FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA
Mol Med Rep. 2022 Mar;25(3):95. doi: 10.3892/mmr.2022.12611. Epub 2022 Jan 21.ABSTRACTGlioblastoma is a common central nervous system tumor and despite considerable advancements in treatment patient prognosis remains poor. Angiogenesis is a significant prognostic factor in glioblastoma, anti‑angiogenic treatments represent a promising therapeutic approach. Vascular endothelial growth factor A (VEGFA) is a predominant regulator of angiogenesis and mounting evidence suggests that the Wnt signaling pathway serves a significant role in tumor angiogenesis. As a positive regulator of the Wnt/β‑catenin signaling pathway,...
Source: Molecular Medicine Reports - January 21, 2022 Category: Molecular Biology Authors: Biao Yang Dong Liu Ye-Qing Ren Yan-Qi Sun Jian-Ping Zhang Xiao-Gang Wang Yong-Qiang Wu Shu-Le Wang Shi-Hao Guo Geng Guo Source Type: research

Nicotine promotes chronic obstructive pulmonary disease via inducing pyroptosis activation in bronchial epithelial cells
Mol Med Rep. 2022 Mar;25(3):92. doi: 10.3892/mmr.2022.12608. Epub 2022 Jan 21.ABSTRACTNicotine is one of the primary components in cigarettes, which is responsible for addiction. Numerous studies have investigated the effects of nicotine on pulmonary disease. The health of epithelial cells is important in the development of chronic obstructive pulmonary disease (COPD). Accumulating evidence has suggested that epithelial cell death may initiate or contribute to the progression of a number of lung diseases via airway remodeling. Pyroptosis is a unique form of inflammatory cell death mediated by the activation of caspase‑1 ...
Source: Molecular Medicine Reports - January 21, 2022 Category: Molecular Biology Authors: Rubing Mo Jun Zhang Yongxing Chen Yipeng Ding Source Type: research

Protective effect of H < sub > 2 < /sub > S on LPS ‑induced AKI by promoting autophagy
Mol Med Rep. 2022 Mar;25(3):96. doi: 10.3892/mmr.2022.12612. Epub 2022 Jan 21.ABSTRACTThe present study explored the protective effect of exogenous hydrogen sulfide (H2S) on lipopolysaccharide (LPS)‑induced acute kidney injury (AKI) and the underlying mechanisms. To establish an AKI injury mouse model, LPS (10 mg/kg) was intraperitoneally injected into mice pretreated with 0.8 mg/kg sodium hydrosulfide hydrate (NaHS), an H2S donor. The mouse survival rate and the degree of kidney injury were examined. To construct a cell damage model, HK‑2 cells were pretreated with different concentrations (0.1, 0.3 and 0.5 mM) of NaH...
Source: Molecular Medicine Reports - January 21, 2022 Category: Molecular Biology Authors: Ting Li Jie Zhao Shuying Miao Yiyang Chen Yunfei Xu Ying Liu Source Type: research

Ginsenoside Rg3 protects glucocorticoid ‑induced muscle atrophy < em > in vitro < /em > through improving mitochondrial biogenesis and myotube growth
Mol Med Rep. 2022 Mar;25(3):94. doi: 10.3892/mmr.2022.12610. Epub 2022 Jan 21.ABSTRACTGinsenoside Rg3 (Rg3), amplified by iterative heating processing with fresh ginseng, has a broad range of pharmacological activities and improves mitochondrial biogenesis in skeletal muscle. However, thus far no study has examined how Rg3 affects myotube growth or muscle atrophy, to the best of the authors' knowledge. The present study was conducted to examine the myogenic effect of Rg3 on dexamethasone (DEX)‑induced myotube atrophy and the underlying molecular mechanisms. Rg3 activated Akt/mammalian target of rapamycin signaling to pre...
Source: Molecular Medicine Reports - January 21, 2022 Category: Molecular Biology Authors: Ryuni Kim Jee Won Kim Sang-Jin Lee Gyu-Un Bae Source Type: research

[Retracted] MicroRNA ‑145 inhibits the malignant phenotypes of gastric carcinoma cells via downregulation of fascin 1 expression
Mol Med Rep. 2022 Mar;25(3):97. doi: 10.3892/mmr.2022.12613. Epub 2022 Jan 21.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell apoptotic assay data shown in Figs. 3D and 4D were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted f...
Source: Molecular Medicine Reports - January 21, 2022 Category: Molecular Biology Authors: Minghui Xue Lunde Zhao Fang Yang Zhenjuan Li Guangyan Li Source Type: research

