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Grb2-associated binder 2 expression and its roles in uveal melanoma invasion.
Authors: Chen M, Li Y, Sun X, Zhang B, Li W, Wang S, Zhu X, Li F, Shi L Abstract Uveal melanoma (UM) is characterized by high metastasis and poor prognosis. A more improved understanding of the metastatic mechanism in UM cells is essential for the design of molecular therapy. Grb2‑associated binder 2 (Gab2) has been reported to serve important roles in the progression of various types of human cancer. However, the role of Gab2 in the migration and invasion of UM remains unclear. The present study sought to further assess the expression of Gab2 in UM and the role of Gab2 in the invasion of UM cells. Clin...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Generation of a novel TRAIL mutant by proline to arginine substitution based on codon bias and its antitumor effects.
Authors: Zhu A, Wang X, Huang M, Chen C, Yan J, Xu Q, Wei L, Huang X, Zhu H, Yi C Abstract TNF ligand superfamily member 10 (TRAIL) is a member of the tumor necrosis factor superfamily. The present study was performed in an effort to increase the expression of soluble (s)TRAIL by rebuilding the gene sequence of TRAIL. Three principles based on the codon bias of Escherichia coli were put forward to design the rebuild strategy. Relying on these three principles, a P7R mutation near the N‑terminal region of sTRAIL, named TRAIL‑Mu, was designed. TRAIL‑Mu was subsequently cloned into the PTWIN1 plasmid and ex...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

T cell inhibition by pogostone from Pogostemon  cablin (Blanco) Benth: In vitro and in vivo immunosuppressive analysis.
T cell inhibition by pogostone from Pogostemon cablin (Blanco) Benth: In vitro and in vivo immunosuppressive analysis. Mol Med Rep. 2017 Aug 02;: Authors: Su J, He J, Su Z, Zhou L, Zeng Y, Lai X, Li Y Abstract Various plant-derived compounds exhibit immunosuppressive activity in pre‑clinical investigations, suggesting that they may serve as natural alternatives for the prevention of inflammatory disorders and autoimmune diseases. The aim of the current study was to explore the immunosuppressive potential of pogostone (PO) derived from Pogostemon cablin (Blanco) Benth. Carboxyfluor...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Phylogenetic and specific sequence analysis of four paralogs in insect Aquaporins.
Authors: Xia W, Zhao P, Yi Z, Cui Y Abstract Aquaporins (AQP) are proteins that form channels to facilitate the movement of water across cell membranes in plants, bacteria and animals. Insect AQPs are indispensable for cellular water management under stress, including dehydration and cold. To better understand the biological significance of molecular evolution of gene sequences, followed by structural and functional specialization, the present study used ClustalX2.1, MEGA7.0, Jalview and Mesquite software to build an insect AQP phylogenetic tree and visualize the evolutionary associations among insect AQPs. It was ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Dysregulation of zinc/lipid metabolism ‑associated genes in the rat hippocampus and cerebral cortex in early adulthood following recurrent neonatal seizures.
Dysregulation of zinc/lipid metabolism‑associated genes in the rat hippocampus and cerebral cortex in early adulthood following recurrent neonatal seizures. Mol Med Rep. 2017 Aug 03;: Authors: Li ZH, Li LL, Jin MF, Chen XQ, Sun Q, Ni H Abstract Although it has been established that recurrent or prolonged clinical seizures during infancy may cause lifelong brain damage, the underlying molecular mechanism is still not well elucidated. The present study, to the best of our knowledge, is the first to investigate the expression of twenty zinc (Zn)/lipid metabolism‑associated genes in the hippocampus and...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Altered gene expression profile in a rat model of gentamicin-induced ototoxicity and nephrotoxicity, and the potential role of upregulated Ifi44 expression.
