Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats
Brain Res Bull. 2022 Feb 21:S0361-9230(22)00053-3. doi: 10.1016/j.brainresbull.2022.02.014. Online ahead of print.ABSTRACTInflammatory pain is a chronic, persistent and serious disease that greatly impacts public health, which is often accompanied by allodynia, hyperalgesia, and spontaneous pain. It is evident that α7 nicotinic acetylcholine receptor (α7nAChR) plays a key role in cholinergic anti-inflammatory pathway and exhibits the inhibition of neuroinflammation in chronic pain. Trifluoro-icaritin (ICTF), a derivative of icaritin from the extract of a genus of Epimedium plant, is identified to possess profound anti-in...
Source: Brain Research Bulletin - February 24, 2022 Category: Neurology Authors: Yalan Sun Dandan Jia Meng Xue Zhihua Huang Cheng Huang Source Type: research
Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats
Brain Res Bull. 2022 Feb 21:S0361-9230(22)00053-3. doi: 10.1016/j.brainresbull.2022.02.014. Online ahead of print.ABSTRACTInflammatory pain is a chronic, persistent and serious disease that greatly impacts public health, which is often accompanied by allodynia, hyperalgesia, and spontaneous pain. It is evident that α7 nicotinic acetylcholine receptor (α7nAChR) plays a key role in cholinergic anti-inflammatory pathway and exhibits the inhibition of neuroinflammation in chronic pain. Trifluoro-icaritin (ICTF), a derivative of icaritin from the extract of a genus of Epimedium plant, is identified to possess profound anti-in...
Source: Brain Research - February 24, 2022 Category: Neurology Authors: Yalan Sun Dandan Jia Meng Xue Zhihua Huang Cheng Huang Source Type: research
Icariin attenuates thioacetamide ‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway
Mol Med Rep. 2022 Apr;25(4):126. doi: 10.3892/mmr.2022.12642. Epub 2022 Feb 16.ABSTRACTThere is an increasing incidence of destructive bone disease caused by osteoclast proliferation. This is characterized by reduced bone mass and imbalance of bone homeostasis. Icariin (ICA), a flavonoid compound isolated from Epimedium, has anti‑osteoporosis activity and inhibits the formation of osteoclasts and bone resorption. The purpose of the present study was to investigate the protective effect of ICA on osteoclastic differentiation induced by thioacetamide (TAA) and its possible mechanism in Sprague Dawley (SD) rats. In the pres...
Source: Molecular Medicine - February 16, 2022 Category: Molecular Biology Authors: Linyan Cheng Xiaoli Jin Hao Shen Xuanwei Chen Jin Chen Bin Xu Jian Xu Source Type: research
Icariin attenuates thioacetamide ‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway
Mol Med Rep. 2022 Apr;25(4):126. doi: 10.3892/mmr.2022.12642. Epub 2022 Feb 16.ABSTRACTThere is an increasing incidence of destructive bone disease caused by osteoclast proliferation. This is characterized by reduced bone mass and imbalance of bone homeostasis. Icariin (ICA), a flavonoid compound isolated from Epimedium, has anti‑osteoporosis activity and inhibits the formation of osteoclasts and bone resorption. The purpose of the present study was to investigate the protective effect of ICA on osteoclastic differentiation induced by thioacetamide (TAA) and its possible mechanism in Sprague Dawley (SD) rats. In the pres...
Source: Molecular Medicine Reports - February 16, 2022 Category: Molecular Biology Authors: Linyan Cheng Xiaoli Jin Hao Shen Xuanwei Chen Jin Chen Bin Xu Jian Xu Source Type: research
Icariin attenuates thioacetamide ‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway
Mol Med Rep. 2022 Apr;25(4):126. doi: 10.3892/mmr.2022.12642. Epub 2022 Feb 16.ABSTRACTThere is an increasing incidence of destructive bone disease caused by osteoclast proliferation. This is characterized by reduced bone mass and imbalance of bone homeostasis. Icariin (ICA), a flavonoid compound isolated from Epimedium, has anti‑osteoporosis activity and inhibits the formation of osteoclasts and bone resorption. The purpose of the present study was to investigate the protective effect of ICA on osteoclastic differentiation induced by thioacetamide (TAA) and its possible mechanism in Sprague Dawley (SD) rats. In the pres...
