Protective effect of dimethyl fumarate on oxidative damage and signaling in cardiomyocytes.
In conclusion, the results of the present study suggested that DMF may exert protective effects against a myocardial I/R model, and further validated Nrf2 modulation as a primary mode of action. Thus suggesting that DMF may be a potential therapeutic agent for AKT/Nrf2 pathway activation in myocardial, and potentially systemic, diseases. PMID: 32945364 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Propofol protects against oxygen/glucose deprivation ‑induced cell injury via gap junction inhibition in astrocytes.
Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes. Mol Med Rep. 2020 Jul 28;: Authors: Fan Y, Zhu S, Wang J, Zhao Y, Wang X Abstract Stroke is one of the leading causes of mortality and disability worldwide with limited clinical therapies available. The present study isolated primary astrocytes from the brains of rats and treated them with oxygen‑glucose deprivation and re‑oxygenation (OGD/R) to mimic hypoxia/reperfusion (H/R) injury in vitro to investigate stroke. It was revealed that propofol (2,6‑diisopropylphenol), an int...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

NCAPH is negatively associated with Mcl ‑1 in non‑small cell lung cancer.
NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer. Mol Med Rep. 2020 Jul 28;: Authors: Xiong Q, Fan S, Duan L, Liu B, Jiang X, Chen X, Xiong C, Tao Q, Wang J, Zhang H, Chen C, Duan Y Abstract Lung cancer has a high mortality rate worldwide. Non‑SMC condensin I complex subunit H (NCAPH) has been identified to be one of the regulatory subunits of the condensin I complex, which is essential for the correct packaging and segregation of chromosomes in eukaryotes. NCAPH is abnormally overexpressed in various types of cancer. A pro‑survival member of the Bcl‑2 family, myeloid c...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Plasma levels of methylated septin 9 are capable of detecting hepatocellular carcinoma and hepatic cirrhosis.
Authors: He N, Feng G, Zhang C, Wu F, Zhang T, Yang Y Abstract Hepatocellular carcinoma (HCC) was the third most common cause of cancer‑associated mortality in China in 2015. Early detection of HCC and hepatic cirrhosis (HC) can serve a crucial role in the prevention and therapeutic intervention of these diseases. Current early detection methods rely on less sensitive imaging modalities compared with the pathological examination. In the present study, a total of 64 patients with HCC, 44 patients with HC and 298 individuals with no evidence of disease (NED) were recruited, and the ability of methylated s...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Evaluation of the effects of IL ‑22 on the proliferation and differentiation of keratinocytes in vitro.
Evaluation of the effects of IL‑22 on the proliferation and differentiation of keratinocytes in vitro. Mol Med Rep. 2020 Jul 20;: Authors: Zhuang L, Ma W, Yan J, Zhong H Abstract Psoriasis is one of the most common chronic inflammatory skin diseases, it is characterized by hyperproliferation of keratinocytes and infiltration of inflammatory cells. Several in vitro studies have reported that interleukin (IL)‑22 is involved in excessive proliferation and abnormal differentiation of human keratinocytes. However, the association between IL‑22 and CCAAT enhancer binding protein α ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

lncRNA HEIH, an indicator of high malignancy and poor prognosis, functions as an oncogene in breast cancer.
Authors: Chen C, Gu C, Ren Q, Ding F, Pan Q, Niu Y, Ma D, Wu L Abstract Long non‑coding RNA high expression in hepatocellular carcinoma (lncRNA HEIH) acts as an oncogene in multiple tumors, including hepatocellular carcinoma, colorectal cancer, melanoma and non‑small cell lung cancer. However, the role of HEIH in breast cancer remains unknown. The present study focused on the clinical significance and biological function of HEIH in breast cancer. Specifically, the expression levels of HEIH in breast cancer tissues and breast cancer cell lines were investigated. The results indicated high expression levels of HE...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Gallium ions promote osteoinduction of human and mouse osteoblasts via the TRPM7/Akt signaling pathway.
