Lung cancer ‑associated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR‑493.
In conclusion, these results suggested that LUCAT1 may facilitate tumorigenesis in LSCC through the targeted inhibition of miR‑493, which provides evidence for a novel target for the treatment of LSCC. PMID: 33215214 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Klotho attenuates angiotensin II ‑induced cardiotoxicity through suppression of necroptosis and oxidative stress.
Klotho attenuates angiotensin II‑induced cardiotoxicity through suppression of necroptosis and oxidative stress. Mol Med Rep. 2021 Jan;23(1): Authors: Yu S, Yang H, Guo X, Sun Y Abstract Hyperglycemia is known to lead to cardiac injury and inflammation through the reactive oxygen species (ROS)‑Toll‑like receptor 4 (TLR4)‑necroptosis pathway. Similarly, angiotensin II (Ang II) activates the TLR4‑nuclear factor κB (NF‑κB) p65 pathway, while the protein Klotho is known to inhibit this pathway, protecting cardiac cells from Ang II‑induced injury. However, there is currently a lack...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
Authors: Wang Z, Zhuang X, Chen B, Wei M Abstract Extracellular matrix (ECM) proteins serve a major role in the pathogenesis of aortic dissection (AD). The aim of the present study was to investigate the effect of osteoglycin (OGN), an ECM proteoglycan, on aortic dissection (AD), as well as the underlying mechanism. Thoracic aortic tissues from 20 patients with AD and healthy thoracic aortic tissue from 5 patients undergoing coronary artery bypass grafting were collected to detect OGN expression levels. Following OGN knockdown in rat aortic smooth muscle cells, cell proliferation was detected by performin...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Recombinant stromal cell ‑derived factor‑1 protein promotes neurite outgrowth in PC‑12 cells.
Recombinant stromal cell‑derived factor‑1 protein promotes neurite outgrowth in PC‑12 cells. Mol Med Rep. 2021 Jan;23(1): Authors: Yun YR, Jang JH Abstract Stromal cell‑derived factor‑1 (SDF‑1) is a chemokine involved in neuronal differentiation, as well as proliferation and migration. In the present study, the effects of recombinant SDF‑1 on neurite outgrowth for nerve regeneration and engineering were evaluated in PC‑12 cells. The effects of purified SDF‑1 protein on cell toxicity, proliferation and migration were also assessed. SDF‑1 significantly augmented cell proliferation in ...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2  cells induced by oxygen‑glucose deprivation and reoxygenation by upregulating GAB1 expression.
S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen‑glucose deprivation and reoxygenation by upregulating GAB1 expression. Mol Med Rep. 2021 Jan;23(1): Authors: Hu W, Lin C Abstract S100a8 serves an important role in cell differentiation and is abnormally expressed in common tumors, but there are few studies on the association between S100a8 and brain I/R injury. The present study aimed to investigate the role of S100a8 in oxygen‑glucose deprivation and reoxygenation (OGD/R)‑induced BV2 microglia cell injury, and to elucidate the poten...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

HIF ‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia.
HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia. Mol Med Rep. 2021 Jan;23(1): Authors: Qu H, Yu Q, Jia B, Zhou W, Zhang Y, Mu L Abstract Preeclampsia (PE) is a common obstetric disease occurring after 20 weeks of gestation. Hypoxia‑inducible factor (HIF)‑3α potentially functions as a regulatory factor in PE development, however its specific molecular mechanism remains to be elucidated. The present study aimed to investigate the function of HIF‑3α in trophoblast cell line HTR‑8/SVne...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Exogenous sodium hydrosulfide protects against high glucose ‑induced injury and inflammation in human umbilical vein endothelial cells by inhibiting necroptosis via the p38 MAPK signaling pathway.
In conclusion, the findings of the present study indicated that NaHS may protect HUVECs against HG‑induced injury and inflammation by inhibiting necroptosis via the p38 MAPK signaling pathway, which may represent a promising drug for the therapy of diabetic vascular complications. PMID: 33215220 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Construction of tissue engineering bone with the co ‑culture system of ADSCs and VECs on partially deproteinized biologic bone in vitro: A preliminary study.
