Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction
Myocardial contractile dysfunction in diabetic cardiomyocytes is a significant promoter of heart failure. Herein, we investigated the effect of icariin, a flavonoid monomer isolated from Epimedium, on diabetic cardiomyopathy (DCM) and explored the mechanisms underlying its unique pharmacological cardioprotective functions. High glucose (HG) conditions were simulated in vitro using cardiomyocytes isolated from neonatal C57 mice, while DCM was stimulated in vivo in db/db mice. Mice and cardiomyocytes were treated with icariin, with or without overexpression or silencing of Apelin and Sirt3 via transfection with adenoviral ve...
Source: Frontiers in Pharmacology - March 18, 2020 Category: Drugs & Pharmacology Source Type: research
GAPT regulates cholinergic dysfunction and oxidative stress in the brains of learning and memory impairment mice induced by scopolamine
ConclusionsGAPT can improve the learning and memory ability of scopolamine ‐induced mice, and its mechanism may be related to protecting cholinergic neurons and reducing oxidative stress injury. (Source: Brain and Behavior)
Source: Brain and Behavior - March 18, 2020 Category: Neurology Authors: Zhenhong Liu,
Gaofeng Qin,
Lulu Mana,
Yunfang Dong,
Shuaiyang Huang,
Yahan Wang,
Yiqiong Wu,
Jing Shi,
Jinzhou Tian,
Pengwen Wang Tags: ORIGINAL RESEARCH Source Type: research
Pharmacological effects of icariin.
Abstract
Icariin (ICA) is a principal active component from traditional Chinese medicine Epimedium grandiflorum. To explain its traditional medical usages by modern science, a variety of pharmacological effects have been studied for ICA. In this review, we summarized the pharmacokinetics of ICA as well as its pharmacological mechanisms in neurodegenerative disease, cardiovascular disease, anti-osteoporosis, anti-inflammation, anti-oxidative stress, anti-depression and anti-tumors.
PMID: 32089233 [PubMed - in process] (Source: Advances in Pharmacology)
Source: Advances in Pharmacology - February 26, 2020 Category: Drugs & Pharmacology Authors: He C, Wang Z, Shi J Tags: Adv Pharmacol Source Type: research
Icariside II suppresses cervical cancer cell migration through JNK modulated matrix metalloproteinase-2/9 inhibition in vitro and in vivo.
In this study, we proved that Icariside II can inhibit cervical cancer cells migration through JNK-MMP2/9 signaling pathway and is a prospective drug with high-chemopreventive effects on cervical cancer cell metastasis.
PMID: 32092821 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 18, 2020 Category: Drugs & Pharmacology Authors: Sun YS, Thakur K, Hu F, Cespedes-Acuña CL, Zhang JG, Wei ZJ Tags: Biomed Pharmacother Source Type: research
Epimedium polysaccharides attenuates hematotoxicity by reducing oxidative stress and enhancing immune function in mice model of benzene-induced bone marrow failure
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Jin He, Shaolei Zang, Na Liu, Min Ji, Daoxin Ma, Chunyan JiAbstractChronic benzene (BZ) exposure is associated with multiple adverse health effects and leads to progressive bone marrow failure (BMF). BZ-induced BMF is an acquired aplastic anemia characterized by severe anemia, neutropenia and thrombocytopenia, which is likely caused by immunotoxicity and oxidative stress. Previous studies showed that Epimedium polysaccharides (EPS), a natural and major herbal compound derived from Epimedium, has immunomodulatory and antioxidant potential....
Source: Biomedicine and Pharmacotherapy - January 31, 2020 Category: Drugs & Pharmacology Source Type: research
Icariin Protects Hippocampal Neurons From Endoplasmic Reticulum Stress and NF- κB Mediated Apoptosis in Fetal Rat Hippocampal Neurons and Asthma Rats
Icariin is a main component of the Chinese medicinal plant Epimedium brevicornu Maxim, exhibits potent activity against inflammatory diseases. Our previous data demonstrated the valid bioactivity of icariin on mitigating rodent asthma. Endoplasmic reticulum (ER) stress and nuclear factor-κB (NF-κB) pathway were involved in the pathogenesis of asthma. However, it remains poorly defined that whether icariin could inhibit ER stress and NF-κB mediated apoptosis in asthma and further influence the central neural system. Herein, we investigated the effects of icariin on primary cultured fetal rat hippocampal neurons and OVALP...
Source: Frontiers in Pharmacology - January 30, 2020 Category: Drugs & Pharmacology Source Type: research
Icariin stimulates hFOB 1.19 osteoblast proliferation and differentiation via OPG/RANKL mediated by the estrogen receptor.
In conclusions, ICA can regulate bone formation by promoting cell proliferation and differentiation and upregulating the OPG/RANKL expression ratio by the ER in hFOB1.19 human osteoblast cells.
PMID: 31971108 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 21, 2020 Category: Biotechnology Authors: Sun LJ, Li C, Wen XH, Guo L, Guo ZF, Liao LQ, Guo Y Tags: Curr Pharm Biotechnol Source Type: research
In a Rat Model of Acute Liver Failure, Icaritin Improved the Therapeutic Effect of Mesenchymal Stem Cells by Activation of the Hepatocyte Growth Factor/c-Met Pathway.
