Racial differences in the response to multiple sclerosis therapy
Nature Reviews Neurology, Published online: 07 May 2021; doi:10.1038/s41582-021-00507-7Racial differences in the response to multiple sclerosis therapy (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 7, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Defining traumatic encephalopathy syndrome — advances and challenges
Nature Reviews Neurology, Published online: 04 May 2021; doi:10.1038/s41582-021-00500-0Chronic traumatic encephalopathy (CTE) is presumed to be associated with a clinical condition termed traumatic encephalopathy syndrome (TES). A new set of research diagnostic criteria for TES might be an improvement over previous guidelines, but many questions surrounding the putative link between head impacts, CTE neuropathology and neurobehavioural symptoms remain unanswered. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 4, 2021 Category: Neurology Authors: C. Munro Cullum Christian LoBue Source Type: research

A promising new therapy for ALS
Nature Reviews Neurology, Published online: 30 April 2021; doi:10.1038/s41582-021-00504-wA promising new therapy for ALS (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 30, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
Nature Reviews Neurology, Published online: 29 April 2021; doi:10.1038/s41582-021-00487-8The failure to identify disease-modifying therapies for amyotrophic lateral sclerosis (ALS) could relate to the prevailing motor neuron-centric view of this neurodegenerative disorder. This Review considers the evidence for involvement of non-neuronal cells — in particular, microglia, astrocytes and oligodendrocytes — in ALS pathogenesis. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 29, 2021 Category: Neurology Authors: Bj örn F. Vahsen Elizabeth Gray Alexander G. Thompson Olaf Ansorge Daniel C. Anthony Sally A. Cowley Kevin Talbot Martin R. Turner Source Type: research

Reply to: Assessing prospective memory beyond experimental tasks
Nature Reviews Neurology, Published online: 28 April 2021; doi:10.1038/s41582-021-00501-zReply to: Assessing prospective memory beyond experimental tasks (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 28, 2021 Category: Neurology Authors: Julie D. Henry Source Type: research

Assessing prospective memory beyond experimental tasks
Nature Reviews Neurology, Published online: 28 April 2021; doi:10.1038/s41582-021-00499-4Assessing prospective memory beyond experimental tasks (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 28, 2021 Category: Neurology Authors: Mathieu Hainselin Yannick Gounden Geoffrey Blondelle Source Type: research

COVID-19 dominates discussions at AAN 2021
Nature Reviews Neurology, Published online: 27 April 2021; doi:10.1038/s41582-021-00502-yCOVID-19 dominates discussions at AAN 2021 (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 27, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Prodromal Parkinson disease subtypes — key to understanding heterogeneity
Nature Reviews Neurology, Published online: 20 April 2021; doi:10.1038/s41582-021-00486-9In this Review, Berg et al. summarize current understanding of prodromal Parkinson disease and consider the prodrome in the context of the clinical and pathological heterogeneity of the disease. They explore the possibility that prodromal Parkinson disease can be classified into subtypes. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 20, 2021 Category: Neurology Authors: Daniela Berg Per Borghammer Seyed-Mohammad Fereshtehnejad Sebastian Heinzel Jacob Horsager Eva Schaeffer Ronald B. Postuma Source Type: research

High-frequency spinal cord stimulation alleviates painful diabetic neuropathy
Nature Reviews Neurology, Published online: 12 April 2021; doi:10.1038/s41582-021-00493-wHigh-frequency spinal cord stimulation alleviates painful diabetic neuropathy (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 12, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Microglial changes associated with meningeal inflammation in multiple sclerosis
Nature Reviews Neurology, Published online: 12 April 2021; doi:10.1038/s41582-021-00494-9Microglial changes associated with meningeal inflammation in multiple sclerosis (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 12, 2021 Category: Neurology Authors: Heather Wood Source Type: research

