Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia
This study evaluated the expression pattern of Ermin (ERMN) and Listerin E3 ubiquitin protein ligase 1 (LTN1) genes, which play a role in myelination and ribosome quality control, respectively. The expression of theERMN andLTN1 genes in the peripheral blood (PB) of 50 SCZ patients (male/female: 22/28, age (mean  ± standard deviation (SD)): 35.9 ± 5.6) and 50 matched healthy controls (male/female: 23/27, age (mean ± SD): 34.7 ± 5.4) were assessed using quantitative polymerase chain reaction. Additionally, we used a bioinformatics approach ba...
Source: Journal of Molecular Neuroscience - October 21, 2021 Category: Neuroscience Source Type: research

Revelation of Pivotal Genes Pertinent to Alzheimer ’s Pathogenesis: A Methodical Evaluation of 32 GEO Datasets
This study was  aimed to analyze the genetic data retrieved from 32 Gene Expression Omnibus datasets belonging to diverse ethnic cohorts in order to identify overlapping differentially expressed genes (DEGs). Stringent selection criteria were framed to shortlist appropriate datasets based on false discovery rate (FDR)p-value and log FC, and relevant details of upregulated and downregulated DEGs were retrieved. Among the 32 datasets, only six satisfied the selection criteria. The GEO2R tool was employed to retrieve significant DEGs. Nine common DEGs, i.e.,SLC5A3,BDNF,SST,SERPINA3,RTN3,RGS4,NPTX,ENC1 andCRYM were found ...
Source: Journal of Molecular Neuroscience - October 19, 2021 Category: Neuroscience Source Type: research

Aplysia Neurons as a Model of Alzheimer ’s Disease: Shared Genes and Differential Expression
AbstractAlthough Alzheimer ’s disease (AD) is the most common form of dementia in the United States, development of therapeutics has proven difficult. Invertebrate alternatives to current mammalian AD models have been successfully employed to study the etiology of the molecular hallmarks of AD. The marine snailAplysia californica offers a unique and underutilized system in which to study the physiological, behavioral, and molecular impacts of AD. Mapping of theAplysia proteome to humans and cross-referencing with two databases of genes of interest in AD research identified 898 potential orthologs of interest inAplysi...
Source: Journal of Molecular Neuroscience - October 18, 2021 Category: Neuroscience Source Type: research

Long Non-coding RNA GAS5 Knockdown Attenuates H2O2-Induced Human Trabecular Meshwork Cell Apoptosis and Promotes Extracellular Matrix Deposition by Suppressing miR-29b-3p and Upregulating STAT3
AbstractThe long non-coding RNA GAS5 (GAS5) is reportedly implicated in glaucoma. However, its significance in human trabecular meshwork cells (HTMCs) remains largely unclear. Here, we investigated the effect of GAS5 on the function of HTMCs and its interaction with miR-29b-3p in HTMCs. We established an H2O2-induced oxidative injury model using HTMCs. RT-qPCR or western blotting was performed to examine the expression of the indicated genes. Luciferase reporter assay was used to determine the interaction between GAS5, miR-29b-3p, miR-29b-3p, and STAT3. CCK8 assay was used to assess the proliferative rate of HTMCs. Exposur...
Source: Journal of Molecular Neuroscience - October 16, 2021 Category: Neuroscience Source Type: research

Administration of rTMS Alleviates Stroke-Induced Cognitive Deficits by Modulating miR-409-3p/CTRP3/AMPK/Sirt1 Axis
AbstractCognitive deficit is a typical complication induced by stroke injuries. Repetitive transcranial magnetic stimulation (rTMS) is a technique that can both attenuate neuropsychiatric disorders and influence miR levels. We attempted to assess effects of rTMS on post-stroke cognitive deficit (PSCD) by focusing on the activity of miR-409-3p/CTRP3/AMPK/Sirt1 axis. PSCD was induced in rats using middle cerebral artery occlusion (MCAO) method and handled with rTMS. MiRs responding to rTMS administration were determined using microarray method. Changes in cognitive function, brain histological feature, neuron apoptosis, and ...
Source: Journal of Molecular Neuroscience - October 16, 2021 Category: Neuroscience Source Type: research

