Immune-related effects of compound astragalus polysaccharide and sulfated epimedium polysaccharide on newborn piglets
This study aimed to evaluate the immune effects of compound astragalus polysaccharide and sulfated epimedium polysaccharide (APS-sEPS) on the peripheral blood lymphocyte and intestinal mucosa in newborn piglets. A total of 40 newborn piglets were randomly divided into four groups during a 25-day experiment, including APS-sEPS, APS, sEPS and control group. The results showed that supplementation with APS-sEPS to newborn piglets remarkably increased the physiological parameters, especially the WBC. In peripheral blood, piglets that received APS-sEPS showed the highest proliferation of T lymphocytes, the percentage of CD3 + C...
Source: Animal Biotechnology - September 22, 2021 Category: Biotechnology Authors: Qing Jin Lei Cheng Yiling Zhu Xiaona Zhao Wei Zhang Xuejun Gao Tao Xiong Liwei Guo Source Type: research
UPLC-MS/MS method for simultaneously determining nucleosides and methyl-nucleosides in liver mRNA of Epimedin C-induced liver injury mouse model
Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied. mRNA methylation... (Source: Chinese Medicine)
Source: Chinese Medicine - September 21, 2021 Category: Complementary Medicine Authors: Zhizhen Song, Zeyun Li, Xueqian Wen, Ruijuan Liu and Xin Tian Tags: Research Source Type: research
Molecular mechanism of Epicedium treatment for depression based on network pharmacology and molecular docking technology
Increasing attention has been paid to the effect of Epimedium on the nervous system, particularly anti-depression function. In the present study, we applied network pharmacology to introduce a testable hypothesis... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - September 3, 2021 Category: Complementary Medicine Authors: Yankai Dong, Bo Tao, Xing Xue, Caixia Feng, Yating Ren, Hengyu Ma, Junli Zhang, Yufang Si, Sisi Zhang, Si Liu, Hui Li, Jiahao Zhou, Ge Li, Zhifei Wang, Juanping Xie and Zhongliang Zhu Tags: Research article Source Type: research
Epimedokoreanin C, a prenylated flavonoid isolated from Epimedium koreanum, induces non-apoptotic cell death with the characteristics of methuosis in lung cancer cells
Am J Cancer Res. 2021 Jul 15;11(7):3496-3514. eCollection 2021.ABSTRACTMethuosis is a novel type of non-apoptotic cell death characterized by accumulation of cytoplasmic vacuoles. Identification of molecules that induce methuosis may provide alternative therapeutics for cancers that are refractory to apoptosis. Epimedokoreanin C (EKC) is a prenylated flavonoid isolated from a Chinese herb Epimedium koreanum. In this article, we described that EKC reduced cell viability accompanied by extreme vacuolation in human lung cancer cells. The EKC-induced cell death was clarified as non-apoptosis based on the absence of apoptotic c...
Source: Cell Research - August 6, 2021 Category: Cytology Authors: Xiaoqing Liu Shuqi Wang Hao Zheng Qingying Liu Tao Shen Xiaoning Wang Dongmei Ren Source Type: research
Icariin and its phosphorylated derivatives reduce duck hepatitis A virus serotype 1-induced oxidative stress and inflammatory damage in duck embryonic hepatocytes through mitochondrial regulation
In this study, we used duck embryo hepatocytes (DEHs) to investigate the mechanism of the alleviation of DHAV-1-induced inflammation and oxidative stress by ICA and pICA, and to further study their effects on hepatocyte mitochondrial function, apoptosis and cell cycle. It was found that ICA and pICA can inhibit the negative effects of DHAV-1 on apoptosis and cell cycle progression by stabilizing mitochondrial function, thereby reducing inflammation and ultimately protecting liver cells. The effects of pICA are more beneficial than those of ICA. The results of this study may be useful in the development of a new prophylacti...
Source: Cell Research - July 23, 2021 Category: Cytology Authors: Wen Xiong Rui Wang Wensai Mao Yi Wu Deyun Wang Yuanliang Hu Jiaguo Liu Source Type: research
Plastid genome data provide new insights into the phylogeny and evolution of the genus Epimedium
Publication date: Available online 30 June 2021Source: Journal of Advanced ResearchAuthor(s): Mengyue Guo, Xiaohui Pang, Yanqin Xu, Wenjun Jiang, Baosheng Liao, Jingsheng Yu, Jiang Xu, Jingyuan Song, Shilin Chen (Source: Journal of Advanced Research)
Source: Journal of Advanced Research - June 30, 2021 Category: Research Source Type: research
PPAR γ mediates the anti-pulmonary fibrosis effect of icaritin
CONCLUSIONS: Icaritin has therapeutic potential against pulmonary fibrosis via the inhibition of myofibroblast differentiation, which may be mediated by PPARγ.PMID:34153405 | DOI:10.1016/j.toxlet.2021.06.014 (Source: Toxicology Letters)
Source: Toxicology Letters - June 21, 2021 Category: Toxicology Authors: Qingzhong Hua Xiaoting Huang Weixi Xie Feiyan Zhao Haipeng Cheng Ziqiang Luo Jianzhong Han Zun Wang Qian Zeng Miao Lin Tingting Zhou Jialu Zhang Can Gu Wei Liu Siyuan Tang Source Type: research
PPAR γ mediates the anti-pulmonary fibrosis effect of icaritin
CONCLUSIONS: Icaritin has therapeutic potential against pulmonary fibrosis via the inhibition of myofibroblast differentiation, which may be mediated by PPARγ.PMID:34153405 | DOI:10.1016/j.toxlet.2021.06.014 (Source: Toxicology Letters)
