[Corrigendum] Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte ‑like cells in dimethylnitrosamine‑induced liver cirrhosis in mice
Mol Med Rep. 2021 Nov;24(5):808. doi: 10.3892/mmr.2021.12448. Epub 2021 Sep 20.ABSTRACTFollowing the publication of the above article, an interested reader to the authors' attention that there appeared to be several duplications of data panels featured within Figs. 1‑3. After having consulted their original data, the authors have realized that a number of the data panels were inadvertently assembled incorrectly in these figures. The corrected versions of Fig. 1A (showing the correct data for the NC‑2W and NC‑4W experiments), Fig. 1B (including the correct data for the C‑4W, M‑2W, NC‑2W and NC‑4W experiments),...
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Yan Xiang Bing-Yao Pang Yuan Zhang Qiao-Ling Xie Ying Zhu Ai-Jing Leng Long-Qing Lu Hai-Long Chen Source Type: research

JMJD3 deficiency alleviates lipopolysaccharide ‑induced acute lung injury by inhibiting alveolar epithelial ferroptosis in a Nrf2‑dependent manner
Mol Med Rep. 2021 Nov;24(5):807. doi: 10.3892/mmr.2021.12447. Epub 2021 Sep 20.ABSTRACTAcute respiratory distress syndrome (ARDS) is a deadly illness which presents with severe hypoxemia as well as diffuse alveolar damage. Jumonji domain‑containing 3 (JMJD3), which belongs to the UTX/UTY JmjC‑domain protein subfamily, is involved in infection, development, aging and immune disorders. However, the role of JMJD3 in acute lung injury (ALI) is still unclear. The present study explored the roles and potential mechanisms of JMJD3 in ALI. Alveolar epithelial cell‑specific knockout of JMJD3 mice and A549 alveolar epithelial ...
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Junwei Peng Bin Fan Chuanming Bao Chen Jing Source Type: research

Silencing circ ‑BIRC6 inhibits the proliferation, invasion, migration and epithelial‑mesenchymal transition of bladder cancer cells by targeting the miR‑495‑3p/XBP1 signaling axis
In conclusion, these findings demonstrated that circ‑BIRC6 knockdown suppressed BC tumorigenesis and progression via regulation of the miR‑495‑3p/XBP1 signaling axis, offering a promising therapeutic target for the treatment of BC.PMID:34542161 | DOI:10.3892/mmr.2021.12451 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Lei Zhou Bingzhi Wang Yichuan Zhang Kun Yao Bin Liu Source Type: research

[Retracted] MicroRNA ‑338‑3p suppresses tumor growth of esophageal squamous cell carcinoma < em > in  vitro < /em > and < em > in  vivo < /em >
Mol Med Rep. 2021 Nov;24(5):810. doi: 10.3892/mmr.2021.12450. Epub 2021 Sep 20.ABSTRACTFollowing the publication of the above article, the authors have requested that it be retracted. After having repeated some of the experiments, the authors were not able to reproduce certain of the results. Furthermore, following a further investigation in the Editorial Office, it came to light that some of the wstern blotting data shown in Fig. 3 and the tumor images in Fig. 5 were strikingly similar to those that had been submitted for publication prior to the receipt of present article. Therefore, this article has been retracted from ...
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Xinyu Li Zhihong Li Guiyun Yang Zhenxiang Pan Source Type: research

[Corrigendum] FOXO3a ‑mediated suppression of the self‑renewal capacity of sphere‑forming cells derived from the ovarian cancer SKOV3 cell line by 7‑difluoromethoxyl‑5,4'‑di‑n‑octyl genistein
Mol Med Rep. 2021 Nov;24(5):809. doi: 10.3892/mmr.2021.12449. Epub 2021 Sep 20.ABSTRACTSubsequently to the publication of this paper, an interested reader drew to the authors' attention that strikingly similar western blot data were shown in Fig. 2 (to portray the Nagon data in Fig. 2A and the CD133 data in Fig. 2B), and the same data also appeared to have been included in Fig. 4 (to show the p‑FOXO3a data). After having examined their original data, the authors have realized that these figures were inadvertently assembled incorrectly. The corrected versions of Figs. 2 and 4, showing the correct data for the CD133 experi...
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Yingxia Ning Chaoyuan Luo Kaiqun Ren Meifang Quan Jianguo Cao Source Type: research

