Concurrent Assessment of Oxidative Stress and MT-ATP6 Gene Profiling to Facilitate Diagnosis of Autism Spectrum Disorder (ASD) in Tamil Nadu Population
In conclusion, our findings authenticate that oxidative stress and genetics both have an equal and potential role behind ASD and we recommend to conduct more such concurrent research to understand their unique mechanism for better diagnosis and therapeutic for ASD.Graphical Abstract (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - March 17, 2023 Category: Neuroscience Source Type: research
Association Analysis of 27 Single Nucleotide Polymorphisms in a Chinese Population with Essential Tremor
This study aimed to assess variant burden in ET-associated genes in a relatively large Chinese population cohort. We genotyped 27 single nucleotide polymorphisms (SNPs) previously reported to be associated with ET by multiplex PCR amplicon sequencing assay in 488 familial and sporadic ET patients and 514 healthy controls (HCs). Then, we performed allelic and genotypic association test by Pearson chi-square test or Fisher ’s exact test. A total of 1002 samples were included in our analysis, consisting of 488 ET patients and 514 sex and age-matched HCs. For rs10937625, the C allele was linked to increased risk of ET (P =...
Source: Journal of Molecular Neuroscience - March 16, 2023 Category: Neuroscience Source Type: research
Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer ’s Disease
AbstractAlzheimer ’s disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological processes, and we mainly explore the relationship between chromatin regulators and Alzheimer’s disease. Eight hundred seventy chromatin regulators were collected from previous studies, and data related to Alzheimer’s disease patients were downloaded from the GEO database. Finally, we screened chromatin regul ators relat...
Source: Journal of Molecular Neuroscience - February 24, 2023 Category: Neuroscience Source Type: research
Fibroblast Growth Factor 2 Levels in Patients with Major Depressive Disorder: A Meta-analysis
AbstractFibroblast growth factor 2 (FGF2) plays an essential role in neurogenesis, oxidative stress, and emotional behavior. However, the evidence regarding the role of FGF2 in the pathophysiology of depression remains limited and inconclusive. We conducted a systematic review and meta-analysis to investigate peripheral blood FGF2 levels in patients with depression and healthy controls. The PubMed and Web of Science databases were used to identify relevant articles for systematic retrieval. Eight studies involving 310 patients with depression and 268 healthy controls were included in this meta-analysis. A random-effects me...
Source: Journal of Molecular Neuroscience - February 20, 2023 Category: Neuroscience Source Type: research
Cytohesin-4 Upregulation in Glioma-Associated M2 Macrophages Is Correlated with Pyroptosis and Poor Prognosis
AbstractCytohesin-4 (CYTH4) is a member of the PSCD family. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. In previous studies, CYTH4 has been linked with multiple brain diseases, but not glioma, the most common type of brain tumor. We utilized multiple glioma single-cell RNA sequencing datasets and bulk data from the TCGA and CGGA and conducted GSEA and KEGG and GO analyses. Biomarker potential was tested via ROC curve analysis. Radar plots were used to study TMB and MSI correlations. Immune cell studies were conducted using CIBERSORT. All statistical analyses were per...
Source: Journal of Molecular Neuroscience - February 7, 2023 Category: Neuroscience Source Type: research
Neuron –Glia-Ratio-Like Approach Evidenced for Limited Variability and In-Aggregate Circadian Shifts in Cortical Cell-Specific Transcriptomes
AbstractRegardless of shifts in levels of individual transcripts, it remains elusive whether natural variability in cell-specific transcriptomes within the cerebral cortex is limited in aggregate. It is also unclear whether cortical cell-specific transcriptomes might change dynamically in absence of cell number changes. Total variation in neuron- and glia-specific in-aggregate transcriptomes could be identified in a model-free way via glia-neuron ratio approach, by univariate median-to-median ratios comparing integral levels of cell-specific transcripts within a tissue sample. When deleterious, regenerative or developmenta...
Source: Journal of Molecular Neuroscience - February 6, 2023 Category: Neuroscience Source Type: research
A Novel Cuprotosis-Related lncRNA Signature Effectively Predicts Prognosis in Glioma Patients
In conclusion, we successfully constructed a formula of cuprotosis-related lncRNAs with a powerful predictive function. More importantly, our study paves the way for exploring cuprotosis mechanisms in glioma o ccurrence and development and helps to find new relevant biomarkers for glioma early identification and diagnosis and to investigate new therapeutic approaches. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - January 27, 2023 Category: Neuroscience Source Type: research
FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction
In conclusion, this study revealed a role for FAS-centered circRNA-miRNA-mRNA crosstalk network in regulating immune cell infiltration of CI, which may be a viable target for CI prevention. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - January 19, 2023 Category: Neuroscience Source Type: research
