Therapeutic Response of Epimedium gandiflorum's Different Doses to Restore the Antioxidant Potential and Reproductive Hormones in Male Albino Rats.
Abstract
Current study was planned to explore the therapeutic response of different doses of hydroethanolic extract of Epimedium grandiflorum leaves in male albino rats. Phytochemical analysis, HPLC and FTIR spectroscopy results revealed the presence of wide range of phenolic compounds and functional groups, respectively. Further, extract not induced significant hemolysis (7.56 ± 1.297%) against PBS (3.65 ± 0.35%) as negative control; while have significant clot lysis (44 ± 5.2%) potential, exhibited DPPH (78.87 ± 5.427%) scavenging, H2O2 (31.82 ± 3.491%) scavenging, antioxidant and reducing power act...
Source: Dose Response - June 30, 2020 Category: Drugs & Pharmacology Authors: Munir N, Mahmood Z, Yameen M, Mustafa G Tags: Dose Response Source Type: research
Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model.
Abstract
Cerebral hypoperfusion is a common feature of cerebral small vascular disease (CSVD), which has been considered as one of the causes of cognitive decline in recent years. Epimedium flavonoids (EF) are the main ingredients extracted from Epimedium. The purpose of this study was to investigate the effects of EF on cognitive impairment, and the underlying mechanisms in rats with permanent occlusion of the bilateral common carotid artery (2VO). EF (50, 100, and 200 mg/kg) was intragastrically administered for 12 weeks starting 2 weeks after 2VO surgery. The results showed that EF treatment improved ...
Source: Brain Research Bulletin - June 23, 2020 Category: Neurology Authors: Niu HM, Ma DL, Wang MY, Chen XP, Zhang L, Li YL, Zhang L, Li L Tags: Brain Res Bull Source Type: research
An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury
ConclusionsIcariin liposome has excellent therapeutic effects on acute blunt muscle injury in rats by improving immunity, repairing cytoskeleton and cellular integrity, anti ‐inflammation, anti‐fibrosis and antioxidant stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 21, 2020 Category: Drugs & Pharmacology Authors: Jinwu Wang,
Gaosheng Zhu,
Xingyu Wang,
Jie Cai,
Linzhen Xie,
Wenhao Zheng,
Yongzeng Feng,
Qiang Guo,
Hua Chen,
Leyi Cai Tags: Research Paper Source Type: research
Effects of icariin on cell injury and glucocorticoid resistance in BEAS-2B cells exposed to cigarette smoke extract.
In conclusion, icariin may potentially be used in combination with GCs to increase therapeutic efficacy and reduce GC resistance in COPD.
PMID: 32550884 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - June 21, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse –a pilot study
Nicotine, a pharmacologically active component of tobacco adversely affects the male reproductive system and fertility whereas icariin (ICA), the main active ingredient in Epimedium herba has been used in the tre... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - June 18, 2020 Category: Endocrinology Authors: Guochao Ni, Xuhui Zhang, Seth Yaw Afedo and Rong Rui Tags: Research Source Type: research
Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse -a pilot study.
CONCLUSIONS: These findings indicate that nicotine-induced reproductive toxicity and oxidative damage on male reproductive tissues could be attenuated by ICA.
PMID: 32552695 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - June 17, 2020 Category: Reproduction Medicine Authors: Ni G, Zhang X, Afedo SY, Rui R Tags: Reprod Biol Endocrinol Source Type: research
Icariin Alleviates Glucocorticoid-Induced Osteoporosis through EphB4/Ephrin-B2 Axis.
Conclusion: Icariin could improve the characteristics of OP through regulating the balance of the EphB4/Ephrin-B2 pathway. Further preclinical trial is needed to provide certainty of clinical benefits for OP patients.
PMID: 32508946 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 9, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration.
CONCLUSION: The inhibition of liver cancer by Baohuoside-1 is through targeting mTOR signaling not JAK2 signaling to induce apoptosis. Our study indicates that Baohuoside-1 is a potential candidate drug for therapy against liver cancer.
