Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)
Mol Med Rep. 2024 Jun;29(6):103. doi: 10.3892/mmr.2024.13227. Epub 2024 Apr 19.ABSTRACTMacrophage‑inducible C‑type lectin receptor (Mincle) is predominantly found on antigen‑presenting cells. It can recognize specific ligands when stimulated by certain pathogens such as fungi and Mycobacterium tuberculosis. This recognition triggers the activation of the nuclear factor‑κB pathway, leading to the production of inflammatory factors and contributing to the innate immune response of the host. Moreover, Mincle identifies lipid damage‑related molecules discharged by injured cells, such as Sin3‑associated protein 130...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Yuanxia Zou Jianchun Li Hongwei Su Nathupakorn Dechsupa Jian Liu Li Wang Source Type: research
Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis
In conclusion, the present findings demonstrated that dicoumarol could impede the progression of KOA by inhibiting NLRP3 activation, providing a potential treatment strategy for KOA.PMID:38639180 | PMC:PMC11040416 | DOI:10.3892/mmr.2024.13224 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Wenjie Ge Xian Zhang Qing Wang Jianjie Mao Pengfei Jia Jianping Cai Source Type: research
[Retracted] MicroRNA ‑671‑5p inhibits cell proliferation, migration and invasion in non‑small cell lung cancer by targeting MFAP3L
Mol Med Rep. 2024 Jun;29(6):101. doi: 10.3892/mmr.2024.13225. Epub 2024 Apr 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 4B and the Transwell cell invasion data shown in Figs. 2D and 4E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports (one of which has been retracted). Moreover, there appeared to be inappropriately...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Junhui Ye Wujun Luo Lingling Luo Limin Zhai Pingping Huang Source Type: research
Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis
Mol Med Rep. 2024 Jun;29(6):102. doi: 10.3892/mmr.2024.13226. Epub 2024 Apr 19.ABSTRACTKnee osteoarthritis (KOA) is a chronic degenerative disease that affects the quality of life of middle‑aged and elderly individuals, and is one of the major factors leading to disability. Rongjin Niantong Fang (RJNTF) can alleviate the clinical symptoms of patients with KOA, but the molecular mechanism underlying its beneficial effects on KOA remains unknown. Using pharmacological analysis and in vitro experiments, the active components of RJNTF were analyzed to explore their potential therapeutic targets and mechanisms in KOA. The pot...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Jun Chen Ting Zhang Qingqing Luo Ruyi Wang Yuting Dai Zhenyuan Chen Chutian Zhang Xuzheng Chen Guangwen Wu Source Type: research
Deciphering microglial activation and neuronal apoptosis post ‑traumatic brain injury: The role of TYROBP in inflammation regulation networks
Mol Med Rep. 2024 Jun;29(6):104. doi: 10.3892/mmr.2024.13228. Epub 2024 Apr 19.ABSTRACTTraumatic Brain Injury (TBI) represents a significant public health challenge. Recovery from brain injury necessitates the collaborative efforts of various resident neural cells, predominantly microglia. The present study analyzed rat and mouse RNA expression micro‑arrays, high‑throughput RNA sequencing and single‑cell sequencing data sourced from public databases. To construct an inflammation regulation network around TYRO protein tyrosine kinase‑binding protein (TYROBP), to evaluate the role of TYROBP in cell death after TBI. T...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Xudong Zhou Huiping Song Jingjing He Wei Han Qin Li Source Type: research
Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)
Mol Med Rep. 2024 Jun;29(6):103. doi: 10.3892/mmr.2024.13227. Epub 2024 Apr 19.ABSTRACTMacrophage‑inducible C‑type lectin receptor (Mincle) is predominantly found on antigen‑presenting cells. It can recognize specific ligands when stimulated by certain pathogens such as fungi and Mycobacterium tuberculosis. This recognition triggers the activation of the nuclear factor‑κB pathway, leading to the production of inflammatory factors and contributing to the innate immune response of the host. Moreover, Mincle identifies lipid damage‑related molecules discharged by injured cells, such as Sin3‑associated protein 130...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Yuanxia Zou Jianchun Li Hongwei Su Nathupakorn Dechsupa Jian Liu Li Wang Source Type: research
Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis
In conclusion, the present findings demonstrated that dicoumarol could impede the progression of KOA by inhibiting NLRP3 activation, providing a potential treatment strategy for KOA.PMID:38639180 | DOI:10.3892/mmr.2024.13224 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Wenjie Ge Xian Zhang Qing Wang Jianjie Mao Pengfei Jia Jianping Cai Source Type: research
[Retracted] MicroRNA ‑671‑5p inhibits cell proliferation, migration and invasion in non‑small cell lung cancer by targeting MFAP3L
Mol Med Rep. 2024 Jun;29(6):101. doi: 10.3892/mmr.2024.13225. Epub 2024 Apr 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 4B and the Transwell cell invasion data shown in Figs. 2D and 4E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports (one of which has been retracted). Moreover, there appeared to be inappropriately...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Junhui Ye Wujun Luo Lingling Luo Limin Zhai Pingping Huang Source Type: research
Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis
Mol Med Rep. 2024 Jun;29(6):102. doi: 10.3892/mmr.2024.13226. Epub 2024 Apr 19.ABSTRACTKnee osteoarthritis (KOA) is a chronic degenerative disease that affects the quality of life of middle‑aged and elderly individuals, and is one of the major factors leading to disability. Rongjin Niantong Fang (RJNTF) can alleviate the clinical symptoms of patients with KOA, but the molecular mechanism underlying its beneficial effects on KOA remains unknown. Using pharmacological analysis and in vitro experiments, the active components of RJNTF were analyzed to explore their potential therapeutic targets and mechanisms in KOA. The pot...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Jun Chen Ting Zhang Qingqing Luo Ruyi Wang Yuting Dai Zhenyuan Chen Chutian Zhang Xuzheng Chen Guangwen Wu Source Type: research
Deciphering microglial activation and neuronal apoptosis post ‑traumatic brain injury: The role of TYROBP in inflammation regulation networks
Mol Med Rep. 2024 Jun;29(6):104. doi: 10.3892/mmr.2024.13228. Epub 2024 Apr 19.ABSTRACTTraumatic Brain Injury (TBI) represents a significant public health challenge. Recovery from brain injury necessitates the collaborative efforts of various resident neural cells, predominantly microglia. The present study analyzed rat and mouse RNA expression micro‑arrays, high‑throughput RNA sequencing and single‑cell sequencing data sourced from public databases. To construct an inflammation regulation network around TYRO protein tyrosine kinase‑binding protein (TYROBP), to evaluate the role of TYROBP in cell death after TBI. T...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Xudong Zhou Huiping Song Jingjing He Wei Han Qin Li Source Type: research
Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)
Mol Med Rep. 2024 Jun;29(6):103. doi: 10.3892/mmr.2024.13227. Epub 2024 Apr 19.ABSTRACTMacrophage‑inducible C‑type lectin receptor (Mincle) is predominantly found on antigen‑presenting cells. It can recognize specific ligands when stimulated by certain pathogens such as fungi and Mycobacterium tuberculosis. This recognition triggers the activation of the nuclear factor‑κB pathway, leading to the production of inflammatory factors and contributing to the innate immune response of the host. Moreover, Mincle identifies lipid damage‑related molecules discharged by injured cells, such as Sin3‑associated protein 130...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Yuanxia Zou Jianchun Li Hongwei Su Nathupakorn Dechsupa Jian Liu Li Wang Source Type: research
Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis
In conclusion, the present findings demonstrated that dicoumarol could impede the progression of KOA by inhibiting NLRP3 activation, providing a potential treatment strategy for KOA.PMID:38639180 | DOI:10.3892/mmr.2024.13224 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Wenjie Ge Xian Zhang Qing Wang Jianjie Mao Pengfei Jia Jianping Cai Source Type: research
[Retracted] MicroRNA ‑671‑5p inhibits cell proliferation, migration and invasion in non‑small cell lung cancer by targeting MFAP3L
Mol Med Rep. 2024 Jun;29(6):101. doi: 10.3892/mmr.2024.13225. Epub 2024 Apr 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 4B and the Transwell cell invasion data shown in Figs. 2D and 4E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports (one of which has been retracted). Moreover, there appeared to be inappropriately...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Junhui Ye Wujun Luo Lingling Luo Limin Zhai Pingping Huang Source Type: research
Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis
Mol Med Rep. 2024 Jun;29(6):102. doi: 10.3892/mmr.2024.13226. Epub 2024 Apr 19.ABSTRACTKnee osteoarthritis (KOA) is a chronic degenerative disease that affects the quality of life of middle‑aged and elderly individuals, and is one of the major factors leading to disability. Rongjin Niantong Fang (RJNTF) can alleviate the clinical symptoms of patients with KOA, but the molecular mechanism underlying its beneficial effects on KOA remains unknown. Using pharmacological analysis and in vitro experiments, the active components of RJNTF were analyzed to explore their potential therapeutic targets and mechanisms in KOA. The pot...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Jun Chen Ting Zhang Qingqing Luo Ruyi Wang Yuting Dai Zhenyuan Chen Chutian Zhang Xuzheng Chen Guangwen Wu Source Type: research
Deciphering microglial activation and neuronal apoptosis post ‑traumatic brain injury: The role of TYROBP in inflammation regulation networks
Mol Med Rep. 2024 Jun;29(6):104. doi: 10.3892/mmr.2024.13228. Epub 2024 Apr 19.ABSTRACTTraumatic Brain Injury (TBI) represents a significant public health challenge. Recovery from brain injury necessitates the collaborative efforts of various resident neural cells, predominantly microglia. The present study analyzed rat and mouse RNA expression micro‑arrays, high‑throughput RNA sequencing and single‑cell sequencing data sourced from public databases. To construct an inflammation regulation network around TYRO protein tyrosine kinase‑binding protein (TYROBP), to evaluate the role of TYROBP in cell death after TBI. T...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Xudong Zhou Huiping Song Jingjing He Wei Han Qin Li Source Type: research