CpG site hypomethylation at ETS1 ‑binding region regulates DLK1 expression in Chinese patients with Tetralogy of Fallot
In this study, immunohistochemistry was used to detect the protein expression of DLK1 and the methylation status of the DLK1 promoter was measured via bisulfite sequencing PCR. Dual‑luciferase reporter assays were performed to examine the influence of transcription factor ETS proto‑oncogene 1 (ETS1) on DLK1 gene expression. The electrophoretic mobility shift assay and chromatin immunoprecipitation assay, both in vivo and in vitro, were used to verify the binding of the ETS1 transcription factor to the DLK1 promoter as well as the influence of methylation status of DLK1 promoter on this binding affinity. The expression ...
Source: Molecular Medicine Reports - January 21, 2022 Category: Molecular Biology Authors: Guixiang Tian Lili He Ruoyi Gu Jingwei Sun Weicheng Chen Yanyan Qian Xiaojing Ma Weili Yan Zhenshan Zhao Ziqing Xu Meijiao Suo Wei Sheng Guoying Huang Source Type: research

Long non ‑coding RNA CTBP1‑AS2 upregulates USP22 to promote pancreatic carcinoma progression by sponging miR‑141‑3p
In conclusion, lncRNA CTBP1‑AS2 may be involved in pancreatic carcinoma progression by regulating miR‑141‑3p and USP22 expressions; in addition, CTBP1‑AS2 may be a diagnostic biomarker and treatment target for pancreatic carcinoma.PMID:35039872 | DOI:10.3892/mmr.2022.12602 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Mingliang Zhang Songbo Ma Xuzhao Li Henghai Yu Yizheng Tan Jun He Xiaoping Wei Junming Ma Source Type: research

A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy
Mol Med Rep. 2022 Mar;25(3):88. doi: 10.3892/mmr.2022.12604. Epub 2022 Jan 18.ABSTRACTProgressive supranuclear palsy (PSP) is a neurodegenerative tauopathy described as a syndrome of postural instability, supranuclear vertical gaze palsy, dysarthria, dystonic rigidity of the neck and trunk, dementia, and pseudobulbar palsy. The clinical diagnosis of PSP is often difficult because there are no established biomarkers, and diagnosis is currently based on clinical and imaging findings. Furthermore, the etiology and pathogenesis of PSP remain unknown. Dysregulation of microRNAs (miRNAs/miRs) has been reported to serve an import...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Wakako Nonaka Tadayuki Takata Hisakazu Iwama Satoshi Komatsubara Hideki Kobara Masaki Kamada Kazushi Deguchi Tetsuo Touge Osamu Miyamoto Takehiro Nakamura Toshifumi Itano Tsutomu Masaki Source Type: research

Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice
Mol Med Rep. 2022 Mar;25(3):90. doi: 10.3892/mmr.2022.12606. Epub 2022 Jan 18.ABSTRACTType‑2 diabetes mellitus (T2DM) causes several complications that affect the quality of life and life span of patients. Hyperbaric oxygen therapy (HBOT) has been used to successfully treat several diseases, including carbon monoxide poisoning, ischemia, infections and diabetic foot ulcer, and increases insulin sensitivity in T2DM. The present study aimed to determine the effect of HBOT on β‑cell function and hepatic gluconeogenesis in streptozotocin (STZ)‑induced type‑2 diabetic mice. To establish a T2DM model, 7‑week‑old...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Caishun Zhang Di Zhang Haidan Wang Qian Lin Manwen Li Junhua Yuan Guangkai Gao Jing Dong Source Type: research

Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway
In conclusion, EGCG may be able to protect against UVB‑induced HLECs apoptosis through the mitochondria‑mediated apoptotic signaling pathway, indicating its potential application in clinical practice.PMID:35039875 | DOI:10.3892/mmr.2022.12603 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Qiuxin Wu Jike Song Yan'e Gao Yingying Zou Junguo Guo Xiuyan Zhang Dongmei Liu Dadong Guo Hongsheng Bi Source Type: research

Comparison of the effect of rotenone and 1 ‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models
Mol Med Rep. 2022 Mar;25(3):91. doi: 10.3892/mmr.2022.12607. Epub 2022 Jan 18.ABSTRACTAnimal models for Parkinson's disease (PD) are very useful in understanding the pathogenesis of PD and screening for new therapeutic approaches. The present study compared two commonly used neurotoxin‑induced mouse models of chronic PD to guide model selection, explore the pathogenesis and mechanisms underlying PD and develop effective treatments. The chronic PD mouse models were established via treatment with rotenone or 1‑methyl‑4‑phenyl‑1,2,3,6-tetrahydropyridine (MPTP) for 6 weeks. The effects of rotenone and MPTP in the mic...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Jing Zhang Bohao Sun Jifeng Yang Zhuo Chen Zhengzheng Li Nan Zhang Hongzhi Li Luxi Shen Source Type: research

