NF ‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.
NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model. Mol Med Rep. 2018 Oct 03;: Authors: Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K Abstract PM2.5 is a particle with a diameter
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Microarray analysis reveals long non ‑coding RNA SOX2OT as a novel candidate regulator in diabetic nephropathy.
Microarray analysis reveals long non‑coding RNA SOX2OT as a novel candidate regulator in diabetic nephropathy. Mol Med Rep. 2018 Oct 04;: Authors: Zhang X, Shang J, Wang X, Cheng G, Jiang Y, Liu D, Xiao J, Zhao Z Abstract Diabetic nephropathy (DN) is a highly complex syndrome involving multiple dysregulated biological processes. Long non‑coding RNAs (lncRNAs) are now believed to have an important function in various diseases. However, their roles in DN remain largely unknown. Therefore, the present study was performed in order to investigate the lncRNAs that have a crucial role in DN. db/db mice we...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyurea.
Authors: Azevedo AP, Silva SN, Reichert A, Lima F, Júnior E, Rueff J Abstract Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether SNPs in genes involved in apoptosis and the base excision repair (BER) pathway was evaluated. In addition, some known risk factors in PN‑MPNs that may influence survival and therapeutic response to hydroxyurea (HU) were analyzed, t...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Involvement of caspase ‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer.
Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer. Mol Med Rep. 2018 Oct 08;: Authors: Sato Y, Yoshino H, Kazama Y, Kashiwakura I Abstract Retinoic acid‑inducible gene‑I‑like receptors (RLRs) serve an important role in antiviral immune responses. Recent studies demonstrated that RLR activation exerts antitumor activity by inducing an anticancer immune response and apoptosis in various cancer cells. The authors' recent study demonstrated that the cytotoxic e...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Synergistic effects of vemurafenib and fingolimod (FTY720) in vemurafenib ‑resistant melanoma cell lines.
Synergistic effects of vemurafenib and fingolimod (FTY720) in vemurafenib‑resistant melanoma cell lines. Mol Med Rep. 2018 Oct 08;: Authors: Takahashi T, Abe N, Kanoh H, Banno Y, Seishima M Abstract Vemurafenib, a selective inhibitor of mutated BRAF, is used to treat late‑stage melanoma. However, resistance to vemurafenib is urgently required as it can have fatal consequences. Fingolimod (FTY720), a sphingosine‑1‑phosphate receptor modulator, has been used for the treatment of several malignant neoplasms in clinical trials. The present study investigated the effects of FTY720 and vemurafenib co...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Abnormal expression of miR ‑133a in patients with acute myocardial infarction following radical surgery for gastric cancer and the underlying mechanism.
In conclusion, the results of the present study suggested that miR‑133a was involved in the endothelial injury process after AMI by targeting Bcl2l1. PMID: 30320356 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑3666 suppresses cellular proliferation and invasion in colorectal cancer by targeting SATB2.
miR‑3666 suppresses cellular proliferation and invasion in colorectal cancer by targeting SATB2. Mol Med Rep. 2018 Oct 09;: Authors: Yang D, Li R, Xia J, Li W, Zhou H Abstract MicroRNA‑3666 (miR‑3666) acts as a tumor suppressor in cervical cancer, non‑small cell lung cancer and thyroid carcinoma; however, the function of miR‑3666 in colorectal cancer (CRC) remains largely unknown. In the present study, was demonstrated that miR‑3666 was significantly downregulated in CRC tissues compared with in adjacent normal tissues by reverse transcription‑quantitative polymerase chain reaction. Addit...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Lutein protects human retinal pigment epithelial cells from oxidative stress ‑induced cellular senescence.
Lutein protects human retinal pigment epithelial cells from oxidative stress‑induced cellular senescence. Mol Med Rep. 2018 Oct 08;: Authors: Chae SY, Park SY, Park G Abstract Oxidative stress‑induced cellular senescence is an important contributor to the pathogenesis of age‑related macular degeneration (AMD). Characteristics of premature cellular senescence include a loss of proliferation, change in cell shape, irreversible cell cycle arrest, and elevated senescence‑associated β‑galactosidase (SA‑β‑gal) activity. It was hypothesized that lutein may have anti‑senescence potent...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

An effective range of polydeoxyribonucleotides is critical for wound healing quality.