Construction of tissue engineering bone with the co‑culture system of ADSCs and VECs on partially deproteinized biologic bone in vitro: A preliminary study. Mol Med Rep. 2021 Jan;23(1): Authors: Yang G, Wang F, Li Y, Hou J, Liu D Abstract Scaffold‑based bone tissue engineering has therapeutic potential in the regeneration of osseous defects. The present study aimed to explore the adhesion and cell viability of a co‑culture system composed of vascular endothelial cells PI‑/Annexin V+ represents early apoptotic cells, and PI+/Annexin V+ represents late apoptotic cells (VECs) a...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Long non ‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197.
Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197. Mol Med Rep. 2021 Jan;23(1): Authors: Han X, Liu Z Abstract Long non‑coding RNAs (lncRNAs) serve a crucial role in gastric cancer (GC) progression. However, the molecular mechanism underlying lncRNA JPX transcript, XIST activator (JPX) in the tumorigenesis of GC is not completely understood. Reverse transcription‑quantitative PCR (RT‑qPCR) and western blotting were performed to detect gene expression. A luciferase reporter gene assay was conducted to determine the re...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF ‑1α and VEGF expression.
Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression. Mol Med Rep. 2021 Jan;23(1): Authors: Dong D, Fu Y, Chen F, Zhang J, Jia H, Li J, Wang H, Wen J Abstract The current study investigated whether hyperoxia may reverse hypoxia‑induced radioresistance (RR) in cervical cancer. Human HeLa cells exposed to hypoxic, normoxic or hyperoxic conditions were irradiated using X‑rays. Cell proliferation and apoptosis were analyzed using MTT assays and flow cytometry. The expression levels of hypoxia‑inducible factor‑1α (HIF‑1&...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects and molecular mechanism of pachymic acid on  ferroptosis in renal ischemia reperfusion injury.
Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury. Mol Med Rep. 2021 Jan;23(1): Authors: Jiang GP, Liao YJ, Huang LL, Zeng XJ, Liao XH Abstract Acute kidney injury (AKI) is a common clinical disease. Ferropotosis, a new type of regulatory cell death, serves an important regulatory role in AKI. Pachymic acid (PA), a lanostane‑type triterpenoid from Poria cocos, has been reported to be protective against AKI. However, the protective mechanism of PA in AKI is not yet fully understood. The present study aimed to investigate the effect and molec...
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mol Med Rep[journal]; +103 new citations
103 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Mol Med Rep[journal] These pubmed results were generated on 2020/11/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - November 13, 2020 Category: Molecular Biology Tags: Report Source Type: research

Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus.
Authors: Luo Q, Li X, Fu B, Zhang L, Fang L, Qing C, Guo Y, Huang Z, Li J Abstract Circular RNAs (circRNAs) have gained attention due to their performance in disease diagnosis. However, the characteristics of circRNAs in peripheral blood from patients with systemic lupus erythematosus (SLE) remain unknown. Therefore, the aim of the present study was to determine the expression profile and diagnostic potential of circRNAs in peripheral blood from patients with SLE. The global circRNA expression in the peripheral blood of patients with SLE and healthy controls (HCs) was detected using a circRNA microar...
Source: Molecular Medicine Reports - November 11, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Upregulation of centromere protein  M promotes tumorigenesis: A potential predictive target for cancer in humans.
In conclusion, the data from the present study revealed that CENPM exerted its pro‑tumorigenic function by regulating cell cycle‑associated protein expression and suggested that CENPM could be used as a prognostic marker for breast cancer. PMID: 33000180 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

GSK ‑3β inhibition promotes doxorubicin‑induced apoptosis in human cholangiocarcinoma cells via FAK/AKT inhibition.
GSK‑3β inhibition promotes doxorubicin‑induced apoptosis in human cholangiocarcinoma cells via FAK/AKT inhibition. Mol Med Rep. 2020 Nov;22(5):4432-4441 Authors: Li L, Xiang Y, Zeng Y, Xiao B, Yu W, Duan C, Xia X, Zhang T, Zeng Y, Liu Y, Dai R Abstract Cholangiocarcinoma (CCA) is the most common type of malignant tumor of the bile duct and is characterized by high morbidity and mortality; it is difficult to diagnose in the early stages and responds poorly to current conventional radiotherapy and chemotherapy. The present study investigated the role of GSK‑3β signaling on the anticancer ...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Hydrogen sulfide is a regulator of mammary gland development in prepubescent female mice.