Authors: Yu M, Wang Y, Zhang Y, Cui D, Gu G, Zhao D Abstract Gallium (Ga) ions have been widely utilized for biomedical applications; however, their role in osteoblast regulation is not completely understood. The aim of the present study was to investigate the potential effect of Ga ions on osteoinduction in two osteoblast cell lines and to explore the underlying mechanisms. Human hFOB1.19 and mouse MC3T3‑E1 osteoblasts were treated with Ga nitride (GaN) at different concentrations, and the degree of osteoinduction was assessed. Ga ion treatment was found to increase alkaline phosphatase activity a...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Role of the HIF ‑1α/SDF‑1/CXCR4 signaling axis in accelerated fracture healing after craniocerebral injury.
Role of the HIF‑1α/SDF‑1/CXCR4 signaling axis in accelerated fracture healing after craniocerebral injury. Mol Med Rep. 2020 Jul 28;: Authors: Xue Y, Li Z, Wang Y, Zhu X, Hu R, Xu W Abstract The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑1 (SDF‑1) in the microenvironment. Stem cells express the SDF‑1 r...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑92a promotes non‑small cell lung cancer cell growth by targeting tumor suppressor gene FBXW7.
In conclusion, miR‑92a could serve as a potential therapeutic target in NSCLC treatment. PMID: 32945381 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF ‑1α and apoptosis.
Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis. Mol Med Rep. 2020 Jul 28;: Authors: Sun W, Li A, Wang Z, Sun X, Dong M, Qi F, Wang L, Zhang Y, Du P Abstract The aim of the present study was to investigate the protective effect and underlying mechanism of tetramethylpyrazine (TMP) on renal ischemia reperfusion injury (RIRI) in rats, which refers to the injury caused by the restoration of blood supply and reperfusion of the kidney after a period of ischemia. Sprague‑Dawley rats were randomly divided into a Sham group, renal ischemia‑reperfusio...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Impaired lipophagy in endothelial cells with prolonged exposure to oxidized low ‑density lipoprotein.
Impaired lipophagy in endothelial cells with prolonged exposure to oxidized low‑density lipoprotein. Mol Med Rep. 2020 Jul 16;: Authors: Zhang CP, Ding XX, Tian T, Li BJ, Wang CY, Jiang SS, Shao JQ, Yuan YL, Tian Y, Zhang M, Long SY Abstract Oxidative stress induces the formation of oxidized low‑density lipoprotein (ox‑LDL), which accelerates the development of atherosclerosis and the rupture of atherosclerotic plaques by promoting lipid accumulation and inhibiting autophagy in vascular cells. Lipophagy is known to be involved in maintaining the balance of neutral lipid metabolism; however, the p...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Role of exercise and rapamycin on the expression of energy metabolism genes in liver tissues of rats fed a high ‑fat diet.
Role of exercise and rapamycin on the expression of energy metabolism genes in liver tissues of rats fed a high‑fat diet. Mol Med Rep. 2020 Jul 28;: Authors: Tu G, Dai C, Qu H, Wang Y, Liao B Abstract The mTOR pathway serves an important role in the development of insulin resistance induced by obesity. Exercise improves obesity‑associated insulin resistance and hepatic energy metabolism; however, the precise mechanism of this process remains unknown. Therefore, the present study investigated the role of rapamycin, an inhibitor of mTOR, on exercise‑induced expression of hepatic energy metabolism g...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulated Mucin 1 alleviates paclitaxel resistance in non ‑small cell lung cancer cells.
Downregulated Mucin 1 alleviates paclitaxel resistance in non‑small cell lung cancer cells. Mol Med Rep. 2020 Jul 20;: Authors: Xu H, Gao H, Li H, Li D, Yuan W, Zhang L, Cheng P, Su X, Li Z, Wang G, Zhang T Abstract Multidrug resistance of non‑small cell lung cancer (NSCLC) is a common clinical problem, which is one of the main reasons leading to the failure of chemotherapy. Therefore, how to overcome or prevent drug resistance has become a hot and difficult issue in clinical research. The present study was designed to investigate the expression patterns, functions and underlying mechanisms of...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Phosphorylation of STAT3 and ERBB2 mediates hypoxia ‑induced VEGF release in ARPE‑19 cells.