MiR-124 Prevents the Microglial Proinflammatory Response by Inhibiting the Activities of TLR4 and Downstream NLRP3 in Palmitic Acid-Treated BV2 Cells
AbstractNeuroinflammation is a mechanism by which obesity or a high-fat diet leads to cognitive impairment. MiR-124, a highly expressed microRNA in the brain, can alleviate neuroinflammation by regulating microglial activation, but its mechanism is unclear. The aim of the study was to explore whether miR-124 exerted this effect through TLR4/MyD88/NF- κB p65/NLRP3 signaling in palmitic acid-treated BV2 cells. Prepared BV2 cells were treated with palmitic acid to establish an in vitro model of a high-fat diet. An miR-124 mimic and inhibitor were adopted to upregulate and downregulate the expression of miR-124, respecti...
Source: Journal of Molecular Neuroscience - October 15, 2021 Category: Neuroscience Source Type: research

Attenuation of Activated eIF2 α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function
AbstractFollowing spinal cord injury (SCI), multiple signaling cascades are activated instantaneously in the injured segments of the spinal cord to create a complex and pathogenic microenvironment, making it difficult to treat SCI. Nevertheless, the significance of the integrated stress response (ISR) to the series of physiological and pathological changes that occur after SCI remains unclear. Through western blotting (WB), we determined that the autophosphorylation of stress receptors (GCN2, PERK, PKR, and HRI) was enhanced after SCI, leading to increased phosphorylation of eIF2 α at Ser51. Strikingly, we found that...
Source: Journal of Molecular Neuroscience - October 13, 2021 Category: Neuroscience Source Type: research

Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal Stem Cells Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis
AbstractMesenchymal stem cells (MSCs)-derived exosomes play significant roles in alleviating spinal cord injury (SCI). Previous study showed that long non-coding RNA tectonic family member 2 (TCTN2) was able to relieve SCI. Herein, whether TCTN2 exerted its roles in functional recovery after SCI via exosomes derived from MSCs was explored. The SCI model was established in rats, and the neurological function was evaluated using the Basso, Beattie, and Bresnahan (BBB) scoring. Lipopolysaccharide (LPS)-induced differentiated PC12 cells were used as an in vitro model for neurotoxicity research. The expression of genes and prot...
Source: Journal of Molecular Neuroscience - October 8, 2021 Category: Neuroscience Source Type: research