Upregulation of miR ‑335 exerts protective effects against sepsis‑induced myocardial injury
In conclusion, the upregulation of miR‑335 exerted ameliorative effects on myocardial injury following sepsis and may indicate a novel therapeutic intervention for SIMI.PMID:34542164 | DOI:10.3892/mmr.2021.12446 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Xian Long Yongpan Huang Jianbin He Xiang Zhang Yan Zhou Yingmin Wei Ying Tang Lijing Liu Source Type: research

Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy
Mol Med Rep. 2021 Nov;24(5):805. doi: 10.3892/mmr.2021.12445. Epub 2021 Sep 20.ABSTRACTCycloastragenol (CAG), a secondary metabolite from the roots of Astragalus zahlbruckneri, has been reported to exert anti‑inflammatory effects in heart, skin and liver diseases. However, its role in asthma remains unclear. The present study aimed to investigate the effect of CAG on airway inflammation in an ovalbumin (OVA)‑induced mouse asthma model. The current study evaluated the lung function and levels of inflammation and autophagy via measurement of airway hyperresponsiveness (AHR), lung histology examination, inflammatory cytok...
Source: Molecular Medicine Reports - September 20, 2021 Category: Molecular Biology Authors: Xueyi Zhu Yuxue Cao Mingyue Su Mengmeng Chen Congcong Li La Yi Jingjing Qin Wuniqiemu Tulake Fangzhou Teng Yuanyuan Zhong Weifeng Tang Shiyuan Wang Jingcheng Dong Source Type: research

[Corrigendum] Murine and Chinese cobra venom ‑derived nerve growth factor stimulate chondrogenic differentiation of BMSCs < em > in vitro < /em > : A comparative study
Mol Med Rep. 2021 Nov;24(5):804. doi: 10.3892/mmr.2021.12444. Epub 2021 Sep 16.ABSTRACTSubsequently to the publication of this paper, an interested reader drew to the authors' attention that Figs. 2 and 3, showing the results from experiments designed to assess the viability of bone‑derived mesenchymal stem cells culture with or without nerve growth factors (NGFs) via fluorescein diacetate/propidium iodide or H&E staining respectively, contained apparently duplicated data panels within the figures. After having examined their original data, the authors have realized that these figures were inadvertently assembled inc...
Source: Molecular Medicine Reports - September 16, 2021 Category: Molecular Biology Authors: Zhikang Miao Zhenhui Lu Shixing Luo Danqing Lei Yi He Huayu Wu Jinmin Zhao Li Zheng Source Type: research

Novel compound heterozygous mutations in < em > CYP1B1 < /em > identified in a Chinese family with developmental glaucoma
In conclusion, the findings of the present study suggested that the aforementioned compound heterozygous mutations in CYP1B1 may have caused developmental glaucoma in this Chinese family. The c.3G>A mutation in CYP1B1 is a novel mutation, and this study expands the gene mutation spectrum of CYP1B1.PMID:34528698 | DOI:10.3892/mmr.2021.12443 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 16, 2021 Category: Molecular Biology Authors: Suping Cai Daren Zhang Xiaodong Jiao Tingting Wang Mengjie Fan Yun Wang James Fielding Hejtmancik Xuyang Liu Source Type: research

Ginsenoside Rg1 ameliorates aging ‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
In conclusion, the findings of the present study suggested that Rg1 may attenuate aging‑induced liver injury and fibrosis by reducing NOX4‑mediated ROS oxidative stress and inhibiting NLRP3 inflammasome activation.PMID:34523690 | DOI:10.3892/mmr.2021.12441 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Yan Li Duoduo Zhang Lan Li Yuli Han Xianan Dong Liu Yang Xuewang Li Weizu Li Weiping Li Source Type: research

