A pediatrician's guide to epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101578. doi: 10.1016/j.cppeds.2024.101578. Online ahead of print.ABSTRACTSurgical intervention for epilepsy emerged in the second half of the 20th century as an important option for pediatric patients with medically refractory epilepsy. Both the number of patients undergoing epilepsy surgery and the available surgical procedures for epilepsy have expanded in the last 3 decades, and now range from surgical resection to neuromodulatory device placement1,2 Studies showing that many patients who would be excellent candidates for surgery are still not being offered appropriate...
Source: Epilepsy Curr - March 14, 2024 Category: Neurology Authors: Ania Dabrowski Caren Armstrong Source Type: research
A pediatrician's guide to epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101578. doi: 10.1016/j.cppeds.2024.101578. Online ahead of print.ABSTRACTSurgical intervention for epilepsy emerged in the second half of the 20th century as an important option for pediatric patients with medically refractory epilepsy. Both the number of patients undergoing epilepsy surgery and the available surgical procedures for epilepsy have expanded in the last 3 decades, and now range from surgical resection to neuromodulatory device placement1,2 Studies showing that many patients who would be excellent candidates for surgery are still not being offered appropriate...
Source: Epilepsy Curr - March 14, 2024 Category: Neurology Authors: Ania Dabrowski Caren Armstrong Source Type: research
Genetic testing for unexplained epilepsy: A review of diagnostic approach, benefits, and referral algorithm
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101579. doi: 10.1016/j.cppeds.2024.101579. Online ahead of print.ABSTRACTIn the last several decades, advances in genetic testing have transformed the diagnostic and therapeutic approach to pediatric epilepsy. However, the interpretation of these genetic tests often requires expert analysis and counseling. For this reason, as our molecular understanding of the linkages between abnormal cerebral physiology and genetics has grown, so too has the field of clinical epilepsy genetics. Here we explore recent advances in genetic testing, describe the benefits of genetic testing ...
Source: Epilepsy Curr - March 13, 2024 Category: Neurology Authors: Alexis Karlin Sarah Ruggiero Mark Fitzgerald Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 11:101576. doi: 10.1016/j.cppeds.2024.101576. Online ahead of print.ABSTRACTGene-targeted therapies for genetic neurodevelopmental disorders (NDDs) are becoming a reality. The Center for Epilepsy and Neurodevelopmental Disorders (ENDD) is currently focused on the development of therapeutics for STXBP1 and SYNGAP1 disorders. Here we review the known clinical features of these disorders, highlight the biological role of STXBP1 and SYNGAP1, and discuss our current understanding of pathogenic mechanisms and therapeutic development. Finally, we provide our perspective as scientis...
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Nicolas Marotta Michael J Boland Benjamin L Prosser Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 11:101576. doi: 10.1016/j.cppeds.2024.101576. Online ahead of print.ABSTRACTGene-targeted therapies for genetic neurodevelopmental disorders (NDDs) are becoming a reality. The Center for Epilepsy and Neurodevelopmental Disorders (ENDD) is currently focused on the development of therapeutics for STXBP1 and SYNGAP1 disorders. Here we review the known clinical features of these disorders, highlight the biological role of STXBP1 and SYNGAP1, and discuss our current understanding of pathogenic mechanisms and therapeutic development. Finally, we provide our perspective as scientis...
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Nicolas Marotta Michael J Boland Benjamin L Prosser Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Editorial: Epilepsy advances in 2023
Curr Opin Neurol. 2024 Apr 1;37(2):97-98. doi: 10.1097/WCO.0000000000001251. Epub 2024 Mar 7.NO ABSTRACTPMID:38451481 | DOI:10.1097/WCO.0000000000001251 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 7, 2024 Category: Neurology Authors: Philippe Ryvlin Source Type: research
Editorial: Epilepsy advances in 2023
Curr Opin Neurol. 2024 Apr 1;37(2):97-98. doi: 10.1097/WCO.0000000000001251. Epub 2024 Mar 7.NO ABSTRACTPMID:38451481 | DOI:10.1097/WCO.0000000000001251 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 7, 2024 Category: Neurology Authors: Philippe Ryvlin Source Type: research
Editorial: Epilepsy advances in 2023
Curr Opin Neurol. 2024 Apr 1;37(2):97-98. doi: 10.1097/WCO.0000000000001251. Epub 2024 Mar 7.NO ABSTRACTPMID:38451481 | DOI:10.1097/WCO.0000000000001251 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 7, 2024 Category: Neurology Authors: Philippe Ryvlin Source Type: research
Editorial: Epilepsy advances in 2023
Curr Opin Neurol. 2024 Apr 1;37(2):97-98. doi: 10.1097/WCO.0000000000001251. Epub 2024 Mar 7.NO ABSTRACTPMID:38451481 | DOI:10.1097/WCO.0000000000001251 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 7, 2024 Category: Neurology Authors: Philippe Ryvlin Source Type: research
Status epilepticus: what's new for the intensivist
Curr Opin Crit Care. 2024 Feb 14. doi: 10.1097/MCC.0000000000001137. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Status epilepticus (SE) is a common neurologic emergency affecting about 36.1/100 000 person-years that frequently requires intensive care unit (ICU) admission. There have been advances in our understanding of epidemiology, pathophysiology, and EEG monitoring of SE, and there have been large-scale treatment trials, discussed in this review.RECENT FINDINGS: Recent changes in the definitions of SE have helped guide management protocols and we have much better predictors of outcome. Observational studies have ...
Source: Epilepsy Curr - March 5, 2024 Category: Neurology Authors: Sarah Benghanem Estelle Pruvost Robieux Aidan Neligan Matthew C Walker Source Type: research
Status epilepticus: what's new for the intensivist
Curr Opin Crit Care. 2024 Feb 14. doi: 10.1097/MCC.0000000000001137. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Status epilepticus (SE) is a common neurologic emergency affecting about 36.1/100 000 person-years that frequently requires intensive care unit (ICU) admission. There have been advances in our understanding of epidemiology, pathophysiology, and EEG monitoring of SE, and there have been large-scale treatment trials, discussed in this review.RECENT FINDINGS: Recent changes in the definitions of SE have helped guide management protocols and we have much better predictors of outcome. Observational studies have ...
Source: Epilepsy Curr - March 5, 2024 Category: Neurology Authors: Sarah Benghanem Estelle Pruvost Robieux Aidan Neligan Matthew C Walker Source Type: research
Evaluation of risk factors for recurrence of cutaneous adverse reactions due to anti-seizure medications in children: A retrospective study
Conclusion: Careful use of aromatic drugs may prevent recurrence of ASM-related CAR in children, particularly in cases of personal history of allergic disease and family history of drug allergy.PMID:38425358 | PMC:PMC10899536 | DOI:10.18502/cjn.v22i4.14524 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 1, 2024 Category: Neurology Authors: Çağatay Günay Gamze Sar ıkaya Uzan Suna Asilsoy Nevin Uzuner Özge Kangallı Semra H ız Kurul Ulu ç Yiş Source Type: research