Proteomic analysis of inhibitor of apoptosis protein ‑like protein‑2 on breast cancer cell proliferation
Mol Med Rep. 2022 Mar;25(3):89. doi: 10.3892/mmr.2022.12605. Epub 2022 Jan 18.ABSTRACTAlthough inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) is considered to be a novel enhancer of breast cancer proliferation, its underlying mechanism of action remains unknown. Therefore, the present study aimed to investigate the expression profile of ILP‑2‑related proteins in MCF‑7 cells to reveal their effect on promoting breast cancer cell proliferation. The isobaric tags for relative and absolute quantification (iTRAQ) method was used to analyse the expression profile of ILP‑2‑related proteins in MCF‑7 breast...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Siqi Xiang Lin Zhu Zhiliang Zhang Siyuan Wang Ruxia Cui Mingjun Xiang Source Type: research

Long non ‑coding RNA CTBP1‑AS2 upregulates USP22 to promote pancreatic carcinoma progression by sponging miR‑141‑3p
In conclusion, lncRNA CTBP1‑AS2 may be involved in pancreatic carcinoma progression by regulating miR‑141‑3p and USP22 expressions; in addition, CTBP1‑AS2 may be a diagnostic biomarker and treatment target for pancreatic carcinoma.PMID:35039872 | DOI:10.3892/mmr.2022.12602 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Mingliang Zhang Songbo Ma Xuzhao Li Henghai Yu Yizheng Tan Jun He Xiaoping Wei Junming Ma Source Type: research

A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy
Mol Med Rep. 2022 Mar;25(3):88. doi: 10.3892/mmr.2022.12604. Epub 2022 Jan 18.ABSTRACTProgressive supranuclear palsy (PSP) is a neurodegenerative tauopathy described as a syndrome of postural instability, supranuclear vertical gaze palsy, dysarthria, dystonic rigidity of the neck and trunk, dementia, and pseudobulbar palsy. The clinical diagnosis of PSP is often difficult because there are no established biomarkers, and diagnosis is currently based on clinical and imaging findings. Furthermore, the etiology and pathogenesis of PSP remain unknown. Dysregulation of microRNAs (miRNAs/miRs) has been reported to serve an import...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Wakako Nonaka Tadayuki Takata Hisakazu Iwama Satoshi Komatsubara Hideki Kobara Masaki Kamada Kazushi Deguchi Tetsuo Touge Osamu Miyamoto Takehiro Nakamura Toshifumi Itano Tsutomu Masaki Source Type: research

Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice
Mol Med Rep. 2022 Mar;25(3):90. doi: 10.3892/mmr.2022.12606. Epub 2022 Jan 18.ABSTRACTType‑2 diabetes mellitus (T2DM) causes several complications that affect the quality of life and life span of patients. Hyperbaric oxygen therapy (HBOT) has been used to successfully treat several diseases, including carbon monoxide poisoning, ischemia, infections and diabetic foot ulcer, and increases insulin sensitivity in T2DM. The present study aimed to determine the effect of HBOT on β‑cell function and hepatic gluconeogenesis in streptozotocin (STZ)‑induced type‑2 diabetic mice. To establish a T2DM model, 7‑week‑old...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Caishun Zhang Di Zhang Haidan Wang Qian Lin Manwen Li Junhua Yuan Guangkai Gao Jing Dong Source Type: research

Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway
In conclusion, EGCG may be able to protect against UVB‑induced HLECs apoptosis through the mitochondria‑mediated apoptotic signaling pathway, indicating its potential application in clinical practice.PMID:35039875 | DOI:10.3892/mmr.2022.12603 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Qiuxin Wu Jike Song Yan'e Gao Yingying Zou Junguo Guo Xiuyan Zhang Dongmei Liu Dadong Guo Hongsheng Bi Source Type: research

Comparison of the effect of rotenone and 1 ‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models
Mol Med Rep. 2022 Mar;25(3):91. doi: 10.3892/mmr.2022.12607. Epub 2022 Jan 18.ABSTRACTAnimal models for Parkinson's disease (PD) are very useful in understanding the pathogenesis of PD and screening for new therapeutic approaches. The present study compared two commonly used neurotoxin‑induced mouse models of chronic PD to guide model selection, explore the pathogenesis and mechanisms underlying PD and develop effective treatments. The chronic PD mouse models were established via treatment with rotenone or 1‑methyl‑4‑phenyl‑1,2,3,6-tetrahydropyridine (MPTP) for 6 weeks. The effects of rotenone and MPTP in the mic...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Jing Zhang Bohao Sun Jifeng Yang Zhuo Chen Zhengzheng Li Nan Zhang Hongzhi Li Luxi Shen Source Type: research