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells
In conclusion, HOXC10 overexpression activated MTFR2 expression to enhance the proliferation, clone formation, invasion and migration of CRC cells.PMID:34523692 | DOI:10.3892/mmr.2021.12437 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Ying Xie Ran Chen Liujia Yan Zhangjun Jia Guangshu Liang Qin Wang Source Type: research

Triamcinolone acetonide modulates TGF ‑β2‑induced angiogenic and tissue‑remodeling effects in cultured human retinal pigment epithelial cells
In conclusion, TA may be considered a useful therapeutic agent for treating TGF‑β2‑associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways.PMID:34523693 | DOI:10.3892/mmr.2021.12442 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Chih-Cheng Hsiao Yo-Chen Chang Yu-Ting Hsiao Po-Han Chen Ming-Chu Hsieh Wen-Chuan Wu Ying-Hsien Kao Source Type: research

Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the  miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia
Mol Med Rep. 2021 Nov;24(5):798. doi: 10.3892/mmr.2021.12438. Epub 2021 Sep 15.ABSTRACTGlobally, pre‑eclampsia (PE) is a gestational disorder that causes increased morbidity of the fetus and mortality induced by pregnancy. Despite various studies, the understanding of the causes or mechanism of the development of PE remains elusive. Thus, the present study aimed to investigate the role of circular (circ)RNA hsa_circ_0026552 (hsa_circ_0026552) in the development of PE and its mechanism of regulation. hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Li Shan Xiaofei Hou Source Type: research

PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer
Mol Med Rep. 2021 Nov;24(5):800. doi: 10.3892/mmr.2021.12440. Epub 2021 Sep 15.ABSTRACTPlacenta‑specific protein 1 (PLAC1) is inversely associated with survival in several types of cancer. However, whether PLAC1 is involved in the progression of cervical cancer (CC) remains to be elucidated. Therefore, the present study aimed to evaluate the prognostic role of PLAC1 in CC by determining the relationship between clinicopathological factors, PLAC1 gene expression and survival prognosis using univariate and multivariate Cox proportional‑hazards regression analyses. Similarly, Kaplan‑Meier curves were evaluated with the ...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Rujun Chen Chan Sheng Ruyue Ma Liwen Zhang Lina Yang Yaping Chen Source Type: research

α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
In conclusion, the results of the present study suggested that ARR may exert anti‑inflammatory effects by downregulating NF‑κB and activating Nrf2‑mediated inflammatory responses, suggesting that ARR may be an attractive anti‑inflammatory candidate drug.PMID:34523697 | DOI:10.3892/mmr.2021.12439 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Jiang Tao Zhou Kai Da Ren Jing Hou Jie Chen Guan'e Yang Source Type: research

Ginsenoside Rg1 ameliorates aging ‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
In conclusion, the findings of the present study suggested that Rg1 may attenuate aging‑induced liver injury and fibrosis by reducing NOX4‑mediated ROS oxidative stress and inhibiting NLRP3 inflammasome activation.PMID:34523690 | DOI:10.3892/mmr.2021.12441 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Yan Li Duoduo Zhang Lan Li Yuli Han Xianan Dong Liu Yang Xuewang Li Weizu Li Weiping Li Source Type: research

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells
In conclusion, HOXC10 overexpression activated MTFR2 expression to enhance the proliferation, clone formation, invasion and migration of CRC cells.PMID:34523692 | DOI:10.3892/mmr.2021.12437 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Ying Xie Ran Chen Liujia Yan Zhangjun Jia Guangshu Liang Qin Wang Source Type: research

