Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury
AbstractTo study the effect of photobiomodulation (PBM) on axon regeneration and secretion change of dorsal root ganglion (DRG) under oxidative stress after spinal cord injury (SCI), and further explore the effect of changes in DRG secretion caused by PBM on the polarization of macrophages. The PBM-DRG model was constructed to perform PBM on neurons under oxidative stress simulated in vitro. And the irradiation conditions were as follows: wavelength, 810  nm; power density, 2 mW/cm2; irradiation area, 4.5  cm2; and irradiation time, 440  s. Then resulted in an energy of 4 J (2 mW/cm2 &tim...
Source: Journal of Molecular Neuroscience - January 8, 2021 Category: Neuroscience Source Type: research

Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes
AbstractThe existence of Gram-negative bacteria in the brain, regardless of underlying immune status has been demonstrated by recent studies. The colocalization of lipopolysaccharide (LPS) with A β1-40/42 in amyloid plaques supports the hypothesis that brain microbes may be the cause, triggering chronic neuroinflammation, leading to Alzheimer ’s disease (AD). To investigate the behavioral changes induced by infectious neuroinflammation, we chose the third ventricle as the site of a single LPS injection (20 μg or 80 μg) in male Wistar rats to avoid mechanical injury to forebrain structures while i...
Source: Journal of Molecular Neuroscience - January 6, 2021 Category: Neuroscience Source Type: research

Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients
AbstractLong non-coding RNAs (lncRNAs) play a decisive role in the development of the central nervous system and modulation, differentiation, and function of neurons. Thus, any abnormal pattern of expression of these transcripts might alter normal development leading to neuropsychiatric disorders. In this regard, transcripts of brain-derived neurotrophic factor (BDNF) and four BDNF-associated lncRNAs (BDNF-AS,MIR137HG,MIAT, andPNKY) were evaluated in the peripheral blood of schizophrenia (SCZ) patients as well as normal subjects. The results indicated that the relative expression (RE) ofPNKY was higher in SCZ patients as c...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

PACAP and NAP: Effect of Two Functionally Related Peptides in Diabetic Retinopathy
AbstractPituitary adenylate cyclase-activating polypeptide (PACAP) is a peptide involved in physio-pathological processes of the eye. It exerts multiple effects directly through activation of its related receptors and indirectly through increases in the synthesis of activity-dependent neuroprotective protein (ADNP). To study the role of ADNP and protect against ADNP deficiencies, a small peptide called NAP was synthetized. It includes an eight amino acid active site sequence of ADNP. In this review, we summarize the knowledge regarding the neuroprotective function played by PACAP and NAP in retinal tissue and provide an ov...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats
This study provides a potential mechanism underlying the Baihui-penetrating-Qubin acupuncture improving the early injury after ICH. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Beneficial Effect of Melatonin on Motor and Memory Disturbances in 6-OHDA-Lesioned Rats
AbstractPrevious evidence has shown a link between neurodegenerative diseases, including Parkinson's disease (PD), and melatonin. The data in the literature about the impact of the hormone under different experimental PD conditions are quite controversial, and its effect on memory impairment in the disease is very poorly explored. The current research was aimed at investigating the role of melatonin pretreatment on memory and motor behavior in healthy rats and those with the partial 6-hydroxydopamine (6-OHDA) model of PD. All rodents were pretreated with melatonin (20  mg/kg, intraperitoneally) for 5 days. At 24&...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer ’s Disease
AbstractT-006, a small-molecule compound derived from tetramethylpyrazine (TMP), has potential for the treatment of neurological diseases. In order to investigate the effect of T-006 prophylactic treatment on an Alzheimer ’s disease (AD) model and identify the target of T-006, we intragastrically administered T-006 (3 mg/kg) to Alzheimer’s disease (AD) transgenic mice (APP/PS1-2xTg and APP/PS1/Tau-3xTg) for 6 and 8 months, respectively. T-006 improved cognitive ability after long-term administration in two AD m ouse models and targeted mitochondrial-related protein alpha-F1-ATP synthase (ATP5A). T-006...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Genetic Knockout of the Serotonin Reuptake Transporter Results in the Reduction of Dendritic Spines in In vitro Rat Cortical Neuronal Culture
AbstractDysregulation of the serotonergic system has been reported to have a significant role in several neurological disorders including depression, autism and substance abuse disorders. Changes in the expression of the serotonin transporter (SERT) through polymorphisms in the regulatory regions of the SERT gene have been associated, but not yet been conclusively linked to, neuropsychiatric disorders. In turn, dendritic spine structure and function are critical for neuronal function and the disruption of dendritic spine formation at glutamatergic synapses is a hallmark of several neuropsychiatric disorders. To understand ...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I
This study aimed to determine the pathogenesis of TLE from an epigenetic perspective in patients with TLE-HS type I (TLE-HSTI) and TLE without HS (TLE-nHS) using whole-genome bisulfite sequencing (WGBS). We defined 1171 hypermethylated and 2537 hypomethylated regions and found 632 differentially methylated genes (DMG) in the promoter region that were primarily involved in the regulation of various aspects of epilepsy development. Twelve DMG overlapped with differentially expressed genes (DEG) in the promoter region, and RT-qPCR findings revealed significant overexpression of theSBNO2,CBX3,RASAL3, andTMBIM4 genes in TLE-HST...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

