Comparative analysis of chemical components in different parts of Epimedium Herb
Publication date: Available online 17 February 2021Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Ming Zhou, Wei Zheng, Xinguang Sun, Ming Yuan, Jie Zhang, Xiaojuan Chen, Kate Yu, Baolin Guo, Baiping Ma (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - February 18, 2021 Category: Drugs & Pharmacology Source Type: research
Icariin Treatment Protects Against Gentamicin-Induced Ototoxicity via Activation of the AMPK-SIRT3 Pathway
In this study, we found that icariin pretreatment improved the survival rate of gentamicin-treated House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and cochlear explants. Icariin remarkably suppressed HEI-OC1 cell apoptosis and inhibited ROS production in cells. Notably, icariin upregulated PGC-1α (SIRT3 promoter) and SIRT3 expression in HEI-OC1 cells. In addition, SIRT3 inhibition significantly attenuated the anti-apoptotic effect of icariin. We also found that icariin can increase AMPK phosphorylation. Further studies showed that inhibition of SIRT3 activity had no significant effect on AMPK phosphorylation. Further...
Source: Frontiers in Pharmacology - February 18, 2021 Category: Drugs & Pharmacology Source Type: research
A Network Pharmacology Approach to Estimate Potential Targets of the Active Ingredients of Epimedium for Alleviating Mild Cognitive Impairment and Treating Alzheimer's Disease.
Conclusions: The present study provides theoretical evidence for in-depth analysis of the mechanisms and molecular targets by which Epimedium protects against MCI, AD, and other neurodegenerative diseases and lays the foundation for pragmatic clinical applications and potential new drug development.
PMID: 33574879 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 14, 2021 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway.
CONCLUSIONS: Further research needs to verify the expression changes of AMPK/mTOR/ULK1 and the improvement effect of ICA in elderly. These results will further accelerate the applications of ICA and the treatment for senescence.
PMID: 33556283 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 10, 2021 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Systems pharmacology dissection of Epimedium targeting tumor microenvironment to enhance cytotoxic T lymphocyte responses in lung cancer.
Abstract
The clinical notably success of immunotherapy fosters an enthusiasm in developing drugs by enhancing antitumor immunity in the tumor microenvironment (TME). Epimedium, is a promising herbal medicine for tumor immunotherapy due to the pharmacological actions in immunological function modulation and antitumor. Here, we developed a novel systems pharmacology strategy to explore the polypharmacology mechanism of Epimedium involving in targeting TME of non-small cell lung cancer (NSCLC). This strategy integrates the active compounds screening, target predicting, network pharmacology analysis and onco-i...
Source: Aging - January 17, 2021 Category: Biomedical Science Authors: Huang C, Li Z, Zhu J, Chen X, Hao Y, Yang R, Huang R, Zhou J, Wang Z, Xiao W, Zheng C, Wang Y Tags: Aging (Albany NY) Source Type: research
Zhuang-Gu-Fang Treats Osteoporosis in Ovariectomized Rats by Increasing the Osteogenesis-Related Factors Leptin, Ghrelin, and PYY.
Authors: Chen Y, Bai R, Chen W, Li S, Jiang Y
Abstract
Zhuang-Gu-Fang is a Chinese medicinal compound mixture, which is mainly composed of traditional remedies like the Epimedium Herb, Astragalus, and Eucommia among many others. The study is aimed at investigating the therapeutic effect of Zhuang-Gu-Fang in ovariectomized rats. Fifty six-month-old Wistar rats were randomly selected and divided into 5 groups (n = 10), namely, model group, positive group, low-dose Chinese medicine group, medium-dose group, and high-dose group. Another 10 sham operation Wistar rats were taken as a negative control group. ...
Source: Evidence-based Complementary and Alternative Medicine - December 9, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Icaritin inhibited ovalbumin-induced airway inflammation in murine model
Conclusion: Our findings suggest that Icaritin may inhibit inflammation in asthma by regulating the imbalance of Th1/Th2. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Yao, D., Xiao, B., Zhou, G., Mo, B. Tags: Airway pharmacology and treatment Source Type: research
Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo.
In conclusion, we found for the first time that the intestine is considered as the major metabolic organ, liver as the main recycling organ for the enterohepatic recycling (EHR) of ICT. Moreover, DIG is the main species in the systemic circulation following oral administration of ICT which explains the low toxicity of ICT in clinical settings.
