Pigment epithelium ‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling  in placenta accreta spectrum
Mol Med Rep. 2024 May;29(5):75. doi: 10.3892/mmr.2024.13199. Epub 2024 Mar 15.ABSTRACTPlacenta accreta spectrum (PAS) is one of the most dangerous complications in obstetrics, which can lead to severe postpartum bleeding and shock, and even necessitate uterine removal. The abnormal migration and invasion of extravillous trophoblast cells (EVTs) and enhanced neovascularization occurring in an uncontrolled manner in time and space are closely related to the abnormal expression of pro‑angiogenic and anti‑angiogenic factors. The pigment epithelium‑derived factor (PEDF) is a multifunctional regulatory factor that particip...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Rui Li Xiaoying Weng Xuyang Hu Junjun Wang Lin Zheng Source Type: research

Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research

Resveratrol ameliorates ulcerative colitis by upregulating Nrf2/HO ‑1 pathway activity: Integrating animal experiments and network pharmacology
In conclusion, Res treatment activated the Nrf2/HO‑1 pathway to decrease clinical symptoms, inflammatory responses, and intestinal mucosal barrier damage in experimental UC mice.PMID:38488031 | DOI:10.3892/mmr.2024.13201 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Xinya Yu Xiaoxi Li Yunchun Xu Yuwei Li Ye Zhou Junhua Zhang Le Guo Source Type: research

[Retracted] miR ‑34a is downregulated in human osteosarcoma stem‑like cells and promotes invasion, tumorigenic ability and self‑renewal capacity
Mol Med Rep. 2024 May;29(5):72. doi: 10.3892/mmr.2024.13196. Epub 2024 Mar 15.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 4B on p. 1635 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were submitted at around the same time. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medici...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Yonggen Zou Yuanshuai Huang Jiexiang Yang Jian Wu Cheng Luo Source Type: research

IFN ‑γ induces apoptosis in gemcitabine‑resistant pancreatic cancer cells
In conclusion, IFN‑γ exhibited antitumor immune properties by upregulating MRP and downregulating BCRP expression, reversing drug‑resistance gene expression, and reducing cell viability and migration, while promoting apoptosis in PANC‑1/GEM cells. IFN‑γ could potentially serve as a treatment option for patients with GEM‑resistant pancreatic cancer.PMID:38488034 | DOI:10.3892/mmr.2024.13200 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Xiangxin Kong Denglong Cheng Xu Xu Yuan Zhang Xin Li Wanlong Pan Source Type: research

Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research

Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress
In conclusion, NCTD induces apoptosis by activating ER stress and ultimately curtails the progression of cervical cancer.PMID:38456480 | DOI:10.3892/mmr.2024.13195 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Zhongbao Zhang Beibei Sun Jinqiu Lu Penglai Bai Yu Su Yanchun Li Source Type: research

[Corrigendum] Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):70. doi: 10.3892/mmr.2024.13194. Epub 2024 Mar 8.ABSTRACTSubsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerrning the Transwell cell migration and invasion assay data shown in Fig. 6A and B for the 786‑O cell line on p. 7206, the pcDNA3.1‑EGOT 'Migration' and 'Invasion' (a‑1 and b‑1) data panels appeared to contain overlapping sections of data, such that they were potentially derived from the same original source, where these panels were intended to show the results from differently performed experiments. The authors have r...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Lu Jin Jing Quan Xiang Pan Tao He Jia Hu Yifan Li Yaoting Gui Shangqi Yang Xiangming Mao Yun Chen Yongqing Lai Source Type: research

Bif ‑1 inhibits activation of inflammasome through autophagy regulatory mechanism
Mol Med Rep. 2024 Apr;29(4):67. doi: 10.3892/mmr.2024.13191. Epub 2024 Mar 8.ABSTRACTInflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine triphosphate (ATP)‑induced inflammatory model in J774A.1 cells, the effect of Bif‑1 on inflammasome activation and the underly...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Yuehui Zhang Wenhui Su Yaoyun Niu Hongli Zeng Lu Liu Lijun Wang Weidong Xie Source Type: research

[Retracted] Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
Mol Med Rep. 2024 May;29(5):68. doi: 10.3892/mmr.2024.13192. Epub 2024 Mar 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Huiying Qiao Haiyan Ren He Du Minfang Zhang Xiaofang Xiong Rong Lv Source Type: research

RICH1 is a novel key suppressor of isoproterenol ‑ or angiotensin II‑induced cardiomyocyte hypertrophy
Mol Med Rep. 2024 May;29(5):69. doi: 10.3892/mmr.2024.13193. Epub 2024 Mar 8.ABSTRACTCardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge, its role in cardiac hypertrophy remains unknown. In the present study, the role of RICH1 in cardiomyocyte hypertrophy was assessed. Cell ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Siqi Wang Xin Wang Li Ling Cairong Li Zhanhong Ren Source Type: research

Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress
In conclusion, NCTD induces apoptosis by activating ER stress and ultimately curtails the progression of cervical cancer.PMID:38456480 | DOI:10.3892/mmr.2024.13195 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Zhongbao Zhang Beibei Sun Jinqiu Lu Penglai Bai Yu Su Yanchun Li Source Type: research

[Corrigendum] Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):70. doi: 10.3892/mmr.2024.13194. Epub 2024 Mar 8.ABSTRACTSubsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerrning the Transwell cell migration and invasion assay data shown in Fig. 6A and B for the 786‑O cell line on p. 7206, the pcDNA3.1‑EGOT 'Migration' and 'Invasion' (a‑1 and b‑1) data panels appeared to contain overlapping sections of data, such that they were potentially derived from the same original source, where these panels were intended to show the results from differently performed experiments. The authors have r...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Lu Jin Jing Quan Xiang Pan Tao He Jia Hu Yifan Li Yaoting Gui Shangqi Yang Xiangming Mao Yun Chen Yongqing Lai Source Type: research

Bif ‑1 inhibits activation of inflammasome through autophagy regulatory mechanism
Mol Med Rep. 2024 Apr;29(4):67. doi: 10.3892/mmr.2024.13191. Epub 2024 Mar 8.ABSTRACTInflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine triphosphate (ATP)‑induced inflammatory model in J774A.1 cells, the effect of Bif‑1 on inflammasome activation and the underly...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Yuehui Zhang Wenhui Su Yaoyun Niu Hongli Zeng Lu Liu Lijun Wang Weidong Xie Source Type: research

[Retracted] Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
Mol Med Rep. 2024 May;29(5):68. doi: 10.3892/mmr.2024.13192. Epub 2024 Mar 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Huiying Qiao Haiyan Ren He Du Minfang Zhang Xiaofang Xiong Rong Lv Source Type: research