2,5-Dimethyl Celecoxib Inhibits Proliferation and Cell Cycle and Induces Apoptosis in Glioblastoma by Suppressing CIP2A/PP2A/Akt Signaling Axis
In this study, we evaluated the efficacy and the molecular basis of DMC in the treatment of human glioblastoma multiforme (GBM). DMC inhibited the growth and proliferation of GBM cell lines (LN229, A172, U251, and U87MG) in a dose-dependent manner (P 
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Depression Augments Plasma APOA4 without Changes of Plasma Lipids and Glucose in Female Adolescents Carrying G Allele of APOA4 rs5104
AbstractThe association of apolipoprotein AIV (APOA4) with depression or plasma levels of lipids and glucose has been inconsistently reported. However, interplays between APOA4 and depression on the levels have not been explored yet. The present study aimed to investigate plasma levels of APOA4, lipids, and glucose in adolescents with different genotypes ofAPOA4 rs5104 and with or without depression. Depressive symptoms were assessed in 631 adolescents by Beck Depression Inventory (BDI). A total score of 14 was defined as the cutoff point for depression. Plasma levels of triglycerides (TG), total cholesterol (TC), low-dens...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Association of KATP Gene Polymorphisms with Dyslipidemia and Ischemic Stroke Risks Among Hypertensive Patients in South China
This study investigates the potential association between KATP polymorphisms and hypertension (HTN), dyslipidemia, and consequently ischemic stroke (IS). Nine hundred and fourteen (914) patients genotyped for KATP polymorphisms (rs2285676, rs1799858, rs4148671, rs61928479, and rs141294036) were analyzed. KATP rs141294036 (CC, adjusted OR  = 1.59, 95%CI: 1.17–2.14,P = 0.003) was related to higher HTN risk. Meanwhile, rs2285676 (AA + GA, adjusted OR = 1.53, 95%CI: 1.08–2.19,P = 0.018) was associated with increased triglyceride level (≥ 1.7 mmol/L). rs...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

IGF-1 Alleviates Mitochondrial Apoptosis through the GSK3 β/NF-κB/NLRP3 Signaling Pathway in LPS-Treated PC-12 Cells
In conclusion, IGF-1 alleviated mitochondrial apoptosis through GSK3β/NF-κB/NLRP3 signaling pathway in LPS-trea ted PC-12 cells. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Correction to: Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a
It has come to our notice that there was an inadvertent misupload of Fig. 2 (c, d) in the loading control (GAPDH) for ASIC1a and NLRP1 blots. We would like to replace the same with the correct image. This change anyhow does not affect the conclusion of the study. However, the use of GAPDH as a loading control for stroke studies sometimes is debatable (Zhai et al. 2014; Kang et al. 2018). Hence, we repeated our experiments to check the expression of ASIC1a and NLRP1 at different time points following stroke, using beta actin as a loading control. We found that at 24 h post stroke, maximal and significant expression of both ...
Source: Journal of Molecular Neuroscience - January 1, 2021 Category: Neuroscience Source Type: research

