A new flavonoid from < em > Epimedium brevicornu < /em > Maxim
In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.PMID:37029621 | DOI:10.1080/14786419.2023.2199213 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Juan Jiang Bao-Guo Jiang Bing Liu Source Type: research
A new flavonoid from < em > Epimedium brevicornu < /em > Maxim
In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.PMID:37029621 | DOI:10.1080/14786419.2023.2199213 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Juan Jiang Bao-Guo Jiang Bing Liu Source Type: research
Flavonoids and prenylhydroquinones from the prepared folium of Epimedium sagittatum maxim. And their inhibition against phosphodiesterase5A
Fitoterapia. 2023 Feb 28:105465. doi: 10.1016/j.fitote.2023.105465. Online ahead of print.ABSTRACTAn effort to identify novel active substance of the prepared folium of Epimedium sagittatum Maxim. (PFES) that was an important herb for male erectile dysfunction (ED) was taken. At present, phosphodiesterase-5A (PDE5A) is the most important target of new drugs for the treatment of ED. Therefore, the inhibition ingredients in PFES were systematically screened for the first time in this study. Eleven compounds, including eight new flavonoids and three prenylhydroquinones were isolated: sagittatosides DN (1-11), and their struct...
Source: Fitoterapia - March 2, 2023 Category: Biochemistry Authors: Juntao Li Youan He Xinyu Zheng Senjie Li Yue Wu Wanyin Shi Kaijin Pan Jijia Sun Zhe Wang Jian Xu Xiangwei Zheng Source Type: research
Flavonoids and prenylhydroquinones from the prepared folium of Epimedium sagittatum maxim. And their inhibition against phosphodiesterase5A
Fitoterapia. 2023 Feb 28:105465. doi: 10.1016/j.fitote.2023.105465. Online ahead of print.ABSTRACTAn effort to identify novel active substance of the prepared folium of Epimedium sagittatum Maxim. (PFES) that was an important herb for male erectile dysfunction (ED) was taken. At present, phosphodiesterase-5A (PDE5A) is the most important target of new drugs for the treatment of ED. Therefore, the inhibition ingredients in PFES were systematically screened for the first time in this study. Eleven compounds, including eight new flavonoids and three prenylhydroquinones were isolated: sagittatosides DN (1-11), and their struct...
Source: Fitoterapia - March 2, 2023 Category: Biochemistry Authors: Juntao Li Youan He Xinyu Zheng Senjie Li Yue Wu Wanyin Shi Kaijin Pan Jijia Sun Zhe Wang Jian Xu Xiangwei Zheng Source Type: research
Flavonoids and prenylhydroquinones from the prepared folium of Epimedium sagittatum maxim. And their inhibition against phosphodiesterase5A
Fitoterapia. 2023 Feb 28:105465. doi: 10.1016/j.fitote.2023.105465. Online ahead of print.ABSTRACTAn effort to identify novel active substance of the prepared folium of Epimedium sagittatum Maxim. (PFES) that was an important herb for male erectile dysfunction (ED) was taken. At present, phosphodiesterase-5A (PDE5A) is the most important target of new drugs for the treatment of ED. Therefore, the inhibition ingredients in PFES were systematically screened for the first time in this study. Eleven compounds, including eight new flavonoids and three prenylhydroquinones were isolated: sagittatosides DN (1-11), and their struct...
Source: Fitoterapia - March 2, 2023 Category: Biochemistry Authors: Juntao Li Youan He Xinyu Zheng Senjie Li Yue Wu Wanyin Shi Kaijin Pan Jijia Sun Zhe Wang Jian Xu Xiangwei Zheng Source Type: research
Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition
Molecules. 2023 Jan 22;28(3):1109. doi: 10.3390/molecules28031109.ABSTRACTBreast cancer is one of the most prevalent malignancies and the leading cause of cancer-associated mortality in China. Icaritin (ICT), a prenyl flavonoid derived from the Epimedium Genus, has been proven to inhibit the proliferation and stemness of breast cancer cells. Our previous study demonstrated that IC2, a derivative of ICT, could induce breast cancer cell apoptosis by Stearoyl-CoA desaturase 1 (SCD1) inhibition. The present study further investigated the mechanism of the inhibitory effects of IC2 on breast cancer cells in vitro and in vivo. Ou...
Source: Cancer Control - February 11, 2023 Category: Cancer & Oncology Authors: Yi-Xuan Wang Yi-Yuan Jin Jie Wang Zi-Cheng Zhao Ke-Wen Xue He Xiong Hui-Lian Che Yun-Jun Ge Guo-Sheng Wu Source Type: research
Systematic quality evaluation of Epimedium wushanense T. S. Ying based on two quality control standards: total flavonoid glycosides and epimedin C
Chem Biodivers. 2023 Feb 5. doi: 10.1002/cbdv.202200579. Online ahead of print.ABSTRACTTwo quality control standards, total flavonoid glycosides of Epimedii Folium and epimedin C of Epimedii Wushanensis Folium, were used to systematically evaluate the quality of Epimedium wushanense T. S. Ying, so as to provide reference for its germplasm screening and resource utilization. Seven representative populations of E. wushanense covering its main distribution areas were uniformly sampled during the flowering period. There were significant quality differences among the populations of E. wushanense. According to the quality standa...