Proteomic analysis of inhibitor of apoptosis protein ‑like protein‑2 on breast cancer cell proliferation
Mol Med Rep. 2022 Mar;25(3):89. doi: 10.3892/mmr.2022.12605. Epub 2022 Jan 18.ABSTRACTAlthough inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) is considered to be a novel enhancer of breast cancer proliferation, its underlying mechanism of action remains unknown. Therefore, the present study aimed to investigate the expression profile of ILP‑2‑related proteins in MCF‑7 cells to reveal their effect on promoting breast cancer cell proliferation. The isobaric tags for relative and absolute quantification (iTRAQ) method was used to analyse the expression profile of ILP‑2‑related proteins in MCF‑7 breast...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Siqi Xiang Lin Zhu Zhiliang Zhang Siyuan Wang Ruxia Cui Mingjun Xiang Source Type: research

Long non ‑coding RNA CTBP1‑AS2 upregulates USP22 to promote pancreatic carcinoma progression by sponging miR‑141‑3p
In conclusion, lncRNA CTBP1‑AS2 may be involved in pancreatic carcinoma progression by regulating miR‑141‑3p and USP22 expressions; in addition, CTBP1‑AS2 may be a diagnostic biomarker and treatment target for pancreatic carcinoma.PMID:35039872 | DOI:10.3892/mmr.2022.12602 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Mingliang Zhang Songbo Ma Xuzhao Li Henghai Yu Yizheng Tan Jun He Xiaoping Wei Junming Ma Source Type: research

A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy
Mol Med Rep. 2022 Mar;25(3):88. doi: 10.3892/mmr.2022.12604. Epub 2022 Jan 18.ABSTRACTProgressive supranuclear palsy (PSP) is a neurodegenerative tauopathy described as a syndrome of postural instability, supranuclear vertical gaze palsy, dysarthria, dystonic rigidity of the neck and trunk, dementia, and pseudobulbar palsy. The clinical diagnosis of PSP is often difficult because there are no established biomarkers, and diagnosis is currently based on clinical and imaging findings. Furthermore, the etiology and pathogenesis of PSP remain unknown. Dysregulation of microRNAs (miRNAs/miRs) has been reported to serve an import...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Wakako Nonaka Tadayuki Takata Hisakazu Iwama Satoshi Komatsubara Hideki Kobara Masaki Kamada Kazushi Deguchi Tetsuo Touge Osamu Miyamoto Takehiro Nakamura Toshifumi Itano Tsutomu Masaki Source Type: research

Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice
Mol Med Rep. 2022 Mar;25(3):90. doi: 10.3892/mmr.2022.12606. Epub 2022 Jan 18.ABSTRACTType‑2 diabetes mellitus (T2DM) causes several complications that affect the quality of life and life span of patients. Hyperbaric oxygen therapy (HBOT) has been used to successfully treat several diseases, including carbon monoxide poisoning, ischemia, infections and diabetic foot ulcer, and increases insulin sensitivity in T2DM. The present study aimed to determine the effect of HBOT on β‑cell function and hepatic gluconeogenesis in streptozotocin (STZ)‑induced type‑2 diabetic mice. To establish a T2DM model, 7‑week‑old...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Caishun Zhang Di Zhang Haidan Wang Qian Lin Manwen Li Junhua Yuan Guangkai Gao Jing Dong Source Type: research

Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway
In conclusion, EGCG may be able to protect against UVB‑induced HLECs apoptosis through the mitochondria‑mediated apoptotic signaling pathway, indicating its potential application in clinical practice.PMID:35039875 | DOI:10.3892/mmr.2022.12603 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Qiuxin Wu Jike Song Yan'e Gao Yingying Zou Junguo Guo Xiuyan Zhang Dongmei Liu Dadong Guo Hongsheng Bi Source Type: research

Comparison of the effect of rotenone and 1 ‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models
Mol Med Rep. 2022 Mar;25(3):91. doi: 10.3892/mmr.2022.12607. Epub 2022 Jan 18.ABSTRACTAnimal models for Parkinson's disease (PD) are very useful in understanding the pathogenesis of PD and screening for new therapeutic approaches. The present study compared two commonly used neurotoxin‑induced mouse models of chronic PD to guide model selection, explore the pathogenesis and mechanisms underlying PD and develop effective treatments. The chronic PD mouse models were established via treatment with rotenone or 1‑methyl‑4‑phenyl‑1,2,3,6-tetrahydropyridine (MPTP) for 6 weeks. The effects of rotenone and MPTP in the mic...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Jing Zhang Bohao Sun Jifeng Yang Zhuo Chen Zhengzheng Li Nan Zhang Hongzhi Li Luxi Shen Source Type: research

