Neurological onset in patients with V122I hereditary transthyretin amyloidosis: a glitch in the paradigm
(Source: Neurological Sciences)
Source: Neurological Sciences - November 13, 2023 Category: Neurology Source Type: research
Delayed onset Bickerstaff brainstem encephalitis overlapping Miller-Fisher Syndrome during SARS-CoV-2 infection
We report a case of a patient affected by delayed onset BBE overlapping MFS during a mild SARS-CoV-2 infection. To the best of our knowledge, similar cases have never been reported. (Source: Neurological Sciences)
Source: Neurological Sciences - November 13, 2023 Category: Neurology Source Type: research
Dramatic improvement of a rare patient with PARK-14 linked young-onset parkinsonism after STN-DBS therapy
(Source: Neurological Sciences)
Source: Neurological Sciences - November 13, 2023 Category: Neurology Source Type: research
The incidence and prevalence of crude and familial multiple sclerosis in Tehran, Iran in 2021
AbstractOur registry-based cross-sectional study covered 27,508 PwMS in Tehran with a point incidence rate and prevalence of 7.87 and 194.62 per 100,000 in 2021, respectively. We found that the incidence and prevalence of MS in Tehran are still on an upward trend which requires general attention and measures to overcome. The proportion of men with a family history of MS was significantly higher. Whilst IMSS deals with economic difficulties, it continues to collect new PwMS to reach regional-level coverage in Tehran for better MS care services. (Source: Neurological Sciences)
Source: Neurological Sciences - November 13, 2023 Category: Neurology Source Type: research
Progressive multifocal leukoencephalopathy in patients with chronic kidney disease
AbstractProgressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system infection caused by the human polyomavirus 2, leading to demyelination from oligodendrocyte death and rapid neurologic decline. Most commonly, PML affects patients in immunocompromised states. However, rare reports of PML in an immunocompetent host exist. Here, we report two cases of PML in older individuals with chronic kidney disease (CKD). CKD can ultimately lead to immune system dysfunction and place patients in a relatively immunosuppressed state. Testing for JC virus should remain a consideration for rapid, unexplained...
Source: Neurological Sciences - November 11, 2023 Category: Neurology Source Type: research
Incidence of amyotrophic lateral sclerosis-associated genetic variants: a clinic-based study
ConclusionOver half of our ALS patients carried variants of ALS-related genes, most of which were variants of uncertain significance (VUS). Family history of ALS could work as strong evidence for carrying P/LP variants regarding ALS. There was no additionally suggestive effect of indicators including early onset, progression rate, cognitive decline, or cerebellar ataxia on the recommendation of genetic testing in clinical practice. (Source: Neurological Sciences)
Source: Neurological Sciences - November 11, 2023 Category: Neurology Source Type: research
Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis
ConclusionThis meta-analysis identified risk factors for postoperational VTE in patients with brain tumor, which can serve as a theoretical foundation for medical staff to manage and treat VTE.Trial registrationCRD42023357459 (Source: Neurological Sciences)
Source: Neurological Sciences - November 10, 2023 Category: Neurology Source Type: research
Exploring the knowledge, attitudes, and practices on sexual and gender minorities patients: a survey on Italian Neurologists
ConclusionTo enhance healthcare quality for SGM populations, healthcare professionals must receive appropriate training in how to approach, assess, and treat patients within this demographic. (Source: Neurological Sciences)
Source: Neurological Sciences - November 10, 2023 Category: Neurology Source Type: research
Progress in direct reprogramming of dopaminergic cell replacement therapy
AbstractParkinson ’s disease (PD) is a gradual neurodegenerative disease. While drug therapy and surgical treatments have been the primary means of addressing PD, they do not offer a cure, and the risks associated with surgical treatment are high. Recent advances in cell reprogramming have given rise to new prospec ts for the treatment of Parkinson’s disease (PD), with induced pluripotent stem cells (iPSCs), induced dopamine neurons (iDNs), and induced neural stem cells (iNSCs) being created. These cells can potentially be used in the treatment of Parkinson’s disease. On the other hand, this article emphas izes the l...
Source: Neurological Sciences - November 10, 2023 Category: Neurology Source Type: research
The effect of the COVID-19 pandemic and its related social restriction measures on emergency department visits for transient global amnesia: an interrupted time-series analysis
(Source: Neurological Sciences)
Source: Neurological Sciences - November 10, 2023 Category: Neurology Source Type: research
Acute Symptomatic Seizures and Risk of Seizure Recurrence in Patients with Anti-NMDAR, Anti-LGI1, and Anti-GABABR Encephalitis
ConclusionsAcute symptomatic seizure is a common clinical feature observed in patients with anti-NMDAR, anti-LGI1, and anti-GABABR encephalitis, with 50% of patients presenting with seizures as an initial symptom. The prognosis of patients with acute symptomatic seizures can be improved after receiving immunotherapy. Nevertheless, a minority of patients will experience seizure recurrence; therefore, restarting immunotherapy is recommended. (Source: Neurological Sciences)
Source: Neurological Sciences - November 9, 2023 Category: Neurology Source Type: research
Safety and neutralization antibody levels of inactivated SARS-CoV-2 vaccine in adult patients with Myasthenia Gravis: a prospective observational cohort study
DiscussionThe safety of the SARS-CoV-2 inactivated vaccine was reconfirmed in this study. No significant difference in Nabs level was found between patients with MG and HCs. Nabs levels correlated with AChR-Ab levels before vaccination and ΔAChR-Ab levels. (Source: Neurological Sciences)
Source: Neurological Sciences - November 9, 2023 Category: Neurology Source Type: research
No causal relationship between thyroid function and Parkinson ’s disease: A bidirectional Mendelian randomization study
ConclusionMR analysis did not support a causal relationship between thyroid function and PD. (Source: Neurological Sciences)
Source: Neurological Sciences - November 9, 2023 Category: Neurology Source Type: research
Progression of enlarged perivascular spaces contributes to occurrence of silent lacunar infarction in the elderly
Conclusion3D volume quantification allows for a more sensitive assessment of EPVS changes, and the progression of EPVS volume may contribute to the occurrence of SLI. (Source: Neurological Sciences)
Source: Neurological Sciences - November 9, 2023 Category: Neurology Source Type: research
Early detection of nerve involvement in presymptomatic TTR mutation carriers: exploring potential markers of disease onset
ConclusionsA close, multidisciplinary monitoring of presymptomaticTTR mutation carriers is fundamental, and diagnostic workup should include both routine and “unconventional” tests. Assessment of SF involvement is important also in non-endemic countries. (Source: Neurological Sciences)
Source: Neurological Sciences - November 8, 2023 Category: Neurology Source Type: research