Authors: Hwang KH, Kim JH, Park EY, Cha SK Abstract Wound healing is a physiological restorative response to tissue and cell injury. This process occurs in collaboration with a complex cascade of cellular events, including biochemical alterations to the extracellular matrix. Polydeoxyribonucleotide (PDRN) is a fragmented DNA mixture from Oncorhynchus mykiss or Oncorhynchus keta sperm known to promote tissue regeneration under different pathophysiological conditions. However, the most effective molecular size of PDRNs for promoting the wound healing process and quality has not been established. In the present study,...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

( ‑)Epigallocatechin‑3‑gallate attenuates anesthesia‑induced memory deficit in young mice via modulation of nitric oxide expression.
(‑)Epigallocatechin‑3‑gallate attenuates anesthesia‑induced memory deficit in young mice via modulation of nitric oxide expression. Mol Med Rep. 2018 Oct 10;: Authors: Ding L, Gao X, Hu J, Yu S Abstract (‑)Epigallocatechin‑3‑gallate (EGCG) is a type of polyphenol monomer and is the predominant component of catechin compounds extractable from green tea. Previous studies have demonstrated that EGCG exhibits numerous bioactivities both in vitro and in vivo, including antitumor, antioxidant and anti‑inflammatory activities, as well as lowering blood lipid levels and protecting aga...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Interleukin ‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.
Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro. Mol Med Rep. 2018 Oct 10;: Authors: Deng G, Li K, Chen S, Chen P, Zheng H, Yu B, Zhang K Abstract Tendon repair follows a slow course of early inflammatory, proliferative and remodeling phases, which commonly results in the failure and loss of normal biomechanical properties. Previous studies have demonstrated that tendon‑derived stem cells (TDSCs) are vital healing cells and that mRNA expression of anti‑inflammatory cytokine interleukin ...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Long non ‑coding RNA CASC2 inhibits progression and predicts favorable prognosis in epithelial ovarian cancer.
Long non‑coding RNA CASC2 inhibits progression and predicts favorable prognosis in epithelial ovarian cancer. Mol Med Rep. 2018 Oct 10;: Authors: Xue Z, Zhu X, Teng Y Abstract Epithelial ovarian cancer (EOC) is one of the leading causes of cancer‑associated mortality in women. At present, the overall 5‑year survival rate of patients with EOC remains poor despite advancements in diagnosis and treatment. Long non‑coding RNAs (lncRNAs) have attracted increasing attention in recent years for their extensive roles in tumorigenesis and cancer development. The lncRNA cancer susceptibility candidate&nb...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis.
Authors: Wang W, Xu Z, Zhu X, Chang X Abstract The present study aimed to mine therapeutic molecular targets that play an important part in the progression of coronary artery disease (CAD). The gene expression profile GSE28829 dataset and the microRNA (miRNA) expression profile GSE59421 dataset were downloaded from the Gene Expression Omnibus (GEO) database. The GEO2R online analytical tool was used to identify differentially expressed genes (DEGs) and miRNAs (DEMs). The target genes of DEMs were identified using the miRWalk2.0 web‑based tool and 2 miRNA‑gene regulatory networks were constructed using Cytoscape...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

High ‑throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars.
High‑throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars. Mol Med Rep. 2018 Oct 15;: Authors: Li M, Wang J, Liu D, Huang H Abstract Growing evidence suggests that long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are involved in the occurrence and development of tumors and fibrotic diseases. However, the integrated analysis of lncRNA and circRNA expression, alongside associated co‑expression and competing endogenous RNA (ceRNA) networks, has not yet been performed in human hypertrophic scars (HS)....
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

EP4 knockdown alleviates glomerulosclerosis through Smad and MAPK pathways in mesangial cells.
Authors: Cao Y, Pan T, Chen X, Wu J, Guo N, Wang B Abstract Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. Clinical parameters were monitored post‑surgery. At 8 weeks post‑surgery, glomerular fibrosis‑associated indicators were measured by immunohistochemical staining and trichrome staining. In vitro, mesangial cells in diff...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Upregulated miR ‑203a‑3p and its potential molecular mechanism in breast cancer: A study based on bioinformatics analyses and a comprehensive meta‑analysis.