In conclusion, the present study demonstrated that exogenous H2S supplied by NaHS may exert bidirectional effects on mammary gland ductal development; promoting ductal development at a low concentration and inhibiting it at a high concentration. The effects of H2S may occur via the intracellular PI3K/Akt‑mTOR signaling pathway, or by regulation of the secretion of IGF‑1 and E2. PMID: 33000185 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma.
MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma. Mol Med Rep. 2020 Nov;22(5):3911-3921 Authors: Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Sun L, Sun C, Feng W, Guo SB Abstract Osteosarcoma (OS) is a primary malignant tumor of bone tissue. Effective chemotherapy may improve the survival of patients with OS. MicroRNAs (miRs) serve significant roles in the regulatory function of tumorigenesis and chemosensitivity of different types of cancer. miR‑22 has been revealed to inhibit the proliferation and migration of OS cells, as well as increasing their sensitivi...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The AKT inhibitor MK2206 suppresses airway inflammation and the pro ‑remodeling pathway in a TDI‑induced asthma mouse model.
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model. Mol Med Rep. 2020 Nov;22(5):3723-3734 Authors: Cui H, Cheng Y, He Y, Cheng W, Zhao W, Zhao H, Zhou FH, Wang L, Dong J, Cai S Abstract The cellular and molecular mechanisms via which MK2206, an AKT inhibitor, prevents the activation of AKT in toluene diisocyanate (TDI)‑induced asthma remain unclear. Thus, the present study aimed to evaluate the potential effects of MK2206 on airway AKT activation, inflammation and remodeling in a TDI‑induced mouse model of asthma. A to...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mesenchymal stem cell ‑derived extracellular vesicles prevent neural stem cell hypoxia injury via promoting miR‑210‑3p expression.
Mesenchymal stem cell‑derived extracellular vesicles prevent neural stem cell hypoxia injury via promoting miR‑210‑3p expression. Mol Med Rep. 2020 Nov;22(5):3813-3821 Authors: Li F, Zhang J, Liao R, Duan Y, Tao L, Xu Y, Chen A Abstract Neural stem cells (NSCs) have the potential to give rise to offspring cells and hypoxic injury can impair the function of NSCs. The present study investigated the effects of mesenchymal stem cell (MSC)‑derived extracellular vesicles (EVs) on NSC injury, as well as the underlying mechanisms. MSC‑EVs were isolated and identified via morphological and particle si...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Icariin modulates the sirtuin/NF ‑κB pathway and exerts anti‑aging effects in human lung fibroblasts.
Icariin modulates the sirtuin/NF‑κB pathway and exerts anti‑aging effects in human lung fibroblasts. Mol Med Rep. 2020 Nov;22(5):3833-3839 Authors: Xu C, Huang X, Tong Y, Feng X, Wang Y, Wang C, Jiang Y Abstract Icariin (ICA) has been used as a promising anti‑aging drug; however, its underlying molecular mechanism is yet to be elucidated. The present study aimed to determine the anti‑aging molecular mechanisms of ICA. D‑galactose (D‑gal) was used to generate a cell aging model. IMR‑90 human lung fibroblasts were pretreated with different concentrations of ICA (1, 2, 4, 8 and 16 ...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Pinealectomy increases thermogenesis and decreases lipogenesis.
In conclusion, the results presented in the current study suggested that Pnx increases thermogenesis in BAT and decreases lipogenesis in WAT and the liver. PMID: 33000192 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of PEG anchors in PEGylated siRNA lipoplexes on in  vitro gene‑silencing effects and siRNA biodistribution in mice.
Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution in mice. Mol Med Rep. 2020 Nov;22(5):4183-4196 Authors: Hattori Y, Tamaki K, Sakasai S, Ozaki KI, Onishi H Abstract Polyethylene glycol (PEG)‑modifications (PEGylations) of cationic liposome/small interfering RNA complexes (siRNA lipoplexes) can enhance their systemic stability. The present study determined the effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution after intravenous injection. Three types of dialkyl ...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells.
miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells. Mol Med Rep. 2020 Nov;22(5):3695-3704 Authors: Yang N, Cheng H, Mo Q, Zhou X, Xie M Abstract Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved with tissue remodeling of nasal polyps. The present study investigated the molecular mechanisms through which miR‑155‑5p regulated EMT in chronic rhinosinusitis (CRS). Patients were divided into the following groups: CRSsNP, CRS without nasal polyposis group, CRSwNP, CRS with nasal polyposis and co...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

AMP ‑activated protein kinase family member 5 is an independent prognostic indicator of pancreatic adenocarcinoma: A study based on The Cancer Genome Atlas.
In conclusion, these findings suggested that ARK5 may represent an independent prognostic indicator of PAAD. PMID: 33000197 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Neuropeptide  Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism.
Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism. Mol Med Rep. 2020 Nov;22(5):4376-4382 Authors: Zhang B, Zhang X, Xiao J, Zhou X, Chen Y, Gao C Abstract The neuropeptide Y (NPY) system is considered one of the primary neural signaling pathways. NPY, produced by osteoblasts and other peripheral tissues, is known to inhibit biological functions of osteoblasts. However, until recently, little was known of the autocrine mechanism by which NPY is regulated. To investigate this mechanism, overexpression plasmids and small i...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Resveratrol decreases high glucose ‑induced apoptosis in renal tubular cells via suppressing endoplasmic reticulum stress.
Resveratrol decreases high glucose‑induced apoptosis in renal tubular cells via suppressing endoplasmic reticulum stress. Mol Med Rep. 2020 Nov;22(5):4367-4375 Authors: Zhang J, Dong XJ, Ding MR, You CY, Lin X, Wang Y, Wu MJ, Xu GF, Wang GD Abstract Diabetic nephropathy (DN) is the second most common complication of diabetes mellitus after cardiovascular complications. Endoplasmic reticulum (ER) stress is known to be associated with DN. Resveratrol (RSV) exhibits anti‑oxidative, anti‑inflammatory and cytoprotective effects. Therefore, the aims of the present study were to investigate the role of ...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression.
Authors: Hu Q, Wang Q, Han C, Yang Y Abstract The present study aimed to investigate the effects of sufentanil on sepsis-induced acute lung injury (ALI), and identify the potential molecular mechanisms underlying its effect. In order to achieve this, a rat sepsis model was established. Following treatment with sufentanil, the lung wet/dry (W/D) weight ratio was calculated. Histopathological analysis was performed via hematoxylin and eosin staining. Levels of inflammatory factors in bronchoalveolar lavage fluid were determined via ELISA. Furthermore, malondialdehyde (MDA) content and the activities of superoxide dis...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Deletion of P110 δ promotes the development of myocarditis in ApoE‑deficient mice by increasing mononuclear cell peritoneal infiltration.
Deletion of P110δ promotes the development of myocarditis in ApoE‑deficient mice by increasing mononuclear cell peritoneal infiltration. Mol Med Rep. 2020 Nov;22(5):3629-3634 Authors: Zhang QZ, Xue AY, Wei W, Pang AM, Cao LN, Liu F Abstract Phosphoinositide 3-kinase catalytic subunit δ isoform (P110δ) is mainly expressed in white blood cells. It is involved in T and B lymphocyte differentiation, maturation and the neutrophil chemotaxis process. Apolipoprotein E (ApoE) is an arginine‑rich alkaline protein, which is present in plasma chylomicron, low‑density lipoprotein and very l...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑214 promotes the EMT process in melanoma by downregulating CADM1 expression.
MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression. Mol Med Rep. 2020 Nov;22(5):3795-3803 Authors: Wang SJ, Li WW, Wen CJ, Diao YL, Zhao TL Abstract Melanoma is a malignant skin cancer type associated with a high mortality rate, but its treatment is currently not ideal. Both microRNA (miR)‑214 and cell adhesion molecule 1 (CADM1) are differentially expressed in melanoma, but their role in this cancer type remains unknown. Therefore, the aim of the present study was to investigate the role of CADM1 and miR‑214 in melanoma to identify novel targets for its tre...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF ‑κB signaling pathway.