PMID: 32918091 [PubMed - as supplied by publisher] (Source: Archives of Toxicology)
Source: Archives of Toxicology - September 10, 2020 Category: Toxicology Authors: Rong Y, Tu Y, Yin T, Meng Z, Dou G, Hu M Tags: Arch Toxicol Source Type: research
Icariin Protects Mouse Insulinoma Min6 Cell Function by Activating the PI3K/AKT Pathway.
CONCLUSIONS ICA protected Min6 cell function, an effect likely mediated by the PI3K pathway. ICA may inhibit the progression of diabetes.
PMID: 32885795 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research
High-Throughput Metabolomics Method for Discovering Metabolic Biomarkers and Pathways to Reveal Effects and Molecular Mechanism of Ethanol Extract From Epimedium Against Osteoporosis
Metabolomics is an effective strategy to explore the molecular mechanism of herbal medicine. Epimedium, a traditional Chinese herb from the Epimedium brevicornu Maxim., has a therapeutic effect on osteoporosis (OP), however the molecular mechanism of the anti-OP effect is uncle\ar. Therefore, we investigated the pharmacological effect and action mechanism of ethanol extract of epimedium (Ext-epi) onOP rat model. The serum of OP rats was analyzed utilized UPLC-Q-TOF/MS metabolomics, and the potential biomarkers were screened and identified using multivariate data analysis systems and network databases. To further apprais...
Source: Frontiers in Pharmacology - August 26, 2020 Category: Drugs & Pharmacology Source Type: research
Icariin Ameliorates Lower Back Pain in Rats via Suppressing the Secretion of Cytokine-Induced Neutrophil Chemoatractant-1.
Conclusion: ICA is a novel herbal extract to relieve LBP, and it may be a promising alternative pain killer in the future.
PMID: 32802846 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 19, 2020 Category: Research Authors: Li J, Luo M, Wang S, Jin G, Han Z, Ma Y, Tang G, Guo Z Tags: Biomed Res Int Source Type: research
Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai
Publication date: Available online 16 August 2020Source: Biochemical Engineering JournalAuthor(s): Yunbin Lyu, Shike Liu, Song Gao, Jingwen Zhou (Source: Biochemical Engineering Journal)
Source: Biochemical Engineering Journal - August 17, 2020 Category: Biochemistry Source Type: research
A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods.
A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods.
Drug Deliv. 2020 Dec;27(1):1176-1187
Authors: Li H, Li Y, Ao H, Fu J, Guo Y, Han M, Yan X, Chen X, Wang X
Abstract
Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro and in vivo antitumor effects. Nanorods (NRs) were prepared for ICT and HICT by anti-solvent precipitation method using D-alpha tocopherol acid polyethylene glycol succinate (TPGS) as a stabili...
Source: Drug Delivery - August 13, 2020 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Icaritin Improves Memory and Learning Ability by Decreasing BACE-1 Expression and the Bax/Bcl-2 Ratio in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice.
Authors: Li YY, Huang NQ, Feng F, Li Y, Luo XM, Tu L, Qu JQ, Xie YM, Luo Y
Abstract
Icaritin (ICT) is the main component in the traditional Chinese herb Epimedium, and it has been shown to have anti-Alzheimer's disease (AD) effects, but its neuroprotective effects and the pharmacological mechanisms are unclear. In the present study, senescence-accelerated mouse prone 8 (SAMP8) mice were randomly divided into a model group and an ICT-treated group. Learning and memory abilities were detected by the Morris water maze assay, and the expression of amyloid beta protein (Aβ) and β-site APP cleavage enzyme 1 (B...
Source: Evidence-based Complementary and Alternative Medicine - July 29, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Antitumor effects of icaritin and the molecular mechanisms.
Authors: Zhang C, Sui X, Jiang Y, Wang X, Wang S
Abstract
Traditional Chinese Medicine (TCM) has been increasingly studied for antitumor activities. Icaritin, a hydrolytic product of icariin, is an effective ingredient of the traditional Chinese herb epimedium with multiple pharmacological activities. Among them, the antitumor activity of icaritin has been widely studied and reported in tumors both in vitro and in vivo. While its exact antitumor mechanisms await revelation, icaritin has been found to regulate several key molecules and pathways concerning cell fate, including CDK-dependent pathways, mitogen...
Source: Discovery Medicine - July 1, 2020 Category: Research Tags: Discov Med Source Type: research