Upregulated miR‑203a‑3p and its potential molecular mechanism in breast cancer: A study based on bioinformatics analyses and a comprehensive meta‑analysis. Mol Med Rep. 2018 Oct 10;: Authors: Cai KT, Feng CX, Zhao JC, He RQ, Ma J, Zhong JC Abstract Breast cancer (BC) has been identified as the leading malignancy in women worldwide. However, the potential molecular mechanism of microRNA (miR)‑203a‑3p in BC remains to be elucidated. The present study evaluated the expression of miR‑203a‑3p in BC and adjacent normal tissue in several publically available datasets. The distinguishability of p...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease.
Authors: Fu J, Zou J, Chen C, Li H, Wang L, Zhou Y Abstract Reactive oxygen species (ROS) impair neovascularization and perfusion recovery following limb ischemia in patients with peripheral arterial disease (PAD). Hydrogen molecules (H2) comprise an antioxidant gas that has been reported to neutralize cytotoxic ROS. The present study investigated whether H2 may serve as a novel therapeutic strategy for PAD. H2‑saturated water or dehydrogenized water was supplied to mice with experimental PAD. Laser Doppler perfusion imaging demonstrated that H2‑saturated water improved perfusion recovery, decreased the rate of...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

CXCL12 modulates the radiosensitivity of cervical cancer by regulating CD44.
In conclusion, the present data demonstrated that CXCL12 served an important role in the radioresistance of cervical cancer, suggestinh a novel therapeutic target. PMID: 30320394 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Biomarkers associated with binaprofen ‑induced liver injury.
Biomarkers associated with binaprofen‑induced liver injury. Mol Med Rep. 2018 Oct 10;: Authors: Guo Q, Guo J, Chen G, Han Z, Xiao B, Jin R, Liang C, Yang W Abstract Drug‑induced liver injury (DILI) is a common hepatic disease. The identification of biomarkers for DILI prediction is critical for rational drug use. The aim of the present study was to investigate liver injury caused by binaprofen and identify proteins that may serve as early biomarkers to predict DILI. For in vivo DILI assays, zebrafish were exposed to acetaminophen (APAP) and binaprofen for 12‑96 h before lethal concentra...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Helicobacter  pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells.
Helicobacter pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells. Mol Med Rep. 2018 Oct 15;: Authors: Liu L, Zhao Y, Fan G, Shuai T, Li B, Li Y Abstract Helicobacter pylori (H. pylori) infection is the most important factor in the development of gastric cancer. Heparanase (HPA) is involved in tissue remodelling and cell migration, which leads to inflammation and tumour metastasis. The current study aimed was to explore whether a H. pylori infection leads to an increase in the level of HPA ...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑339‑5p inhibits cell proliferation of acute myeloid leukaemia by directly targeting SOX4.
In conclusion, miR‑339‑5p may serve its antiproliferative role in AML by directly targeting SOX4, which suggests that miR‑339‑5p may be considered an effective novel therapeutic target for treating patients with such an aggressive haematological malignancy. PMID: 30320397 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation.
In conclusion, the present study demonstrated that formononetin was able to alleviate I/R‑induced cellular apoptosis in aged cells by facilitating autophagy. PMID: 30320398 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell.
Authors: Wu R, Yang H, Wan J, Deng X, Chen L, Hao S, Ma L Abstract Leukemia and lymphoma are common hematological malignancies in children and young adults, which pose a tremendous threat to the survival of these young patients worldwide, despite availability of various effective treatments. The Hippo pathway is a novel‑signaling pathway that regulates organ size, cell proliferation, apoptosis and tumorigenesis. The chief component of this pathway is the transducer yes‑associated protein (YAP) which is over‑expressed in numerous categories of tumors. However, little is known about the effect of YAP in hematol...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The possible association between AQP9 in the intestinal epithelium and acute liver injury ‑induced intestinal epithelium damage.