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway. Mol Med Rep. 2020 Nov;22(5):4227-4235 Authors: Zhai J, Li Z, Zhang H, Ma L, Ma Z, Zhang Y, Zou J, Li M, Ma L, Wang X, Li X Abstract A number of studies have reported that diabetic retinopathy (DR) is the major cause of blindness. Berberine (BBR) is a bioactive constituent that displays effects on blood glucose; however, the mechanism underlying the role of BBR during the development of DR is not completely understood. In the present study, a rat model of DR was successfu...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of local dexmedetomidine administration on the neurotoxicity of ropivacaine for sciatic nerve block in rats.
Authors: Xue X, Fan J, Ma X, Liu Y, Han X, Leng Y, Yu J Abstract Dexmedetomidine, used as an adjuvant to local anesthetics (LAs), may prolong the duration of peripheral nerve block. However, the effect of dexmedetomidine on the neurotoxicity of LAs is not completely understood. The present study was designed to investigate the efficacy of two doses of dexmedetomidine as an adjuvant to ropivacaine and its protective effect against the neurotoxicity of LAs. Paw withdrawal thermal latency testing was used to detect the sensory blockade. Extensor postural thrust testing was used to detect the motor blockade. The result...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma.
miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma. Mol Med Rep. 2020 Nov;22(5):3804-3812 Authors: Tang D, Gao W, Yang J, Liu J, Zhao J, Ge J, Chen Q, Liu B Abstract Glioma is a malignant brain cancer that exhibits high invasive ability and poor prognosis. MicroRNA (miR)‑181d has been reported to be involved in the development of glioma. Therefore, the aim of the present study was to investigate whether miR‑181d affected cellular progression by influencing the insulin like growth factor (IGF1)/PI3K/AKT axis. Western blot analysis was performed to analyze the expression leve...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of tacrolimus on the TGF ‑β1/SMAD signaling pathway in paraquat‑exposed rat alveolar type II epithelial cells.
In conclusion, tacrolimus can reduce the levels of TGF‑β1, SMAD3 and CTGF, increase the level of SMAD7 in TGF‑β1 signaling pathway and protect the development of pulmonary fibrosis in paraquat exposed alveolar epithelial cells. PMID: 33000210 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

In  vivo and in vitro anti‑allergic and anti‑inflammatory effects of Dryopteris crassirhizoma through the modulation of the NF‑ĸB signaling pathway in an ovalbumin‑induced allergic asthma mouse model.
In vivo and in vitro anti‑allergic and anti‑inflammatory effects of Dryopteris crassirhizoma through the modulation of the NF‑ĸB signaling pathway in an ovalbumin‑induced allergic asthma mouse model. Mol Med Rep. 2020 Nov;22(5):3597-3606 Authors: Piao CH, Bui TT, Fan YJ, Nguyen TV, Shin DU, Song CH, Lee SY, Shin HS, Kim HT, Chai OH Abstract Dryopteris crassirhizoma (DC) has a wide range of pharmacological effects, including antibacterial, anti‑influenza virus, anti‑tumor, anti‑reverse transcriptase and antioxidant effects. However, the inhibitory effect of DC on aller...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Tumor ‑associated macrophages in lung cancer: Friend or foe? (Review).
Tumor‑associated macrophages in lung cancer: Friend or foe? (Review). Mol Med Rep. 2020 Nov;22(5):4107-4115 Authors: Xu F, Wei Y, Tang Z, Liu B, Dong J Abstract Typically, tumor‑associated macrophages (TAMs), an abundant population of leukocytes in lung cancer, are affected by tumor microenvironment (TME) and shift towards either a pro‑tumor (M2‑like) or an anti‑tumor phenotype (M1‑like). M2‑polarized macrophages, are one of the primary tumor‑infiltrating immune cells and were reported to be associated with the promotion of cancer cell growth, invasion, metastasis, and angiogenesis. TAM...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Histone deacetylase 4 deletion results in abnormal chondrocyte hypertrophy and premature ossification from collagen type 2 α1‑expressing cells.