IDH1 vaccine shows potential in astrocytoma
Nature Reviews Neurology, Published online: 12 April 2021; doi:10.1038/s41582-021-00495-8IDH1 vaccine shows potential in astrocytoma (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 12, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Could perampanel treat Parkinson disease?
Nature Reviews Neurology, Published online: 12 April 2021; doi:10.1038/s41582-021-00492-xCould perampanel treat Parkinson disease? (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 12, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Crosstalk between prolactin and CGRP signalling contributes to migraine in females
Nature Reviews Neurology, Published online: 07 April 2021; doi:10.1038/s41582-021-00491-yCrosstalk between prolactin and CGRP signalling contributes to migraine in females (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 7, 2021 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Microglial optogenetics triggers chronic pain in mice
Nature Reviews Neurology, Published online: 07 April 2021; doi:10.1038/s41582-021-00490-zMicroglial optogenetics triggers chronic pain in mice (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 7, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

Prodromal Parkinson disease — time is brain
Nature Reviews Neurology, Published online: 06 April 2021; doi:10.1038/s41582-021-00489-6Biomarkers that predict conversion from isolated REM sleep behaviour disorder to Parkinson disease are urgently needed. A new study finds that detection of misfolded α-synuclein in the cerebrospinal fluid is a good marker of conversion risk, but an inability to predict the timeline of progression might limit its utility. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 6, 2021 Category: Neurology Authors: Sandrina Weber Brit Mollenhauer Source Type: research

Cluster headache pathophysiology — insights from current and emerging treatments
Nature Reviews Neurology, Published online: 29 March 2021; doi:10.1038/s41582-021-00477-wIn this Review, Wei and Goadsby discuss the pathophysiology of cluster headache, the treatments available and their mechanisms, and the insights being provided by results from trials of emerging treatments, which indicate mechanistic differences between episodic and chronic cluster headache. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 29, 2021 Category: Neurology Authors: Diana Y. Wei Peter J. Goadsby Source Type: research

Reply to: Neuroimmune interactions and COVID-19 in lung transplant recipients
Nature Reviews Neurology, Published online: 24 March 2021; doi:10.1038/s41582-021-00485-wReply to: Neuroimmune interactions and COVID-19 in lung transplant recipients (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 24, 2021 Category: Neurology Authors: Francesco De Virgiliis Simone Di Giovanni Source Type: research

Neuroimmune interactions and COVID-19 in lung transplant recipients
Nature Reviews Neurology, Published online: 24 March 2021; doi:10.1038/s41582-021-00484-xNeuroimmune interactions and COVID-19 in lung transplant recipients (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 24, 2021 Category: Neurology Authors: Joan Arenas-Prat Source Type: research

Isoform-dependent APOE secretion modulates neuroinflammation
Nature Reviews Neurology, Published online: 16 March 2021; doi:10.1038/s41582-021-00483-yApolipoprotein E (APOE) is the most abundant apolipoprotein in the brain, where it is primarily expressed and secreted by astrocytes and microglia. APOE seems to exert immunomodulatory effects in an isoform-dependent way, and a new study indicates that the APOE isoform dictates the glycosylation state and secretion of this apolipoprotein. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 16, 2021 Category: Neurology Authors: Philip Hasel Shane A. Liddelow Source Type: research

Cycles in epilepsy
Nature Reviews Neurology, Published online: 15 March 2021; doi:10.1038/s41582-021-00464-1In this Review, the authors provide an overview of the evidence for daily, multi-day and yearly cycles in epileptic brain activity. They also discuss advances in our understanding of the mechanisms underlying these cycles and the potential clinical applications of this knowledge. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 15, 2021 Category: Neurology Authors: Philippa J. Karoly Vikram R. Rao Nicholas M. Gregg Gregory A. Worrell Christophe Bernard Mark J. Cook Maxime O. Baud Source Type: research

Multifaceted microglia — key players in primary brain tumour heterogeneity
Nature Reviews Neurology, Published online: 10 March 2021; doi:10.1038/s41582-021-00463-2Microglia are the first immune cells to encounter a developing primary brain tumour and have both tumour-supporting and antitumour effects. Here, Keane et al. consider the emerging evidence indicating that tumour-associated macrophages and microglia influence tumour initiation and progression as well as responses to therapy. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 10, 2021 Category: Neurology Authors: Lily Keane Mathilde Cheray Klas Blomgren Bertrand Joseph Source Type: research