The possible association between AQP9 in the intestinal epithelium and acute liver injury‑induced intestinal epithelium damage. Mol Med Rep. 2018 Oct 10;: Authors: Xiang T, Ge S, Wen J, Xie J, Yang L, Wu X, Cheng N Abstract The present study aimed to investigate the expression and function of aquaporin (AQP)9 in the intestinal tract of acute liver injury rat models. A total of 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group and acute liver injury groups (24, 48 and 72 h). Acute liver injury rat models were established using D‑amino galactose, and t...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Role of JNK signalling pathway and platelet ‑lymphocyte aggregates in myocardial ischemia‑reperfusion injury and the cardioprotective effect of ischemic postconditioning in rats.
Role of JNK signalling pathway and platelet‑lymphocyte aggregates in myocardial ischemia‑reperfusion injury and the cardioprotective effect of ischemic postconditioning in rats. Mol Med Rep. 2018 Oct 10;: Authors: Ren F, Mu N, Gao M, Sun J, Zhang C, Sun X, Li L, Li J, Liu T, Tse G, Dong M Abstract In myocardial ischemia‑reperfusion injury (MIRI), increased activity of the c‑Jun N‑terminal kinase (JNK) pathway and the activation of platelets that leads to the formation of platelet‑leukocyte aggregates (PLAs) have been observed. It was hypothesized that ischemic postconditioning in MIRI exert...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

[Corrigendum] High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE ‑NOXs pathway.
[Corrigendum] High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE‑NOXs pathway. Mol Med Rep. 2018 Oct 12;: Authors: Liao YF, Yin S, Chen ZQ, Li F, Zhao B Abstract Following the publication of the above article, the authors have realized that the Materials and methods section and Figs. 1, 3 and 4 contained certain errors. In the Materials and methods section, the high glucose concentration was reported incorrectly as being 25 mmol/l; this should have been stated as 15 mmol/l. Furthermore, the normal concentration of glucose sho...
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Suppressing cell growth and inducing apoptosis by inhibiting miR ‑23a‑5p in human bladder cancer.
Suppressing cell growth and inducing apoptosis by inhibiting miR‑23a‑5p in human bladder cancer. Mol Med Rep. 2018 Oct 02;: Authors: Li Y, Quan J, Pan X, Zhou J, He A, Lai Y, Zhou G Abstract MicroRNAs (miRNAs) are a class of non‑coding RNAs, which are important in the initiation and progression of cancer. miRNA‑23a‑5p (miR‑23a‑5p) is a novel miRNA, which promotes cell growth and survival in several types of cancer. The aim of the present study was to investigate the expression and functional significance of miR‑23a‑5p in bladder cancer. Microchip assays have shown that miR‑23a‑5p ...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mangiferin: An effective therapeutic agent against several disorders (Review).
Authors: Du S, Liu H, Lei T, Xie X, Wang H, He X, Tong R, Wang Y Abstract Mangiferin (1,3,6,7‑tetrahydroxyxanthone‑C2‑β‑D‑glucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, anti‑hyperuricemic, neuroprotective, antioxidant, anti‑inflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several health‑endorsing properties and is a promising candidate for ...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Ketamine destabilizes growth of dendritic spines in developing hippocampal neurons in  vitro via a Rho‑dependent mechanism.
Ketamine destabilizes growth of dendritic spines in developing hippocampal neurons in vitro via a Rho‑dependent mechanism. Mol Med Rep. 2018 Oct 02;: Authors: Jiang S, Hao Z, Li X, Bo L, Zhang R, Wang Y, Duan X, Kang R, Huang L Abstract The safety of anesthetics on the developing brain has caused concern. Ketamine, an N‑methyl‑D‑aspartate receptor antagonist, is widely used as a general pediatric anesthetic. Recent studies suggested that ketamine alters the plasticity of dendritic spines in the developing brain and may be an important contributing factor to learning and cognitive impairmen...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MrgX2 ‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells.
MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells. Mol Med Rep. 2018 Oct 02;: Authors: Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I Abstract LL‑37 is the sole antimicrobial peptide of human cathelicidin comprising 37 amino acids, which is expressed mainly in epithelial cells and neutrophils, and activates mast cells. In the present study, in order to elucidate the mechanism of mast cell activation by LL‑37, the associations between the internalization of LL‑37 and Mas‑related gene X2 (MrgX2)‑mediated mast cell activation (de...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Overexpression of small ubiquitin ‑like modifier 2 ameliorates high glucose‑induced reductions in cardiomyocyte proliferation via the transforming growth factor‑β/Smad pathway.