Proteomic analysis of inhibitor of apoptosis protein ‑like protein‑2 on breast cancer cell proliferation
Mol Med Rep. 2022 Mar;25(3):89. doi: 10.3892/mmr.2022.12605. Epub 2022 Jan 18.ABSTRACTAlthough inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) is considered to be a novel enhancer of breast cancer proliferation, its underlying mechanism of action remains unknown. Therefore, the present study aimed to investigate the expression profile of ILP‑2‑related proteins in MCF‑7 cells to reveal their effect on promoting breast cancer cell proliferation. The isobaric tags for relative and absolute quantification (iTRAQ) method was used to analyse the expression profile of ILP‑2‑related proteins in MCF‑7 breast...
Source: Molecular Medicine Reports - January 18, 2022 Category: Molecular Biology Authors: Siqi Xiang Lin Zhu Zhiliang Zhang Siyuan Wang Ruxia Cui Mingjun Xiang Source Type: research

NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
In conclusion, intervening with the Sirt1/Nrf2/ATF signaling pathway may be an effective strategy for resisting oxidative stress damage in the heart during hypoxia.PMID:35029280 | DOI:10.3892/mmr.2022.12600 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Zhi-Yu Li Ying Liu Yue-Ying Wang Xiang Li Zhuo-Na Han Lan Hong Ying-Shun Li Xun Cui Source Type: research

Synergetic protective effect of remote ischemic preconditioning and prolyl 4 ‑hydroxylase inhibition in ischemic cardiac injury
In conclusion, the present study demonstrated that RIP and PHD inhibition exerted synergetic protective effects on cardiac injury via activation of HIF‑1α and the downstream VEGF/AKT‑eNOS signaling pathway.PMID:35029283 | DOI:10.3892/mmr.2022.12596 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Juesheng Yang Jiajun Xu Lei Tao Shiyong Wang Haiyan Xiang Yanhua Tang Source Type: research

[Retracted] MicroRNA ‑155 enhances the activation of Wnt/β‑catenin signaling in colorectal carcinoma by suppressing HMG‑box transcription factor 1
Mol Med Rep. 2022 Mar;25(3):81. doi: 10.3892/mmr.2022.12597. Epub 2022 Jan 14.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blot assay data shown in Figs. 1C and 6A were strikingly similar to data appearing in different form in another article written by different authors. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were a...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Ying-Chun Wan Tao Li Yang-Dong Han Hai-Yan Zhang Hai Lin Bin Zhang Source Type: research

Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7 ‑TGF‑β pathway in allergic rhinitis
Mol Med Rep. 2022 Mar;25(3):83. doi: 10.3892/mmr.2022.12599. Epub 2022 Jan 14.ABSTRACTTotal glucosides of paeony (TGP), an active ingredient extracted from the root of Paeonia alba, has been reported to display an anti‑inflammatory effect. However, the effect of TGP on allergic rhinitis (AR) is still unknown. The present study aimed to assess the role of TGP in an AR mouse model. An AR mouse model was established using the ovalbumin method. The expression levels of Smad7/TGF‑β pathway‑related prtoeins in nasal mucosa tissues were determined by immunofluorescence, immunohistochemistry and western blotting. The se...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Yangzi Jin Aichun Zhang Source Type: research

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells
Mol Med Rep. 2022 Mar;25(3):85. doi: 10.3892/mmr.2022.12601. Epub 2022 Jan 14.ABSTRACTMultiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Repulsive guidance molecule a (RGMa) has been indicated to act as a bone morphogenetic protein (BMP) co‑receptor, enhancing BMP signalling activity. However, the role and downstream pathways of the BMP signalling pathway mediated by RGMa have yet to be fully elucidated. A recent study revealed that C‑C motif chemokine ligand 5 (CCL5) has a major role in the pathogenesis of MS via the recruitment of macrophages and T‑lymphocytes into the CNS. The ...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Shi Tang Bao Su Tao Tao Weiping Yan Rongrong Zhang Xinyue Qin Jinzhou Feng Source Type: research

B7 ‑H3 promotes the epithelial‑mesenchymal transition of NSCLC by targeting SIRT1 through the PI3K/AKT pathway
Mol Med Rep. 2022 Mar;25(3):79. doi: 10.3892/mmr.2022.12595. Epub 2022 Jan 14.ABSTRACTEpithelial‑mesenchymal transition (EMT) is a key step in cancer metastasis. B7‑H3, a co‑signaling molecule associated with poor prognosis of non‑small cell lung cancer (NSCLC), promotes the metastasis of NSCLC by activating the EMT process. However, its underlying mechanism remains poorly understood. In the present study, it was shown that CRISPR/Cas9‑mediated B7‑H3 deletion downregulated the expression of the class III histone deacetylase, sirtuin‑1 (SIRT1), in NSCLC A549 cells. Accordingly, SIRT1 silencing resulted in mark...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Haixiu Liao Meng Ding Nannan Zhou Ying Yang Liwen Chen Source Type: research