Source: Chemistry and Biodiversity - February 5, 2023 Category: Biochemistry Authors: Congying Wang Shuyun Tian Qin Tang Ziwei Zhou Xinheng Peng Xiaoxue Cai Yanqin Xu Source Type: research
Systematic quality evaluation of Epimedium wushanense T. S. Ying based on two quality control standards: total flavonoid glycosides and epimedin C
Chem Biodivers. 2023 Feb 5. doi: 10.1002/cbdv.202200579. Online ahead of print.ABSTRACTTwo quality control standards, total flavonoid glycosides of Epimedii Folium and epimedin C of Epimedii Wushanensis Folium, were used to systematically evaluate the quality of Epimedium wushanense T. S. Ying, so as to provide reference for its germplasm screening and resource utilization. Seven representative populations of E. wushanense covering its main distribution areas were uniformly sampled during the flowering period. There were significant quality differences among the populations of E. wushanense. According to the quality standa...
Source: Chemistry and Biodiversity - February 5, 2023 Category: Biochemistry Authors: Congying Wang Shuyun Tian Qin Tang Ziwei Zhou Xinheng Peng Xiaoxue Cai Yanqin Xu Source Type: research
Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid
Discussion: Inhibition of CYP3A4 function by epimedium and its active compound kaempferol leads to enhancement of CS anti-inflammatory effect. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 30, 2023 Category: Drugs & Pharmacology Source Type: research
Screening and characterization of a β-xylosidase from Bifidobacterium breve K-110 and its application in the biotransformation of the total flavonoids of epimedium to icariin with α-l-rhamnosidase
This study is the first to screen xylosidases for the targeted conversion of epimedin B to produce icariin, and the first to report that epimedin B and epimedin C in the raw epimedium flavonoids can convert efficiently to icariin by a collaborative of β-xylosidase and α-l-rhamnosidase.PMID:36706530 | DOI:10.1016/j.bioorg.2023.106364 (Source: Bioorganic Chemistry)
Source: Bioorganic Chemistry - January 27, 2023 Category: Chemistry Authors: Jingwen Su Tao Wu Shiping Cao Jianjun Pei Linguo Zhao Source Type: research
Screening and characterization of a β-xylosidase from Bifidobacterium breve K-110 and its application in the biotransformation of the total flavonoids of epimedium to icariin with α-l-rhamnosidase
This study is the first to screen xylosidases for the targeted conversion of epimedin B to produce icariin, and the first to report that epimedin B and epimedin C in the raw epimedium flavonoids can convert efficiently to icariin by a collaborative of β-xylosidase and α-l-rhamnosidase.PMID:36706530 | DOI:10.1016/j.bioorg.2023.106364 (Source: Bioorganic Chemistry)
Source: Bioorganic Chemistry - January 27, 2023 Category: Chemistry Authors: Jingwen Su Tao Wu Shiping Cao Jianjun Pei Linguo Zhao Source Type: research
Integrating strategies of metabolomics, network pharmacology, and experiment validation to investigate the processing mechanism of Epimedium fried with suet oil to warm kidney and enhance yang
Discussion: These finds may elucidate the underlying mechanism of yang enhancement via kidney warming effects. Our study indicated that the mechanism of action mainly involved oxidative stress and amino acid metabolism. Here, we demonstrated the novel strategies of integrating metabolomics and network pharmacology in exploring of the mechanisms of traditional Chinese medicines. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 25, 2023 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 28, Pages 1109: Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition
Ge
Guo-Sheng Wu
Breast cancer is one of the most prevalent malignancies and the leading cause of cancer-associated mortality in China. Icaritin (ICT), a prenyl flavonoid derived from the Epimedium Genus, has been proven to inhibit the proliferation and stemness of breast cancer cells. Our previous study demonstrated that IC2, a derivative of ICT, could induce breast cancer cell apoptosis by Stearoyl-CoA desaturase 1 (SCD1) inhibition. The present study further investigated the mechanism of the inhibitory effects of IC2 on breast cancer cells in vitro and in vivo. Our results proved that IC2 could stimulate autophagy ...
Source: Molecules - January 22, 2023 Category: Chemistry Authors: Yi-Xuan Wang Yi-Yuan Jin Jie Wang Zi-Cheng Zhao Ke-Wen Xue He Xiong Hui-Lian Che Yun-Jun Ge Guo-Sheng Wu Tags: Article Source Type: research
Comparative analysis of codon usage patterns in chloroplast genomes of ten Epimedium species
The Phenomenon of codon usage bias exists in the genomes of prokaryotes and eukaryotes. The codon usage pattern is affected by environmental factors, base mutation, gene flow and gene expression level, among w... (Source: BMC Genetics)
Source: BMC Genetics - January 9, 2023 Category: Genetics & Stem Cells Authors: Yingzhe Wang, Dacheng Jiang, Kun Guo, Lei Zhao, Fangfang Meng, Jinglei Xiao, Yuan Niu and Yunlong Sun Tags: Research Source Type: research
Molecules, Vol. 28, Pages 517: Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation
Conclusion: Icariin showed an ameliorative effect on hepatic steatosis induced by HFD and letrozole, which was associated with improved fatty acid oxidation and reduced lipid accumulation in the liver. (Source: Molecules)
Source: Molecules - January 5, 2023 Category: Chemistry Authors: Yang Hai Ling Zuo Meng Wang Ruoyu Zhang Munan Wang Li Ren Congwen Yang Jianwei Wang Tags: Article Source Type: research
