Icariin Improves Glucocorticoid Resistance in a Murine Model of Asthma with Depression Associated with Enhancement of GR Expression and Function
In this study, a murine model of asthma with depression was established by exposure to ovalbumin combined with chronic
unpredictable mild stress, and icariin was given orally during ovalbumin challenge and chronic unpredictable mild stress exposure. Depression-like behaviors were assessed by the open field
test, forced swim test, and tail suspension test. The characteristic features of allergic asthma, including airway hyperreactivity, histopathology, inflammatory cytokine levels in
bronchoalveolar lavage fluid, and immunoglobulin E and corticosterone levels in serum, were examined. Following splenocyte isol...
Source: Planta Medica - August 22, 2022 Category: Drugs & Pharmacology Authors: Jin, Hualiang Zhou, Yan Ye, Jian Qiu, Chenhui Jin, Weizhong Wang, Limin Tags: Original Papers Source Type: research
Deciphering the molecular mechanism underlying the effects of epimedium on osteoporosis through system bioinformatic approach
This study aims to elucidate the molecular mechanism of epimedium in the treatment of OP based on system bioinformatic approach. (Source: Medicine)
Source: Medicine - August 12, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways
Mol Biol Rep. 2022 Aug 8. doi: 10.1007/s11033-022-07778-3. Online ahead of print.ABSTRACTIcariin is a primary active component of the traditional Chinese medicinal plant Epimedium grandiflorum. A range of pharmacological effects of icariin has been researched by modern science to explain its traditional medicinal uses. Attributing to the wide range of pharmacological properties like anti-osteoporosis, anti-inflammation, anti-oxidative stress, anti-depression, and anti-tumor property possessed by icariin, it is now being considered a potential therapeutic agent for a wide variety of disorders ranging from neoplasm, neurodeg...
Source: Molecular Biology Reports - August 8, 2022 Category: Molecular Biology Authors: Aanchal Verma Kritika Aggarwal Ritik Agrawal Kajal Pradhan Ahsas Goyal Source Type: research
Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways
Mol Biol Rep. 2022 Aug 8. doi: 10.1007/s11033-022-07778-3. Online ahead of print.ABSTRACTIcariin is a primary active component of the traditional Chinese medicinal plant Epimedium grandiflorum. A range of pharmacological effects of icariin has been researched by modern science to explain its traditional medicinal uses. Attributing to the wide range of pharmacological properties like anti-osteoporosis, anti-inflammation, anti-oxidative stress, anti-depression, and anti-tumor property possessed by icariin, it is now being considered a potential therapeutic agent for a wide variety of disorders ranging from neoplasm, neurodeg...
Source: Molecular Biology Reports - August 8, 2022 Category: Molecular Biology Authors: Aanchal Verma Kritika Aggarwal Ritik Agrawal Kajal Pradhan Ahsas Goyal Source Type: research
Icaritin and intratumoral injection of CpG treatment synergistically promote T cell infiltration and antitumor immune response in mice
Int Immunopharmacol. 2022 Aug 2;111:109093. doi: 10.1016/j.intimp.2022.109093. Online ahead of print.ABSTRACTThe development of combination therapy that can modulate the tumor immunosuppressive microenvironment is highly desirable for cancer immunotherapy. Icaritin (ICT), a hydrolytic product of icariin from genus Epimedium, has been used as an anti-cancer immunoregulatory agent for many types of cancers. Herein, we design a novel therapeutic strategy for mice melanoma that combines systemic administration of icaritin with intratumoral injection of unmethylated cytosine-guanine oligodeoxynucleotide (CpG). Icaritin induces ...
Source: International Immunopharmacology - August 5, 2022 Category: Allergy & Immunology Authors: Zhangchi Dongye Xiaoping Wu Yuxiang Wen Xuelei Ding Chuanjie Wang Tingting Zhao Jian Li Yuzhang Wu Source Type: research
Icaritin and intratumoral injection of CpG treatment synergistically promote T cell infiltration and antitumor immune response in mice
Int Immunopharmacol. 2022 Aug 2;111:109093. doi: 10.1016/j.intimp.2022.109093. Online ahead of print.ABSTRACTThe development of combination therapy that can modulate the tumor immunosuppressive microenvironment is highly desirable for cancer immunotherapy. Icaritin (ICT), a hydrolytic product of icariin from genus Epimedium, has been used as an anti-cancer immunoregulatory agent for many types of cancers. Herein, we design a novel therapeutic strategy for mice melanoma that combines systemic administration of icaritin with intratumoral injection of unmethylated cytosine-guanine oligodeoxynucleotide (CpG). Icaritin induces ...
Source: International Immunopharmacology - August 5, 2022 Category: Allergy & Immunology Authors: Zhangchi Dongye Xiaoping Wu Yuxiang Wen Xuelei Ding Chuanjie Wang Tingting Zhao Jian Li Yuzhang Wu Source Type: research
Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens
Xian-Ling-Gu-Bao (XLGB) capsule, a well-known traditional Chinese medicine prescription, is widely used for the treatment of osteoporosis. It could significantly increase the levels of estrogen in ovariectomized rats and mice. However, this working mechanism has not been well elucidated. Considering that UDP-glucuronosyltransferase (UGT) enzymes are the important enzymes that inactivate and regulate estrogen activity in vivo, this study aimed to identify the bioactive compounds from XLGB against the glucuronidation of estrogens. First, thirty compounds were considered as candidate bioactive compounds based on our previous ...
