The Nose Knows: Intranasal Midazolam To Treat Acute Seizures During Inpatient Epilepsy Monitoring.
Abstract [Box: see text]. PMID: 32940057 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - September 17, 2020 Category: Neurology Authors: Vossler DG Tags: Epilepsy Curr Source Type: research

Brain calcification because of neurocysticercosis: a vast field to be explored.
Abstract PURPOSE OF REVIEW: Neurocysticercosis is the most common helminthic infection of the central nervous system caused by the larval stage of the pork tapeworm, Taenia solium. Endemic regions include Latin American countries, sub-Saharan Africa, and large regions of Asia, including the Indian subcontinent and is a global health problem. Seizures are the most common manifestation and approximately 30% of adult-onset seizures in endemic regions are attributable to NCC. Calcifications because of neurocysticercosis is the most common finding on imaging in endemic regions and are important seizure foci contributin...
Source: Epilepsy Curr - August 29, 2020 Category: Neurology Authors: Bustos JA, Coyle CM Tags: Curr Opin Infect Dis Source Type: research

Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee.
Abstract PURPOSE: Established tonic-clonic status epilepticus (SE) does not stop in one-third of patients when treated with an intravenous (IV) benzodiazepine bolus followed by a loading dose of a second antiseizure medication (ASM). These patients have refractory status epilepticus (RSE) and a high risk of morbidity and death. For patients with convulsive refractory status epilepticus (CRSE), we sought to determine the strength of evidence for 8 parenteral ASMs used as third-line treatment in stopping clinical CRSE. METHODS: A structured literature search (MEDLINE, Embase, CENTRAL, CINAHL) was performed to i...
Source: Epilepsy Curr - August 21, 2020 Category: Neurology Authors: Vossler DG, Bainbridge JL, Boggs JG, Novotny EJ, Loddenkemper T, Faught E, Amengual-Gual M, Fischer SN, Gloss DS, Olson DM, Towne AR, Naritoku D, Welty TE Tags: Epilepsy Curr Source Type: research

Genetics of Epileptic Networks: from Focal to Generalized Genetic Epilepsies.
Abstract PURPOSE OF REVIEW: Seizures can arise in neocortical, thalamocortical, limbic or brainstem networks. Here, we review recent genetic mechanisms implicated in focal and genetic generalized epilepsies (GGEs). RECENT FINDINGS: Pathogenic variation in GAP activity toward RAGs 1 (GATOR1) complex genes (i.e., DEPDC5, NPRL2 and NPRL3) mainly result in focal epilepsies. They are associated with high rates of sudden unexpected death in epilepsy and malformations of cortical development (MCD), where "two-hits" in GATOR1-related pathways are also found in MCDs. Large-scale sequencing studies continue t...
Source: Epilepsy Curr - August 13, 2020 Category: Neurology Authors: Qaiser F, Yuen RKC, Andrade DM Tags: Curr Neurol Neurosci Rep Source Type: research

Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole.
CONCLUSION: These findings indicate that CY-09 may represent an important treatment agent for epilepsy and other NLRP3 inflammasome-associated diseases. PMID: 32778044 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - August 10, 2020 Category: Neurology Authors: Shen K, Jiang W, Zhang C, Cai L, Wang Q, Yu H, Tang Z, Gu Z, Chen B Tags: Curr Mol Pharmacol Source Type: research

Advances in repeat expansion diseases and a new concept of repeat motif-phenotype correlation.
Abstract Recently repeat expansions have been found in more than 10 diseases in the past two years. Because the same repeat motifs are found in similar disease (as exemplified by benign adult familial myoclonic epilepsy) or in diseases with overlapping phenotype (as exemplified by fragile X tremor/ataxia syndrome, neuronal intranuclear inclusion disease, oculopharyngeal myopathy with leukoencephalopathy, and oculopharyngodistal myopathy), we propose a new concept of 'repeat motif-phenotype correlation', which argue for toxic gain-of-function mechanism caused by expanded repeats, rather than altered functions of ge...
Source: Epilepsy Curr - August 7, 2020 Category: Neurology Authors: Ishiura H, Tsuji S Tags: Curr Opin Genet Dev Source Type: research

