Sudden unexpected death in epilepsy and ictal asystole in patients with autoimmune encephalitis: a systematic review
DiscussionSUDEP and IA can be linked to AE, suggesting a role of the limbic system in their pathogenesis. IA tends to manifest in female patients with temporal lobe seizures early in AE, highlighting the importance of early diagnosis and treatment. (Source: Neurological Sciences)
Source: Neurological Sciences - January 9, 2024 Category: Neurology Source Type: research

Efficacy of dual-task augmented reality rehabilitation in non-hospitalized adults with self-reported long COVID fatigue and cognitive impairment: a pilot study
ConclusionThe preliminary results  from this study suggest that dual-task rehabilitation could be a feasible protocol to support cognitive symptoms recovery after COVID-19 and could be helpful in those individuals suffering from persisting and invalidating symptoms. (Source: Neurological Sciences)
Source: Neurological Sciences - January 9, 2024 Category: Neurology Source Type: research

Chitinases as a potential diagnostic and prognostic biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis
AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, and there is currently a lack of reliable diagnostic biomarkers. This meta-analysis aimed to evaluate CHIT1, CHI3L1, and CHI3L2 levels in the cerebrospinal fluid (CSF) or blood and their diagnostic potential in ALS patients. A systematic, comprehensive search was performed of peer-reviewed English-language articles published before April 1, 2023, in PubMed, Scopus, Embase, Cochrane Library, and Web of Science. After a thorough screening, 13 primary articles were included, and their chitinases...
Source: Neurological Sciences - January 9, 2024 Category: Neurology Source Type: research

The TsiogkaSpaeth grid for detection of neurological visual field defects: a validation study
ConclusionThe sensitivity and specificity of the TS grid test were high in detecting VF defects in neurological disease. The TS grid test appears to be a reliable, low-cost, and easily accessed alternative to traditional VF tests in diagnosing typical neurological patterns of visual field defects. It would be useful in screening subjects for neurologically derived ocular morbidity in everyday clinical practice and in remote areas deprived of specialized health care services. (Source: Neurological Sciences)
Source: Neurological Sciences - January 8, 2024 Category: Neurology Source Type: research

Anti-pan-neurofascin nodopathy: cause of fulminant neuropathy
We describe the clinical case of a patient with autoimmune nodopathy caused by the coexistence of anti-neurofascin (NF) 186/140 and 155, characterized by progressive weakness in all limbs leading to tetraplegia, involving cranial nerves, and respiratory insufficiency. Response to first-line treatments was good followed by rapid dramatic clinical relapse. There are few reported cases of anti-pan NF neuropathy in the literature, and they present a clinical phenotype similar to our patient. In these cases, early recognition of clinical red flags of nodopathies and serial neurophysiological studies can facilitate the diagnosis...
Source: Neurological Sciences - January 8, 2024 Category: Neurology Source Type: research

Reading the mind in the eyes in patients with idiopathic REM sleep behavior disorder
ConclusionsThe changes in RME had a relationship with cognitive impairments, especially memory, in patients with iRBD. (Source: Neurological Sciences)
Source: Neurological Sciences - January 8, 2024 Category: Neurology Source Type: research

Kinect-based objective assessment of the acute levodopa challenge test in parkinsonism: a feasibility study
ConclusionThis study demonstrated the feasibility of measuring the effect of levodopa and objectively assessing ALCT based on kinematic data derived from an Azure Kinect-based system. (Source: Neurological Sciences)
Source: Neurological Sciences - January 6, 2024 Category: Neurology Source Type: research

Impact of delirium on acute stroke outcomes: A systematic review and meta-analysis
AbstractDelirium is a common complication in acute stroke patients. A 2011 meta-analysis showed an increased risk of in-hospital mortality and mortality within 12  months post-stroke, longer hospitalization durations, and increased likelihood of being discharged to a nursing home for patients experiencing post-stroke delirium. There is a need for an updated meta-analysis with several new studies having been since published. The PubMed and Scopus databases we re screened for relevant studies. Inclusion criteria were as follows: retrospective or prospective studies reporting on the effects of delirium accompanying acute str...
Source: Neurological Sciences - January 5, 2024 Category: Neurology Source Type: research

Enhancing clinical awareness: retrospective analysis of neurosyphilis cases and diagnostic predictors for early recognition and treatment
ConclusionThe study highlights the importance of neurological and/or ocular symptoms in diagnosing symptomatic neurosyphilis. Individuals with hypomnesia should be closely monitored for potential neurosyphilis. Integrating clinical manifestations, laboratory tests, EEG, and imaging can reduce misdiagnosis. This comprehensive approach shows promise in improving early identification and management of neurosyphilis. (Source: Neurological Sciences)
Source: Neurological Sciences - January 4, 2024 Category: Neurology Source Type: research

Associations of liver function with plasma biomarkers for Alzheimer ’s Disease
ConclusionLiver function was associated with the plasma levels of AD biomarkers. It needs to consider the potential influence of liver function on the reference ranges and the interpretation of results for AD biomarkers before clinical use. (Source: Neurological Sciences)
Source: Neurological Sciences - January 4, 2024 Category: Neurology Source Type: research

Acute disseminated encephalomyelitis following Saint Louis encephalitis virus infection
We present a case of a 55-year-old man hailing from Manaus, a city situated in the heart of theAmazon Rainforest, who exhibited symptoms of vertigo, tremors, urinary and fecal retention, compromised gait, and encephalopathy 3  weeks following SLEV infection. Neuroaxis MRI revealed diffuse, asymmetric, and poorly defined margins hyperintense lesions with peripheral and ring enhancement in subcortical white matter, as well as severe spinal cord involvement. Serology for SLEV was positive both on serum and cerebrospinal fl uid. To the best of our knowledge, the present report is the first to show brain lesions along with mye...
Source: Neurological Sciences - January 4, 2024 Category: Neurology Source Type: research

SARS-CoV-2 ’s brain impact: revealing cortical and cerebellar differences via cluster analysis in COVID-19 recovered patients
ConclusionThis data-driven division into two groups based on the brain structural differences, and the possible link to D-dimer values may provide insights into the underlying mechanisms of SARS-COV-2 neurological disruption and its impact on the brain during and after recovery from the disease. (Source: Neurological Sciences)
Source: Neurological Sciences - January 4, 2024 Category: Neurology Source Type: research

Influence of cognition on the correlation between objective and subjective upper limb measures in people with multiple sclerosis
DiscussionFindings suggest that cognitive impairment is associated with subjects ’ performance on 9-HPT, BBT, and MAM-36 (but not HGS), resulting in scores indicating a poorer UL function. Interestingly, cognitive impairment slightly affected the congruence between subjective and objective UL measures, although only minor differences in the correlation pattern across groups re porting different cognitive performances emerged. (Source: Neurological Sciences)
Source: Neurological Sciences - January 4, 2024 Category: Neurology Source Type: research

Causal associations between 25-hydroxyvitamin D levels and NMOSD: a two-Sample Mendelian randomization analysis
(Source: Neurological Sciences)
Source: Neurological Sciences - January 4, 2024 Category: Neurology Source Type: research

Safety and efficacy of bone marrow mononuclear cell therapy for ischemic stroke recovery: a systematic review and meta-analysis of randomized controlled trials
ConclusionOur meta-analysis demonstrated that the transplantation of BMMNCs was safe; however, the efficacy of this procedure requires further validation in larger RTCs. (Source: Neurological Sciences)
Source: Neurological Sciences - January 3, 2024 Category: Neurology Source Type: research