Triamcinolone acetonide modulates TGF ‑β2‑induced angiogenic and tissue‑remodeling effects in cultured human retinal pigment epithelial cells
In conclusion, TA may be considered a useful therapeutic agent for treating TGF‑β2‑associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways.PMID:34523693 | DOI:10.3892/mmr.2021.12442 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Chih-Cheng Hsiao Yo-Chen Chang Yu-Ting Hsiao Po-Han Chen Ming-Chu Hsieh Wen-Chuan Wu Ying-Hsien Kao Source Type: research

Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the  miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia
Mol Med Rep. 2021 Nov;24(5):798. doi: 10.3892/mmr.2021.12438. Epub 2021 Sep 15.ABSTRACTGlobally, pre‑eclampsia (PE) is a gestational disorder that causes increased morbidity of the fetus and mortality induced by pregnancy. Despite various studies, the understanding of the causes or mechanism of the development of PE remains elusive. Thus, the present study aimed to investigate the role of circular (circ)RNA hsa_circ_0026552 (hsa_circ_0026552) in the development of PE and its mechanism of regulation. hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Li Shan Xiaofei Hou Source Type: research

PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer
Mol Med Rep. 2021 Nov;24(5):800. doi: 10.3892/mmr.2021.12440. Epub 2021 Sep 15.ABSTRACTPlacenta‑specific protein 1 (PLAC1) is inversely associated with survival in several types of cancer. However, whether PLAC1 is involved in the progression of cervical cancer (CC) remains to be elucidated. Therefore, the present study aimed to evaluate the prognostic role of PLAC1 in CC by determining the relationship between clinicopathological factors, PLAC1 gene expression and survival prognosis using univariate and multivariate Cox proportional‑hazards regression analyses. Similarly, Kaplan‑Meier curves were evaluated with the ...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Rujun Chen Chan Sheng Ruyue Ma Liwen Zhang Lina Yang Yaping Chen Source Type: research

α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
In conclusion, the results of the present study suggested that ARR may exert anti‑inflammatory effects by downregulating NF‑κB and activating Nrf2‑mediated inflammatory responses, suggesting that ARR may be an attractive anti‑inflammatory candidate drug.PMID:34523697 | DOI:10.3892/mmr.2021.12439 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Jiang Tao Zhou Kai Da Ren Jing Hou Jie Chen Guan'e Yang Source Type: research

Ginsenoside Rg1 ameliorates aging ‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
In conclusion, the findings of the present study suggested that Rg1 may attenuate aging‑induced liver injury and fibrosis by reducing NOX4‑mediated ROS oxidative stress and inhibiting NLRP3 inflammasome activation.PMID:34523690 | DOI:10.3892/mmr.2021.12441 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Yan Li Duoduo Zhang Lan Li Yuli Han Xianan Dong Liu Yang Xuewang Li Weizu Li Weiping Li Source Type: research

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells
In conclusion, HOXC10 overexpression activated MTFR2 expression to enhance the proliferation, clone formation, invasion and migration of CRC cells.PMID:34523692 | DOI:10.3892/mmr.2021.12437 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Ying Xie Ran Chen Liujia Yan Zhangjun Jia Guangshu Liang Qin Wang Source Type: research

Triamcinolone acetonide modulates TGF ‑β2‑induced angiogenic and tissue‑remodeling effects in cultured human retinal pigment epithelial cells
In conclusion, TA may be considered a useful therapeutic agent for treating TGF‑β2‑associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways.PMID:34523693 | DOI:10.3892/mmr.2021.12442 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Chih-Cheng Hsiao Yo-Chen Chang Yu-Ting Hsiao Po-Han Chen Ming-Chu Hsieh Wen-Chuan Wu Ying-Hsien Kao Source Type: research

Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the  miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia
Mol Med Rep. 2021 Nov;24(5):798. doi: 10.3892/mmr.2021.12438. Epub 2021 Sep 15.ABSTRACTGlobally, pre‑eclampsia (PE) is a gestational disorder that causes increased morbidity of the fetus and mortality induced by pregnancy. Despite various studies, the understanding of the causes or mechanism of the development of PE remains elusive. Thus, the present study aimed to investigate the role of circular (circ)RNA hsa_circ_0026552 (hsa_circ_0026552) in the development of PE and its mechanism of regulation. hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Li Shan Xiaofei Hou Source Type: research

PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer
Mol Med Rep. 2021 Nov;24(5):800. doi: 10.3892/mmr.2021.12440. Epub 2021 Sep 15.ABSTRACTPlacenta‑specific protein 1 (PLAC1) is inversely associated with survival in several types of cancer. However, whether PLAC1 is involved in the progression of cervical cancer (CC) remains to be elucidated. Therefore, the present study aimed to evaluate the prognostic role of PLAC1 in CC by determining the relationship between clinicopathological factors, PLAC1 gene expression and survival prognosis using univariate and multivariate Cox proportional‑hazards regression analyses. Similarly, Kaplan‑Meier curves were evaluated with the ...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Rujun Chen Chan Sheng Ruyue Ma Liwen Zhang Lina Yang Yaping Chen Source Type: research

α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
In conclusion, the results of the present study suggested that ARR may exert anti‑inflammatory effects by downregulating NF‑κB and activating Nrf2‑mediated inflammatory responses, suggesting that ARR may be an attractive anti‑inflammatory candidate drug.PMID:34523697 | DOI:10.3892/mmr.2021.12439 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Jiang Tao Zhou Kai Da Ren Jing Hou Jie Chen Guan'e Yang Source Type: research

Ginsenoside Rg1 ameliorates aging ‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
In conclusion, the findings of the present study suggested that Rg1 may attenuate aging‑induced liver injury and fibrosis by reducing NOX4‑mediated ROS oxidative stress and inhibiting NLRP3 inflammasome activation.PMID:34523690 | DOI:10.3892/mmr.2021.12441 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Yan Li Duoduo Zhang Lan Li Yuli Han Xianan Dong Liu Yang Xuewang Li Weizu Li Weiping Li Source Type: research

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells
In conclusion, HOXC10 overexpression activated MTFR2 expression to enhance the proliferation, clone formation, invasion and migration of CRC cells.PMID:34523692 | DOI:10.3892/mmr.2021.12437 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Ying Xie Ran Chen Liujia Yan Zhangjun Jia Guangshu Liang Qin Wang Source Type: research

Triamcinolone acetonide modulates TGF ‑β2‑induced angiogenic and tissue‑remodeling effects in cultured human retinal pigment epithelial cells
In conclusion, TA may be considered a useful therapeutic agent for treating TGF‑β2‑associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways.PMID:34523693 | DOI:10.3892/mmr.2021.12442 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Chih-Cheng Hsiao Yo-Chen Chang Yu-Ting Hsiao Po-Han Chen Ming-Chu Hsieh Wen-Chuan Wu Ying-Hsien Kao Source Type: research

Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the  miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia
Mol Med Rep. 2021 Nov;24(5):798. doi: 10.3892/mmr.2021.12438. Epub 2021 Sep 15.ABSTRACTGlobally, pre‑eclampsia (PE) is a gestational disorder that causes increased morbidity of the fetus and mortality induced by pregnancy. Despite various studies, the understanding of the causes or mechanism of the development of PE remains elusive. Thus, the present study aimed to investigate the role of circular (circ)RNA hsa_circ_0026552 (hsa_circ_0026552) in the development of PE and its mechanism of regulation. hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Li Shan Xiaofei Hou Source Type: research

PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer
Mol Med Rep. 2021 Nov;24(5):800. doi: 10.3892/mmr.2021.12440. Epub 2021 Sep 15.ABSTRACTPlacenta‑specific protein 1 (PLAC1) is inversely associated with survival in several types of cancer. However, whether PLAC1 is involved in the progression of cervical cancer (CC) remains to be elucidated. Therefore, the present study aimed to evaluate the prognostic role of PLAC1 in CC by determining the relationship between clinicopathological factors, PLAC1 gene expression and survival prognosis using univariate and multivariate Cox proportional‑hazards regression analyses. Similarly, Kaplan‑Meier curves were evaluated with the ...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Rujun Chen Chan Sheng Ruyue Ma Liwen Zhang Lina Yang Yaping Chen Source Type: research