Authors: Hu JG, Fu Y, Xu JJ, Ding XP, Xie HQ, Li-Ling J Abstract As demonstrated by Alport syndrome, the co‑occurrence of auditory and urinary system malformations, and gentamicin-induced ototoxicity and nephrotoxicity, the ears and kidneys potentially share certain molecular pathways. In the present study, microarray chips were used to analyze the changes in the gene expression profile using a rat model of gentamicin‑induced ototoxicity and nephrotoxicity, using rat liver tissue as a control. A number of genes were identified to exhibit similar expression changes in the rat ears and kidney tissues, among which...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Establishment of a murine pancreatic cancer pain model and microarray analysis of pain ‑associated genes in the spinal cord dorsal horn.
In conclusion, the present study has developed a novel animal model of pancreatic cancer pain in BALB/c‑nu mice that resembles human pancreatic cancer pain, and the expression of pain‑associated genes in the spinal cord dorsal horn has been profiled. The results of the present study may further the understanding of the molecular mechanisms that mediate pancreatic cancer pain. PMID: 28791352 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor- β1.
Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1. Mol Med Rep. 2017 Aug 04;: Authors: Shang P, Liu T, Liu W, Li Y, Dou F, Zhang Y, Sun L, Zhang T, Zhu Z, Mu F, Ding Y, Wen A Abstract Vascular remodeling is a common complication and pathological basis of hypertension. Transforming growth factor‑β1 (TGF‑β1)/small mothers against decapentaplegic 3 (Smad3) is considered a potential therapeutic target for vascular remodeling in hypertension. The present study aimed ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells.
In conclusion, collagen type II exhibited protective effects in suppressing NP cell degeneration through its anticatabolic, proanabolic and antiapoptotic effects, suggesting that it may be a promising therapeutic agent for the prevention and treatment of DDD. PMID: 28791354 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti ‑thrombotic effect in a rat carotid artery thrombosis model.
In conclusion, injectable PEGylated LK with prolonged half-life and enhanced anti‑thrombotic effect is a potential anti‑thrombotic agent for long‑acting treatment of the thrombus diseases. PMID: 28791355 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Construction of a recombinant pIRES2-EGFP-ARTS plasmid and its effect on LX-2 cells.
Authors: Xu F, Han Y, Zhu D, Tian H, Zhu H, Ren J, Gu D, Duan Y Abstract The inhibition of the activation of hepatic stellate cells (HSCs) and the induction of their apoptosis have been investigated as potential strategies to counteract the development and progression of liver fibrosis. Previous research has suggested that apoptosis‑related protein in the transforming growth factor‑β signaling pathway (ARTS) may serve a significant role in numerous cell types; however, little is known regarding its roles in HSCs. Total RNA was extracted from LX‑2 cells, and the human full‑length ARTS gene was obtained ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Synergistic effects of fibroblast growth factor-2 and bone morphogenetic protein-2 on bone induction.
Authors: Song R, Wang D, Zeng R, Wang J Abstract The present study investigated the synergistic effect of co‑administering fibroblast growth factor‑2 (FGF‑2) and bone morphogenetic protein‑2 (BMP‑2) on osteoblastic differentiation in C2C12 cells and in rats. C2C12 murine myoblast cells represent a well‑accepted in vitro model system to study the ability of BMP‑2 to alter cell lineage from the myogenic to the osteogenic phenotype. The osteoblastic differentiation potency was determined by alkaline phosphatase (ALP) and Alizarin red S staining. ALP activity and calcium concentrations were colorimet...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway.
Authors: Qu Y, Hao C, Xu J, Cheng Z, Wang W, Liu H Abstract Breast cancer is a very common malignant tumor, whose incidence ranks the first among various types of cancer in women worldwide. An important hallmark of cancer is the activation of oncogenes, which lead to overgrowth of cancer cells. Therefore, it is necessary to identify the critical genes involved in regulating the progression of breast cancer and elucidate the corresponding molecular mechanisms. The present study demonstrated that integrin‑linked kinase (ILK) overexpression promoted cell proliferation and growth in MCF‑7 cells, while ILK knockdown...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Stromal cell-derived factor 1 protects human periodontal ligament stem cells against hydrogen peroxide-induced apoptosis.