Correction to: MicroRNA-206 Inhibited the Progression of Glioblastoma Through BCL-2
The original version of this article unfortunately contained a mistake in the AuthorGroup section. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - December 22, 2020 Category: Neuroscience Source Type: research

Oligodendrocyte Lineage Marker Expression in eGFP-GFAP Transgenic Mice
In this study, we used transgenic mice in which astrocytes are labeled by the enhanced green fluorescent protein (eGFP) under the control of the human glial fibrillary acidic protein (GFAP) promoter. By detailed co-localization studies we were able to demonstrate that a significant proportion of eGFP-expressing cells co-express markers of the oligodendrocyte lineage, such as the transcription factor Oligodendrocyte Transcription Factor 2 (OLIG2); the NG2 proteoglycan, also known as chrondroitin sulfate proteoglycan 4 (CSPG4); or APC. The current finding that the GFAP promoter drives transgene expression in cells of the oli...
Source: Journal of Molecular Neuroscience - December 21, 2020 Category: Neuroscience Source Type: research

Molecular Mechanisms of Cognitive Impairment and Intellectual Disability —Virtual ESN Mini-Conference in Conjunction with the FENS Forum, July 11–15, 2020
(Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - November 12, 2020 Category: Neuroscience Source Type: research

Silencing RNF13 Alleviates Parkinson ’s Disease – Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress–Mediated IRE1α-TRAF2-ASK1-JNK Pathway
The objective of this study was to understand if RNF13 can affect Parkinson ’s disease (PD) model mice by modulating the endoplasmic reticulum stress (ERS)-mediated IRE1α-TRAF2-ASK1-JNK pathway. C57BL/6 mice injected with MPTP to establish PD mice models were divided into Control, MPTP, MPTP + sh-RNF13, and MPTP + sh-NC groups. Rotarod, balance beam, and open-field tests were used to assess the behavioral changes of experimental mice. Immunofluorescence assay was used to determine TH-positive expression in substantia nigra, TUNEL staining to detect apoptosis, and Western blotting to measure the expression of IR...
Source: Journal of Molecular Neuroscience - November 12, 2020 Category: Neuroscience Source Type: research

Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP + Toxicity in SH-SY5Y Cells
In this study, we investigated the function and mechanism of PDGF-BB against 1-methyl-4-phenylpyr idinium (MPP+) toxicity in SH-SY5Y cells, a widely used cellular tool for PD-related molecular study. Our results indicated that PDGF-BB exerts a prominent protective effect against neurotoxin MPP+-triggered ROS generation and cellular loss. We further dissected the molecular mechanism involved in this process by using specific pharmacological inhibitors and validated that the distinct signaling pathways PI3K/Akt/GSK-3 β and MEK/ERK are involved in the process against MPP+ toxicity upon PDGF-BB treatment. We also detected...
Source: Journal of Molecular Neuroscience - November 9, 2020 Category: Neuroscience Source Type: research

Correction to: Establishment of Neurobehavioral Assessment System in Tree Shrew SCT Model
A Correction to this paper has been published:https://doi.org/10.1007/s12031-020-01741-2 (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - November 9, 2020 Category: Neuroscience Source Type: research

Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment
This study aimed to measure the serum levels of progesterone and testosterone in 125 SCZ patients at different stages of treatment and 96 healthy control (HC) subjects. Our results showed that first-episode drug-free SCZ patients had significantly increased testosterone levels when compared with HC subjects, and chronic medication, but not short-term medication, further increased the serum testosterone levels in the patients. Further analysis suggested that the sex of the patients did not affect testosterone levels. In contrast, serum progesterone levels did not show significant differences between first-episode, drug-free...
Source: Journal of Molecular Neuroscience - November 7, 2020 Category: Neuroscience Source Type: research