α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
In conclusion, the results of the present study suggested that ARR may exert anti‑inflammatory effects by downregulating NF‑κB and activating Nrf2‑mediated inflammatory responses, suggesting that ARR may be an attractive anti‑inflammatory candidate drug.PMID:34523697 | DOI:10.3892/mmr.2021.12439 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Jiang Tao Zhou Kai Da Ren Jing Hou Jie Chen Guan'e Yang Source Type: research

Ginsenoside Rg1 ameliorates aging ‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
In conclusion, the findings of the present study suggested that Rg1 may attenuate aging‑induced liver injury and fibrosis by reducing NOX4‑mediated ROS oxidative stress and inhibiting NLRP3 inflammasome activation.PMID:34523690 | DOI:10.3892/mmr.2021.12441 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Yan Li Duoduo Zhang Lan Li Yuli Han Xianan Dong Liu Yang Xuewang Li Weizu Li Weiping Li Source Type: research

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells
In conclusion, HOXC10 overexpression activated MTFR2 expression to enhance the proliferation, clone formation, invasion and migration of CRC cells.PMID:34523692 | DOI:10.3892/mmr.2021.12437 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Ying Xie Ran Chen Liujia Yan Zhangjun Jia Guangshu Liang Qin Wang Source Type: research

Triamcinolone acetonide modulates TGF ‑β2‑induced angiogenic and tissue‑remodeling effects in cultured human retinal pigment epithelial cells
In conclusion, TA may be considered a useful therapeutic agent for treating TGF‑β2‑associated intraocular angiogenesis and tissue remodeling, the underlying mechanism of which may involve the ERK and p38 MAPK signaling pathways.PMID:34523693 | DOI:10.3892/mmr.2021.12442 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Chih-Cheng Hsiao Yo-Chen Chang Yu-Ting Hsiao Po-Han Chen Ming-Chu Hsieh Wen-Chuan Wu Ying-Hsien Kao Source Type: research

Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the  miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia
Mol Med Rep. 2021 Nov;24(5):798. doi: 10.3892/mmr.2021.12438. Epub 2021 Sep 15.ABSTRACTGlobally, pre‑eclampsia (PE) is a gestational disorder that causes increased morbidity of the fetus and mortality induced by pregnancy. Despite various studies, the understanding of the causes or mechanism of the development of PE remains elusive. Thus, the present study aimed to investigate the role of circular (circ)RNA hsa_circ_0026552 (hsa_circ_0026552) in the development of PE and its mechanism of regulation. hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Li Shan Xiaofei Hou Source Type: research

PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer
Mol Med Rep. 2021 Nov;24(5):800. doi: 10.3892/mmr.2021.12440. Epub 2021 Sep 15.ABSTRACTPlacenta‑specific protein 1 (PLAC1) is inversely associated with survival in several types of cancer. However, whether PLAC1 is involved in the progression of cervical cancer (CC) remains to be elucidated. Therefore, the present study aimed to evaluate the prognostic role of PLAC1 in CC by determining the relationship between clinicopathological factors, PLAC1 gene expression and survival prognosis using univariate and multivariate Cox proportional‑hazards regression analyses. Similarly, Kaplan‑Meier curves were evaluated with the ...
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Rujun Chen Chan Sheng Ruyue Ma Liwen Zhang Lina Yang Yaping Chen Source Type: research