Source: Toxicology Letters - June 21, 2021 Category: Toxicology Authors: Qingzhong Hua Xiaoting Huang Weixi Xie Feiyan Zhao Haipeng Cheng Ziqiang Luo Jianzhong Han Zun Wang Qian Zeng Miao Lin Tingting Zhou Jialu Zhang Can Gu Wei Liu Siyuan Tang Source Type: research
PPAR γ mediates the anti-pulmonary fibrosis effect of icaritin
CONCLUSIONS: Icaritin has therapeutic potential against pulmonary fibrosis via the inhibition of myofibroblast differentiation, which may be mediated by PPARγ.PMID:34153405 | DOI:10.1016/j.toxlet.2021.06.014 (Source: Toxicology Letters)
Source: Toxicology Letters - June 21, 2021 Category: Toxicology Authors: Qingzhong Hua Xiaoting Huang Weixi Xie Feiyan Zhao Haipeng Cheng Ziqiang Luo Jianzhong Han Zun Wang Qian Zeng Miao Lin Tingting Zhou Jialu Zhang Can Gu Wei Liu Siyuan Tang Source Type: research
PPAR γ mediates the anti-pulmonary fibrosis effect of icaritin
CONCLUSIONS: Icaritin has therapeutic potential against pulmonary fibrosis via the inhibition of myofibroblast differentiation, which may be mediated by PPARγ.PMID:34153405 | DOI:10.1016/j.toxlet.2021.06.014 (Source: Toxicology Letters)
Source: Toxicology Letters - June 21, 2021 Category: Toxicology Authors: Qingzhong Hua Xiaoting Huang Weixi Xie Feiyan Zhao Haipeng Cheng Ziqiang Luo Jianzhong Han Zun Wang Qian Zeng Miao Lin Tingting Zhou Jialu Zhang Can Gu Wei Liu Siyuan Tang Source Type: research
Molecules, Vol. 26, Pages 3590: Prenylated Flavonoid Glycosides with PCSK9 mRNA Expression Inhibitory Activity from the Aerial Parts of Epimedium koreanum
inwoong Kim
Phytochemical investigation on the n-BuOH-soluble fraction of the aerial parts of Epimedium koreanum using the PCSK9 mRNA monitoring assay led to the identification of four previously undescribed acylated flavonoid glycosides and 18 known compounds. The structures of new compounds were elucidated by NMR, MS, and other chemical methods. All isolated compounds were tested for their inhibitory activity against PCSK9 mRNA expression in HepG2 cells. Of the isolates, compounds 6, 7, 10, 15, and 17–22 were found to significantly inhibit PCSK9 mRNA expression. In particular, compound 7 was shown to increase LDLR ...
Source: Molecules - June 11, 2021 Category: Chemistry Authors: Eeray Kim Young-Mi Kim Jongmin Ahn Hee-Sung Chae Young-Won Chin Jinwoong Kim Tags: Article Source Type: research
Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model
In this study, we found that icariside I, a novel anti-cancer agent isolated from Epimedium, significantly inhibited B16F10 melanoma growth in vivo through regulation of gut microbiota and host immunity. Oral administration of icariside I improved the microbiota community structure with marked restoration of Lactobacillus spp. and Bifidobacterium spp. abundance in the cecal contents of tumor-bearing mice. We also found that icariside I improves the levels of microbiota-derived metabolites such as short-chain fatty acids (SCFAs) and indole derivatives, consequently promoting repair of the intestinal barrier and reducing sys...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2021 Category: Drugs & Pharmacology Authors: Gui Chen Zheng Cao Zunji Shi Hehua Lei Chuan Chen Peihong Yuan Fang Wu Caixiang Liu Manyuan Dong Yuchen Song Jinlin Zhou Yujing Lu Limin Zhang Source Type: research
Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model
In this study, we found that icariside I, a novel anti-cancer agent isolated from Epimedium, significantly inhibited B16F10 melanoma growth in vivo through regulation of gut microbiota and host immunity. Oral administration of icariside I improved the microbiota community structure with marked restoration of Lactobacillus spp. and Bifidobacterium spp. abundance in the cecal contents of tumor-bearing mice. We also found that icariside I improves the levels of microbiota-derived metabolites such as short-chain fatty acids (SCFAs) and indole derivatives, consequently promoting repair of the intestinal barrier and reducing sys...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2021 Category: Drugs & Pharmacology Authors: Gui Chen Zheng Cao Zunji Shi Hehua Lei Chuan Chen Peihong Yuan Fang Wu Caixiang Liu Manyuan Dong Yuchen Song Jinlin Zhou Yujing Lu Limin Zhang Source Type: research
Up-regulation of long non-coding RNA CYTOR induced by icariin promotes the viability and inhibits the apoptosis of chondrocytes
Icariin (ICAR) is the main effective component extracted from epimedium, and is reported to have the potential to treat osteoarthritis (OA). However, its pharmacological function on chondrocytes has not been f... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 26, 2021 Category: Complementary Medicine Authors: Guoyou Wang, Lei Zhang, Huarui Shen, Qi Hao, Shijie Fu and Xia Liu Tags: Research article Source Type: research
Antiplatelet and Antithrombotic Effects of < em > Epimedium koreanum < /em > Nakai
Conclusion and Implications. E. koreanum inhibited platelet aggregation and thrombus formation by attenuating calcium mobilization, ATP secretion, TXB2 formation, and integrin α IIb β 3 activation. Therefore, it may be considered as a potential candidate to treat and prevent platelet-related cardiovascular disorders.PMID:33953788 | PMC:PMC8068545 | DOI:10.1155/2021/7071987 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 6, 2021 Category: Complementary Medicine Authors: Muhammad Irfan Tae-Hyung Kwon Dong-Ha Lee Seung-Bok Hong Jae-Wook Oh Sung-Dae Kim Man Hee Rhee Source Type: research