TNFAIP1 Is Upregulated in APP/PS1 Mice and Promotes Apoptosis in SH-SY5Y Cells by Binding to RhoB
In this study, our experimental results show that TNFAIP1 and p-TNFAIP1 (phosphorylation of TNFAIP1 at Ser280) are overexpressed in the neurons of the cortex and hippocampus in the brains of APP/PS1 mice, and the transcription factor NF- κB is involved in the Aβ-induced upregulation of TNFAIP1. Moreover, our results suggest that TNFAIP1 contributes to the Aβ-induced reactive oxygen species (ROS) production, decreased mitochondrial membrane potential (∆Ψm), and neuronal cell death in human SH-SY5Y cells. We further revealed tha t Aβ increases the binding of TNFAIP1 to RhoB, and knockdown of RhoB a...
Source: Journal of Molecular Neuroscience - November 7, 2020 Category: Neuroscience Source Type: research

Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke
AbstractAtherosclerotic plaque instability is a major cause of ischemic stroke. Researchers must develop novel strategies for the detection and treatment of unstable atherosclerotic plaque (UAP)-related stroke. We aimed to identify potential biomarkers and therapeutic targets of UAP-related stroke. Differentially expressed genes (DEGs) of UAP, ischemic stroke and smoking were identified by microarray analyses from the Gene Expression Omnibus. Gene Ontology (GO) and pathway functional enrichment analyses of DEGs were performed to analyze plaque destabilization and ischemic stroke physiopathology. An integrative analysis of ...
Source: Journal of Molecular Neuroscience - November 6, 2020 Category: Neuroscience Source Type: research

Correction to: Silencing RNF13 Alleviates Parkinson ’s Disease – Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress–Mediated IRE1α-TRAF2-ASK1-JNK Pathway
A Correction to this paper has been published: https://doi.org/10.1007/s12031-020-01746-x (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - November 4, 2020 Category: Neuroscience Source Type: research

Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain
AbstractThe activity-dependent neuroprotective protein (ADNP) syndrome is an autistic-like disorder, instigated by mutations inADNP. This syndrome is characterized by developmental delays, impairments in speech, motor function, abnormal hearing, and intellectual disabilities. In theAdnp-haploinsufficient mouse model, many of these impediments are evident, appearing in a sex-dependent manner. In zebra finch songbird (ZF;Taeniopygia guttata), an animal model used for song/language studies,ADNP mRNA most robust expression is observed in the cerebrum of young males, potentially corroborating with male ZF exclusive singing beha...
Source: Journal of Molecular Neuroscience - October 16, 2020 Category: Neuroscience Source Type: research

GNG13 Is a Potential Marker of the State of Health of Alzheimer ’s Disease Patients’ Cerebellum
AbstractBrain regions such as the cerebellum (CB) have been neglected for a long time in the study of Alzheimer ’s disease (AD) pathogenesis. In reference to a new emerging hypothesis according to which there is an altered cerebellar synaptic processing in AD, we verified the possible role played by new biomarkers in the CB of AD patients compared with not-demented healthy control subjects (NDHS). Using a b ioinformatics approach, we have collected several microarray datasets and obtained 626 cerebella sample biopsies belonging to subjects who did not die from causes related to neurological diseases and 199 cerebella...
Source: Journal of Molecular Neuroscience - October 15, 2020 Category: Neuroscience Source Type: research

Over-Expression of Immune-Related lncRNAs in Inflammatory Demyelinating Polyradiculoneuropathies
AbstractLong non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namelyTUG1,FAS-AS1,NEAT1, andGAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies (AIDP/CIDP) compared with healthy subjects. Notably, all lncRNAs were over-expressed in patients compared with controls (P
Source: Journal of Molecular Neuroscience - October 15, 2020 Category: Neuroscience Source Type: research