Ketogenic diet as a metabolic treatment for mental illness.
Abstract PURPOSE OF REVIEW: Ketogenic diets, which have been used to treat drug-refractory paediatric epilepsy for over 100 years, are becoming increasingly popular for the treatment of other neurological conditions, including mental illnesses. We aim to explain how ketogenic diets can improve mental illness biopathology and review the recent clinical literature. RECENT FINDINGS: Psychiatric conditions, such as schizophrenia, depression, bipolar disorder and binge eating disorder, are neurometabolic diseases that share several common mechanistic biopathologies. These include glucose hypometabolism, neurotrans...
Source: Epilepsy Curr - August 6, 2020 Category: Neurology Authors: Norwitz NG, Dalai SS, Palmer CM Tags: Curr Opin Endocrinol Diabetes Obes Source Type: research

Contribution of PET-MRI in brain diseases in clinical practice.
Abstract PURPOSE OF REVIEW: Hybrid PET- MRI is a technique that has the ability to improve diagnostic accuracy in many applications, whereas PET and MRI performed separately often fail to provide accurate responses to clinical questions. Here, we review recent studies and current developments in PET-MRI, focusing on clinical applications. RECENT FINDINGS: The combination of PET and MRI imaging methods aims at increasing the potential of each individual modality. Combined methods of image reconstruction and correction of PET-MRI attenuation are being developed, and a number of applications are being introduced...
Source: Epilepsy Curr - July 15, 2020 Category: Neurology Authors: Pyatigorskaya N, Habert MO, Rozenblum L Tags: Curr Opin Neurol Source Type: research

Recent genetic advances in early-onset dystonia.
Abstract PURPOSE OF REVIEW: The discovery of new disease-causing genes and availability of next-generation sequencing platforms have both progressed rapidly over the last few years. For the practicing neurologist, this presents an increasingly bewildering array both of potential diagnoses and of means to investigate them. We review the latest newly described genetic conditions associated with dystonia, and also address how the changing landscape of gene discovery and genetic testing can best be approached, from both a research and a clinical perspective. RECENT FINDINGS: Several new genetic causes for disorde...
Source: Epilepsy Curr - July 15, 2020 Category: Neurology Authors: Steel D, Kurian MA Tags: Curr Opin Neurol Source Type: research

When Drugs Do Not Work: Alternatives to Antiseizure Medications.
Abstract PURPOSE OF REVIEW: Despite the increase in the number of novel antiseizure medications over the past 20 years, approximately one-third of patients will not have adequate seizure control on medications. For these patients, additional options need to be considered, including dietary, device, and surgical treatments. In addition, many complementary therapies can be considered as adjunctive treatment, with the intent of improving quality of life for persons with epilepsy and potentially allowing for improvement in seizure control. RECENT FINDINGS: This review outlines established and developing trea...
Source: Epilepsy Curr - July 9, 2020 Category: Neurology Authors: Dawit S, Crepeau AZ Tags: Curr Neurol Neurosci Rep Source Type: research

Network Dysfunction in Comorbid Psychiatric Illnesses and Epilepsy.
Abstract The episodic nature of both epilepsy and psychiatric illnesses suggests that the brain switches between healthy and pathological states. The most obvious example of transitions between network states related to epilepsy is the manifestation of ictal events. In addition to seizures, there are more subtle changes in network communication within and between brain regions, which we propose may contribute to psychiatric illnesses associated with the epilepsies. This review will highlight evidence supporting aberrant network activity associated with epilepsy and the contribution to cognitive impairments and com...
Source: Epilepsy Curr - July 6, 2020 Category: Neurology Authors: Colmers PLW, Maguire J Tags: Epilepsy Curr Source Type: research

Neurological and Medical Complications in Brain Tumor Patients.
Abstract PURPOSE OF REVIEW: Patients with brain tumors are susceptible to multiple complications that can affect their survival or quality of life. The scope of these complications is widening due to prolonged overall survival and improved therapies. In this review, we discuss the most common complications in this patient population focusing on the recent literature. We specifically concentrated on tumor-related epilepsy, vasogenic edema, infectious, vascular, chemotherapeutic, radiation, endocrine, and cognitive complications. RECENT FINDINGS: Molecular biomarkers play a role in epileptogenicity in brain tum...
Source: Epilepsy Curr - June 29, 2020 Category: Neurology Authors: Schiff D, Alyahya M Tags: Curr Neurol Neurosci Rep Source Type: research