α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
In conclusion, the results of the present study suggested that ARR may exert anti‑inflammatory effects by downregulating NF‑κB and activating Nrf2‑mediated inflammatory responses, suggesting that ARR may be an attractive anti‑inflammatory candidate drug.PMID:34523697 | DOI:10.3892/mmr.2021.12439 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 15, 2021 Category: Molecular Biology Authors: Jiang Tao Zhou Kai Da Ren Jing Hou Jie Chen Guan'e Yang Source Type: research

Exosomal ‑miR‑1184 derived from mesenchymal stem cells alleviates cisplatin‑associated acute kidney injury
In conclusion, the present study demonstrated that exosomal‑miR‑1184 derived from MSCs alleviates cisplatin‑associated AKI. Thus, the findings presented herein may shed new light onto the exploration of novel strategies for the treatment of AKI.PMID:34515319 | DOI:10.3892/mmr.2021.12435 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Jinshi Zhang Wenfang He Danna Zheng Qiang He Mingming Tan Juan Jin Source Type: research

Knockdown of lncRNA PVT1 inhibits the proliferation and accelerates the apoptosis of colorectal cancer cells via the miR ‑761/MAPK1 axis
Mol Med Rep. 2021 Nov;24(5):794. doi: 10.3892/mmr.2021.12434. Epub 2021 Sep 13.ABSTRACTColorectal cancer (CRC) is associated with high morbidity rates. Long non‑coding RNAs (lncRNAs) participate in the development of CRC. However, the potential roles of lncRNA plasmacytoma variant translocation 1 (PVT1) in CRC remain unknown. Therefore, the aim of the present study was to investigate the potential roles of PVT1 in CRC. Reverse transcription‑quantitative PCR and western blot analyses were conducted to determine the mRNA and protein expression levels. The cellular behaviors were detected using 5‑Ethynyl‑2'‑deoxyuri...
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Yujing Liu Yongyou Wu Zhu Zhu Jiangbo Gong Wenhuan Dou Source Type: research

Rab6c is a new target of miR ‑218 that can promote the progression of bladder cancer
In this study, the expression levels of miR‑218 and Rab6c were evaluated via reverse transcription‑quantitative PCR and western blotting, respectively. The association between Rab6c and miR‑218 was recognized via TargetScan analysis and dual luciferase reporter gene detection. Cell proliferation was analyzed using Cell Counting Kit‑8 and colony formation assays, and the invasive ability was measured via Transwell assays. Rab6c was highly expressed in bladder cancer, while miR‑218 had abnormally low expression in bladder cancer. In addition, there was a mutual regulation between Rab6c and miR‑218 in bladder canc...
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Long He Xiang Pan Xialu Wang Yuhua Cao Peng Chen Cheng Du Daifa Huang Source Type: research

MicroRNA ‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1
Mol Med Rep. 2021 Nov;24(5):793. doi: 10.3892/mmr.2021.12433. Epub 2021 Sep 13.ABSTRACTDiabetes mellitus is a metabolic disorder caused by insufficient insulin secretion. The expression of microRNA (miR)‑532‑5P is downregulated in diabetes, but its specific role in diabetes has not yet been elucidated. The present study aimed to investigate the specific mechanism underlying the effects of miR‑532‑5p on diabetes. Cell viability was determined using an MTT assay. The expression levels of miR‑532‑5P, cyclin D1 (CCND1), Insulin1 and Insulin2 were detected using reverse transcription‑quantitative PCR. The expressi...
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Zhibiao Zhong Weilan Su Hongmei Chen Source Type: research

Buyang Huanwu Decoction promotes neurogenesis via sirtuin  1/autophagy pathway in a cerebral ischemia model
In conclusion, the present study suggested that post‑surgical treatment with BHD could protect rat brains from I/R injury, potentially through the SIRT1/autophagy pathway.PMID:34515326 | DOI:10.3892/mmr.2021.12431 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Han Li Dong Peng Shi-Jie Zhang Yang Zhang Qi Wang Li Guan Source Type: research