Overexpression of small ubiquitin‑like modifier 2 ameliorates high glucose‑induced reductions in cardiomyocyte proliferation via the transforming growth factor‑β/Smad pathway. Mol Med Rep. 2018 Oct 01;: Authors: Zhao C, Shen Q Abstract Hyperglycemia may induce diabetic cardiomyopathy (DC). In the current study, the mechanism underlying the alleviation of high glucose (HG)‑induced impairments in the proliferation of H9c2 embryo cardiomyocyte proliferation by small ubiquitin‑like modifier 2 (SUMO2) overexpression was investigated. H9c2 cell morphology was identified as classical long ...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Whole exome sequencing identification of a novel insertion mutation in the phospholipase C ε‑1 gene in a family with steroid resistant inherited nephrotic syndrome.
Whole exome sequencing identification of a novel insertion mutation in the phospholipase C ε‑1 gene in a family with steroid resistant inherited nephrotic syndrome. Mol Med Rep. 2018 Oct 02;: Authors: Hashmi JA, Safar RA, Afzal S, Albalawi AM, Abdu-Samad F, Iqbal Z, Basit S Abstract Nephrotic syndrome (NS) represents a heterogeneous group of kidney disorders characterized by excessive proteinuria, hypoalbuminemia and edema. Defects in the filtration barrier of the glomeruli results in the development of NS. The genetic cause of NS remains to be fully elucidated. However, previous studies base...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Compound pathogenic mutation in the USH2A gene in Chinese RP families detected by whole ‑exome sequencing.
Compound pathogenic mutation in the USH2A gene in Chinese RP families detected by whole‑exome sequencing. Mol Med Rep. 2018 Oct 02;: Authors: Fu YC, Chen N, Qiu ZL, Liu L, Shen J Abstract Retinitis pigmentosa (RP) is a common form of inherited retinal degeneration that causes progressive loss of vision or adult blindness, characterized by the impairment of rod and cone photoreceptors. At present, mutations in>60 pathogenic genes have been confirmed to cause RP. The predominant modes of inheritance are autosomal dominant, autosomal recessive and X‑linked. In addition, other modes of inheritance, ...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Salmonella ‑induced miR‑155 enhances necroptotic death in macrophage cells via targeting RIP1/3.
Salmonella‑induced miR‑155 enhances necroptotic death in macrophage cells via targeting RIP1/3. Mol Med Rep. 2018 Oct 01;: Authors: Ro YT, Jo GH, Jung SA, Lee EH, Shin J, Lee JH Abstract Salmonella enterica serovar Typhimurium (hereafter referred to as Salmonella), a virulent pathogen, is known to induce host‑cell death. Using reverse transcription‑quantitative polymerase chain reaction, a 28‑fold increase of microRNA (miR)‑155 expression in RAW 264.7 macrophages was observed following infection with Salmonella for 24 h. This miR‑155 upregulation increased macrophage cell death by up...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑944 targets vascular endothelial growth factor to inhibit cell proliferation and invasion in osteosarcoma.
MicroRNA‑944 targets vascular endothelial growth factor to inhibit cell proliferation and invasion in osteosarcoma. Mol Med Rep. 2018 Oct 01;: Authors: Yan T, Zhu S, Zhang J, Lu G, Lv C, Wei Y, Luo M Abstract Emerging evidence has demonstrated that the dysregulation of microRNA (miRNA/miR) serves a crucial role in the tumorigenesis and tumor development of osteosarcoma (OS), primarily by affecting various pathological behaviors. Therefore, better knowledge of miRNA in OS may provide novel insights into the pathogenesis of OS, and may facilitate the development of promising therapeutics for patients w...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma.