Authors: Feng Y, Fu X, Lou X, Fu B Abstract Periodontal ligament stem cells (PDLSCs) are considered a promising cell source for dental tissue regeneration. Stromal cell-derived factor 1 [SDF‑1, also known as chemokine (C‑X‑C motif) ligand 12] is regarded as a critical cytokine involved in stem/progenitor cell chemotaxis and homing during tissue regeneration. The present study described a previously unsuspected role for SDF‑1 in the protection of PDLSCs against oxidative stress‑induced apoptosis. In the present study, apoptosis was induced by exposure of PDLSCs to various concentrations of H2O2 for 12 ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Classical VEGF, Notch and Ang signalling in cancer angiogenesis, alternative approaches and future directions (Review).
Authors: Caporarello N, Lupo G, Olivieri M, Cristaldi M, Cambria MT, Salmeri M, Anfuso CD Abstract Angiogenesis is the formation of new vessels starting from pre-existing vasculature. Tumour environment is characterized by 'aberrant angiogenesis', whose main features are tortuous and permeable blood vessels, heterogeneous both in their structure and in efficiency of perfusion and very different from normal vessels. Therapeutic strategies targeting the three pathways chiefly involved in tumour angiogenesis, VEGF, Notch and Ang signalling, have been identified to block the vascular supply to the tumour. However, phen...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway.
Authors: Niu C, Yuan K, Ma R, Gao L, Jiang W, Hu X, Lin W, Zhang X, Huang Z Abstract Gold nanoparticles (AuNPs) are a promising material for use in regenerative medicine due to their biocompatibility and easy functionalization with biomolecules including growth factors, DNA and peptides. In the present study, transmission electron microscopy indicated that the AuNPs were monodisperse and spherical in shape, with an estimated average diameter of 13 nm. And the cellular effects of AuNPs on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and the associated signaling pathways in c...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD.
Authors: Lin X, Wu Z, Fan Y, Chi M, Wang X, Zhang X, Sun D Abstract Pulmonary surfactant protein A (SP‑A) and pulmonary surfactant protein D (SP‑D) are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to determine the correlation between SP‑A, SP‑D and lung function in patients with COPD. A total of 60 patients with lung cancer undergoing unilateral lobectomy were selected and divided into three groups, including a non‑COPD group (n=20), a COPD treatment group (n=20) and a COPD control group (n=20). The levels of SP‑A and SP‑D were...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology.
Authors: Huang J, Cheung F, Tan HY, Hong M, Wang N, Yang J, Feng Y, Zheng Q Abstract Yinchenhao decoction (YCHD) is a traditional Chinese medicine formulation, which has been widely used for the treatment of jaundice for 2,000 years. Currently, YCHD is used to treat various liver disorders and metabolic diseases, however its chemical/pharmacologic profiles remain to be elucidated. The present study identified the active compounds and significant pathways of YCHD based on network pharmacology. All of the chemical ingredients of YCHD were retrieved from the Traditional Chinese Medicine Systems Pharmacology ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Molecular mechanisms of breast cancer metastasis by gene expression profile analysis.
Authors: Zheng T, Wang A, Hu D, Wang Y Abstract Metastasis is the main cause of breast cancer‑related mortalities. The present study aimed to uncover the relevant molecular mechanisms of breast cancer metastasis and to explore potential biomarkers that may be used for prognosis. Expression profile microarray data GSE8977, which contained 22 stroma samples (15 were from normal breast and 7 were from invasive ductal carcinoma tumor samples), were obtained from the Gene Expression Omnibus database. Following data preprocessing, differentially expressed genes (DEGs) were selected based on analyses conducted using the...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Two novel cross ‑protective antigens for bovine Pasteurella multocida.