Therapeutic Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders
AbstractNeurodegenerative disorders have become the leading cause of chronic pain and death. Treatments available are not sufficient to help the patients as they only alleviate the symptoms and not the cause. In this regard, stem cells therapy has emerged as an upcoming option for the replacement of dead and damaged neurons. Stem cells, in general, are characterized as cells exhibiting potency properties, i.e., on being subjected to specific conditions they transform into cells of another lineage. Of all the types, mesenchymal stem cells (MSCs) are known for their pluripotent nature without the obstacle of ethical concern ...
Source: Journal of Molecular Neuroscience - October 13, 2020 Category: Neuroscience Source Type: research

Bsm I- Apa I- Taq I TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder
AbstractHeritability of major depressive disorder (MDD) is between 36 and 44%, suggesting that up to  nearly half of the phenotypic variability is attributable to genes. A number of genetic polymorphisms have been shown to predispose certain individuals to depression. Of particular interest are the polymorphisms of the vitamin D receptor (VDR) gene. Although the VDR gene has been well characterize d and a vast number of polymorphisms have been identified, the association betweenBsmI (rs1544410),ApaI (rs7975232) andTaqI (rs731236) single-nucleotide polymorphisms (SNPs), together with their haplotypes, and MDD risk have...
Source: Journal of Molecular Neuroscience - October 9, 2020 Category: Neuroscience Source Type: research

A review of the role of genetic factors in Guillain –Barré syndrome
AbstractGuillain –Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy syndrome. Several genetic and environmental risk factors have been recognized for GBS. AS GBS is an immune-related disorder, abnormal functions of T cells, production of autoantibodies, and dysregulation of gene expression have been detected in GBS patients. Based on the critical role of human leukocyte antigen (HLA) in the regulation of immune responses, HLA alleles are among the mostly investigated loci in GBS. A number of polymorphisms within different genes, especially those linked with the regulation of immune respon se...
Source: Journal of Molecular Neuroscience - October 6, 2020 Category: Neuroscience Source Type: research

Regeneration of Rat Sciatic Nerve Using PLGA Conduit Containing Rat ADSCs with Controlled Release of BDNF and Gold Nanoparticles
In this study, we found that the combina tion of AuNPs and BDNF releases in NGC with r-ADSCs may represent a new potential strategy for peripheral nerve regeneration. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - October 6, 2020 Category: Neuroscience Source Type: research

Functional Analysis of a Compound Heterozygous Mutation in the VPS13B Gene in a Chinese Pedigree with Cohen Syndrome
AbstractCohen syndrome (CS) is an autosomal recessive congenital disorder characterized by mutation in the vacuolar protein sorting 13 homolog B (VPS13B; formerly COH1) gene. In the current study, a Chinese family has two young sibling cases having a developmental delay, physical obesity, high myopia, and a special face, which suspected to be CS. The purpose of the study was to identify variants and further analyze their pathogenicity for CS. Next-generation sequencing (NGS) revealed a compound heterozygous mutation inVPS13B gene in the proband, which comprises a frameshift mutation in NM_017890.4: c.10076_10077delCA (p.T3...
Source: Journal of Molecular Neuroscience - October 5, 2020 Category: Neuroscience Source Type: research

Learning-Dependent Transcriptional Regulation of BDNF by its Truncated Protein Isoform in Turtle
AbstractThe vertebrate brain-derived neurotrophic factor (BDNF) gene produces a number of alternatively spliced transcripts only some of which generate the BDNF protein required for synaptic plasticity and learning. Many of the transcripts are uncharacterized and are of unknown biological significance. Previously, we described alternative splicing within the protein-coding sequence of theBDNF gene in the pond turtle (tBDNF) that generates a functionally distinct truncated protein isoform (trcBDNF) that is regulated during a neural correlate of eyeblink classical conditioning in ex vivo brainstem preparations. We hypothesiz...
Source: Journal of Molecular Neuroscience - October 5, 2020 Category: Neuroscience Source Type: research