Phosphorylation of STAT3 and ERBB2 mediates hypoxia‑induced VEGF release in ARPE‑19 cells. Mol Med Rep. 2020 Jul 16;: Authors: Hwang S, Seong H, Ryu J, Jeong JY, Kang TS, Nam KY, Seo SW, Kim SJ, Kang SS, Han YS Abstract Neovascularization in the retina can cause loss of vision. Vascular endothelial growth factor (VEGF) serves an important role in the pathogenesis of retinal vascular diseases. Hypoxia is a notable cause of VEGF release and both STAT3 and ERBB2 are known to be associated with VEGF. In addition, STAT3 and ERBB2 interact with each other. In the present study, it was hypothesized that s...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Decrease in matrix metalloproteinase ‑3 activity in systemic sclerosis fibroblasts causes α2‑antiplasmin and extracellular matrix deposition, and contributes to fibrosis development.
Decrease in matrix metalloproteinase‑3 activity in systemic sclerosis fibroblasts causes α2‑antiplasmin and extracellular matrix deposition, and contributes to fibrosis development. Mol Med Rep. 2020 Jul 28;: Authors: Niwa H, Kanno Y, Shu E, Seishima M Abstract Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by fibrosis of the skin and visceral organs, and peripheral circulatory disturbance. α2‑antiplasmin (α2AP) is the major circulating inhibitor of plasmin and is a key regulator of fibrinolysis. It has been demonstrated that the expre...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Enriched high ‑throughput reverse transcription‑quantitative PCR template preparation without pre‑amplification.
In conclusion, the results demonstrate the novel method was an easy and reproducible method for performing robust and highly accurate targeted amplification. PMID: 32945391 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells.
Authors: Gao C, Liu SG, Lu WT, Yue ZX, Zhao XX, Xing TY, Chen ZP, Zheng HY, Li ZG Abstract Low expression levels of CREB‑binding protein (CREBBP) have been demonstrated to be associated with high minimal residual disease at the end of induction therapy and adverse long‑term outcomes in pediatric patients with acute lymphoblastic leukemia (ALL). However, the effect of low CREBBP expression on the prognosis of ALL has not yet been investigated. In the present study, CREBBP was downregulated and overexpressed in ALL cell lines (Jurkat and Reh). Sensitivity to chemotherapy and cell proliferation activity was determ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Long non ‑coding RNA SNHG12 regulates cell proliferation, invasion and migration in endometrial cancer by targeting miR‑4429.
Long non‑coding RNA SNHG12 regulates cell proliferation, invasion and migration in endometrial cancer by targeting miR‑4429. Mol Med Rep. 2020 Jul 28;: Authors: Cai P, Wu M, Zhang B, Wu S, Wei H, Wei L Abstract Long non‑coding RNA small nucleolar RNA host gene 12 (SNHG12) has been demonstrated to be oncogenic. The aim of the present study was to examine the effects of SNHG12 on the progression of endometrial cancer (EC). The expression levels of SNHG12 and microRNA (miR)‑4429 were assessed in EC cell lines by reverse transcription‑quantitative PCR. Plasmids, including SNHG12 short hairpin RNA...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Angiotensin ‑converting enzyme‑2 improves diabetic nephropathy by targeting Smad7 for ubiquitin degradation.
In conclusion, ACE2 is protective in DN, which may be due to the inhibition of Arkadia‑mediated Smad7 degradation, whereby TGF‑β/Smad‑mediated EMT is ameliorated in high‑glucose‑stimulated HRPTEpiCs. PMID: 32945396 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A clinical and multi ‑omics study of Van der Woude syndrome in three generations of a Chinese family.
A clinical and multi‑omics study of Van der Woude syndrome in three generations of a Chinese family. Mol Med Rep. 2020 Jul 28;: Authors: Yang K, Dong XY, Wu J, Zhu JJ, Tan Y, Yan YS, Lin L, Zhang DL Abstract Previous studies have suggested that pathogenic variants in interferon regulatoryse factor 6 (IRF6) can account for almost 70% of familial Van der Woude Syndrome (VWS) cases. However, gene modifiers that account for the phenotypic variability of IRF6 in the context of VWS remain poorly characterized. The aim of this study was to report a family with VWS with variable expressivity and to iden...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

EphA2 ‑enriched exosomes promote cell migration and are a potential diagnostic serum marker in pancreatic cancer.