Astroglial connexins in neurological, neuropsychological disorders and radiation exposure.
Abstract Radiotherapy is a common treatment for brain and spinal cord tumors and also a risk factor for brain neuropathological changes in different neurological and neuropsychological disorders. Astroglial connexins have been involved in the brain inflammation, development of Alzheimer's disease (AD), depressive, epilepsy, and amyotrophic lateral sclerosis, and are affected by radiation exposure. Therefore, it is speculated that radiation-induced changes of astroglial connexins may be related to the brain neuropathology and development of neurological and neuropsychological disorders. In this paper, we reviewed t...
Source: Epilepsy Curr - June 10, 2020 Category: Neurology Authors: Liu YD, Tang G, Qian F, Liu L, Huang JR, Tang FR Tags: Curr Med Chem Source Type: research

Recent genetic advances in early-onset dystonia.
Abstract PURPOSE OF REVIEW: The discovery of new disease-causing genes and availability of next-generation sequencing platforms have both progressed rapidly over the last few years. For the practicing neurologist, this presents an increasingly bewildering array both of potential diagnoses and of means to investigate them. We review the latest newly described genetic conditions associated with dystonia, and also address how the changing landscape of gene discovery and genetic testing can best be approached, from both a research and a clinical perspective. RECENT FINDINGS: Several new genetic causes for disorde...
Source: Epilepsy Curr - June 8, 2020 Category: Neurology Authors: Steel D, Kurian MA Tags: Curr Opin Neurol Source Type: research

Contribution of PET-MRI in brain diseases in clinical practice.
Abstract PURPOSE OF REVIEW: Hybrid PET- MRI is a technique that has the ability to improve diagnostic accuracy in many applications, whereas PET and MRI performed separately often fail to provide accurate responses to clinical questions. Here, we review recent studies and current developments in PET-MRI, focusing on clinical applications. RECENT FINDINGS: The combination of PET and MRI imaging methods aims at increasing the potential of each individual modality. Combined methods of image reconstruction and correction of PET-MRI attenuation are being developed, and a number of applications are being introduced...
Source: Epilepsy Curr - June 8, 2020 Category: Neurology Authors: Pyatigorskaya N, Habert MO, Rozenblum L Tags: Curr Opin Neurol Source Type: research

Migraine Aura: Updates in Pathophysiology and Management.
Abstract PURPOSE OF REVIEW: To provide an updated review of the pathophysiology, diagnosis, and management of migraine with aura. RECENT FINDINGS: Thalamic and other subcortical regions may play a role in the pathophysiology of migraine. There is inter-patient and intra-patient attack variability in the characteristics of typical aura especially visual aura symptoms. Migraine with brainstem aura may originate cortically. Migraine with retinal aura may be associated with structural and functional changes in the retina. Although cortical spreading depression (CSD) continues to be the predominant theory surround...
Source: Epilepsy Curr - May 19, 2020 Category: Neurology Authors: Lai J, Dilli E Tags: Curr Neurol Neurosci Rep Source Type: research

Somatic variants in epilepsy - advancing gene discovery and disease mechanisms.
Abstract In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the burden of a variant in specific tissues and cells. By discovering these variants, shared pathophysiological mechanisms are being revealed between clinically distinct disorders. Beyond informing disease mechanisms, mosaic variants also offer a powerful research tool to trace cellular lineages, to...
Source: Epilepsy Curr - May 15, 2020 Category: Neurology Authors: Heinzen EL Tags: Curr Opin Genet Dev Source Type: research

nticonvulsant, Anxiolytic and Antidepressant Properties of the Βcaryophyllene in Swiss Mice: Involvement of Benzodiazepine-Gabaaergic, Serotonergic and Nitrergic Systems.
CONCLUSION: The results obtained provide additional support in understanding the neuromolecular mechanisms underlying the anxiolytic, antidepressant and anticonvulsive properties of β-CBP in female Swiss mice. PMID: 32386503 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - May 9, 2020 Category: Neurology Authors: da Silva Oliveira GL, da Silva JCCL, Dos Santos C L da Silva AP, Feitosa CM, de Castro Almeida FR Tags: Curr Mol Pharmacol Source Type: research