Authors: Eun HS, Cho SY, Lee BS, Seong IO, Kim KH Abstract Cytochrome P450 family 4 (CYP4) enzymes are known as microsomal omega (ω)-hydroxylases that metabolize fatty acids, eicosanoids, vitamin D and carcinogens. Thus, CYP4 enzymes may influence tumor development and progression. The aim of the present study was to evaluate the CYP4 expression profile in hepatocellular carcinoma (HCC) and its clinical relevance. The present study obtained CYP4 mRNA expression data for 377 HCC cases from The Cancer Genome Atlas cohort and performed Kaplan‑Meier survival, Gene Ontology functional enrichment, and gene s...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

S100B regulates inflammatory response during osteoarthritis via fibroblast growth factor receptor 1 signaling.
Authors: Zhu L, Weng Z, Shen P, Zhou J, Zeng J, Weng F, Zhang X, Yang H Abstract The present study aimed to investigate the role of S100B in the inflammation process during osteoarthritis (OA). OA cartilage samples were collected for S100B expression analysis. S100B expression levels were significantly increased in patients with OA compared with the Controls (1.28±0.66 vs. 0.42±0.31; P=0.01) and were determined to be correlated with TNF‑α (r=0.42; P=0.04) and IL‑1β (r=0.73; P=0.001) expression levels. Orthopedic casting tape was used to immobilize the right knee at 180˚ exten...
Source: Molecular Medicine Reports - October 5, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Electroacupuncture inhibits sodium nitroprusside ‑mediated chondrocyte apoptosis through the mitochondrial pathway.
In conclusion, the present study demonstrated that EA modulated the mitochondrial pathway to suppress SNP‑mediated chondrocyte apoptosis. Therefore, EA may be of value in the treatment of OA. PMID: 30272266 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Synonymous mutation adenomatous polyposis coli Δ486s affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation‑negative familial adenomatous polyposis.
Synonymous mutation adenomatous polyposis coliΔ486s affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation‑negative familial adenomatous polyposis. Mol Med Rep. 2018 Sep 20;: Authors: Liu WQ, Dong J, Peng YX, Li WL, Yang J Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant‑inherited colorectal cancer. Recent advances in genetics have indicated that the majority of patients with FAP carry germline mutations of the adenomatous polyposis coli (APC) and mutY DNA glycosylase (MUTYH) genes. However, a large subset of familie...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Astragalus root induces ovarian β‑oxidation and suppresses estrogen‑dependent uterine proliferation.
Astragalus root induces ovarian β‑oxidation and suppresses estrogen‑dependent uterine proliferation. Mol Med Rep. 2018 Sep 19;: Authors: Orkhon B, Kobayashi K, Javzan B, Sasaki K Abstract Continuous estrogen stimulation in the uterus has been known to cause excess proliferation of the functional layer of endometrium, resulting in endometrial hyperplasia and leading to infertility. Estrogens can modulate other nuclear receptor signaling pathways, such as peroxisome proliferator‑activated receptors (PPARs). Astragalus root (AsR) has exhibited strong PPARα agonistic activity. Female Impri...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Endoplasmic reticulum stress associated apoptosis as a novel mechanism in indoxyl sulfate ‑induced cardiomyocyte toxicity.
Endoplasmic reticulum stress associated apoptosis as a novel mechanism in indoxyl sulfate‑induced cardiomyocyte toxicity. Mol Med Rep. 2018 Sep 20;: Authors: Tan X, Cao XS, Zhang P, Xiang FF, Teng J, Zou JZ, Ding XQ Abstract Indoxyl sulfate (IS), a typical uremic toxin, is of great importance in the development of chronic kidney disease. In addition to its nephrotoxicity, previous studies have provided increasing evidence for its cardiovascular toxicity. The mechanism underlying IS‑induced cardiovascular toxicity has been elusive to date. The present study aimed to evaluate whether IS treatment cou...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP ‑induced Parkinson's disease models in vitro and in vivo.
Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo. Mol Med Rep. 2018 Sep 25;: Authors: Chen H, Xu J, Lv Y, He P, Liu C, Jiao J, Li S, Mao X, Xue X Abstract The pathological alterations of Parkinson's disease (PD) predominantly manifest as a loss of dopaminergic neurons in the substantia nigra, which may be caused by oxidative stress damage. Proanthocyanidins (PCs) are a class of compounds found in various plants, which have significant antioxidant and free radical‑scavenging activity. The present study in...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Construction of an miRNA ‑gene regulatory network in colorectal cancer through integrated analysis of mRNA and miRNA microarrays.
