Future treatment options for facial nerve palsy: a review on electrical stimulation devices for the orbicularis oculi muscle
This article offers a comprehensive review of electrical stimulation parameters necessary to achieve full functionality and a natural-looking eye blink in human subjects. At present, readily available portable electrical stimulation devices remain unavailable. This review lays the foundation for advancing knowledge from laboratory research to clinical practice, with the ultimate objective of developing a portable electrical stimulation device. Further research is essential to enhance our understanding of electrical stimulation, establish safety standards, determine optimal current settings, and investigate potential side e...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research

Cerebral hemodynamics and cognitive functions in the acute and subacute stage of mild ischemic stroke: a longitudinal pilot study
AbstractThe association between cerebral hemodynamics and cognitive impairment has been reported in neurodegenerative and cerebrovascular disorders (CVD). However, it is still unclear whether changes occur in the acute phase of CVD. Here we investigated cognitive and hemodynamic parameters and their association in patients with CVD during the acute and subacute phases. Seventy-three patients with mild stroke, not undergoing endovascular treatment, were recruited. All subjects were devoid of intracranial or external carotid stenosis, significant chronic cerebrovascular pathology, dementia or non-compensated cardiovascular d...
Source: Neurological Sciences - December 20, 2023 Category: Neurology Source Type: research

Cognitive function in amyotrophic lateral sclerosis: a cross-sectional and prospective pragmatic clinical study with review of the literature
ConclusionThe incorporation of cognitive screening in the diagnostic workup of ALS may be beneficial, as early detection can enhance symptom management and improve the quality of life for both individuals with ALS and their care partners. (Source: Neurological Sciences)
Source: Neurological Sciences - December 18, 2023 Category: Neurology Source Type: research

Masitinib as a neuroprotective agent: a scoping review of preclinical and clinical evidence
ConclusionThe current evidence suggests a promising therapeutic benefit of masitinib in neurodegenerative diseases. However, further research is necessary to validate and expand upon these findings, particularly regarding the precise mechanisms through which masitinib exerts its therapeutic effects. Future studies should also focus on addressing the safety concerns associated with masitinib use. (Source: Neurological Sciences)
Source: Neurological Sciences - December 18, 2023 Category: Neurology Source Type: research

Eculizumab for myasthenic exacerbation during treatment with immune-checkpoint inhibitors
DiscussionEculizumab potentially offers a mechanism-based treatment of MG in patients under anti-programmed cell death protein 1 (PD-1) agents, without interfering with their mechanism of action and avoiding their discontinuation. Larger case series deserve to be evaluated. (Source: Neurological Sciences)
Source: Neurological Sciences - December 18, 2023 Category: Neurology Source Type: research

Cognitive function in amyotrophic lateral sclerosis: a cross-sectional and prospective pragmatic clinical study with review of the literature
ConclusionThe incorporation of cognitive screening in the diagnostic workup of ALS may be beneficial, as early detection can enhance symptom management and improve the quality of life for both individuals with ALS and their care partners. (Source: Neurological Sciences)
Source: Neurological Sciences - December 18, 2023 Category: Neurology Source Type: research

Masitinib as a neuroprotective agent: a scoping review of preclinical and clinical evidence
ConclusionThe current evidence suggests a promising therapeutic benefit of masitinib in neurodegenerative diseases. However, further research is necessary to validate and expand upon these findings, particularly regarding the precise mechanisms through which masitinib exerts its therapeutic effects. Future studies should also focus on addressing the safety concerns associated with masitinib use. (Source: Neurological Sciences)
Source: Neurological Sciences - December 18, 2023 Category: Neurology Source Type: research

Eculizumab for myasthenic exacerbation during treatment with immune-checkpoint inhibitors
DiscussionEculizumab potentially offers a mechanism-based treatment of MG in patients under anti-programmed cell death protein 1 (PD-1) agents, without interfering with their mechanism of action and avoiding their discontinuation. Larger case series deserve to be evaluated. (Source: Neurological Sciences)
Source: Neurological Sciences - December 18, 2023 Category: Neurology Source Type: research

Clinical application of repetitive transcranial magnetic stimulation in improving functional impairments post-stroke: review of the current evidence and potential challenges
This article reviews the application and research progress of rTMS in treating different f unctional impairments (cognitive impairment, motor dysfunction, unilateral spatial neglect, depression) after stroke in recent years, and preliminary summarized the possible mechanisms. It has been found that the key parameters that determine the effectiveness of rTMS in improving post-stroke functi onal impairments include pulse number, stimulated brain areas, stimulation intensity and frequency, as well as duration. Generally, high-frequency stimulation is used to excite the ipsilateral cerebral cortex, while low-frequency stimulat...
Source: Neurological Sciences - December 16, 2023 Category: Neurology Source Type: research

Effectiveness of transcranial direct current stimulation in chronic pain and neurogenic claudication related to lumbar spinal stenosis
ConclusiontDCS shows potential as a safe, non-invasive technique for alleviating chronic LSS-related pain, enhancing mobility, functionality, and quality of life.Trial registrationClinicaltrials.gov ID: NCT03958526. (Source: Neurological Sciences)
Source: Neurological Sciences - December 13, 2023 Category: Neurology Source Type: research

Neuromyelitis optica associated with the use of Atezolizumab in a patient with advanced lung adenocarcinoma
We describe a case of seropositive neuromyelitis optica in a patient with locally advanced lung adenocarcinoma treated with Atezolizumab. (Source: Neurological Sciences)
Source: Neurological Sciences - December 13, 2023 Category: Neurology Source Type: research

Objective assessment of the effects of opicapone in Parkinson ’s disease through kinematic analysis
ConclusionsThis study is the first objective assessment of the effects of adding OPC to L-DOPA on bradykinesia in patients with PD and motor fluctuations. OPC, in addition to the standard dopaminergic therapy, leads to significant improvements in bradykinesia during clinically relevant periods associated with peripheral L-DOPA dynamics, i.e., the OFF state in the morning, delayed-ON, and wearing-OFF periods. (Source: Neurological Sciences)
Source: Neurological Sciences - December 13, 2023 Category: Neurology Source Type: research

Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum
AbstractSleep abnormalities may represent an independent risk factor for neurodegeneration. An international expert group convened in 2021 to discuss the state-of-the-science in this domain. The present article summarizes the presentations and discussions concerning the importance of a strategy for studying sleep- and circadian-related interventions for early detection and prevention of neurodegenerative diseases. An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5  years; discussed the current challenges in the field of relationships among slee...
Source: Neurological Sciences - December 13, 2023 Category: Neurology Source Type: research

Are anti-calcitonin gene-related peptide monoclonal antibodies effective in treating migraine aura? A pilot prospective observational cohort study
ConclusionOur findings suggest that anti-CGRP mAbs are highly effective in migraine with aura, both in reducing mean monthly aura days and mean monthly days with headache. (Source: Neurological Sciences)
Source: Neurological Sciences - December 13, 2023 Category: Neurology Source Type: research