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/ β‑catenin signaling pathway
In conclusion, the findings of the present study suggested that FOXO3a may inhibit nephroblastoma cell proliferation, migration and invasion, while inducing apoptosis, by downregulating the Wnt/β‑catenin signaling pathway. These results may provide a novel method for the early diagnosis and precise treatment of nephroblastoma.PMID:34515328 | DOI:10.3892/mmr.2021.12436 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Cheng Qian Qiang Liu Source Type: research

Exosomal ‑miR‑1184 derived from mesenchymal stem cells alleviates cisplatin‑associated acute kidney injury
In conclusion, the present study demonstrated that exosomal‑miR‑1184 derived from MSCs alleviates cisplatin‑associated AKI. Thus, the findings presented herein may shed new light onto the exploration of novel strategies for the treatment of AKI.PMID:34515319 | DOI:10.3892/mmr.2021.12435 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Jinshi Zhang Wenfang He Danna Zheng Qiang He Mingming Tan Juan Jin Source Type: research

Knockdown of lncRNA PVT1 inhibits the proliferation and accelerates the apoptosis of colorectal cancer cells via the miR ‑761/MAPK1 axis
Mol Med Rep. 2021 Nov;24(5):794. doi: 10.3892/mmr.2021.12434. Epub 2021 Sep 13.ABSTRACTColorectal cancer (CRC) is associated with high morbidity rates. Long non‑coding RNAs (lncRNAs) participate in the development of CRC. However, the potential roles of lncRNA plasmacytoma variant translocation 1 (PVT1) in CRC remain unknown. Therefore, the aim of the present study was to investigate the potential roles of PVT1 in CRC. Reverse transcription‑quantitative PCR and western blot analyses were conducted to determine the mRNA and protein expression levels. The cellular behaviors were detected using 5‑Ethynyl‑2'‑deoxyuri...
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Yujing Liu Yongyou Wu Zhu Zhu Jiangbo Gong Wenhuan Dou Source Type: research

Rab6c is a new target of miR ‑218 that can promote the progression of bladder cancer
In this study, the expression levels of miR‑218 and Rab6c were evaluated via reverse transcription‑quantitative PCR and western blotting, respectively. The association between Rab6c and miR‑218 was recognized via TargetScan analysis and dual luciferase reporter gene detection. Cell proliferation was analyzed using Cell Counting Kit‑8 and colony formation assays, and the invasive ability was measured via Transwell assays. Rab6c was highly expressed in bladder cancer, while miR‑218 had abnormally low expression in bladder cancer. In addition, there was a mutual regulation between Rab6c and miR‑218 in bladder canc...
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Long He Xiang Pan Xialu Wang Yuhua Cao Peng Chen Cheng Du Daifa Huang Source Type: research

MicroRNA ‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1
Mol Med Rep. 2021 Nov;24(5):793. doi: 10.3892/mmr.2021.12433. Epub 2021 Sep 13.ABSTRACTDiabetes mellitus is a metabolic disorder caused by insufficient insulin secretion. The expression of microRNA (miR)‑532‑5P is downregulated in diabetes, but its specific role in diabetes has not yet been elucidated. The present study aimed to investigate the specific mechanism underlying the effects of miR‑532‑5p on diabetes. Cell viability was determined using an MTT assay. The expression levels of miR‑532‑5P, cyclin D1 (CCND1), Insulin1 and Insulin2 were detected using reverse transcription‑quantitative PCR. The expressi...
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Zhibiao Zhong Weilan Su Hongmei Chen Source Type: research

Buyang Huanwu Decoction promotes neurogenesis via sirtuin  1/autophagy pathway in a cerebral ischemia model
In conclusion, the present study suggested that post‑surgical treatment with BHD could protect rat brains from I/R injury, potentially through the SIRT1/autophagy pathway.PMID:34515326 | DOI:10.3892/mmr.2021.12431 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 13, 2021 Category: Molecular Biology Authors: Han Li Dong Peng Shi-Jie Zhang Yang Zhang Qi Wang Li Guan Source Type: research