Disrupted Spatial Maps in Epilepsy Highlight the Importance of Timing in Neural Codes.
Abstract [Box: see text]. PMID: 32345042 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - April 29, 2020 Category: Neurology Authors: Ewell L Tags: Epilepsy Curr Source Type: research

The Frail Male: Early Life Inflammation Promotes Chloride Loading in Adult Male Mice.
Abstract [Box: see text]. PMID: 32347118 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - April 29, 2020 Category: Neurology Authors: Joshi S, Beenhakker M Tags: Epilepsy Curr Source Type: research

Why do seizures impair consciousness and how can we reverse this?
Abstract PURPOSE OF REVIEW: Consciousness disorders occurring during seizures are a major source of disability in people with epilepsy. The purpose of this review is to show recent developments in the assessment and understanding of consciousness disorders in epilepsy. RECENT FINDINGS: The most frequent alterations in consciousness are alterations in the level of awareness. They are linked to disruptions on a large-scale network of fronto-parietal associative systems in different forms of focal seizures or in absences. Different theories account for these alterations. SUMMARY: Although there is no specif...
Source: Epilepsy Curr - March 7, 2020 Category: Neurology Authors: Lambert I, Bartolomei F Tags: Curr Opin Neurol Source Type: research

Pediatric APS: State of the Art.
Abstract PURPOSE OF REVIEW: The purpose of this report is to review recent research findings on APS in children and neonates. RECENT FINDINGS: European evidence-based recommendations for diagnosis and treatment of pediatric APS has recently been published by the SHARE Initiative. Recent studies have shown a high prevalence of non-thrombotic manifestations in children with aPL, domains 4/5 specificity of 'innocent' anti-β2GPI antibodies in infants, and a higher risk for developmental delays and learning disabilities, hence, the need for neurodevelopmental monitoring in children born to mothers with APS. A...
Source: Epilepsy Curr - March 3, 2020 Category: Neurology Authors: Soybilgic A, Avcin T Tags: Curr Rheumatol Rep Source Type: research

A Tale of two Networks-Glial Contributions to Generalized Seizures.
Abstract [Box: see text]. PMID: 32100552 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 26, 2020 Category: Neurology Authors: Rosch RE, Dulla CG Tags: Epilepsy Curr Source Type: research

mTORC2 Steals the Spotlight.
Abstract [Box: see text]. PMID: 32100554 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 26, 2020 Category: Neurology Authors: Jansen LA Tags: Epilepsy Curr Source Type: research

Organic Lesions in the Brain MRI of Children with Febrile Seizure.
CONCLUSION: The results showed that organic brain lesions in children with fever-unrelated seizure, which had a significant relation with the history of seizure and obstructed maternal labor. PMID: 32101131 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 25, 2020 Category: Neurology Authors: Nezami A, Tarhani F, Shoshtari NK Tags: Curr Med Imaging Source Type: research

Time to Start Calling Things by Their Own Names? The Case for Antiseizure Medicines.
Abstract Medicines currently used in the management of epilepsy have been developed to suppress seizures, and they have no known impact on the underlying disease. Using the term "antiepileptic" to describe these compounds is misleading because it suggests an action on the epilepsy itself. Pharmacological agents that have a merely symptomatic effect should be referred to as antiseizure medicines. Using appropriate terminology is especially important at a time innovative treatments targeting the development of epilepsy and its comorbidities are being actively pursued. PMID: 32077329 [PubMed - as suppl...
Source: Epilepsy Curr - February 20, 2020 Category: Neurology Authors: French JA, Perucca E Tags: Epilepsy Curr Source Type: research

EPO And EPO-Receptor System As Potential Actionable Mechanism To Protection of Brain And Heart In Refractory Epilepsy And SUDEP.
li A Abstract The most important activity of erythropoietin (EPO) is the regulation of erythrocyte production by activation of the erythropoietin receptor (EPO-R), which triggers the activation of antiapoptotic and proliferative responses of erythroid progenitor cells. Additionally, to erythropoietic EPO activity, an antiapoptotic effect has been described in a wide spectrum of tissues. EPO low levels are found in the central nervous system (CNS), while EPO-R is expressed in most CNS cell types. In spite of EPO-R high levels expressed during hypoxic-ischemic brain, insufficient production of endogenous cerebral EP...
Source: Epilepsy Curr - February 18, 2020 Category: Neurology Authors: Auzmendi J, Pûchulu MB, Garcia Rodriguez JC, Balaszczuk AM, Lazarowski A, Merelli A Tags: Curr Pharm Des Source Type: research