Cellular response of lung fibroblasts and epithelial cells to particulate matter < sub > 10 < /sub > treatment examined via comparative transcriptome analysis
Mol Med Rep. 2022 Mar;25(3):82. doi: 10.3892/mmr.2022.12598. Epub 2022 Jan 14.ABSTRACTParticulate matter (PM) can be categorized by particle size (PM10, PM2.5 and PM1.0), which is an important factor affecting the biological response. Exposure to PM in the air (dust, smoke, dirt and biological contaminants) is clearly associated with lung disease (lung cancer, pneumonia and asthma). Although PM primarily affects lung epithelial cells, the specific response of related cell types to PM remains to be elucidated. The present study performed Gene Ontology (GO) analysis programs (Clustering GO and Database for Annotation, Visual...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Kunhyang Park Kwangho Kim Tae Young Ryu Jinkwon Lee Moo-Seung Lee Mi-Young Son Seon-Jin Lee Young-Jun Park Hyun-Soo Cho Dae-Soo Kim Source Type: research

NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
In conclusion, intervening with the Sirt1/Nrf2/ATF signaling pathway may be an effective strategy for resisting oxidative stress damage in the heart during hypoxia.PMID:35029280 | DOI:10.3892/mmr.2022.12600 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Zhi-Yu Li Ying Liu Yue-Ying Wang Xiang Li Zhuo-Na Han Lan Hong Ying-Shun Li Xun Cui Source Type: research

Synergetic protective effect of remote ischemic preconditioning and prolyl 4 ‑hydroxylase inhibition in ischemic cardiac injury
In conclusion, the present study demonstrated that RIP and PHD inhibition exerted synergetic protective effects on cardiac injury via activation of HIF‑1α and the downstream VEGF/AKT‑eNOS signaling pathway.PMID:35029283 | DOI:10.3892/mmr.2022.12596 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Juesheng Yang Jiajun Xu Lei Tao Shiyong Wang Haiyan Xiang Yanhua Tang Source Type: research

[Retracted] MicroRNA ‑155 enhances the activation of Wnt/β‑catenin signaling in colorectal carcinoma by suppressing HMG‑box transcription factor 1
Mol Med Rep. 2022 Mar;25(3):81. doi: 10.3892/mmr.2022.12597. Epub 2022 Jan 14.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blot assay data shown in Figs. 1C and 6A were strikingly similar to data appearing in different form in another article written by different authors. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were a...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Ying-Chun Wan Tao Li Yang-Dong Han Hai-Yan Zhang Hai Lin Bin Zhang Source Type: research

Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7 ‑TGF‑β pathway in allergic rhinitis
Mol Med Rep. 2022 Mar;25(3):83. doi: 10.3892/mmr.2022.12599. Epub 2022 Jan 14.ABSTRACTTotal glucosides of paeony (TGP), an active ingredient extracted from the root of Paeonia alba, has been reported to display an anti‑inflammatory effect. However, the effect of TGP on allergic rhinitis (AR) is still unknown. The present study aimed to assess the role of TGP in an AR mouse model. An AR mouse model was established using the ovalbumin method. The expression levels of Smad7/TGF‑β pathway‑related prtoeins in nasal mucosa tissues were determined by immunofluorescence, immunohistochemistry and western blotting. The se...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Yangzi Jin Aichun Zhang Source Type: research

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells
Mol Med Rep. 2022 Mar;25(3):85. doi: 10.3892/mmr.2022.12601. Epub 2022 Jan 14.ABSTRACTMultiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Repulsive guidance molecule a (RGMa) has been indicated to act as a bone morphogenetic protein (BMP) co‑receptor, enhancing BMP signalling activity. However, the role and downstream pathways of the BMP signalling pathway mediated by RGMa have yet to be fully elucidated. A recent study revealed that C‑C motif chemokine ligand 5 (CCL5) has a major role in the pathogenesis of MS via the recruitment of macrophages and T‑lymphocytes into the CNS. The ...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Shi Tang Bao Su Tao Tao Weiping Yan Rongrong Zhang Xinyue Qin Jinzhou Feng Source Type: research

B7 ‑H3 promotes the epithelial‑mesenchymal transition of NSCLC by targeting SIRT1 through the PI3K/AKT pathway
Mol Med Rep. 2022 Mar;25(3):79. doi: 10.3892/mmr.2022.12595. Epub 2022 Jan 14.ABSTRACTEpithelial‑mesenchymal transition (EMT) is a key step in cancer metastasis. B7‑H3, a co‑signaling molecule associated with poor prognosis of non‑small cell lung cancer (NSCLC), promotes the metastasis of NSCLC by activating the EMT process. However, its underlying mechanism remains poorly understood. In the present study, it was shown that CRISPR/Cas9‑mediated B7‑H3 deletion downregulated the expression of the class III histone deacetylase, sirtuin‑1 (SIRT1), in NSCLC A549 cells. Accordingly, SIRT1 silencing resulted in mark...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Haixiu Liao Meng Ding Nannan Zhou Ying Yang Liwen Chen Source Type: research

