chart review of patients prescribed pimavanserin was performed in August, 2017. Data on demographics, psychotic features,...
Source: Neurological Sciences - September 20, 2018 Category: Neurology Source Type: research

Language use at Italian medical congresses
(Source: Neurological Sciences)
Source: Neurological Sciences - September 20, 2018 Category: Neurology Source Type: research

Headache secondary to cervical artery dissections: practice pointers
AbstractCervical artery dissections may present with mild and misleading symptoms such as a headache or cervical pain. In the absence of early diagnosis and therapy, such patients may have a high risk of cerebrovascular events. In order to refine evaluation of cervical artery dissections, we report the experience of a single center, focusing on clinical findings (e.g., headache and pain-related features at onset). From 2012 to 2017, 49 patients with cervical arteries dissections were admitted to our institution; 28 out of 49 patients (57%) presented with a headache or cervical pain, which were evaluated according to the In...
Source: Neurological Sciences - September 19, 2018 Category: Neurology Source Type: research

Ernst Tr ömner: beyond the reflex hammer
This article briefly summarizes Professor Ernst Trömner’s life and his contributions to clinical neurology and psychiatry beyond his most famous eponyms, the hammer and the finger flexor reflex. (Source: Neurological Sciences)
Source: Neurological Sciences - September 19, 2018 Category: Neurology Source Type: research

Atypical clinical manifestations of Miller Fisher syndrome
AbstractMiller Fisher syndrome (MFS) is characterized by a clinical triad of ophthalmoplegia, ataxia, and areflexia, and is closely associated with serum anti-GQ1b antibody. Although the clinical triad is the cardinal diagnostic clue, a variety of other symptoms and signs beyond the triad have been reported. To elucidate the frequency and characteristics of atypical clinical manifestations of MFS, we recruited 38 patients with MFS and evaluated the symptoms or signs beyond the classic triad. Eleven (29%) of 38 patients had atypical clinical manifestations of MFS such as headache (n = 6), delayed facial palsy ...
Source: Neurological Sciences - September 19, 2018 Category: Neurology Source Type: research