Lemierre ’s: a forgotten disease and a rare cause of cranial neuropathy – a case report
(Source: Neurological Sciences)
Source: Neurological Sciences - December 27, 2023 Category: Neurology Source Type: research
Bariatric surgery and dimethyl fumarate-induced lymphopenia in patients with multiple sclerosis
ConclusionsSeveral mechanisms might modify DMF pharmacokinetic profiles after bariatric surgery and its bioavailability. Absolute lymphocyte count should be monitored in pwMS treated with DMF and history of bariatric surgery and weight loss. (Source: Neurological Sciences)
Source: Neurological Sciences - December 27, 2023 Category: Neurology Source Type: research
Hyperglycemia affects axial signs in patients with Parkinson ’s disease through mechanisms of insulin resistance or non-insulin resistance
ConclusionsPWP with high HbA1c showed worse axial symptoms, including dysfunction of automatic walking, dynamic balance, and postural control than those with low HbA1c. In PWP, the effects of hyperglycemia on automatic walking speed may be associated with the IR-related mechanisms, and the effects on dynamic balance and postural control may be related to mechanisms other than IR. (Source: Neurological Sciences)
Source: Neurological Sciences - December 26, 2023 Category: Neurology Source Type: research
Neuro-oncological research output in Africa: a scoping review of primary brain tumors
ConclusionThe interest in African neuro-oncological research is increasing. Hence, there is a need for ongoing efforts to address issues with clinical practice and public health related to neurological tumors in the continent. Future studies should concentrate on filling in knowledge gaps and investigating novel methods for neuro-oncological conditions that affect African populations in terms of prevention, diagnosis, treatment, and management strategies. (Source: Neurological Sciences)
Source: Neurological Sciences - December 26, 2023 Category: Neurology Source Type: research
Neurofilament light chain as a biomarker in neuromyelitis optica spectrum disorder: a comprehensive review and integrated analysis with glial fibrillary acidic protein
ConclusionsNfL and GFAP hold promise as biomarkers for NMOSD, demonstrating their usefulness in distinguishing patients from healthy individuals, assessing disease severity, and possibly reflecting treatment response. However, it is important to recognize that NfL and GFAP may, at some point, have different roles. (Source: Neurological Sciences)
Source: Neurological Sciences - December 23, 2023 Category: Neurology Source Type: research
Very late onset methylmalonic acidemia (cblB type) as a cause of status epilepticus, leukoencephalopathy and myelopathy
(Source: Neurological Sciences)
Source: Neurological Sciences - December 22, 2023 Category: Neurology Source Type: research
Advancements in investigating the role of cerebral small vein loss in Alzheimer ’s disease–related pathological changes
AbstractAlzheimer ’s disease (AD) is the prevailing type of dementia in the elderly, yet a comprehensive comprehension of its precise underlying mechanisms remains elusive. The investigation of the involvement of cerebral small veins in the advancement of AD has yet to be sufficiently explored in previous studies, primarily due to constraints associated with pathological staining techniques. However, recent research has provided valuable insights into multiple pathophysiological occurrences concerning cerebral small veins in AD, which may manifest sequentially, concurrently, or in a self-perpetuating manner. These events...
Source: Neurological Sciences - December 22, 2023 Category: Neurology Source Type: research
Verbal and non-verbal recognition memory assessment: validation of a computerized version of the Recognition Memory Test
ConclusionThe computerized version of the RMT can be used as a reliable alternative to the traditional version. (Source: Neurological Sciences)
Source: Neurological Sciences - December 22, 2023 Category: Neurology Source Type: research
Is blood pTau a reliable indicator of the CSF status? A narrative review
ConclusionsOur results encourage the use of blood pTau for the early identification of patients with AD continuum. (Source: Neurological Sciences)
Source: Neurological Sciences - December 22, 2023 Category: Neurology Source Type: research
Malignant atrophic papulosis (Degos disease) with central nervous system involvement
AbstractA 49-year-old man presented with a 2-year history of weakness and sensory disturbances in the bilateral lower extremities, vesicorectal dysfunction, and progressive gait disturbances. Brain MRI revealed multiple ischemic and hemorrhagic cortical/subcortical lesions with patchy enhancement involving the frontal and parietal lobes, suggesting the possibility of distal perforating arteries injury. Spine MRI revealed lesions of the cervical and thoracic spinal cord with associated enhancement. The diagnosis of malignant atrophic papulosis (Degos disease) with central nervous system involvement was prompted by the chara...
Source: Neurological Sciences - December 21, 2023 Category: Neurology Source Type: research
Future treatment options for facial nerve palsy: a review on electrical stimulation devices for the orbicularis oculi muscle
This article offers a comprehensive review of electrical stimulation parameters necessary to achieve full functionality and a natural-looking eye blink in human subjects. At present, readily available portable electrical stimulation devices remain unavailable. This review lays the foundation for advancing knowledge from laboratory research to clinical practice, with the ultimate objective of developing a portable electrical stimulation device. Further research is essential to enhance our understanding of electrical stimulation, establish safety standards, determine optimal current settings, and investigate potential side e...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research
Therapeutic effects of repetitive transcranial magnetic stimulation in patients with cerebral palsy: a systematic review and network meta-analysis
AbstractThe purpose of this study was to systematically evaluate the efficacy of repetitive transcranial magnetic stimulation in children with cerebral palsy and to compare the differences in efficacy of different treatment parameters. Computer searches of PubMed, Embase, Cochrane Library, Scopus, Web of Science, China Knowledge Network, Wanfang Data Knowledge Service Platform, Vipshop and China Biomedical Literature Database were conducted to collect randomized controlled trials (RCTs) of TMS to improve function in children with cerebral palsy. The search period was from the establishment of the database to April 2023. Tw...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research
Current use of fluid biomarkers as outcome measures in Multiple Sclerosis (MS): a review of ongoing pharmacological clinical trials
AbstractThe present study aims to describe the state of the art of fluid biomarkers use in ongoing multiple sclerosis (MS) clinical trials.A review of 608 ongoing protocols in the clinicaltrials.gov and EudraCT databases was performed. The trials enrolled patients with a diagnosis of relapsing remitting MS, secondary progressive MS, and/or primary progressive MS according to Revised McDonald criteria or relapsing MS according to Lublin et al. (2014). The presence of fluid biomarkers among the primary and/or secondary study outcomes was assessed.Overall, 5% of ongoing interventional studies on MS adopted fluid biomarkers. T...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research
Cerebral hemodynamics and cognitive functions in the acute and subacute stage of mild ischemic stroke: a longitudinal pilot study
AbstractThe association between cerebral hemodynamics and cognitive impairment has been reported in neurodegenerative and cerebrovascular disorders (CVD). However, it is still unclear whether changes occur in the acute phase of CVD. Here we investigated cognitive and hemodynamic parameters and their association in patients with CVD during the acute and subacute phases. Seventy-three patients with mild stroke, not undergoing endovascular treatment, were recruited. All subjects were devoid of intracranial or external carotid stenosis, significant chronic cerebrovascular pathology, dementia or non-compensated cardiovascular d...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research
Future treatment options for facial nerve palsy: a review on electrical stimulation devices for the orbicularis oculi muscle
This article offers a comprehensive review of electrical stimulation parameters necessary to achieve full functionality and a natural-looking eye blink in human subjects. At present, readily available portable electrical stimulation devices remain unavailable. This review lays the foundation for advancing knowledge from laboratory research to clinical practice, with the ultimate objective of developing a portable electrical stimulation device. Further research is essential to enhance our understanding of electrical stimulation, establish safety standards, determine optimal current settings, and investigate potential side e...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research