Cellular response of lung fibroblasts and epithelial cells to particulate matter < sub > 10 < /sub > treatment examined via comparative transcriptome analysis
Mol Med Rep. 2022 Mar;25(3):82. doi: 10.3892/mmr.2022.12598. Epub 2022 Jan 14.ABSTRACTParticulate matter (PM) can be categorized by particle size (PM10, PM2.5 and PM1.0), which is an important factor affecting the biological response. Exposure to PM in the air (dust, smoke, dirt and biological contaminants) is clearly associated with lung disease (lung cancer, pneumonia and asthma). Although PM primarily affects lung epithelial cells, the specific response of related cell types to PM remains to be elucidated. The present study performed Gene Ontology (GO) analysis programs (Clustering GO and Database for Annotation, Visual...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Kunhyang Park Kwangho Kim Tae Young Ryu Jinkwon Lee Moo-Seung Lee Mi-Young Son Seon-Jin Lee Young-Jun Park Hyun-Soo Cho Dae-Soo Kim Source Type: research

NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
In conclusion, intervening with the Sirt1/Nrf2/ATF signaling pathway may be an effective strategy for resisting oxidative stress damage in the heart during hypoxia.PMID:35029280 | DOI:10.3892/mmr.2022.12600 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Zhi-Yu Li Ying Liu Yue-Ying Wang Xiang Li Zhuo-Na Han Lan Hong Ying-Shun Li Xun Cui Source Type: research

Synergetic protective effect of remote ischemic preconditioning and prolyl 4 ‑hydroxylase inhibition in ischemic cardiac injury
In conclusion, the present study demonstrated that RIP and PHD inhibition exerted synergetic protective effects on cardiac injury via activation of HIF‑1α and the downstream VEGF/AKT‑eNOS signaling pathway.PMID:35029283 | DOI:10.3892/mmr.2022.12596 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Juesheng Yang Jiajun Xu Lei Tao Shiyong Wang Haiyan Xiang Yanhua Tang Source Type: research

[Retracted] MicroRNA ‑155 enhances the activation of Wnt/β‑catenin signaling in colorectal carcinoma by suppressing HMG‑box transcription factor 1
Mol Med Rep. 2022 Mar;25(3):81. doi: 10.3892/mmr.2022.12597. Epub 2022 Jan 14.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blot assay data shown in Figs. 1C and 6A were strikingly similar to data appearing in different form in another article written by different authors. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were a...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Ying-Chun Wan Tao Li Yang-Dong Han Hai-Yan Zhang Hai Lin Bin Zhang Source Type: research

Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7 ‑TGF‑β pathway in allergic rhinitis
Mol Med Rep. 2022 Mar;25(3):83. doi: 10.3892/mmr.2022.12599. Epub 2022 Jan 14.ABSTRACTTotal glucosides of paeony (TGP), an active ingredient extracted from the root of Paeonia alba, has been reported to display an anti‑inflammatory effect. However, the effect of TGP on allergic rhinitis (AR) is still unknown. The present study aimed to assess the role of TGP in an AR mouse model. An AR mouse model was established using the ovalbumin method. The expression levels of Smad7/TGF‑β pathway‑related prtoeins in nasal mucosa tissues were determined by immunofluorescence, immunohistochemistry and western blotting. The se...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Yangzi Jin Aichun Zhang Source Type: research

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells
Mol Med Rep. 2022 Mar;25(3):85. doi: 10.3892/mmr.2022.12601. Epub 2022 Jan 14.ABSTRACTMultiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Repulsive guidance molecule a (RGMa) has been indicated to act as a bone morphogenetic protein (BMP) co‑receptor, enhancing BMP signalling activity. However, the role and downstream pathways of the BMP signalling pathway mediated by RGMa have yet to be fully elucidated. A recent study revealed that C‑C motif chemokine ligand 5 (CCL5) has a major role in the pathogenesis of MS via the recruitment of macrophages and T‑lymphocytes into the CNS. The ...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Shi Tang Bao Su Tao Tao Weiping Yan Rongrong Zhang Xinyue Qin Jinzhou Feng Source Type: research