Epilepsy, antiepileptic drugs and dementia.
Abstract PURPOSE OF REVIEW: To illustrate the frequency and trends of the comorbidity of epilepsy and dementia and the effects of antiepileptic drugs (AEDs) on cognitive functions. RECENT FINDINGS: Although the mortality and incidence of epilepsy are decreasing overall, they are increasing in the elderly as a result of population growth and increased life expectancy. Alzheimer's disease and other dementias are among the commonest causes of seizures and epilepsy. Epilepsy can be also complicated by cognitive impairment, suggesting a bidirectional association. Although epilepsy with onset in the elderly can be ...
Source: Epilepsy Curr - February 18, 2020 Category: Neurology Authors: Beghi E, Beghi M Tags: Curr Opin Neurol Source Type: research

The cognitive costs, contraindications and complications of epilepsy surgery in adults.
Abstract PURPOSE OF REVIEW: Access to epilepsy surgery is rapidly growing throughout the world. While it is an established and effective treatment for seizures, epilepsy surgery has the potential to exacerbate cognitive comorbidities of the condition. RECENT FINDINGS: Not all surgical patients experience a postoperative decline in cognitive function. Postoperative cognitive function depends upon the functional integrity of the tissue to be removed and the functional reserve of the structures that remain in situ. While developments in surgical technique can reduce the cognitive morbidity of epilepsy surgery, t...
Source: Epilepsy Curr - February 18, 2020 Category: Neurology Authors: Baxendale S Tags: Curr Opin Neurol Source Type: research

Epigenetic Therapeutic Intervention for a Rare Epilepsy Disorder.
Abstract [Box: see text]. PMID: 32064921 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 17, 2020 Category: Neurology Authors: Sint Jago SC, Lubin FD Tags: Epilepsy Curr Source Type: research

Vulnerabilities in a Dominant Receptor Subunit.
Abstract [Box: see text]. PMID: 32064923 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 17, 2020 Category: Neurology Authors: Weston M Tags: Epilepsy Curr Source Type: research

Chance and risk in epilepsy.
Abstract PURPOSE OF REVIEW: Epilepsy is a dynamical disorder of the brain characterized by sudden, seemingly unpredictable transitions to the ictal state. When and how these transitions occur remain unresolved questions in neurology. RECENT FINDINGS: Modelling work based on dynamical systems theory proposed that a slow control parameter is necessary to explain the transition between interictal and ictal states. Recently, converging evidence from chronic EEG datasets unravelled the existence of cycles of epileptic brain activity at multiple timescales - circadian, multidien (over multiple days) and circannual ...
Source: Epilepsy Curr - February 11, 2020 Category: Neurology Authors: Baud MO, Proix T, Rao VR, Schindler K Tags: Curr Opin Neurol Source Type: research

What has been the impact of new drug treatments on epilepsy?
Abstract PURPOSE OF REVIEW: Nearly two dozen antiseizure medications (ASMs) with different mechanisms of action have been introduced over the past three decades with the aim of providing better efficacy or safety profile than the previous drugs. Several new ASMs with improvement on a classic drug family or have novel mechanisms of action have been recently approved for epilepsy. The present review explored recent studies or guidelines on new agents and discussed the potential impact of these novel treatments on epilepsy management and future directions of research. RECENT FINDINGS: Long-term cohort studies sh...
Source: Epilepsy Curr - February 11, 2020 Category: Neurology Authors: Chen Z, Brodie MJ, Kwan P Tags: Curr Opin Neurol Source Type: research

Clinical advances in the understanding, diagnosis, and treatment of epilepsy.
PMID: 32049740 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 11, 2020 Category: Neurology Authors: Walker MC Tags: Curr Opin Neurol Source Type: research