In conclusion, chondrocyte‑derived HDAC4 was responsible for regulating chondrocyte proliferation and differentiation as well as endochondral bone formation. PMID: 33000215 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Vitamin D receptor knockdown attenuates the antiproliferative, pro ‑apoptotic and anti‑invasive effect of vitamin D by activating the Wnt/β‑catenin signaling pathway in papillary thyroid cancer.
In conclusion, the present study revealed that VDR‑KD attenuated the antiproliferative, pro‑apoptotic and anti‑invasive effects of vitamin D in PTC by activating the Wnt/β‑catenin signaling pathway. PMID: 33000217 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

IKK ε deficiency inhibits acute lung injury following renal ischemia reperfusion injury.
IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury. Mol Med Rep. 2020 Nov;22(5):4213-4220 Authors: Meng C, Qian Y, Zhang C, Liu H, Mu X, Zhang A Abstract Renal ischemia reperfusion injury (IRI) after surgery may promote acute lung injury (ALI) by inducing an inflammatory response. However, the underlying molecular mechanism is still unclear. Studies have reported that inhibitor of κB kinase (IKK)ε primarily regulates inflammation and cell proliferation. The present study aimed to investigate the regulatory role of IKK&epsilon...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Gangliosides and CD82 inhibit the motility of colon cancer by downregulating the phosphorylation of EGFR at different tyrosine sites and signaling pathways.
Authors: Huang X, Li Y, He X, Chen Y, Wei W, Yang X, Ma K Abstract Previous studies have shown that (GM3), a ganglioside, suppresses hepatoma cell motility and migration by inhibiting phosphorylation of EGFR and the activity of the PI3K/AKT signaling pathway. Therefore, the aim of the present study was to investigate whether the combined treatment of CD82 with gangliosides can exert a synergistic inhibitory effect on cell motility and migration. Epidermal growth factor receptor (EGFR) signaling was studied for its role in the mechanism through which CD82 and gangliosides synergistically inhibit the motility and mig...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Neuropilin ‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19.
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19. Mol Med Rep. 2020 Nov;22(5):4221-4226 Authors: Davies J, Randeva HS, Chatha K, Hall M, Spandidos DA, Karteris E, Kyrou I Abstract Infection by the severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) is the cause of the new viral infectious disease (coronavirus disease 2019; COVID‑19). Emerging evidence indicates that COVID‑19 may be associated with a wide spectrum of neurological symptoms and complications with cen...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mutations of the cystic fibrosis transmembrane conductance regulator gene in males with congenital bilateral absence of the vas deferens: Reproductive implications and genetic counseling (Review).
Authors: Cui X, Wu X, Li Q, Jing X Abstract Congenital bilateral absence of the vas deferens (CBAVD) is predominantly caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CBAVD accounts for 2‑6% of male infertility cases and up to 25% of cases of obstructive azoospermia. With the use of pre‑implantation genetic diagnosis, testicular or epididymal sperm aspiration, intracytoplasmic sperm injection and in vitro fertilization, patients affected by CBAVD are able to have children who do not carry CFTR gene mutations, thereby preventing disease. Therefore, genetic counseli...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑181b‑5p inhibits trophoblast cell migration and invasion through targeting S1PR1 in multiple abnormal trophoblast invasion‑related events.
miR‑181b‑5p inhibits trophoblast cell migration and invasion through targeting S1PR1 in multiple abnormal trophoblast invasion‑related events. Mol Med Rep. 2020 Nov;22(5):4442-4451 Authors: Miao J, Zhu Y, Xu L, Huang X, Zhou X Abstract Normal placentation and successful maintenance of pregnancy depend on the successful migration and invasion of trophoblasts into maternal tissues. Previous studies reported that microRNAs (miRs) are expressed in trophoblasts, and can regulate their migration and invasion. The present study aimed to investigate miR‑181b‑5p function in HTR‑8/SVneo trophoblasts ...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

KCTD1 mutants in scalp ‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling.