PMID: 32526459 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2020 Category: Drugs & Pharmacology Authors: Guo Y, Zhu H, Weng M, Chen B, Wang C, Sun L Tags: Biomed Pharmacother Source Type: research
Icariin improves cognitive deficits by reducing the deposition of β-amyloid peptide and inhibition of neurons apoptosis in SAMP8 mice
This study investigated the neuroprotective effects of ICA in SAMP8 mice model of aspects of early AD and explored potential underlying mechanisms. Our results showed that intragastric administration of ICA could reverse the learning and memory impairment of SAMP8 mice in the Morris water maze. Western blot of hippocampal specimens revealed that ICA down-regulated the expression of BACE1 to reduce the expression of cytotoxic Aβ1-42. Furthermore, ICA siginificantly increase the Bcl-2/Bax ratio by increasing the expression of anti-apoptotic protein Bcl-2, and decreasing the expression of pro-apoptotic protein Bax, and thus ...
Source: NeuroReport - May 22, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research
Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats.
Abstract
Chronic cerebral hypoperfusion is a common cause of cerebral small vascular disease (CSVD). White matter (WM) lesions are the typical pathological manifestation of CSVD and contribute to cognitive decline. Epimedium flavonoids (EF) are the main component in Epimedium brevicornu Maxim., which is commonly used in traditional Chinese medicine. The purpose of this study was to investigate the effects of EF on cognitive impairment and the underlying mechanisms in a CSVD rat model induced with chronic cerebral hypoperfusion. The model was established by permanent bilateral common carotid artery occlusio...
Source: Brain Research - May 20, 2020 Category: Neurology Authors: Niu HM, Wang MY, Ma DL, Chen XP, Zhang L, Li YL, Zhang L, Li L Tags: Brain Res Source Type: research
Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ER α/Nrf2-Signaling Pathway
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular function via protection from Sertoli cell injury remains unclear. In the present study, we evaluated the protective effect of icariin on Sertoli cell injury and explored the possible mechanism(s) in vivo and in vitro. Dietary administration of icariin for 4 months significantly ameliorated the age-related decline in testicular func...
Source: Frontiers in Pharmacology - May 11, 2020 Category: Drugs & Pharmacology Source Type: research
Epimedium Polysaccharide Ameliorates Benzene-Induced Aplastic Anemia in Mice.
In this study, we investigated the protective effects of epimedium polysaccharide (EPS), a natural compound with antioxidant and immune-enhancing potency, on aplastic anemia induced by benzene exposure in mice. Male CD-1 mice were randomly divided into five groups including control, BZ (880 mg/kg), LE (EPS low-dose, 20 mg/kg + BZ), ME (EPS middle-dose, 100 mg/kg + BZ), and HE (EPS high-dose, 200 mg/kg + BZ) groups. Animals were exposed to BZ by subcutaneous injection in the presence or absence of EPS via oral administration. All mice were treated 3 times a week for 8 consecutive weeks to develop a mouse...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice
Publication date: Available online 21 March 2020Source: Journal of Ginseng ResearchAuthor(s): Evelyn Saba, Yuan Yee Lee, Minki Kim, Sun-Hee Hyun, Chae-Kyu Park, Eunjung Son, Dong-Seon Kim, Sung-Dae Kim, Man Hee Rhee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 9, 2020 Category: Complementary Medicine Source Type: research
Icariin alleviates transforming growth factor- β1-induced epithelial-mesenchymal transition by targeting Smad and MAPK signaling pathways.
Icariin alleviates transforming growth factor-β1-induced epithelial-mesenchymal transition by targeting Smad and MAPK signaling pathways.
Am J Transl Res. 2020;12(2):343-360
Authors: Li Z, Yuan X, Wang B, Gao F
Abstract
The pathogenesis of airway remodeling and airway inflammation is related to epithelial-mesenchymal transition (EMT), which is correlated with TGF-β1 levels. Icariin is one of the major compounds in Epimedium brevicornum Maxim, and plays emerging roles in relieving cough and asthma, enhancing immunity, and anti-allergy. In the present study, we investigated the me...
Source: American Journal of Translational Research - March 22, 2020 Category: Research Tags: Am J Transl Res Source Type: research
A novel herbal formulation consisting of Red ginseng extract and Epimedium Koreanum Nakai attenuated dextran sulfate sodium induced colitis in mice
Publication date: Available online 21 March 2020Source: Journal of Ginseng ResearchAuthor(s): Evelyn Saba, Yuan Yee Lee, Minki Kim, Sun-Hee Hyun, Chae-Kyu Park, Eunjung Son, Dong-Seon Kim, Sung-Dae Kim, Man Hee Rhee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 22, 2020 Category: Complementary Medicine Source Type: research