Source: Molecular Medicine - February 16, 2022 Category: Molecular Biology Authors: Linyan Cheng Xiaoli Jin Hao Shen Xuanwei Chen Jin Chen Bin Xu Jian Xu Source Type: research
Icariin attenuates thioacetamide ‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway
Mol Med Rep. 2022 Apr;25(4):126. doi: 10.3892/mmr.2022.12642. Epub 2022 Feb 16.ABSTRACTThere is an increasing incidence of destructive bone disease caused by osteoclast proliferation. This is characterized by reduced bone mass and imbalance of bone homeostasis. Icariin (ICA), a flavonoid compound isolated from Epimedium, has anti‑osteoporosis activity and inhibits the formation of osteoclasts and bone resorption. The purpose of the present study was to investigate the protective effect of ICA on osteoclastic differentiation induced by thioacetamide (TAA) and its possible mechanism in Sprague Dawley (SD) rats. In the pres...
Source: Molecular Medicine Reports - February 16, 2022 Category: Molecular Biology Authors: Linyan Cheng Xiaoli Jin Hao Shen Xuanwei Chen Jin Chen Bin Xu Jian Xu Source Type: research
The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure
Aging (Albany NY). 2022 Feb 14;14(undefined). doi: 10.18632/aging.203893. Online ahead of print.ABSTRACTEpimedium brevicornum Maxim, a Traditional Chinese Medicine, has been used for the treatment of impotence, sinew and bone disorders, "painful impediment caused by wind-dampness," numbness, spasms, hypertension, coronary heart disease, menopausal syndrome, bronchitis, and neurasthenia for many years in China. Recent animal experimental studies indicate that icariin, a major bioactive component of epimedium may effectively treat Alzheimer's disease, cerebral ischemia, depression, Parkinson's disease, multiple sclerosis, as...
Source: Aging - February 15, 2022 Category: Biomedical Science Authors: Ling Rui Li Gautam Sethi Xing Zhang Cui Liu Liu Yan Huang Qun Liu Bo Xu Ren Feng Ru Tang Source Type: research
The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure
Aging (Albany NY). 2022 Feb 14;14(undefined). doi: 10.18632/aging.203893. Online ahead of print.ABSTRACTEpimedium brevicornum Maxim, a Traditional Chinese Medicine, has been used for the treatment of impotence, sinew and bone disorders, "painful impediment caused by wind-dampness," numbness, spasms, hypertension, coronary heart disease, menopausal syndrome, bronchitis, and neurasthenia for many years in China. Recent animal experimental studies indicate that icariin, a major bioactive component of epimedium may effectively treat Alzheimer's disease, cerebral ischemia, depression, Parkinson's disease, multiple sclerosis, as...
Source: Aging - February 15, 2022 Category: Biomedical Science Authors: Ling Rui Li Gautam Sethi Xing Zhang Cui Liu Liu Yan Huang Qun Liu Bo Xu Ren Feng Ru Tang Source Type: research
Icariin attenuates cyclophosphamide-induced cystitis via down-regulation of NF- кB and up-regulation of Nrf-2/HO-1 signaling pathways in mice model
Int Immunopharmacol. 2022 Feb 8;106:108604. doi: 10.1016/j.intimp.2022.108604. Online ahead of print.ABSTRACTCystitis is a chronic bladder pain associated with frequency and nocturia. In the present study, Icariin a prenylated flavonoid extracted from Epimedium koreanum, was investigated against cyclophosphamide (CYP)-induced cystitis pain in mice model. Preliminarily in an acute model, single dose of CYP (150 mg/kg; i.p) was administered followed by Icariin (5, 25 and 50 mg/kg, i.p.). The visceral sensitivity and nociceptive behaviors were significantly ameliorated by pretreatment with Icariin (25, 50 mg/kg) that were ass...
Source: International Immunopharmacology - February 12, 2022 Category: Allergy & Immunology Authors: Safa Amanat Bushra Shal Eun Kyoung Seo Hussain Ali Salman Khan Source Type: research
Icariin attenuates cyclophosphamide-induced cystitis via down-regulation of NF- кB and up-regulation of Nrf-2/HO-1 signaling pathways in mice model
Int Immunopharmacol. 2022 Feb 8;106:108604. doi: 10.1016/j.intimp.2022.108604. Online ahead of print.ABSTRACTCystitis is a chronic bladder pain associated with frequency and nocturia. In the present study, Icariin a prenylated flavonoid extracted from Epimedium koreanum, was investigated against cyclophosphamide (CYP)-induced cystitis pain in mice model. Preliminarily in an acute model, single dose of CYP (150 mg/kg; i.p) was administered followed by Icariin (5, 25 and 50 mg/kg, i.p.). The visceral sensitivity and nociceptive behaviors were significantly ameliorated by pretreatment with Icariin (25, 50 mg/kg) that were ass...