EphA2‑enriched exosomes promote cell migration and are a potential diagnostic serum marker in pancreatic cancer. Mol Med Rep. 2020 Jul 28;: Authors: Wei Q, Wei L, Zhang J, Li Z, Feng H, Ren L Abstract Pancreatic cancer (PC) is the fourth most common cause of cancer‑related mortality worldwide and is characterized by high invasiveness and early metastasis. To identify novel diagnostic markers, the present study aimed to understand the mechanism underlying PC progression. The present study demonstrated that exosomes derived from the highly metastatic Panc‑1 PC cell line were internalized by a low m...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑15a inhibits cell apoptosis and inflammation in a temporal lobe epilepsy model by downregulating GFAP.
In conclusion, the results of the present study suggested that the upregulation of miR‑15a may inhibit cell apoptosis and inflammation in TLE by targeting GFAP, thus providing a potential therapeutic target for the treatment of TLE. PMID: 32945401 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Metformin promotes cell proliferation and osteogenesis under high glucose condition by regulating the ROS ‑AKT‑mTOR axis.
Metformin promotes cell proliferation and osteogenesis under high glucose condition by regulating the ROS‑AKT‑mTOR axis. Mol Med Rep. 2020 Jul 30;: Authors: Zhou R, Ma Y, Qiu S, Gong Z, Zhou X Abstract Metformin, a cost‑effective and safe orally administered antidiabetic drug used by millions of patients, has exhibited great interest for its potential osteogenic‑promoting properties in different types of cells, including mesenchymal stem cells (MSCs). Diabetic osteopathy is a common comorbidity of diabetes mellitus; however, the underlying molecular mechanisms of metformin on the physiological ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effect of ultra ‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats.
Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats. Mol Med Rep. 2020 Jul 28;: Authors: Gao P, Chen Q, Hu J, Lin Y, Lin J, Guo Q, Yue H, Zhou Y, Zeng L, Li J, Ding G, Guo G Abstract The restrictive nature of the blood brain barrier (BBB) brings a particular challenge to the treatment of central nervous system (CNS) disorders. The effect of ultra‑wide band electromagnetic pulses (UWB‑EMPs) on BBB permeability was examined in the present study in order to develop a safe and effective technology that opens the BBB to improve treatment options for CNS dis...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide ‑induced acute pneumonia in rats.
Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide‑induced acute pneumonia in rats. Mol Med Rep. 2020 Aug 04;: Authors: Wang X Abstract Pneumonia is one of the commonest causes of death worldwide. High‑temperature requirement A2 (HtrA2) is a proapoptotic mitochondrial serine protease involved in caspase‑dependent or caspase‑independent cell apoptosis. UCF‑101 (5‑[5‑(2‑nitrophenyl) furfuryl iodine]‑1,3‑diphenyl‑2‑thiobarbituric acid), an inhibitor of HtrA2, has a protective effect on organs in various diseases by inhibiting cell apo...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

[Comment] The COVID ‑19 pandemic as a scientific and social challenge in the 21st century.
[Comment] The COVID‑19 pandemic as a scientific and social challenge in the 21st century. Mol Med Rep. 2020 Jul 30;: Authors: Zoumpourlis V, Goulielmaki M, Rizos E, Baliou S, Spandidos DA Abstract The coronavirus disease‑2019 (COVID‑19) pandemic, caused by the new coronavirus SARS‑CoV‑2, has spread around the globe with unprecedented consequences for the health of millions of people. While the pandemic is still in progress, with new incidents being reported every day, the resilience of the global society is constantly being challenged. Under these circumstances, the future seems uncertain. SA...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Different MAPK signal transduction pathways play different roles in the impairment of glucose ‑stimulated insulin secretion in response to IL‑1β.
Different MAPK signal transduction pathways play different roles in the impairment of glucose‑stimulated insulin secretion in response to IL‑1β. Mol Med Rep. 2020 Jul 28;: Authors: Ou Y, Zheng Z, Niu B, Su J, Su H Abstract Mitogen‑activated protein kinase (MAPK) signal transduction pathways may be involved in the destruction of pancreatic islet β cells induced by inflammatory cytokines. The present study aimed to investigate the role of different MAPK signal transduction pathways in the interleukin‑1β (IL‑1β)‑induced inhibition of glucose‑stimulated insulin secretion (...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Small RNA deep sequencing reveals novel miRNAs in peripheral blood mononuclear cells from patients with IgA nephropathy.
