Neurolymphomatosis as primary presentation of extra-nodal NK/T-cell lymphoma, nasal type
We describe a case of a 64-year-old female patient with NL associated with extra-nodal NK/T-cell lymphoma (ENKTL), nasal type, presenting as a painful progressive mononeuropathy multiplex with an oral cavity lesion. ENKTL is usually associated with Epstein-Barr virus (EBV) infection and rarely affects the central and peripheral nervous system. Lumbar puncture, magnetic resonance imaging (MRI), nerve biopsy, and18F-fluorodeoxyglucose positron emission tomography (FDG-PET) help to establish the diagnosis. Thereby, NL should be considered in the differential diagnosis of painful progressive multiple neuropathies, even in pati...
Source: Neurological Sciences - March 12, 2024 Category: Neurology Source Type: research
Ocrelizumab use in multiple sclerosis: a real-world experience in a changing therapeutic scenario
ConclusionOCR has been confirmed to be a highly efficacious option for patients with PP and RR MS, even proving to be a valid exit strategy for natalizumab. (Source: Neurological Sciences)
Source: Neurological Sciences - March 12, 2024 Category: Neurology Source Type: research
How a good laugh can get scary: a case of gelastic stroke —looking for clues of PFO-related events
(Source: Neurological Sciences)
Source: Neurological Sciences - March 12, 2024 Category: Neurology Source Type: research
Epidemiology and management of transient ischemic attack in Trieste district, how day hospital assessment improves outcomes: a five-year retrospective study
ConclusionsIncidence of TIA in Trieste district is in line with previous data. We demonstrate the crucial role of DH evaluation over the outpatient/ED in reducing overall mortality and recurrence rate. Prompt recognition of patients at high risk for cerebrovascular events and specialist follow-up may reduce the incidence of major vascular events and death. (Source: Neurological Sciences)
Source: Neurological Sciences - March 11, 2024 Category: Neurology Source Type: research
Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson ’s disease patients
In conclusion, PVF, SVF and AVF tests are reliable, valid and diagnostically sound instruments to detect cognitive impairment in non-demented PD patients and are therefore recommended for use in clinical practice and research. (Source: Neurological Sciences)
Source: Neurological Sciences - March 11, 2024 Category: Neurology Source Type: research
Relationships between obesity and functional outcome after ischemic stroke: a Mendelian randomization study
ConclusionThe current MR study provided evidence that WHR was correlated to unfavorable outcome post-ischemic stroke. Exploring interventions against obesity may potentially improve recovery after ischemic stroke. (Source: Neurological Sciences)
Source: Neurological Sciences - March 11, 2024 Category: Neurology Source Type: research
Tacrolimus-associated neurotoxicity isolated to the brainstem: two illustrative cases and a systematic review of the literature
ConclusionsOur findings suggest that bi-TAN could represent a brainstem variant of posterior reversible encephalopathy syndrome. Recognition of bi-TAN as a potential cause of isolated brainstem lesions is crucial to disentangle the diagnostic work-up and ensure prompt withdrawal or reduction of the offending agent. (Source: Neurological Sciences)
Source: Neurological Sciences - March 9, 2024 Category: Neurology Source Type: research
Meta-analysis of the relationship between the number and location of perivascular spaces in the brain and cognitive function
ConclusionsA higher quantity of perivascular spaces in the brain is correlated with impaired cognitive function. The location of these perivascular spaces and the underlying disease conditions may influence the specific cognitive domains that are affected.Systematic review registrationThe study protocol has been registered in the PROSPERO database (CRD42023443460). (Source: Neurological Sciences)
Source: Neurological Sciences - March 9, 2024 Category: Neurology Source Type: research
Decomposed FDG PET-based phenotypic heterogeneity predicting clinical prognosis and decision-making in temporal lobe epilepsy patients
ConclusionsDecomposing18F-FDG PET-based phenotypic heterogeneity facilitates individual-level predictions relevant to disease monitoring and personalized therapeutic strategies. (Source: Neurological Sciences)
Source: Neurological Sciences - March 8, 2024 Category: Neurology Source Type: research
Before blaming metformin as a trigger for stroke-like lesions in MELAS, alternative etiologies must be off the table
(Source: Neurological Sciences)
Source: Neurological Sciences - March 6, 2024 Category: Neurology Source Type: research
A rare stroke mimic: neuronal intranuclear inclusion disease
(Source: Neurological Sciences)
Source: Neurological Sciences - March 6, 2024 Category: Neurology Source Type: research
Lettre to editor: Case report of an ictal asystole as debut in new onset epilepsy
AbstractThe case report describes a 65-year-old man with arterial hypertension and a metallic aortic valve who presented to the emergency room for a loss of consciousness event and memory impairment. The electroencephalographic recording showed right temporal epileptiform activity followed by a 9 s asystole with quick consciousness recovery. The patient was diagnosed with right temporal epilepsy with asystole and was prescribed levetiracetam to prevent new events. A pacemaker was indicated in the follow-up for the long duration of the asystole, preventing major morbidity. Ictal asystole (I A) is a rare phenomenon of epil...
Source: Neurological Sciences - March 6, 2024 Category: Neurology Source Type: research
Long-term effects of SARS-CoV-2 infection in patients with and without chemosensory disorders at disease onset: a psychophysical and magnetic resonance imaging exploratory study
AbstractA preserved sense of smell and taste allows us to understand many environmental “messages” and results in meaningfully improvements to quality of life. With the COVID-19 pandemic, it became clear how important these senses are for social and nutritionalstatus and catapulted thisniche chemosensory research area towards widespread interest. In the current exploratory work, we assessed two groups of post-COVID-19 patients who reported having had (Group 1) or not (Group 2) a smell/taste impairment at the disease onset. The aim was to compare them using validated smell and taste tests as well as with brain magnetic ...
Source: Neurological Sciences - March 5, 2024 Category: Neurology Source Type: research
JAM2 variants can be more common in primary familial brain calcification (PFBC) cases than those appear; may be due to a founder mutation
ConclusionBased on our results, p.Arg229* may be a founder mutation in the Iranian population. The variant has been detected in two out of seven other reportedJAM2-related families who may originate from the Middle East and exhibit an identical haplotype. Even though this particular mutation may not be classified as a founder mutation, it does appear to be a hotspot, given that it has been observed in 45% of the 11JAM2-associated families. Our study expanded the clinical features and mutation spectrum ofJAM2 and revealed that mutations inJAM2 may be more common than previously reported. (Source: Neurological Sciences)
Source: Neurological Sciences - March 5, 2024 Category: Neurology Source Type: research
Letter regarding the article “Stroke in a young adult: looking beyond the diffusion-weighted imaging sequence”
(Source: Neurological Sciences)
Source: Neurological Sciences - March 5, 2024 Category: Neurology Source Type: research