Intrathecal Injection of SIRT1-modified Human Mesenchymal Stem Cells Alleviates Neuropathic Pain in Rat
AbstractAccumulating evidence has elucidated that human mesenchymal stem cells (hMSCs) exert profound analgesic effects on numerous animal models of neuropathic pain, including drug-induced peripheral nerves, diabetes-induced neuropathy, and chronic constriction injury. We aimed to address whether forcing expression of sirtuin 1 (SIRT1) can enhance the efficacy of hMSCs on alleviation of pain sensation. A rat model of chronic constriction injury (CCI) mimicking peripheral nerve injury was incorporated in the study. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) testing were used to measure pain-related beh...
Source: Journal of Molecular Neuroscience - October 1, 2020 Category: Neuroscience Source Type: research

Effects of Regular Exercise on Diabetes-Induced Memory Deficits and Biochemical Parameters in Male Rats
AbstractThe main objective of current work was to determine the effects of treadmill-running and swimming exercise on passive avoidance learning (PAL) and blood biochemical parameters in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats were divided into the following 6 groups (N = 6–8 per group): CON, healthy rats without exercise (N = 8); STZ, diabetic rats without exercise (N = 8); CON-SE, healthy rats subjected to swimming exercise (2 months;N = 6); STZ-SE, diabetic rats subjected to swimming exercise (2 months;N = 7);...
Source: Journal of Molecular Neuroscience - September 30, 2020 Category: Neuroscience Source Type: research

MicroRNA-107 Ameliorates Damage in a Cell Model of Alzheimer ’s Disease by Mediating the FGF7/FGFR2/PI3K/Akt Pathway
AbstractAlzheimer ’s disease (AD), the most prevalent representation of dementia, is a neurodegenerative disease resulting from the degenerative disturbance of the central nervous system. Previous studies have indicated that miR-107 is reduced in the brain neocortex of patients with AD; however, its underlying mech anism is not clear. Therefore, the objective of this study was to explore the question of whether miR-107 participates in AD development. The study confirmed that the miR-107 expression levels were dramatically decreased in patients with AD and in beta-amyloid (Aβ) (Aβ)-treated SH-SY5Y cells comp...
Source: Journal of Molecular Neuroscience - September 15, 2020 Category: Neuroscience Source Type: research

Plasma Protein Panels for Mild Cognitive Impairment Among Elderly Chinese Individuals with Different Educational Backgrounds
AbstractTo explore plasma protein panels as potential biomarkers to screen for mild cognitive impairment (MCI) among elderly Chinese individuals with different educational backgrounds. Forty-four illiterate, 36 lower education (1 –6 years), and 55 higher education (7 years or more) elderly individuals were included in the present study. Among all subjects, 67 were healthy individuals and 68 were diagnosed with MCI. Fifty plasma proteins in blood samples collected from these subjects were analyzed via the Luminex assay. B inary logistic regression was utilized to explore diagnostic models for MCI among the t...
Source: Journal of Molecular Neuroscience - September 15, 2020 Category: Neuroscience Source Type: research

Correction to: Escin, a Novel Triterpene, Mitigates Chronic MPTP/P-Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis
The original version of this article unfortunately contains an error in Figs. 8 and 9. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 15, 2020 Category: Neuroscience Source Type: research

The Expression of E2F1, p53, and Caspase 3 in the Rat Dorsal Root Ganglia After Sciatic Nerve Transection
AbstractNeurotrauma is among the main causes of human disability and mortality. Nerve injury impairs not only neurons but also causes death of satellite glial cells remote from the injury site. We studied the dynamics of expression of different proapoptotic proteins (E2F1, p53, caspase 3) in the dorsal root ganglia (DRG) of a rat after sciatic nerve transection. TUNEL staining and immunoblotting were used for analysis of cell apoptosis and axotomy-induced biochemical changes. Apoptosis of glial cells was observed at 24  h after sciatic nerve transection and increased on day 7, when apoptosis of some neurons only start...
Source: Journal of Molecular Neuroscience - September 10, 2020 Category: Neuroscience Source Type: research