In conclusion, 44 differentially expressed miRNAs were discovered, 41 of which were newly found to be associated with IgAN. The differentially expressed miRNAs may regulate the progression of IgAN by controlling the behavior of PBMCs or deposition of IgA via targeting of signaling pathways or expression of C1GALT1. These findings may provide a basis for further research regarding IgAN diagnosis and therapy. PMID: 32945407 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats.
In conclusion, hydrogen inhalation may play a protective role by influencing the general state, lipid metabolism parameters, liver histology and liver function indicators in the rat model of metabolic syndrome with NAFLD. PMID: 32945408 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis.
In conclusion, Art significantly inhibited the growth of lung cancer cells by preventing cell cycle progression. This phenomenon indicated its promising therapeutic potential in the treatment of lung cancer. PMID: 32945409 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

High lymphocyte ‑to‑monocyte ratio is associated with low α‑fetoprotein expression in patients with hepatitis B virus‑associated hepatocellular carcinoma.
High lymphocyte‑to‑monocyte ratio is associated with low α‑fetoprotein expression in patients with hepatitis B virus‑associated hepatocellular carcinoma. Mol Med Rep. 2020 Jul 29;: Authors: Wang H, Xiang Y, Li X, Liu S, Liu L Abstract The association of the peripheral lymphocyte‑to‑monocyte ratio (LMR) with α‑fetoprotein (AFP) status in patients with AFP‑positive and AFP‑negative hepatocellular carcinoma (HCC) has not been investigated in detail. The aim of the present study was to examine the association between the LMR and AFP status in these patients. The samples were o...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Preconditioning mesenchymal stromal cells with flagellin enhances the anti ‑inflammatory ability of their secretome against lipopolysaccharide‑induced acute lung injury.
Preconditioning mesenchymal stromal cells with flagellin enhances the anti‑inflammatory ability of their secretome against lipopolysaccharide‑induced acute lung injury. Mol Med Rep. 2020 Jul 28;: Authors: Li R, Li Y, Dong X Abstract Acute lung injury (ALI) is a complex condition frequently encountered in the clinical setting. The aim of the present study was to investigate the effect of conditioned media (CM) from human adipose‑derived mesenchymal stromal cells (MSCs) activated by flagellin (F‑CM), a Toll‑like receptor 5 ligand, on inflammation‑induced lung injury. In the in vitro stud...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Novel oral plasminogen activator inhibitor ‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats.
Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats. Mol Med Rep. 2020 Jul 28;: Authors: Noguchi R, Kaji K, Namisaki T, Moriya K, Kawaratani H, Kitade M, Takaya H, Aihara Y, Douhara A, Asada K, Nishimura N, Miyata T, Yoshiji H Abstract An orally bioavailable small molecule inhibitor of plasminogen activator inhibitor‑1 (PAI‑1) is currently being clinically assessed as a novel antithrombotic agent. Although PAI‑1 is known to serve a key role in the pathogenesis of metabolic ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulation of lncRNA H19 alleviates atherosclerosis through inducing the apoptosis of vascular smooth muscle cells.
Authors: Sun H, Jiang Q, Sheng L, Cui K Abstract Aberrant proliferation and apoptosis of vascular smooth muscle cells (VSMCs) serve a dominant role in the pathogenesis of atherosclerosis (AS). Long non‑coding (lnc)RNA H19 is reported to accelerate the progression of AS by inhibiting the apoptosis of VSMCs, whereas p53 is identified as promoting VSMC apoptosis. The present study aimed to explore the effects of H19/p53 on the pathogenesis of AS. Apolipoprotein E knockout (ApoE‑/‑) mice fed a high‑fat diet were used as in vivo AS models. Reverse transcription‑quantitative PCR and western blot were used ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Long non ‑coding RNA SNHG16 inhibits the oxygen‑glucose deprivation and reoxygenation‑induced apoptosis in human brain microvascular endothelial cells by regulating miR‑15a‑5p/bcl‑2.