Source: International Immunopharmacology - February 12, 2022 Category: Allergy & Immunology Authors: Safa Amanat Bushra Shal Eun Kyoung Seo Hussain Ali Salman Khan Source Type: research
Plastid genome data provide new insights into the phylogeny and evolution of the genus Epimedium
CONCLUSION: These findings provide new insights into the relationships among Epimedium species and pave the way for better elucidation of the classification and evolution of this genus.PMID:35127172 | PMC:PMC8799909 | DOI:10.1016/j.jare.2021.06.020 (Source: Adv Data)
Source: Adv Data - February 7, 2022 Category: Epidemiology Authors: Mengyue Guo Xiaohui Pang Yanqin Xu Wenjun Jiang Baosheng Liao Jingsheng Yu Jiang Xu Jingyuan Song Shilin Chen Source Type: research
Plastid genome data provide new insights into the phylogeny and evolution of the genus Epimedium
CONCLUSION: These findings provide new insights into the relationships among Epimedium species and pave the way for better elucidation of the classification and evolution of this genus.PMID:35127172 | PMC:PMC8799909 | DOI:10.1016/j.jare.2021.06.020 (Source: Adv Data)
Source: Adv Data - February 7, 2022 Category: Epidemiology Authors: Mengyue Guo Xiaohui Pang Yanqin Xu Wenjun Jiang Baosheng Liao Jingsheng Yu Jiang Xu Jingyuan Song Shilin Chen Source Type: research
Molecules, Vol. 27, Pages 1026: Proteomic Analysis of Protective Effects of Epimedium Flavonoids against Ethanol-Induced Toxicity in Retinoic Acid-Treated SH-SY5Y Cells
In conclusion, Gi protein seemed to be an important factor in the alcoholism pathway to suppress the ethanol-induced toxicity of SH-SY5Y cells. These findings suggest a protective potential of Epimedium flavonoids against ethanol-induced toxicity to neurons via the regulation of Gi protein function. (Source: Molecules)
Source: Molecules - February 2, 2022 Category: Chemistry Authors: Xiaohua Yang Huafeng Zhang Lu Li Xuexue Zhou Yichao Liu Jianghua Lai Tags: Article Source Type: research
Plant-Pollinator Specialization: Origin and Measurement of Curvature
Am Nat. 2022 Feb;199(2):206-222. doi: 10.1086/717677. Epub 2021 Dec 8.ABSTRACTAbstractA feature of biodiversity is the abundance of curves displayed by organs and organisms. Curvature is a widespread, convergent trait that has important ecological and evolutionary implications. In pollination ecology, the curvature of flowers and pollinator mouthparts (e.g., hummingbird bills) along the dorsiventral plane has been associated with specialization, competition, and species coexistence. Six differing methods have historically been used to measure curvature in pollination systems; we provide a solution to this inconsistency by ...
Source: The American Naturalist - January 25, 2022 Category: Biology Authors: Mannfred M A Boehm Jill E Jankowski Quentin C B Cronk Source Type: research
Icariin and its metabolites as potential protective phytochemicals against cardiovascular disease: From effects to molecular mechanisms
Biomed Pharmacother. 2022 Jan 21;147:112642. doi: 10.1016/j.biopha.2022.112642. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the leading cause of morbidity and mortality among all types of diseases in the world, affecting many millions of individuals every year. CVD includes hypertension, atherosclerosis, pulmonary hypertension, heart failure, cardiomyopathy, coronary heart disease, etc., which are involved in complex etiology, pathogenesis and many risk factors. Modern pharmacological studies have revealed that Epimedium possesses a variety of beneficial effects in regulating cardiovascular inflammation a...
Source: Atherosclerosis - January 25, 2022 Category: Cardiology Authors: Yufei Zeng Yilin Xiong Tao Yang Yan Wang Jing Zeng Shaoyu Zhou Yunmei Luo Lisheng Li Source Type: research