Effects of microRNA-338 Transfection into Sciatic Nerve on Rats with Experimental Autoimmune Neuritis
In this study, we used microRNA-338 coded lentivirus vector (miR-338-LV) in a Lewis rat EAN model, in with the conjunction P0 peptide 180 –199 which was injected into the footpads of animals to induce immunization. The clinical scores of miR-338-LV and intravenous immunoglobulin (IVIg) (positive drug) groups were significantly superior to those of untreated group at disease peak and disease plateau (p 
Source: Journal of Molecular Neuroscience - September 10, 2020 Category: Neuroscience Source Type: research

The Changes in 1 H-MRS Metabolites in Cuprizone-Induced Model of Multiple Sclerosis: Effects of Prior Psychological Stress
AbstractStress is considered as an important risk factor in the progression and the onset of many disorders such as multiple sclerosis. However, metabolite changes as a result of demyelination under the detrimental effects of stress are not well understood. Thus, 36 female Wistar rats (i.e., groups (1) no-cuprizone (Cont), (2) no-stress + cuprizone-treated (Cup), (3) physical stress + cuprizone-treated (P-Cup), (4) psychological stress + cuprizone-treated (Psy-Cup), (5) physical stress + no-cuprizone-treated (P), (6) psychological stress + no-cuprizone-treated (Psy)) were used in this study. Following induction of repetiti...
Source: Journal of Molecular Neuroscience - September 10, 2020 Category: Neuroscience Source Type: research

Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis
AbstractStroke is one of the highest incidence neurological disorder with great morbidity and mortality rate. The secondary neuroinflammation contributed by microglial activation is a consequential response observed in the pathogenesis of stroke. High-mobility group box  1, a non-histone nuclear protein, interacts with immune cells, such as microglia, and leads to a cascade amplification of the secondary neuroinflammatory responses, which are related to neuronal damage later. Melatonin is a neurohormone, well-known as its anti-oxidative and anti-inflammatory effec ts. However, until now, more findings are required for...
Source: Journal of Molecular Neuroscience - September 9, 2020 Category: Neuroscience Source Type: research

Neuroprotection of Intermedin Against Cerebral Ischemia/Reperfusion Injury Through Cerebral Microcirculation Improvement and Apoptosis Inhibition
AbstractIschemic stroke is the primary cause of disability and mortality worldwide. Ischemia/reperfusion (I/R)-induced microcirculatory dysfunction and organ injury generally occur after ischemic stroke. Several studies have shown that intermedin (IMD) has a regulating function on cerebral microcirculation and blood-brain barrier via relaxing cerebral vessels and improving the local blood supply after cerebral ischemia. However, a unified conclusion has not been reached, and the underlying mechanism remains unclear. To observe and analyze the changes of cerebral microcirculation perfusion of cerebral IRI by IMD post-treatm...
Source: Journal of Molecular Neuroscience - September 9, 2020 Category: Neuroscience Source Type: research

Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain Injury
This study builds on prior research by showing similar results in TBI mice models. After drinking CE for a week, mice were injured using our 70-g weight drop TBI device. For 2 weeks thereafter, th e mice continued drinking CE alongside standard lab nutrition. Subsequently, the mice underwent behavioral tests to assess their memory, motor activity, and anxiety. The mice brains were harvested for immunohistochemistry staining to evaluate overall neuronal survival. Our results show that CE consu mption almost completely mitigates memory impairment and decreases neuronal loss after TBI. Mice that did not consume CE demons...
Source: Journal of Molecular Neuroscience - September 7, 2020 Category: Neuroscience Source Type: research