KCTD1 mutants in scalp‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling. Mol Med Rep. 2020 Nov;22(5):3895-3903 Authors: Hu L, Chen L, Yang L, Ye Z, Huang W, Li X, Liu Q, Qiu J, Ding X Abstract Potassium‑channel tetramerization-domain-containing 1 (KCTD1) mutations are reported to result in scalp‑ear‑nipple syndrome. These mutations occur in the conserved broad‑complex, tramtrack and bric a brac domain, which is associated with inhibited transcriptional activity. However, the mechanisms of KC...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Astragalin alleviates ischemia/reperfusion ‑induced brain injury via suppression of endoplasmic reticulum stress.
In conclusion, these results suggested that AST may protect against I/R‑induced brain injury, thus, highlighting its therapeutic potential in patients with ischemic stroke. PMID: 33000226 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

SNHG12 inhibits oxygen ‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis.
SNHG12 inhibits oxygen‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis. Mol Med Rep. 2020 Nov;22(5):3886-3894 Authors: Yan Y, Chen L, Zhou J, Xie L Abstract Emerging evidence has indicated that long non‑coding RNAs (lncRNAs) are closely associated with the pathogenesis of ischemic stroke. It has been reported that small nucleolar RNA host gene 12 (SNHG12) serves a critical role in ischemic stroke by acting as a competitive endogenous RNA (ceRNA). SNHG12 competes with various microRNAs (miRs) to regulate RNA transcription of specific targets. However, the eff...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis.
In conclusion, the identified miRNAs and mRNAs may be involved in the pathology of MI. PMID: 33000230 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

LncRNA HOTTIP promotes the proliferation and invasion of ovarian cancer cells by activating the MEK/ERK pathway.
In conclusion, HOTTIP was demonstrated to promote the proliferation, migration and invasion of OC cells by activating the MEK/ERK pathway. Therefore, HOTTIP may serve as a potential therapeutic target for OC. PMID: 33000231 [PubMed - in process] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Microecological investigation and comparison of two clinical methods to evaluate axillary osmidrosis.
Authors: Du H, Ding S, Gao L, Zeng J, Lu J Abstract Axillary osmidrosis (AO) is a common disease that causes patients to develop malodor and occurs worldwide. There is a lack of uniform standards to evaluate the severity of the odor and identify a sensitive and convenient method to determine the therapeutic effect of AO treatments in a clinical setting. In the present study, the association between pH value and disease severity was investigated and the potential pathogenic bacteria and probiotic pathogens of AO were further examined. A total of 32 patients with bilateral AO and 32 normal healthy controls were ...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Caveolin ‑1 modulates hypertensive vascular remodeling via regulation of the Notch pathway.
Caveolin‑1 modulates hypertensive vascular remodeling via regulation of the Notch pathway. Mol Med Rep. 2020 Nov;22(5):4320-4328 Authors: Wang Q, Lao M, Xu Z, Ding M, Guo S, Li L Abstract Hypertension is one of the critical risk factors of cerebrovascular disease. Caveolin‑1 (Cav‑1) has been suggested to be involved in the development of hypertension; however, the underlying mechanism remains largely unknown. Therefore, the present study aimed to investigate the mechanism underlying Cav‑1 in hypertension. In the present study, the hypertension model was induced by infusion of angiotensin I...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Clinical characteristics and gene mutation analysis of an adult patient with ETFDH ‑related multiple acyl‑CoA dehydrogenase deficiency.
Clinical characteristics and gene mutation analysis of an adult patient with ETFDH‑related multiple acyl‑CoA dehydrogenase deficiency. Mol Med Rep. 2020 Nov;22(5):4396-4402 Authors: Wang C, Lv H, Xu X, Ma Y, Li Q Abstract Multiple acyl‑CoA dehydrogenase deficiency (MADD) is a rare autosomal recessive disorder of fatty acid metabolism caused by defects in electron transfer flavoprotein (ETF) or electron transfer flavoprotein dehydrogenase (ETFDH). These defects are mainly classified into the neonatal and late‑onset types, based on their clinical manifestations. ETFDH gene mutations are generally...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research