Two novel cross‑protective antigens for bovine Pasteurella multocida. Mol Med Rep. 2017 Aug 03;: Authors: Du H, Wu C, Li C, Fang R, Ma J, Ji J, Li Z, Li N, Peng Y, Zhou Z Abstract Pasteurella multocida is an important pathogen that leads to a range of diseases that have severe economic consequences on cattle production. In order to develop an effective cross‑protective component vaccine, an immunoproteomics approach was used to analyze outer membrane proteins (OMPs) of the P. multocida serotype A, B and F strains. Candidate antigen molecules from the whole genome were screened via linear trap quadr...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Long non ‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer.
Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer. Mol Med Rep. 2017 Aug 03;: Authors: Su JC, Hu XF Abstract Breast cancer is one of the most frequently occurring malignancies in female cancers worldwide, however, its detailed mechanism of tumorigenesis remains to be elucidated. Long non-coding RNAs (LncRNAs) have previously been demonstrated to be important in multiple cancers, including breast cancer. The present study aimed to elucidate the molecular mechanism of the effects of the novel Lnc RNA HOXA11‑AS, on cell proliferation and metastasis in br...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

c ‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization.
c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization. Mol Med Rep. 2017 Aug 03;: Authors: Yu L, Ye J, Liu Q, Feng J, Gu X, Sun Q, Lu G Abstract The glomerular visceral epithelial cells, also termed podocytes, are key in maintaining the normal renal filtration barrier. Although it has been demonstrated that stimulation of c‑Maf inducing protein (CMIP) expression is involved in podocyte damage, the molecular events during this process remain unclear. In the current study, CMIP‑induced proximal signaling was investigated by focusing on its effect on cofi...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Curcumin analog EF24 induces apoptosis and downregulates the mitogen activated protein kinase/extracellular signal-regulated signaling pathway in oral squamous cell carcinoma.
Authors: Lin C, Tu C, Ma Y, Ye P, Shao X, Yang Z, Fang Y Abstract Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide. Diphenyldifluoroketone (EF24) is a curcumin analog that has been demonstrated to improve anticancer activity; however, its therapeutic potential and mechanisms in oral cancer remain unknown. In the present study, the effect of EF24 on apoptosis induction and its potential underlying mechanism in the CAL‑27 human OSCC cell line was investigated. To achieve this, various concentrations of cisplatin or EF24 were administrated to CAL‑27 cells for 24 h, and cell...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Felodipine inhibits ox-LDL-induced reactive oxygen species production and inflammation in human umbilical vein endothelial cells.
Authors: Qi J, Zheng JB, Ai WT, Yao XW, Liang L, Cheng G, Shou XL, Sun CF Abstract Oxidative stress and inflammation are involved in the pathogenesis of atherosclerosis. Calcium channel blockers (CCBs) inhibit the development of atherosclerosis, although the underlying molecular basis has not been completely elucidated. The present study was designed to investigate the effects of felodipine, a CCB, on inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs) and to examine the underlying mechanisms of action. Oxidized low‑density lipoprotein (ox‑LDL) was used to induce an inflammatory...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma.
Authors: Zhu W, Zhuang P, Song W, Duan S, Xu Q, Peng M, Zhou J Abstract Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role of HNF1A‑AS1 in colorectal carcinoma (CRC) remains unclear. In the present study, the role of HNF1A‑AS1 in CRC was examined for the first time and its correlation with CRC cell biological behaviors was analyzed. The resu...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity.
In conclusion, the present study demonstrated that diminazene attenuated AMI in rats via suppression of inflammation, reduction of COX‑2 and iNOS expression, and activation of the ACE2/AT1R/MasR signaling pathway. PMID: 28791381 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation.
Authors: Li X, Fang Q, Tian X, Wang X, Ao Q, Hou W, Tong H, Fan J, Bai S Abstract Angiogenesis is an important process in the pathogenesis of aortic aneurysm. The aim of the present study was to investigate the angiogenic balance and the expression of vascular endothelial growth factor (VEGF) in thoracic aortic aneurysm (TAA). A previous study demonstrated that curcumin exerts a marked effect on aortic aneurysm development. Therefore, the present study determined whether curcumin is able to modulate angiogenesis and inflammatory signaling in TAA by collecting human TAA samples and establishing a rat TAA model using...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress.