Preoperative Chronic and Acute Pain Affects Postoperative Cognitive Function Mediated by Neurotransmitters
AbstractThe effective prevention of postoperative cognitive dysfunction (POCD) needs to be explored, and the effect of preoperative pain on POCD remains unclear. We established a chronic pain model induced by chronic constriction injury (CCI) and models of acute pain and anxiety without pain in mice that were subsequently subjected to partial hepatectomy surgery. Morris water maze (MWM) tests were performed to evaluate the learning and memory abilities of the mice. ELISA was used to measure IL-1 β, IL-6, and TNF-α in serum, and HPLC-MS was used to detect neurotransmitters in the prefrontal cortices and hippocamp...
Source: Journal of Molecular Neuroscience - September 7, 2020 Category: Neuroscience Source Type: research

Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury
AbstractSpinal cord microcirculation plays an important role in maintaining the function of spinal cord neurons and other cells. Previous studies have largely focused on the ability of microtubule stabilization to inhibit the fibroblast migration and promote axon regeneration after spinal cord injury (SCI). However, the effect of microtubule stabilization treatment on microcirculation reconstruction after SCI remains unclear. By using immunofluorescence, we found that microtubule stabilization treatment improved microcirculation reconstruction via increasing the number of microvessels, pericytes, and the perfused microvess...
Source: Journal of Molecular Neuroscience - September 7, 2020 Category: Neuroscience Source Type: research

Identification of SHANK2 Pathogenic Variants in a Chinese Uygur Population with Schizophrenia
AbstractGenomic studies on schizophrenia (SCZ) have revealed several candidate genes involved in excitatory synapse function and plasticity associated with its etiology. SHANK2 is a postsynaptic scaffolding protein, which anchors a protein complex connecting NMDAR, AMPAR, and mGluR receptors at excitatory neuronal synapses. Mutations in theSHANK2 gene have been reported to be associated with human autism spectrum disorders (ASDs) and SCZ. To identify variants in theSHANK2 gene and determine the association ofSHANK2 with SCZ in the Chinese Uygur population, we conducted targeted sequencing of whole exon regions and exon-int...
Source: Journal of Molecular Neuroscience - September 7, 2020 Category: Neuroscience Source Type: research

The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder
AbstractThe mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages. We herein reported the findings of Thai family members who had the compound of uncommon HFE rs2794719, together with transferrin (TF) rs1867504, transferrin receptor 2 (TfR2) rs7385804, and hemojuvelin (HJV) rs16827043 genetic variants involved in the hepcidin transcriptional pathway. These compounded genetic variants could produce the spectrum of clinical phenotypes that spanned from mild to moderate ...
Source: Journal of Molecular Neuroscience - September 6, 2020 Category: Neuroscience Source Type: research

Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish
AbstractSpinal cord injury (SCI) is one of the most common devastating injuries, with little possibility of recovery in humans. However, zebrafish efficiently regenerate functional nervous system tissue after SCI. Therefore, the spinal cord transection model of adult zebrafish was applied to explore the role of ATF6 in neuro-recovery. Activating transcription factor 6 (ATF6) is a type-II transmembrane protein in the endoplasmic reticulum (ER). ATF6 target genes could improve ER homeostasis, which contributes to cytoprotection. Herein, we found that the ATF6 level increased at 12  h and 3 days post SCI, and return...
Source: Journal of Molecular Neuroscience - September 6, 2020 Category: Neuroscience Source Type: research

Association Between REELIN Gene Polymorphisms (rs7341475 and rs262355) and Risk of Schizophrenia: an Updated Meta-analysis
AbstractSchizophrenia (SCZ) is a destructive neuropsychiatric illness affecting millions of people worldwide. The correlation between RELN gene polymorphisms and SCZ was investigated by previous researches, though the results remained conflicting. Based on the available studies, we conducted this meta-analysis to provide a more comprehensive outcome on whether the RELN gene polymorphisms (rs7341475 and rs262355) are associated with SCZ. A total of 15 studies with 25,403 subjects (9047 cases and 16,356 controls) retrieved from PubMed, ScienceDirect, EMBASE, Wiley, BMC, Cochrane, Springer, MDPI, SAGE, and Google Scholar up t...
Source: Journal of Molecular Neuroscience - September 4, 2020 Category: Neuroscience Source Type: research