Antibody targets apolipoprotein E to remove amyloid-β deposits
Nature Reviews Neurology, Published online: 09 March 2021; doi:10.1038/s41582-021-00479-8Antibody targets apolipoprotein E to remove amyloid-β deposits (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 9, 2021 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Distinct microglial profiles associated with amyloid and tau pathology in Alzheimer disease
Nature Reviews Neurology, Published online: 09 March 2021; doi:10.1038/s41582-021-00482-zDistinct microglial profiles associated with amyloid and tau pathology in Alzheimer disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 9, 2021 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Hourly risk score could alert clinicians to delayed cerebral ischaemia
Nature Reviews Neurology, Published online: 09 March 2021; doi:10.1038/s41582-021-00481-0Hourly risk score could alert clinicians to delayed cerebral ischaemia (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 9, 2021 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Blood purine levels as a biomarker in epilepsy
Nature Reviews Neurology, Published online: 09 March 2021; doi:10.1038/s41582-021-00480-1Blood purine levels as a biomarker in epilepsy (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 9, 2021 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Prospective memory impairment in neurological disorders: implications and management
Nature Reviews Neurology, Published online: 08 March 2021; doi:10.1038/s41582-021-00472-1Impairments in prospective memory — that is, memory for future intentions, such as remembering to take medications — are observed in many neurological disorders. Henry reviews the manifestations and neural bases of prospective memory deficits and provides algorithms to guide evaluation and treatment. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 8, 2021 Category: Neurology Authors: Julie D. Henry Source Type: research

hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible
Nature Reviews Neurology, Published online: 03 March 2021; doi:10.1038/s41582-021-00465-0In this Perspective, the authors discuss the steps necessary to achieve predictive modelling of neurological diseases with human induced pluripotent stem cells, including applications to diagnosis and prognosis in the context of a precision medicine paradigm. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 3, 2021 Category: Neurology Authors: Pia Rivetti di Val Cervo Dario Besusso Paola Conforti Elena Cattaneo Source Type: research

Pathway-based stratification of glioblastoma
Nature Reviews Neurology, Published online: 02 March 2021; doi:10.1038/s41582-021-00474-zA recent report in Nature Cancer proposes that glioblastoma can be stratified into four functional subgroups on the basis of pathway inference from single-cell or bulk gene expression data. The analysis disclosed a pathway-based subgroup of glioblastoma that depends on oxidative phosphorylation and could potentially be targeted with mitochondrial metabolism inhibitors. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 2, 2021 Category: Neurology Authors: Tobias Weiss Michael Weller Source Type: research

Guillain–Barré syndrome in low-income and middle-income countries: challenges and prospects
Nature Reviews Neurology, Published online: 01 March 2021; doi:10.1038/s41582-021-00467-yThe incidence and severity of Guillain–Barré syndrome (GBS) are increased in low-income and middle-income countries (LMIC) by distinct geographic, economic and environmental factors. Here, Papri and colleagues highlight the most important challenges and knowledge gaps relating to GBS in LMIC. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 1, 2021 Category: Neurology Authors: Nowshin Papri Zhahirul Islam Sonja E. Leonhard Quazi D. Mohammad Hubert P. Endtz Bart C. Jacobs Source Type: research

Genetic insights into dementia disorders
Nature Reviews Neurology, Published online: 01 March 2021; doi:10.1038/s41582-021-00478-9Genetic insights into dementia disorders (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 1, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

Lessons from lockdown — behavioural interventions in migraine
Nature Reviews Neurology, Published online: 26 February 2021; doi:10.1038/s41582-021-00475-yA recent study reports an improvement in migraine symptoms during a COVID-19 lockdown in the Netherlands. The findings suggest that lifestyle changes can substantially alter the course of migraine, opening the door for greater use of behavioural interventions alongside existing pharmacological therapies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 26, 2021 Category: Neurology Authors: Licia Grazzi Paul Rizzoli Source Type: research