Authors: Ji LL, Peng JB, Fu CH, Tong L, Wang ZY Abstract Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment could be modulated by the brain‑derived neurotrophic factor (BDNF) signaling pathway. However, it remains unclear whether BDNF and its upstream regulator are mechanistically involved in the therapeutic effect of σ‑1R in...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

microRNA ‑630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line.
In conclusion, the present findings suggested that miR‑630 may function as an oncogenic miRNA in colorectal cancer, and may promote cellular proliferation and inhibit apoptosis, through the regulation of the expression of p27 and the AKT signaling pathway. The present study suggested that the inhibition of miR‑630 may have potential as an alternative therapeutic strategy for the treatment of patients with colorectal cancer. PMID: 28791386 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Bioinformatic analysis of microRNA-mRNA expression profiles of bladder tissue induced by bladder outlet obstruction in a rat model.
Authors: Duan LJ, Cao QF, Xu D, Liu HL, Qi J Abstract Various microRNAs (miRNAs) have previously been demonstrated to exhibit an association with the process of bladder remodeling, induced by bladder outlet obstruction (BOO). However, little is known about miRNA and gene expression profiles and the molecular mechanism underlying bladder pathophysiological alterations. The present study used bioinformatic analysis technology to examine the altered miRNA and mRNA expression profiles of bladder tissue in a rat model of BOO and validate the involved signaling pathways. The gene expression profile data was downloaded fr...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Abnormal expression of HAX ‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma.
In conclusion, HAX‑1 is a potential oncogene, and may promote the tumorigenesis and progression of hypopharyngeal carcinoma, as well as serve as a valuable molecular target for the treatment of hypopharyngeal carcinoma. PMID: 28791389 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Beneficial effect of magnolol on lupus nephritis in MRL/lpr mice by attenuating the NLRP3 inflammasome and NF ‑κB signaling pathway: A mechanistic analysis.
Beneficial effect of magnolol on lupus nephritis in MRL/lpr mice by attenuating the NLRP3 inflammasome and NF‑κB signaling pathway: A mechanistic analysis. Mol Med Rep. 2017 Aug 03;: Authors: Huang F, Zhang RY, Song L Abstract Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the activation of NACHT, LRR and PYD domains‑containing ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A20 protein regulates lipopolysaccharide-induced acute lung injury by downregulation of NF- κB and macrophage polarization in rats.
A20 protein regulates lipopolysaccharide-induced acute lung injury by downregulation of NF-κB and macrophage polarization in rats. Mol Med Rep. 2017 Aug 07;: Authors: Wang Y, Song Z, Bi J, Liu J, Tong L, Song Y, Bai C, Zhu X Abstract Modulation of inflammation is a crucial component of the development of acute lung injury. A20, a ubiquitin editing enzyme, may regulate cellular inflammatory reactions, particularly those involving the signaling pathway of nuclear factor NF-κB (NF‑κB). The present study investigated the mechanism by which A20 downregulated NF‑κB and further con...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Elevated expression of yes ‑associated protein is associated with the malignant status and prognosis of laryngeal squamous cell carcinoma.
In conclusion, the expression level of YAP was significantly increased in LSCC and associated with the malignant status of LSCC. Therefore, YAP may represent a novel biomarker for predicting the prognosis of patients with LSCC. PMID: 28791393 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of key genes and pathways associated with classical Hodgkin lymphoma by bioinformatics analysis.
Authors: Kuang Z, Guo L, Li X Abstract The current study aimed to explore the mechanisms associated with classic Hodgkin lymphoma (cHL) to identify novel diagnostic and therapeutic targets. The GES12453 microarray dataset was downloaded from the Gene Expression Omnibus database; the differentially expressed genes (DEGs) between cHL samples and normal B cell samples by were identified using the limma package. Gene ontology (GO) and pathway enrichment analysis of DEGs gene were performed. Furthermore, construction and analysis of protein‑protein interaction (PPI) network was performed, and co‑expression modules o...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass.
