Correction: The Combination of 5-FU and Resveratrol Can Suppress the Growth of Glioblastoma Cells through Downregulation of TRPM2 and β-Catenin
(Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - February 16, 2024 Category: Neuroscience Source Type: research
Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route
In conclusion, our study provided a simple and robust protocol for generating functional sympathetic neurons from hPSCs, which may be an invaluable tool in unraveling the mechanisms of SNS-related diseases. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - February 15, 2024 Category: Neuroscience Source Type: research
Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification
This study highlights the importance of considering both clinical and molecular factors in the management of glioma patients to improve cognitive outcomes. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - February 5, 2024 Category: Neuroscience Source Type: research
The Role of Serum Matrix Metalloproteinase-9 as a Predictor of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
AbstractDelayed cerebral ischemia (DCI) is one of the major causes of a poor neurological outcome following aneurysmal subarachnoid hemorrhage (aSAH). Several biomarkers, including matrix metalloproteinase-9 (MMP-9), have been evaluated to predict the development of DCI for timely management. This prospective cohort study was done on 98 patients with aSAH presenting within 72 h of the ictus. Serum samples were collected preoperatively, 7 days after ictus, 10 days after ictus, or when the patient developed DCI, whichever was earlier. The primary objective was to correlate the serum MMP-9 levels with the development of D...
Source: Journal of Molecular Neuroscience - February 5, 2024 Category: Neuroscience Source Type: research
Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification
This study highlights the importance of considering both clinical and molecular factors in the management of glioma patients to improve cognitive outcomes. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - February 5, 2024 Category: Neuroscience Source Type: research
The Role of Serum Matrix Metalloproteinase-9 as a Predictor of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
AbstractDelayed cerebral ischemia (DCI) is one of the major causes of a poor neurological outcome following aneurysmal subarachnoid hemorrhage (aSAH). Several biomarkers, including matrix metalloproteinase-9 (MMP-9), have been evaluated to predict the development of DCI for timely management. This prospective cohort study was done on 98 patients with aSAH presenting within 72 h of the ictus. Serum samples were collected preoperatively, 7 days after ictus, 10 days after ictus, or when the patient developed DCI, whichever was earlier. The primary objective was to correlate the serum MMP-9 levels with the development of D...
Source: Journal of Molecular Neuroscience - February 5, 2024 Category: Neuroscience Source Type: research
Whole Blood Transcriptome Analysis in Patients with Trigeminal Neuralgia: a Prospective Clinical Study
This study aimed to explore the differentially expressed genes (DEGs) and related enrichment pathways in patients with TN. This was a study of transcriptome sequencing and bioinformatics analysis of human samples. Whole blood samples were collected from the TN patients and pain-free controls. RNA was extracted to conduct the RNA-sequencing and the subsequent bioinformatics analysis. DEGs between the two groups were derived. Kyoto encyclopedia of genes and genomes (KEGG) and Gene ontology (GO) was used to find the enrichment pathways of DEGs. Protein protein interaction (PPI) network was used to depict the interaction betwe...
Source: Journal of Molecular Neuroscience - February 1, 2024 Category: Neuroscience Source Type: research
Longitudinal Genotype-Phenotype (Vineland Questionnaire) Characterization of 15 ADNP Syndrome Cases Highlights Mutated Protein Length and Structural Characteristics Correlation with Communicative Abilities Accentuated in Males
AbstractActivity-dependent neuroprotective protein (ADNP) is essential for neurodevelopment and de novo mutations in ADNP cause the ADNP syndrome. From brain pathologies point of view, tauopathy has been demonstrated at a young age, implying stunted development coupled with early/accelerated neurodegeneration. Given potential genotype –phenotype differences and age-dependency, we have assessed here a cohort of 15 individuals (1–27-year-old), using 1–3 longitudinal parent (caretaker) interview/s (Vineland 3 questionnaire) over several years. Our results indicated developmental delays, or even developmental arrests, co...
Source: Journal of Molecular Neuroscience - January 29, 2024 Category: Neuroscience Source Type: research
Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin
AbstractThe epigenetic factor Methyl-CpG-Binding Protein 2 (MeCP2) is a nuclear protein that binds methylated DNA molecules (both 5-methylcytosine and 5-hydroxymethylcytosine) and controls gene transcription. MeCP2 is an important transcription factor that acts in a dose-dependent manner in the brain; thus, its optimal expression level in brain cells is important. As such, its deregulated expression, as well as gain- or loss-of-function mutation, lead to impaired neurodevelopment, and compromised structure and function of brain cells, particularly in neurons. Studies from others and us have characterized two well-recogni...
Source: Journal of Molecular Neuroscience - January 26, 2024 Category: Neuroscience Source Type: research
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
AbstractHypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors (NMDAR) on hypothalamic neurons and their interaction with GABAA and serotoninergic neuronal circuits. However, the precise mechanisms governing energy homeostasis remain elusive. Notably, in females, the consumption of progesterone-containing preparations, such as hormonal replacement therapy and birth control pills, has been associated with hyperphagia and obesity —effects mediated through the hypothalamus. To elucidate this phenomenon, we employed the progesterone-induced obesity model in f...
Source: Journal of Molecular Neuroscience - January 19, 2024 Category: Neuroscience Source Type: research