Assessing long-term effectiveness of MS treatment — a matter of debate
Nature Reviews Neurology, Published online: 25 February 2021; doi:10.1038/s41582-021-00476-xAssessment of the long-term effectiveness of disease-modifying therapies in multiple sclerosis is plagued by methodological issues, but statistical methods continue to evolve. Use of a novel approach has highlighted the importance of accounting for cumulative exposure to disease-modifying therapies when assessing the long-term effects of treatment on disability accumulation. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 25, 2021 Category: Neurology Authors: Maria Trojano Pietro Iaffaldano Source Type: research

Applying genomic and transcriptomic advances to mitochondrial medicine
Nature Reviews Neurology, Published online: 23 February 2021; doi:10.1038/s41582-021-00455-2In this Review, the authors discuss the unique challenges involved in performing genetic testing for primary mitochondrial diseases and consider the value of advanced approaches such as long-read sequencing, RNA sequencing and the interpretation of transfer RNA variants. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 23, 2021 Category: Neurology Authors: William L. Macken Jana Vandrovcova Michael G. Hanna Robert D. S. Pitceathly Source Type: research

Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap
Nature Reviews Neurology, Published online: 16 February 2021; doi:10.1038/s41582-021-00461-4Biomarkers of epileptogenesis would enable identification of individuals who are risk of developing epilepsy after an insult or as a result of a genetic defect. In this article, Simonato et al. review progress towards such biomarkers and set out a five-phase roadmap to facilitate their development. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 16, 2021 Category: Neurology Authors: Michele Simonato Denes V. Agoston Amy Brooks-Kayal Chris Dulla Brandy Fureman David C. Henshall Asla Pitk änen William H. Theodore Roy E. Twyman Firas H. Kobeissy Kevin K. Wang Vicky Whittemore Karen S. Wilcox Source Type: research

Elevated risk of COVID-19 in people with dementia
Nature Reviews Neurology, Published online: 16 February 2021; doi:10.1038/s41582-021-00473-0Elevated risk of COVID-19 in people with dementia (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 16, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Neurodevelopment affected by HD mutation
Nature Reviews Neurology, Published online: 09 February 2021; doi:10.1038/s41582-021-00471-2Neurodevelopment affected by HD mutation (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 9, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

Tau inclusion turnover could be a target
Nature Reviews Neurology, Published online: 09 February 2021; doi:10.1038/s41582-021-00469-wTau inclusion turnover could be a target (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 9, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

RNA biomarkers of Parkinson disease
Nature Reviews Neurology, Published online: 09 February 2021; doi:10.1038/s41582-021-00470-3RNA biomarkers of Parkinson disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 9, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

COVID-19 database launched in the USA
Nature Reviews Neurology, Published online: 09 February 2021; doi:10.1038/s41582-021-00468-xCOVID-19 database launched in the USA (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 9, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

Changes in brain drainage systems are linked to Parkinson disease
Nature Reviews Neurology, Published online: 02 February 2021; doi:10.1038/s41582-021-00466-zChanges in brain drainage systems are linked to Parkinson disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 2, 2021 Category: Neurology Authors: Heather Wood Source Type: research

White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies
Nature Reviews Neurology, Published online: 27 January 2021; doi:10.1038/s41582-020-00447-8Intraventricular haemorrhage (IVH) is a complication of preterm birth associated with neurodevelopmental sequelae. Here, Ballabh and de Vries review the mechanisms underlying IVH-induced white matter injury, focusing on its effects on oligodendrocyte progenitor cells, and discuss promising novel treatments for IVH-induced white matter injury. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 27, 2021 Category: Neurology Authors: Praveen Ballabh Linda S. de Vries Source Type: research