Epilepsy in brain metastasis: an emerging entity.
ino A Abstract PURPOSE OF REVIEW: The purpose of this review is to highlight advances in the management of seizures in brain metastases from solid tumors. RECENT FINDINGS: The highest risk for seizures is in patients with melanoma and lung cancer. There is lack of data on the efficacy of antiepileptic drugs (AEDs), but interactions between enzyme-inducing AEDs and anticancer agents must be avoided. Levetiracetam and valproic acid are the most appropriate drugs. Prophylaxis with AEDs for patients with brain metastases without a history of seizures is not recommended. Total resection of a brain metastasis allow...
Source: Epilepsy Curr - February 8, 2020 Category: Neurology Authors: Rudà R, Mo F, Pellerino A Tags: Curr Treat Options Neurol Source Type: research

Gene therapy repairs for epileptic brain: Potential for treatment and future directions.
Abstract Gene therapy may provide a valuable alternative for recognized therapeutic approaches to specific types of epilepsy. Focal lesion appears to be best candidate's form of therapeutic approaches for epilepsies. Gene therapy has been explored to generate antiepileptogenic (determent of progress of epilepsy in subject at threat after having an epileptogenic injury), antiseizure (diminution of severity of seizures), and disease-modifying (modification of the instinctive history of the disease) effects. Advancement of innovative therapeutic alternatives, specifically those with the capability to be remedial is a...
Source: Epilepsy Curr - January 31, 2020 Category: Neurology Authors: Ahmad MA, Pottoo FH, Akbar M Tags: Curr Gene Ther Source Type: research

Therapy in Sleep-Related Hypermotor Epilepsy (SHE).
Abstract PURPOSE OF REVIEW: The purpose of this review is to summarize and discuss current options and new advances in the treatment of sleep-related hypermotor epilepsy (SHE), focusing on pharmacological and surgical treatments. RECENT FINDINGS: Carbamazepine (CBZ) has traditionally been regarded as the first-line treatment option in SHE patients. In patients showing an unsatisfactory response to monotherapy, topiramate (TPM), lacosamide (LCM) and acetazolamide (ACZ) could be reasonable add-on strategies. The increasing understanding of the role of neuronal nicotinic acetylcholine receptor (nAChR) in SHE pat...
Source: Epilepsy Curr - January 30, 2020 Category: Neurology Authors: Asioli GM, Rossi S, Bisulli F, Licchetta L, Tinuper P, Provini F Tags: Curr Treat Options Neurol Source Type: research

Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span.
In this study, we review the progress made in these areas since the 2016 review of the Benchmarks Area IV and discuss challenges and opportunities for future study. PMID: 31973592 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 23, 2020 Category: Neurology Authors: Jones JE, Asato MR, Brown MG, Doss JL, Felton EA, Kearney JA, Talos D, Dacks PA, Whittemore V, Poduri A, NINDS/AES Benchmarks Stewards Committee Tags: Epilepsy Curr Source Type: research

Neuroprotective and Neurestorative Effects of Epo and VEGF: Perspectives for New Therapeutic Approaches to Neurological Diseases.
CONCLUSION: Because the Epo and VEGF signalling pathways are connected in several ways, we conclude that more experimental studies, primarily studies designed to thoroughly assess the functional interactions between Epo and VEGF in the brain under both physiological and pathophysiological conditions, are needed. PMID: 31942853 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 13, 2020 Category: Neurology Authors: Ureña-Guerrero ME, Castañeda-Cabral JL, Rivera-Cervantes MC, Macias-Velez RJ, Jarero-Basulto JJ, Gudiño-Cabrera G, Beas-Zárate C Tags: Curr Pharm Des Source Type: research

Cost-Effectiveness of Advanced Imaging Technologies in the Presurgical Workup of  Epilepsy.
Cost-Effectiveness of Advanced Imaging Technologies in the Presurgical Workup of Epilepsy. Epilepsy Curr. 2020 Jan 07;:1535759719894307 Authors: Kwon CS, Chang EF, Jetté N Abstract The cost-effectiveness and benefit of many diagnostic tests used in the presurgical evaluation for persons with epilepsy is for the most part uncertain as is their influence on decision-making. The options we have at our disposal are ever increasing. Advanced imaging modalities aim to improve surgical candidacy by helping us better define the epileptogenic zone and optimize surgical planning. However, judicious ...
Source: Epilepsy Curr - January 7, 2020 Category: Neurology Authors: Kwon CS, Chang EF, Jetté N Tags: Epilepsy Curr Source Type: research

Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats.
CONCLUSION: LCM could exhibit modulatory effects on the GABAergic system of the hippocampus that may be independent of the anticonvulsant action. PMID: 31894752 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 1, 2020 Category: Neurology Authors: Gáll Z, Kelemen K, Mihály I, Salamon P, Miklóssy I, Zsigmond B, Kolcsár M Tags: Curr Mol Pharmacol Source Type: research

Preventing Birth Defects by Changing Maternal Antiepileptic Drug Therapy: We've Come a Long Way, Baby.
Abstract [Box: see text]. PMID: 31847579 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - December 18, 2019 Category: Neurology Authors: Noe K Tags: Epilepsy Curr Source Type: research

KCC2 Much Chloride Might Not Be the Only Problem.
Abstract [Box: see text]. PMID: 31826658 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - December 12, 2019 Category: Neurology Authors: Weston M Tags: Epilepsy Curr Source Type: research

Mortality in Epilepsy: Referral to a Specialty Center Makes a Difference.
Abstract [Box: see text]. PMID: 31826659 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - December 12, 2019 Category: Neurology Authors: Hogan RE Tags: Epilepsy Curr Source Type: research

Strokes or Seizures? What's the Score?
Abstract [Box: see text]. PMID: 31802720 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - December 5, 2019 Category: Neurology Authors: Bermeo-Ovalle A Tags: Epilepsy Curr Source Type: research

Solid Evidence for a Thin Hypothesis.
Abstract [Box: see text]. PMID: 31802721 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - December 5, 2019 Category: Neurology Authors: Shih J Tags: Epilepsy Curr Source Type: research

Therapeutic targets for the treatment of comorbidities associated with epilepsy.
Abstract One of the most common neurological disorder occurs among 1% of population worldwide is epilepsy. Therapeutic failure is common with epilepsy and nearly about 30% of patient fall in this category. Seizure suppression should not be the only goal while treating epilepsy but associated comorbidities which can further worsen the condition should also be considered. Treatment of such comorbidities like depression, anxiety, cognition, attention deficit hyperactivity disorder and, various other disorder which co-exist with epilepsy or are caused due to epilepsy should also be treated. Novel targets or the existi...
Source: Epilepsy Curr - December 2, 2019 Category: Neurology Authors: Gangar K, Bhatt LK Tags: Curr Mol Pharmacol Source Type: research

Long-term outcomes after childhood convulsive status epilepticus.
Abstract PURPOSE OF REVIEW: It is widely accepted that childhood convulsive status epilepticus (CSE) has associated short-term and long-term mortality and morbidity. However, the role of CSE itself on subsequent adverse outcomes is still debated. In addition, whether prolonged seizures cause any long-term hippocampal injury and developmental or memory impairment is uncertain. In this review, we aim to provide an overview of long-term outcomes after childhood CSE, highlighting data from recent literature on this subject. RECENT FINDINGS: Long-term outcome after childhood CSE is favorable in previously normal c...
Source: Epilepsy Curr - November 8, 2019 Category: Neurology Authors: Pujar S, Scott RC Tags: Curr Opin Pediatr Source Type: research

Pharmacological treatments for fragile X syndrome based on synaptic dysfunction.
CONCLUSION: In this concise review, we summarize and analyze the main hypotheses proposed to explain synaptic dysregulation in FXS, by reviewing the scientific evidence that led to pharmaceutical clinical trials and their outcome. PMID: 31682210 [PubMed - as supplied by publisher] (Source: Epilepsy Curr)
Source: Epilepsy Curr - November 2, 2019 Category: Neurology Authors: Telias M Tags: Curr Pharm Des Source Type: research

Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A potential novel drug for epilepsy.
Abstract Epilepsy, an ancient disease, is defined as an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological and social consequences of this condition. Antiepileptic drugs (AEDs) is currently used as first-line treatment for patients with epilepsy, however, around 36% patients are diagnosed into refractory epilepsy, which means two or more AEDs has been considered as failed after sufficiently correct usage. Unfortunately, it is unlikely that the improvement of efficacy of AEDs will be easily achieved, especially no AEDs shows efficacy in ceasing epileptogenesi...
Source: Epilepsy Curr - October 13, 2019 Category: Neurology Authors: Wang X, Li T Tags: Curr Drug Targets Source Type: research