Source: Frontiers in Pharmacology - August 4, 2022 Category: Drugs & Pharmacology Source Type: research
Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape
CONCLUSIONS: These results suggest that icariside I could be an effective small molecule drug for tumor immunotherapy by blocking kynurenine-AhR pathway and tumor immune escape.PMID:35834991 | DOI:10.1016/j.biopha.2022.113387 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 14, 2022 Category: Drugs & Pharmacology Authors: Gui Chen Jiajun Huang Hehua Lei Fang Wu Chuan Chen Yuchen Song Zheng Cao Ce Zhang Cui Zhang Yuxi Ma Mingtao Huang Jinlin Zhou Yujing Lu Yanxia Zhao Limin Zhang Source Type: research
Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape
CONCLUSIONS: These results suggest that icariside I could be an effective small molecule drug for tumor immunotherapy by blocking kynurenine-AhR pathway and tumor immune escape.PMID:35834991 | DOI:10.1016/j.biopha.2022.113387 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 14, 2022 Category: Drugs & Pharmacology Authors: Gui Chen Jiajun Huang Hehua Lei Fang Wu Chuan Chen Yuchen Song Zheng Cao Ce Zhang Cui Zhang Yuxi Ma Mingtao Huang Jinlin Zhou Yujing Lu Yanxia Zhao Limin Zhang Source Type: research
Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape
CONCLUSIONS: These results suggest that icariside I could be an effective small molecule drug for tumor immunotherapy by blocking kynurenine-AhR pathway and tumor immune escape.PMID:35834991 | DOI:10.1016/j.biopha.2022.113387 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 14, 2022 Category: Drugs & Pharmacology Authors: Gui Chen Jiajun Huang Hehua Lei Fang Wu Chuan Chen Yuchen Song Zheng Cao Ce Zhang Cui Zhang Yuxi Ma Mingtao Huang Jinlin Zhou Yujing Lu Yanxia Zhao Limin Zhang Source Type: research
Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape
CONCLUSIONS: These results suggest that icariside I could be an effective small molecule drug for tumor immunotherapy by blocking kynurenine-AhR pathway and tumor immune escape.PMID:35834991 | DOI:10.1016/j.biopha.2022.113387 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 14, 2022 Category: Drugs & Pharmacology Authors: Gui Chen Jiajun Huang Hehua Lei Fang Wu Chuan Chen Yuchen Song Zheng Cao Ce Zhang Cui Zhang Yuxi Ma Mingtao Huang Jinlin Zhou Yujing Lu Yanxia Zhao Limin Zhang Source Type: research
Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape
CONCLUSIONS: These results suggest that icariside I could be an effective small molecule drug for tumor immunotherapy by blocking kynurenine-AhR pathway and tumor immune escape.PMID:35834991 | DOI:10.1016/j.biopha.2022.113387 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 14, 2022 Category: Drugs & Pharmacology Authors: Gui Chen Jiajun Huang Hehua Lei Fang Wu Chuan Chen Yuchen Song Zheng Cao Ce Zhang Cui Zhang Yuxi Ma Mingtao Huang Jinlin Zhou Yujing Lu Yanxia Zhao Limin Zhang Source Type: research
Epimedium koreanum Nakai –Induced Liver Injury—A Mechanistic Study Using Untargeted Metabolomics
In this study, untargeted metabolomics was performed to analyze the serum and liver tissue to explore the mechanism of hepatotoxicity of Epimedium koreanum Nakai. The results of experiments in vivo showed that, after 28 days of exposure to Epimedium koreanum Nakai ethanol extract (EEE), the liver weight, levels of AST, ALP, TBIL, etc. in serum of rats in the EEE group were significantly increased, as well as severe cytoplasmic vacuolation appeared in the liver tissue, which suggested that EEE has significant hepatotoxicity. Subsequently, the results of metabolomics revealed significant changes in the metabolic profile in ...
Source: Frontiers in Pharmacology - July 13, 2022 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory and immunoregulatory effects of icariin and icaritin
In this study, we reviewed the anti-inflammatory and immunomodulatory mechanisms, as well as the pharmacokinetic properties of ICA and its metabolite ICT.PMID:35676785 | DOI:10.1016/j.biopha.2022.113180 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 9, 2022 Category: Drugs & Pharmacology Authors: Zhangyang Bi Wei Zhang Xiaoyan Yan Source Type: research
Anti-inflammatory and immunoregulatory effects of icariin and icaritin
In this study, we reviewed the anti-inflammatory and immunomodulatory mechanisms, as well as the pharmacokinetic properties of ICA and its metabolite ICT.PMID:35676785 | DOI:10.1016/j.biopha.2022.113180 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 9, 2022 Category: Drugs & Pharmacology Authors: Zhangyang Bi Wei Zhang Xiaoyan Yan Source Type: research