B7 ‑H3 promotes the epithelial‑mesenchymal transition of NSCLC by targeting SIRT1 through the PI3K/AKT pathway
Mol Med Rep. 2022 Mar;25(3):79. doi: 10.3892/mmr.2022.12595. Epub 2022 Jan 14.ABSTRACTEpithelial‑mesenchymal transition (EMT) is a key step in cancer metastasis. B7‑H3, a co‑signaling molecule associated with poor prognosis of non‑small cell lung cancer (NSCLC), promotes the metastasis of NSCLC by activating the EMT process. However, its underlying mechanism remains poorly understood. In the present study, it was shown that CRISPR/Cas9‑mediated B7‑H3 deletion downregulated the expression of the class III histone deacetylase, sirtuin‑1 (SIRT1), in NSCLC A549 cells. Accordingly, SIRT1 silencing resulted in mark...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Haixiu Liao Meng Ding Nannan Zhou Ying Yang Liwen Chen Source Type: research

Cellular response of lung fibroblasts and epithelial cells to particulate matter < sub > 10 < /sub > treatment examined via comparative transcriptome analysis
Mol Med Rep. 2022 Mar;25(3):82. doi: 10.3892/mmr.2022.12598. Epub 2022 Jan 14.ABSTRACTParticulate matter (PM) can be categorized by particle size (PM10, PM2.5 and PM1.0), which is an important factor affecting the biological response. Exposure to PM in the air (dust, smoke, dirt and biological contaminants) is clearly associated with lung disease (lung cancer, pneumonia and asthma). Although PM primarily affects lung epithelial cells, the specific response of related cell types to PM remains to be elucidated. The present study performed Gene Ontology (GO) analysis programs (Clustering GO and Database for Annotation, Visual...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Kunhyang Park Kwangho Kim Tae Young Ryu Jinkwon Lee Moo-Seung Lee Mi-Young Son Seon-Jin Lee Young-Jun Park Hyun-Soo Cho Dae-Soo Kim Source Type: research

NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
In conclusion, intervening with the Sirt1/Nrf2/ATF signaling pathway may be an effective strategy for resisting oxidative stress damage in the heart during hypoxia.PMID:35029280 | DOI:10.3892/mmr.2022.12600 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Zhi-Yu Li Ying Liu Yue-Ying Wang Xiang Li Zhuo-Na Han Lan Hong Ying-Shun Li Xun Cui Source Type: research

Synergetic protective effect of remote ischemic preconditioning and prolyl 4 ‑hydroxylase inhibition in ischemic cardiac injury
In conclusion, the present study demonstrated that RIP and PHD inhibition exerted synergetic protective effects on cardiac injury via activation of HIF‑1α and the downstream VEGF/AKT‑eNOS signaling pathway.PMID:35029283 | DOI:10.3892/mmr.2022.12596 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Juesheng Yang Jiajun Xu Lei Tao Shiyong Wang Haiyan Xiang Yanhua Tang Source Type: research

[Retracted] MicroRNA ‑155 enhances the activation of Wnt/β‑catenin signaling in colorectal carcinoma by suppressing HMG‑box transcription factor 1
Mol Med Rep. 2022 Mar;25(3):81. doi: 10.3892/mmr.2022.12597. Epub 2022 Jan 14.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blot assay data shown in Figs. 1C and 6A were strikingly similar to data appearing in different form in another article written by different authors. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were a...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Ying-Chun Wan Tao Li Yang-Dong Han Hai-Yan Zhang Hai Lin Bin Zhang Source Type: research

Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7 ‑TGF‑β pathway in allergic rhinitis
Mol Med Rep. 2022 Mar;25(3):83. doi: 10.3892/mmr.2022.12599. Epub 2022 Jan 14.ABSTRACTTotal glucosides of paeony (TGP), an active ingredient extracted from the root of Paeonia alba, has been reported to display an anti‑inflammatory effect. However, the effect of TGP on allergic rhinitis (AR) is still unknown. The present study aimed to assess the role of TGP in an AR mouse model. An AR mouse model was established using the ovalbumin method. The expression levels of Smad7/TGF‑β pathway‑related prtoeins in nasal mucosa tissues were determined by immunofluorescence, immunohistochemistry and western blotting. The se...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Yangzi Jin Aichun Zhang Source Type: research

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells
Mol Med Rep. 2022 Mar;25(3):85. doi: 10.3892/mmr.2022.12601. Epub 2022 Jan 14.ABSTRACTMultiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Repulsive guidance molecule a (RGMa) has been indicated to act as a bone morphogenetic protein (BMP) co‑receptor, enhancing BMP signalling activity. However, the role and downstream pathways of the BMP signalling pathway mediated by RGMa have yet to be fully elucidated. A recent study revealed that C‑C motif chemokine ligand 5 (CCL5) has a major role in the pathogenesis of MS via the recruitment of macrophages and T‑lymphocytes into the CNS. The ...
Source: Molecular Medicine Reports - January 14, 2022 Category: Molecular Biology Authors: Shi Tang Bao Su Tao Tao Weiping Yan Rongrong Zhang Xinyue Qin Jinzhou Feng Source Type: research