Expression of PIAS Genes in Migraine Patients
AbstractMigraine is a complex disabling condition which is associated with dysregulation of several pathways particularly those being associated with immune responses. In order to assess contribution of protein inhibitor of activated STAT (PIAS) in the pathogenesis of migraine, we quantified expression levels ofPIAS1–PIAS4 genes in the circulation of patients with migraine compared with controls. Expression ofPIAS1 was substantially lower in total migraineurs compared with controls (ratio of mean expressions (RME)  = 0.18, SE = 0.29,P value  
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Study on the Correlation Between NF- κB and Central Fatigue
AbstractIn recent years, the World Health Organization (WHO) has included fatigue as a major risk factor for human life and health. The incidence rate of fatigue is high. In Europe and America, nearly 1/3 of the population is suffering from fatigue. Due to the acceleration of modern people ’s life rhythm and the increase of work pressure, more and more attention has been paid to central fatigue. The activation of NF-κB is related to central fatigue, which has been paid little attention by previous studies. At the same time, previous studies have mostly focused on the immune regulat ion function of NF-κB, ...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Integrating Endocannabinoid Signalling In Depression
AbstractDepression is a common mental disorder and is the leading cause of suicide globally. Because of the significant diversity in mental disorders, accurate diagnosis is difficult. Hence, the investigation of novel biomarkers is a key research perspective in psychotherapy to enable an individually tailored treatment approach. The prefrontal cortex (PFC) is a vital cortical region whose circuitry has been implicated in the development of depressive disorder. The endocannabinoid system (ECS) has garnered increasing attention because of its involvement in several diverse physiological brain processes including regulation o...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Genome-Wide Detection of m6A-Associated Genetic Polymorphisms Associated with Ischemic Stroke
AbstractN6-Methyladenosine (m6A) methylation is the most abundant post-transcription modification in eukaryotes and plays a vital role in many pathological conditions including cerebral ischemia-reperfusion injury and vascular inflammation. Moreover, recent studies have reported that single-nucleotide polymorphisms (SNPs) can affect the m6A modification. Therefore, we investigated the relationship between m6A-SNPs and ischemic stroke (IS) risk through integrative analysis of an IS genome-wide association study and m6A-SNP list from the m6AVar database. Next, we performed eQTL and differential expression analysis to support...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Enriched Environment Minimizes Anxiety/Depressive-Like Behavior in Rats Exposed to Immobilization Stress and Augments Hippocampal Neurogenesis (In Vitro)
AbstractChronic exposure to stress disturbs the homeostasis of the brain, thus, deleteriously affecting the neurological circuits. In literature, there are investigations about the stress-related alterations in behavioral response and adult neurogenesis; however, an effective combating strategy to evade stress is still at stake. Hence, the present study is designed to investigate the effect of an enriched environment in alleviating the anxiety/depressive-like behavioral response and enhancing the adult neurogenesis in the hippocampal region of rats exposed to chronic immobilization stress. The rats were exposed to chronic ...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue
AbstractIn recent years, the incidence of fatigue has been increasing, and the effective prevention and treatment of fatigue has become an urgent problem. As a result, the genetic research of fatigue has become a hot spot. Transcriptome-level regulation is the key link in the gene regulatory network. The transcriptome includes messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). MRNAs are common research targets in gene expression profiling. Noncoding RNAs, including miRNAs, lncRNAs, circRNAs and so on, have been developed rapidly. Studies have shown that miRNAs are closely related to the occurrence and development of fatig...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine
AbstractMigraine is a common neurovascular condition. This disorder has a complex genetic background. Several single-nucleotide polymorphisms (SNPs) or mutations within genes regulating glutamatergic neurotransmission, cortical excitability, ion channels, and solute carriers have been associated with polygenic and monogenic forms of migraine. SNPs withinACE,DBH,TRPM8,COMT,GABRQ,CALCA,TRPV1, and other genes have been reported to affect the risk of migraine or the associated clinical parameters. The distribution of some HLA alleles within the HLA-DRB1, HLA-DR2, HLA-B, and HLA-C regions have also been found to differ between ...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Case –Control Study and Meta-Analysis of the Association Between LIPG rs9958947 SNP and Stroke Risk
AbstractThe rs9958947 single nucleotide polymorphism (SNP) resides in the promoter region of the lipase G (LIPG) gene. This newly discovered SNP increases the risk of stroke in some Asian populations, including Chinese and Korean populations. Stroke is one of the top 5 leading causes of death in Malaysia, so it is of interest to investigate whether this SNP is associated with stroke risk in the Malaysian population. Therefore, this study investigates this association through a case –control study on a Malaysian population along with a comprehensive meta-analysis. Genotyping ofLIPG rs9958947 SNP was performed for 241 ...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Integrated 16S rRNA Gene Sequencing and LC-MS Analysis Revealed the Interplay Between Gut Microbiota and Plasma Metabolites in Rats With Ischemic Stroke
This study aimed to reveal the specific asso-ciation between the microbiota and the metabolites in IS using integrated 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) analysis. Male Sprague Dawley (SD) rats were divided into three groups: normal group (n = 8, Normal), model group (n = 9, IS), and sham-operated group (n = 8, Sham). Rats in the IS group were induced by middle cerebral artery occlusion (MCAO), and rats in the Sham group received an initial anesthesia and neck incision only. A neurological function test and 2,3,5-triphenyltetrazolium chlori...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Association Study Between Genetic Variation in Whole Mitochondrial Genome and Ischemic Stroke
In conclusion, our study provided population genetic information and a reference for IS-relevant research, with wide applications in diagnosis, therapeutic treatments and prediction of IS. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Therapeutic Potential of Cytokines in Demyelinating Lesions After Stroke
AbstractWhite matter damage is a component of most human stroke and usually accounts for at least half of the lesion volume. Subcortical white matter stroke (WMS) accounts for 25% of all strokes and causes severe motor and cognitive dysfunction. The adult brain has a very limited ability to repair white matter damage. Pathological analysis shows that demyelination or myelin loss is the main feature of white matter injury and plays an important role in long-term sensorimotor and cognitive dysfunction. This suggests that demyelination is a major therapeutic target for ischemic stroke injury. An acute inflammatory reaction is...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Unfolding the Role of BDNF as a Biomarker for Treatment of Depression
AbstractDepression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals ’ quality of life. The exact pathophysiology of depression remains ambiguous, though many hypotheses have been proposed. Brain-derived neurotrophic factor (BDNF) has recently been reported to play a vital role in the pathophysiology of depression. BDNF is an important neurotrophic factor found in the human brain and is involved in neuronal grow...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Correction to: Association Study Between Genetic Variation in Whole Mitochondrial Genome and Ischemic Stroke
A correction to this paper has been published: https://doi.org/10.1007/s12031-021-01833-7 (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Correction to: A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine
A correction to this paper has been published: https://doi.org/10.1007/s12031-021-01826-6 (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Possible Engagement of Nicotinic Acetylcholine Receptors in Pathophysiology of Brain Ischemia-Induced Cognitive Impairment
AbstractPost-stroke disabilities like cognitive impairment impose are complex conditions with great economic burdens on health care systems. For these comorbidities, no effective therapies have been identified yet. Nicotinic acetylcholine receptors (nAChRs) are multifunctional receptors participating in various behavioral and neurobiological functions. During brain ischemia, the increased glutamate accumulation leads to neuronal excitotoxicity as well as mitochondrial dysfunction. These abnormalities then cause the increased levels of oxidants, which play key roles in neuronal death and apoptosis in the infarct zone. Addit...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Distribution of HLA Alleles and Genotypes in Patients with Chronic Inflammatory Demyelinating Polyneuropathy
AbstractChronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among ...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Possible Engagement of Nicotinic Acetylcholine Receptors in Pathophysiology of Brain Ischemia-Induced Cognitive Impairment
AbstractPost-stroke disabilities like cognitive impairment impose are complex conditions with great economic burdens on health care systems. For these comorbidities, no effective therapies have been identified yet. Nicotinic acetylcholine receptors (nAChRs) are multifunctional receptors participating in various behavioral and neurobiological functions. During brain ischemia, the increased glutamate accumulation leads to neuronal excitotoxicity as well as mitochondrial dysfunction. These abnormalities then cause the increased levels of oxidants, which play key roles in neuronal death and apoptosis in the infarct zone. Addit...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Distribution of HLA Alleles and Genotypes in Patients with Chronic Inflammatory Demyelinating Polyneuropathy
AbstractChronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among ...
Source: Journal of Molecular Neuroscience - October 1, 2021 Category: Neuroscience Source Type: research