In conclusion, this study demonstrated that ICT enhances the therapeutic effect of MSCs in a model of ALF, improving the antiapoptotic potential of MSCs by upregulation of the HGF/c-Met pathway. The combination of stem cell therapy with traditional herbal extracts may improve MSC-based clinical applications.
PMID: 31915446 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 11, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Molecules, Vol. 25, Pages 137: A Widely Metabolomic Analysis Revealed Metabolic Alterations of Epimedium Pubescens Leaves at Different Growth Stages
Xian’en Li
Epimedium folium is the major medicinally-used organ of Epimedium species and its metabolic changes during the leaf growth have not been studied at the metabolomic level. E. pubescens is one of five recorded species in the Pharmacopoeia of the People’s Republic of China and widely grows in China. A UPLC-ESI-MS/MS-based targeted metabolomic analysis was implemented to explore the metabolite composition in E. pubescens leaves under the cultivation condition and further to investigate their temporal variations among four representative growth stages. A total of 403 metabolites, including 32 hith...
Source: Molecules - December 28, 2019 Category: Chemistry Authors: Zhenxian Qin Dengqun Liao Yalan Chen Chenyang Zhang Ruipeng An Qing Zeng Xian ’en Li Tags: Article Source Type: research
Icariside II Inhibits Tumorigenesis via Inhibiting AKT/Cyclin E/ CDK 2 Pathway and Activating Mitochondria-Dependent Pathway
Publication date: Available online 26 December 2019Source: Pharmacological ResearchAuthor(s): Ya-Sai Sun, Kiran Thakur, Fei Hu, Jian-Guo Zhang, Zhao-Jun WeiAbstractCervical cancer contributes largely in women cancer-related mortality. Herein, Icariside II, a flavonoid extracted from edible and pharmaceutical plant Epimedium brevicornum Maxim, exhibited significant anticancer activity on cervical cancer. At first, it was observed that Icariside II inhibited Hela cell proliferation at IC50 (9.2 μM) and the growth of Hela-originated xenografts in BALB/c nude mice. Next, we studied the underlying mechanisms of Icariside II ...
Source: Pharmacological Research - December 26, 2019 Category: Drugs & Pharmacology Source Type: research
Chemical markers of four species of Epimedium used in drug Yin-Yang-Huo
This study aimed to identify the chemical markers of these species by HPLC-PDA fingerprinting combined with chemometrics methods. The HPLC separation was performed on a Water's Atlantis®T3 column (4.6 × 250 mm, 5 μm) with the gradient elution of acetonitrile-0.1% formic acid aqueous solution using a PDA detector. The HPLC-PDA fingerprints of 88 batches of Yin-Yang-Huo samples were obtained and analysed using principal component analysis (PCA) and hierarchical cluster analysis (HCA). Samples of E. koreanum and E. sagittatum were classified into separate groups, while samples of E. brevicornum and E. pubescens were cl...
Source: Biochemical Systematics and Ecology - December 13, 2019 Category: Biochemistry Source Type: research
Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease.
This study may provide a new strategy for developing novel drugs to treat AD.
PMID: 31816602 [PubMed - as supplied by publisher] (Source: Aging)
Source: Aging - December 8, 2019 Category: Biomedical Science Authors: Yu W, An S, Shao T, Xu H, Chen H, Ning J, Zhou Y, Chai X Tags: Aging (Albany NY) Source Type: research
Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis
Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture due to the reduced bone mass and microstructural degradation. Primary pharmacological strategies for the treatment of osteoporosis, hormone replacement treatment (HRT), and alendronate therapies may produce adverse side-effects and may not be recommended for long-term usage. Some classic and bone-specific natural Chinese medicine are very popularly used to treat osteoporosis and bone fracture effectively in clinical with their potential value in bone growth and development, but with few adverse side-effects. Current evidence suggests ...
Source: Frontiers in Pharmacology - November 24, 2019 Category: Drugs & Pharmacology Source Type: research
The effect of Icaritin on airway smooth muscle cells proliferation and apoptosis
Conclusions: We conclude Icaritin inhibites proliferation but induces apoptosis of rat ASMCs, this finding implys its potential application in asthma modeling intervention. But the detail mechanism needs to be further explored. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Yao, D., Xiao, B., Hou, L., Yang, L., Mo, B. Tags: Airway pharmacology and treatment Source Type: research
Inhibition of airway remodeling and inflammatory response by Icariin in asthma
Icariin (ICA) is the major active ingredient extracted from Chinese herbal medicine Epimedium, which has the effects of improving cardiovascular function, inducing tumor cell differentiation and increasing bon... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - November 19, 2019 Category: Complementary Medicine Authors: Lingli Hu, Lulu Li, Hongying Zhang, Qiuping Li, Shan Jiang, Jian Qiu, Jing Sun and Jingcheng Dong Tags: Research article Source Type: research