Long non‑coding RNA SNHG16 inhibits the oxygen‑glucose deprivation and reoxygenation‑induced apoptosis in human brain microvascular endothelial cells by regulating miR‑15a‑5p/bcl‑2. Mol Med Rep. 2020 Jul 29;: Authors: Teng H, Li M, Qian L, Yang H, Pang M Abstract MicroRNA (miR) 15a‑5p can promote ischemia/reperfusion (I/R)‑induced apoptosis of cerebral vascular endothelial cells, which is inhibited by long non‑coding RNAs (lncRNAs). The present study investigated the potential of lncRNAs targeting miR‑15a‑5p to regulate oxygen‑glucose deprivation and reoxygenation (OGD‑R)‑in...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Solanum  nigrum Linne improves DNCB‑induced atopic dermatitis‑like skin disease in BALB/c mice.
Solanum nigrum Linne improves DNCB‑induced atopic dermatitis‑like skin disease in BALB/c mice. Mol Med Rep. 2020 Jul 28;: Authors: Hong S, Lee B, Kim JH, Kim EY, Kim M, Kwon B, Cho HR, Sohn Y, Jung HS Abstract The present study aimed to investigate the effects of Solanum nigrum Linne (SNL) in a model of 1‑chloro‑2,4‑dinitrobenzene (DNCB)‑induced atopic dermatitis (AD) and in TNF‑α/IFN‑γ‑stimulated HaCaT cells. AD is a chronic inflammatory skin disease and is characterized by erythema, edema, increased pruritus and eczema. Steroids are most commonly used for anti...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Differential roles of Scavenger receptor class B type  I: A protective molecule and a facilitator of atherosclerosis (Review).
Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis (Review). Mol Med Rep. 2020 Jul 28;: Authors: Ma B, Jia J, Wang X, Zhang R, Niu S, Ni L, Di X, Liu C Abstract The scavenger receptor class B type I (SR‑BI) is a multi‑ligand membrane protein receptor that binds to high‑density lipoprotein (HDL) under physiological conditions, promoting the selective uptake of cholesterol esters from HDL into cells. SR‑BI also promotes the reverse transport of excess cholesterol from peripheral tissues to the liver, contributing to t...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA ‑155 expression levels.
In conclusion, DHA inhibited VSMC migration and proliferation by reducing microRNA‑155 expression. This effect may be caused by the microRNA‑155 target gene Socs1. PMID: 32945419 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

De  novo transcriptome analysis and gene expression profiling of fish scales isolated from Carassius auratus during space flight: Impact of melatonin on gene expression in response to space radiation.
De novo transcriptome analysis and gene expression profiling of fish scales isolated from Carassius auratus during space flight: Impact of melatonin on gene expression in response to space radiation. Mol Med Rep. 2020 Jul 28;: Authors: Furusawa Y, Yamamoto T, Hattori A, Suzuki N, Hirayama J, Sekiguchi T, Tabuchi Y Abstract Astronauts are inevitably exposed to two major risks during space flight, microgravity and radiation. Exposure to microgravity has been discovered to lead to rapid and vigorous bone loss due to elevated osteoclastic activity. In addition, long‑term exposure to low‑dose...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Panax  notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway.
Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway. Mol Med Rep. 2020 Jul 30;: Authors: Fei B, Liu Z, Xie L, Lv L, Zhu W, Liu J, Dai Y, She W Abstract Cisplatin‑induced cytotoxicity, such as nephrotoxicity, neurotoxicity and ototoxicity, restricts the clinical application of this compound. Panax notoginseng Saponins (PNS) exhibit potent free radical scavenging and antioxidant activity. PNS have been demonstrated to reduce cisplatin‑induced nephrotoxicity and neurotoxicity. The present study ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulated miR ‑130a enhances the sensitivity of acute myeloid leukemia cells to Adriamycin.
Downregulated miR‑130a enhances the sensitivity of acute myeloid leukemia cells to Adriamycin. Mol Med Rep. 2020 Jul 28;: Authors: Liu H, Liu M, Zhang J, Liang Y Abstract MicroRNA (miR)‑130a has been reported to promote cancer growth; however, its role during acute myeloid leukemia (AML) is not completely understood. In the present study, the effects of miR‑130a on the sensitivity of AML cells to Adriamycin (Adr) were investigated. 5‑Aza‑2'‑deoxycytidine (5‑Aza‑dC) was used to stimulate Adr resistance in AML cells, and cell viability and miR‑130a expression were determined using the C...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of hot ‑water extracts from 26 herbs on α‑glucosidase activity.
Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity. Mol Med Rep. 2020 Jul 31;: Authors: Kikuchi H, Toyoda N, Ezawa S, Yoshida S, Hibino Y, Sunaga K Abstract α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as medicines for type 2 diabetes, but a similar effect is observed in natural resources, including traditional herbs and their phytochemicals. To identify the prese...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑130a‑3p promotes the proliferation and inhibits the apoptosis of cervical cancer cells via negative regulation of RUNX3.
In conclusion, miR‑130a‑3p promoted proliferation, migration and invasion, and inhibited the apoptosis of CC cells via targeting RUNX3, suggesting a novel treatment target for CC. PMID: 32945424 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑204‑5p promotes apoptosis and inhibits migration of gastric cancer cells by targeting HER‑2.
miR‑204‑5p promotes apoptosis and inhibits migration of gastric cancer cells by targeting HER‑2. Mol Med Rep. 2020 Jul 28;: Authors: Yang S, Chen B, Zhang B, Li C, Qiu Y, Yang H, Huang Z Abstract Gastric cancer is one of the most common types of cancer worldwide, with a high incidence and mortality rate. MicroRNAs (miRs) play an important role in tumorigenesis, cell proliferation, migration, apoptosis and metastasis of cancer. The present study aimed to investigate the role and potential mechanism of miR‑204‑5p in gastric cancer. The mRNA expression levels of miR‑204‑5p in gastric cancer ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Expression of TNF ‑α and IL‑β can be suppressed via the PPAR‑γ/mTOR signaling pathway in BV‑2 microglia: A potential anti‑inflammation mechanism.
Expression of TNF‑α and IL‑β can be suppressed via the PPAR‑γ/mTOR signaling pathway in BV‑2 microglia: A potential anti‑inflammation mechanism. Mol Med Rep. 2020 Aug 05;: Authors: Zhao JL, Wei C, Xiao X, Dong YH, Tan B, Yu J, Chen G, Yuan Q, Du ZY, Sun YR, Hu J, Xie R Abstract Currently, microglia are considered as crucial factors in suppressing inflammatory reactions, but the specific molecular mechanism remains unknown. To elucidate whether peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) can inhibit neuroinflammatory cytokine expression via the mTOR...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone.
Authors: Liu B, Cheng Y, Tian J, Zhang L, Cui X Abstract Myocardial infarction (MI) is a leading cause of mortality due to progression to ventricular arrhythmias (VAs) or heart failure (HF). Cardiac remodeling at the infarct border zone (IBZ) is the primary contributor for VAs or HF. Therefore, genes involved in IBZ remodeling may be potential targets for the treatment of MI, but the mechanism remains unclear. The present study aimed to explain the molecular mechanisms of IBZ remodeling based on the roles of long non‑coding RNAs (lncRNAs). After downloading miRNA (GSE76592) and mRNA/lncRNA (GSE52313) datasets fro...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

11 β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis.
In conclusion, increased 11β‑HSD1 expression in the liver may be partially responsible for hepatic fibrogenesis, which is potentially associated with HSC activation and proliferation. PMID: 32945429 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibitor of RAGE and glucose ‑induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action.
Inhibitor of RAGE and glucose‑induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action. Mol Med Rep. 2020 Aug 07;: Authors: Jiang M, Wang X, Wang P, Peng W, Zhang B, Guo L Abstract The occurrence and development of hyperglycemia‑induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL‑1β, TNF‑α and IL‑6. Previous studies have reported that the nucleotide‑binding oligomerization domain‑like receptor protein 3 (NLRP3) inflammasome interacts with thio...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
In conclusion, the findings of the present study suggested that PRMT6 may serve as an oncogene in the progression of LUAD through epigenetically suppressing p18 expression. Thus, PRMT6 may represent a novel potential therapeutic target for LUAD. PMID: 32945431 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effect of autophagy on irradiation ‑induced damage in osteoblast‑like MC3T3‑E1 cells.
In conclusion, DOX‑inhibited autophagy aggravated X‑ray irradiation‑induced apoptosis at an early stage, but maintained cell proliferation and mineralization at a late stage in irradiated MC3T3‑E1 cells. PMID: 32945432 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research