Bioinformatics Analysis of the MicroRNA-Metabolic Gene Regulatory Network in Neuropathic Pain and Prediction of Corresponding Potential Therapeutics
AbstractNeuropathic pain (NP) involves metabolic processes that are regulated by metabolic genes and their non-coding regulator genes such as microRNAs (miRNAs). Here, we aimed at exploring the key miRNA signatures regulating metabolic genes involved in NP pathogenesis. We downloaded NP-related data from public databases and identified differentially expressed microRNAs (miRNAs) and mRNAs through differential gene expression analysis. The miRNA target prediction was performed, and integration with the differentially expressed metabolic genes (DEMGs) was used for constructing the miRNA-DEMG network. Subsequently, functional...
Source: Journal of Molecular Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

Evidence That HFE H63D Variant Is a Potential Disease Modifier in Cluster Headache
The objective of the current study was to examine the association of the more commonHFE H63D variant, with the susceptibility to develop CH and diverse clinical phenotypes in a population of Southeastern European Caucasian (SEC) origin. Genomic DNA samples from 128 CH patients and 294 neurologically healthy controls were genotyped for theHFE rs1799945 (H63D) variant. H63D genotypic and allelic frequency distribution did not differ significantly between patients and controls (p >  0.05). Subgroup analysis revealed a significantly more frequent occurrence of the variant G allele in chronic compared to episod...
Source: Journal of Molecular Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

Identifying Biomarkers of Alzheimer ’s Disease via a Novel Structured Sparse Canonical Correlation Analysis Approach
AbstractUsing correlation analysis to study the potential connection between brain genetics and imaging has become an effective method to understand neurodegenerative diseases. Sparse canonical correlation analysis (SCCA) makes it possible to study high-dimensional genetic information. The traditional SCCA methods can only process single-modal genetic and image data, which to some extent weaken the close connection of the brain ’s biological network. In some recently proposed multimodal SCCA methods, due to the limitations of penalty items, the pre-processed data needs to be further filtered to make the dimensions un...
Source: Journal of Molecular Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

Bioinformatics Analysis of the MicroRNA-Metabolic Gene Regulatory Network in Neuropathic Pain and Prediction of Corresponding Potential Therapeutics
AbstractNeuropathic pain (NP) involves metabolic processes that are regulated by metabolic genes and their non-coding regulator genes such as microRNAs (miRNAs). Here, we aimed at exploring the key miRNA signatures regulating metabolic genes involved in NP pathogenesis. We downloaded NP-related data from public databases and identified differentially expressed microRNAs (miRNAs) and mRNAs through differential gene expression analysis. The miRNA target prediction was performed, and integration with the differentially expressed metabolic genes (DEMGs) was used for constructing the miRNA-DEMG network. Subsequently, functional...
Source: Journal of Molecular Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