Construction of an miRNA‑gene regulatory network in colorectal cancer through integrated analysis of mRNA and miRNA microarrays. Mol Med Rep. 2018 Sep 24;: Authors: Hu J, Yue X, Liu J, Kong D Abstract The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) in CRC tissue samples compared with surrounding control tissue samples (DEGs‑CC), a...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

LncRNA SRA deregulation contributes to the development of atherosclerosis by causing dysfunction of endothelial cells through repressing the expression of adipose triglyceride lipase.
Authors: Yang S, Sun J Abstract It has been well established that long non‑coding RNAs (lncRNAs) are crucial mediators in a diverse range of diseases, including atherosclerosis. The present study aimed to examine the molecular mechanisms underlying the association between steroid receptor RNA activator (SRA) and atherosclerosis. Reverse transcription‑quantitative polymerase chain reaction analysis, western blot analysis and luciferase assays were performed to examine interactions among SRA, adipose triglyceride lipase (ATGL) and peroxisome proliferator‑activated receptor (PPARγ), and the effect of resve...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

LncRNA ‑p21 promotes chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR‑451.
LncRNA‑p21 promotes chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR‑451. Mol Med Rep. 2018 Sep 24;: Authors: Tang L, Ding J, Zhou G, Liu Z Abstract Osteoarthritis (OA) is the most common type of arthritis, and remains to be social and medical challenge. Thus, identifying novel molecular targets is important for the prevention and treatment of OA. Long noncoding RNAs (lncRNAs) have been reported to modulate various biological and pathological processes. The aim of the present study was to investigate the role of lncRNA‑p21 in OA and its underlying mechanism, in order to bette...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6 ‑mediated pathways in vivo and in vitro.
In conclusion, emodin exerted anti‑angiogenic and anti‑metastatic activities in ATC by affecting TRAF6‑mediated pathways. PMID: 30272291 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations.
In conclusion, the present study demonstrated that the FASN c.G7192T and APOBR c.C1883G mutations may be the potential causative variants in this Chinese hypothyroidism pedigree. PMID: 30272292 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Aloe emodin suppresses EGF ‑induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways.
Aloe emodin suppresses EGF‑induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways. Mol Med Rep. 2018 Sep 27;: Authors: Zhang J, Guo L, Zhang Q, Liu K, Dong Z Abstract Natural compounds which can block cell transformation due to potential for chemoprevention have received increased attention. The present study aimed to investigate whether aloe emodin, which is present in aloe latex or the roots of the Rheum palmatum L. are able to block epidermal growth factor (EGF)‑ and tissue plasminogen activator‑induced JB6 C141 cell transformatio...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Characteristics of Nur77 and its ligands as potential anticancer compounds (Review).
Authors: Wu L, Chen L Abstract Nuclear receptor subfamily 4 group A member 1 (NR4A1; also termed Nur77/TR3/NGFIB), a member of the nuclear receptor superfamily, is expressed as an early response gene to regulate the expression of multiple target genes. Nur77 has the typical structure of a nuclear receptor, including an N‑terminal domain, a DNA binding domain, and a ligand‑binding domain. The expression and localization of Nur77 are closely associated with its roles in cell proliferation and apoptosis. Nur77 was first identified as an orphan receptor, the endogenous ligand of which has not yet been identifi...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Co-existence of endometriosis with 13 non-gynecological co-morbidities: Mutation analysis by whole exome sequencing.
Authors: Matalliotaki C, Matalliotakis M, Zervou MI, Trivli A, Matalliotakis I, Mavromatidis G, Spandidos DA, Albertsen HM, Chettier R, Ward K, Goulielmos GN Abstract Endometriosis is an enigmatic condition with an unknown etiology and poorly understood pathogenesis and women with endometriosis represent a high-risk population group for a large category of chronic conditions. The study focused on a 67-year-old woman who presented with a 40-year history of familial endometriosis associated with various non-gynecological co-morbidities, thus representing a unique case from a cohort of 1,000 patients with endometriosi...
Source: Molecular Medicine Reports - October 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research