Markers of vulnerable neurons identified in Alzheimer disease
Nature Reviews Neurology, Published online: 27 January 2021; doi:10.1038/s41582-021-00462-3Markers of vulnerable neurons identified in Alzheimer disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 27, 2021 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal
Nature Reviews Neurology, Published online: 22 January 2021; doi:10.1038/s41582-020-00446-9In this article, members of the International Progressive MS Alliance discuss why experimental medicine trials are important for the development of treatments for progressive multiple sclerosis and set out their funding programme for such trials. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 22, 2021 Category: Neurology Authors: Fernando Dangond Alexis Donnelly Reinhard Hohlfeld Catherine Lubetzki Susan Kohlhaas Letizia Leocani Olga Ciccarelli Bruno Stankoff Maria Pia Sormani Jeremy Chataway Federico Bozzoli Francesco Cucca Lisa Melton Timothy Coetzee Marco Salvetti Source Type: research

Standardization and digitization of clinical data in multiple sclerosis
Nature Reviews Neurology, Published online: 15 January 2021; doi:10.1038/s41582-020-00448-7New tools are being developed for the standardization and digitization of clinical data from patients with multiple sclerosis. In this Perspective, D’Souza and colleagues address the multifaceted impact of these tools on patient care and highlight the challenges and opportunities they create. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 15, 2021 Category: Neurology Authors: Marcus D ’Souza Athina Papadopoulou Christophe Girardey Ludwig Kappos Source Type: research

The African Stroke Organization — a new dawn for stroke in Africa
Nature Reviews Neurology, Published online: 15 January 2021; doi:10.1038/s41582-021-00456-1The African Stroke Organization has been inaugurated as a pan-African coalition of stroke researchers, clinicians, allied health-care professionals, national and regional stroke societies and stroke support organizations in response to the escalating burden of stroke in the continent. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 15, 2021 Category: Neurology Authors: Rufus O. Akinyemi Michael Brainin Source Type: research

Aducanumab and the FDA — where are we now?
Nature Reviews Neurology, Published online: 13 January 2021; doi:10.1038/s41582-020-00454-9The amyloid antibody aducanumab is currently undergoing review by the FDA. The treatment would be the first disease-modifying drug to be approved for Alzheimer disease; however, a medical advisory committee recently convened by the FDA did not recommend approval, raising questions about whether the existing evidence of efficacy is sufficient. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 13, 2021 Category: Neurology Authors: Howard Fillit Allan Green Source Type: research

Mind the gap: from neurons to networks to outcomes in multiple sclerosis
Nature Reviews Neurology, Published online: 12 January 2021; doi:10.1038/s41582-020-00439-8In this Review, Chard and colleagues consider the effects that multiple sclerosis pathology has on brain networks and discuss the ways in which knowledge of brain network changes could inform the targeting of treatments for the condition. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 12, 2021 Category: Neurology Authors: Declan T. Chard Adnan A. S. Alahmadi Bertrand Audoin Thalis Charalambous Christian Enzinger Hanneke E. Hulst Maria A. Rocca Àlex Rovira Jaume Sastre-Garriga Menno M. Schoonheim Betty Tijms Carmen Tur Claudia A. M. Gandini Wheeler-Kingshott Alle Meije Win Source Type: research

Potential benefits of focused ultrasound subthalamotomy in Parkinson disease
Nature Reviews Neurology, Published online: 11 January 2021; doi:10.1038/s41582-021-00457-0Potential benefits of focused ultrasound subthalamotomy in Parkinson disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 11, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Stem cell implants show promise in chronic traumatic brain injury
Nature Reviews Neurology, Published online: 11 January 2021; doi:10.1038/s41582-021-00459-yStem cell implants show promise in chronic traumatic brain injury (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 11, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Neddylation — a new therapeutic target for multiple sclerosis?
Nature Reviews Neurology, Published online: 11 January 2021; doi:10.1038/s41582-021-00460-5Neddylation — a new therapeutic target for multiple sclerosis? (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 11, 2021 Category: Neurology Authors: Heather Wood Source Type: research