Evidence That HFE H63D Variant Is a Potential Disease Modifier in Cluster Headache
The objective of the current study was to examine the association of the more commonHFE H63D variant, with the susceptibility to develop CH and diverse clinical phenotypes in a population of Southeastern European Caucasian (SEC) origin. Genomic DNA samples from 128 CH patients and 294 neurologically healthy controls were genotyped for theHFE rs1799945 (H63D) variant. H63D genotypic and allelic frequency distribution did not differ significantly between patients and controls (p >  0.05). Subgroup analysis revealed a significantly more frequent occurrence of the variant G allele in chronic compared to episod...
Source: Journal of Molecular Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

Identifying Biomarkers of Alzheimer ’s Disease via a Novel Structured Sparse Canonical Correlation Analysis Approach
AbstractUsing correlation analysis to study the potential connection between brain genetics and imaging has become an effective method to understand neurodegenerative diseases. Sparse canonical correlation analysis (SCCA) makes it possible to study high-dimensional genetic information. The traditional SCCA methods can only process single-modal genetic and image data, which to some extent weaken the close connection of the brain ’s biological network. In some recently proposed multimodal SCCA methods, due to the limitations of penalty items, the pre-processed data needs to be further filtered to make the dimensions un...
Source: Journal of Molecular Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

MiR-615 Agomir Encapsulated in Pluronic F-127 Alleviates Neuron Damage and Facilitates Function Recovery After Brachial Plexus Avulsion
In conclusion, our findings demonstrate that miR-615-loaded PF-127 hydrogel may represent a novel therapeutic strategy for BPA treatment. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 26, 2021 Category: Neuroscience Source Type: research

Atorvastatin-Induced Absorption of Chronic Subdural Hematoma Is Partially Attributed to the Polarization of Macrophages
In conclusion, our study shows that atorvastatin could alleviate the symptoms of CSDH and promote hematoma ablation by polarizing macrophages to M2 type and regulating the inflammatory responses. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 26, 2021 Category: Neuroscience Source Type: research

MiR-615 Agomir Encapsulated in Pluronic F-127 Alleviates Neuron Damage and Facilitates Function Recovery After Brachial Plexus Avulsion
In conclusion, our findings demonstrate that miR-615-loaded PF-127 hydrogel may represent a novel therapeutic strategy for BPA treatment. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 26, 2021 Category: Neuroscience Source Type: research

Atorvastatin-Induced Absorption of Chronic Subdural Hematoma Is Partially Attributed to the Polarization of Macrophages
In conclusion, our study shows that atorvastatin could alleviate the symptoms of CSDH and promote hematoma ablation by polarizing macrophages to M2 type and regulating the inflammatory responses. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 26, 2021 Category: Neuroscience Source Type: research

Association of Maternal Diabetes and Autism Spectrum Disorders in Offspring: a Study in a Rodent Model of Autism
AbstractThe present study investigated that maternal type 1 diabetes may contribute to autism pathogenesis in offspring, and that insulin therapy during pregnancy may prevent the onset of autism. As evidenced, selected brain biomarkers representing the accepted etiological mechanism of autism in newborn rats from diabetic mothers and diabetic mothers receiving insulin therapy compared to the propionic acid (PPA) rodent model of autism were screened. Female Wistar rats with a controlled fertility cycle were randomly divided into three groups: a control group, a group treated with a single dose of 65  mg/kg streptozotoc...
Source: Journal of Molecular Neuroscience - September 25, 2021 Category: Neuroscience Source Type: research

A Novel De Novo TUBB3 Variant Causing Developmental Delay, Epilepsy and Mild Ophthalmological Symptoms in a Chinese Child
AbstractHeterozygous missense mutations inTUBB3 have been implicated in various neurological disorders encompassing either isolated congenital fibrosis of the extraocular muscles type 3 (CFEOM3) or complex cortical dysplasia with other brain malformations 1 (CDCBM1). The description of seizures in patients withTUBB3 mutations is rare. Here, we reported a patient who had febrile seizures before and focal seizure this time, which was diagnosed as epilepsy in combination with an abnormal EEG. MRI showed hypoplastic corpus callosum. Mutation analysis showed a novel de novo heterozygous variant of theTUBB3 gene (NM_006086), c.7...
Source: Journal of Molecular Neuroscience - September 25, 2021 Category: Neuroscience Source Type: research

Association of Maternal Diabetes and Autism Spectrum Disorders in Offspring: a Study in a Rodent Model of Autism
AbstractThe present study investigated that maternal type 1 diabetes may contribute to autism pathogenesis in offspring, and that insulin therapy during pregnancy may prevent the onset of autism. As evidenced, selected brain biomarkers representing the accepted etiological mechanism of autism in newborn rats from diabetic mothers and diabetic mothers receiving insulin therapy compared to the propionic acid (PPA) rodent model of autism were screened. Female Wistar rats with a controlled fertility cycle were randomly divided into three groups: a control group, a group treated with a single dose of 65  mg/kg streptozotoc...
Source: Journal of Molecular Neuroscience - September 25, 2021 Category: Neuroscience Source Type: research

A Novel De Novo TUBB3 Variant Causing Developmental Delay, Epilepsy and Mild Ophthalmological Symptoms in a Chinese Child
AbstractHeterozygous missense mutations inTUBB3 have been implicated in various neurological disorders encompassing either isolated congenital fibrosis of the extraocular muscles type 3 (CFEOM3) or complex cortical dysplasia with other brain malformations 1 (CDCBM1). The description of seizures in patients withTUBB3 mutations is rare. Here, we reported a patient who had febrile seizures before and focal seizure this time, which was diagnosed as epilepsy in combination with an abnormal EEG. MRI showed hypoplastic corpus callosum. Mutation analysis showed a novel de novo heterozygous variant of theTUBB3 gene (NM_006086), c.7...
Source: Journal of Molecular Neuroscience - September 25, 2021 Category: Neuroscience Source Type: research

Clinico-Genetic Spectrum of POLG1 Mutation Carriers from India
(Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 24, 2021 Category: Neuroscience Source Type: research

Analysis of the HEXA, HEXB, ARSA, and SMPD1 Genes in 68 Iranian Patients
AbstractLysosomal storage diseases (LSDs) are known as genetic disorders with an overall prevalence of 1 per 7700 live births. Sphingolipidosis, which is a subgroup of LSDs, is resulted from mutations in the coding genes of specific enzymes of sphingolipid hydrolases. The current study aimed to provide additional knowledge on the genotype of sphingolipidoses disease among Iranian patients affected by the disease. In this research, we studied 68 unrelated Iranian patients diagnosed with one kind of sphingolipidoses from 2014 to 2019. Thereafter, genomic DNA was isolated from their peripheral blood leukocytes samples in EDTA...
Source: Journal of Molecular Neuroscience - September 23, 2021 Category: Neuroscience Source Type: research

Correction to: Efonidipine Exerts Cerebroprotective Effect by Down ‑regulation of TGF‑β/SMAD‑2‑Dependent Signaling Pathway in Diabetic Rats
(Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 23, 2021 Category: Neuroscience Source Type: research

Analysis of the HEXA, HEXB, ARSA, and SMPD1 Genes in 68 Iranian Patients
AbstractLysosomal storage diseases (LSDs) are known as genetic disorders with an overall prevalence of 1 per 7700 live births. Sphingolipidosis, which is a subgroup of LSDs, is resulted from mutations in the coding genes of specific enzymes of sphingolipid hydrolases. The current study aimed to provide additional knowledge on the genotype of sphingolipidoses disease among Iranian patients affected by the disease. In this research, we studied 68 unrelated Iranian patients diagnosed with one kind of sphingolipidoses from 2014 to 2019. Thereafter, genomic DNA was isolated from their peripheral blood leukocytes samples in EDTA...
Source: Journal of Molecular Neuroscience - September 23, 2021 Category: Neuroscience Source Type: research

Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF- κB Signaling–Mediated Neuroinflammation
This study provides a new theoretical basis for resveratrol to prevent long-term neurological dysfunction following HIBI. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - September 22, 2021 Category: Neuroscience Source Type: research

Elevation of Pro-inflammatory and Anti-inflammatory Cytokines in Rat Serum after Acute Methamphetamine Treatment and Traumatic Brain Injury
In this study, using a cytokine antibody array chip, we evaluated the serum levels of 19 cytokines in rats 24  h after exposure to a 40 mg/kg acute regimen of METH. Data were compared to rats subjected to experimental TBI using the controlled cortical impact (CCI) injury model and saline controls. Sandwich ELISA method was used to further validate some of the findings obtained from the antibody cytokine a rray. We confirmed that three major inflammatory-linked cytokines (IL-1β, IL-6, and IL-10) were elevated in the METH and TBI groups compared to the saline group. Such finding suggests the involvement of an ...
Source: Journal of Molecular Neuroscience - September 20, 2021 Category: Neuroscience Source Type: research