α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Mol Med Rep. 2017 Aug 04;: Authors: Chen K, Sun Y, Diao Y, Ji L, Song D, Zhang T Abstract The present study aimed to investigate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) agonist on the damage of hippocampal neurons and the expression of toll like receptor 4 (TLR4)/myeloid differentiation primary response 88 (Myd88)/nuclear factor (NF)‑κB signal pathway‑associated factors ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Oxidored-nitro domain-containing protein 1 promotes liver fibrosis by activating the Wnt/ β-catenin signaling pathway in vitro.
In conclusion, the present study demonstrated that NOR1 activates HSCs and contributes to liver fibrosis in vitro and this effect was achieved through the activation of the Wnt/β‑catenin pathway. Therefore, the current study may provide a novel target for the treatment of chronic liver diseases. PMID: 28791396 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

TRPC1 stimulates calcium ‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells.
TRPC1 stimulates calcium‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells. Mol Med Rep. 2017 Aug 04;: Authors: Qu YY, Wang LM, Zhong H, Liu YM, Tang N, Zhu LP, He F, Hu QH Abstract Store‑operated Ca2+ entry (SOCE) via store‑operated Ca2+ channels (SOCC), encoded by transient receptor potential canonical (TRPC) channel proteins, is an important underlying mechanism regulating intracellular Ca2+ concentration ([Ca2+]i) and various intracellular functions in endothelial cells (ECs). TRPC1, the probable candidate for SOCC, is expressed in ECs. Ca...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

PI3K/AKT signaling pathway activation in a rat model of migraine.
Authors: Liu YY, Jiao ZY, Li W, Tian Q Abstract The present study aimed to investigate phosphatidylinositol 4,5-bisphosphate 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway activation in a rat model of migraine. A total of 60 male Sprague‑Dawley rats were randomly divided into three groups: Blank control; suspension control; and migraine model. The model group was subcutaneously injected with a glyceryl trinitrate suspension, using an optimized Tassorelli method to establish a rat model of migraine. The activation status of the PI3K/AKT signaling pathway was assessed via measurement of the phosphorylat...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HK ‑2 cells.
Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HK‑2 cells. Mol Med Rep. 2017 Aug 03;: Authors: Liu D, Liu Y, Xia Z, Dong H, Yi Z Abstract Renal interstitial fibrosis (RIF) is the main process that leads to renal failure. It is necessary to investigate the mechanism of RIF and identify appropriate methods of regulating it. Furthermore, unilateral ureteral obstruction is a frequently used model for the study of RIF. The morphological damage associated with kidney and lung dysfunction was detec...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor.
MicroRNA‑744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor. Mol Med Rep. 2017 Aug 04;: Authors: Xu AJ, Fu LN, Wu HX, Yao XL, Meng R Abstract Gastric cancer is the fourth most common malignancy and the third leading cause of cancer‑associated deaths worldwide. It has previously been demonstrated that microRNAs (miRNAs) are actively involved in the pathogenesis of gastric cancer. Therefore, miRNAs have been proposed as promising therapeutic targets in gastric cancer patients. MiR‑744 is aberrantly expressed in different types of h...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Implications of white matter damage in amyotrophic lateral sclerosis (Review).
Authors: Zhou T, Ahmad TK, Gozda K, Truong J, Kong J, Namaka M Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which involves the progressive degeneration of motor neurons. ALS has long been considered a disease of the grey matter; however, pathological alterations of the white matter (WM), including axonal loss, axonal demyelination and oligodendrocyte death, have been reported in patients with ALS. The present review examined motor neuron death as the primary cause of ALS and evaluated the associated WM damage that is guided by neuronal‑glial interactions. Previous studies hav...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Role of the ACE2 ‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review).
Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review). Mol Med Rep. 2017 Aug 04;: Authors: Lin S, Pan H, Wu H, Ren D, Lu J Abstract The renin‑angiotensin system (RAS) serves a critical role in blood pressure regulation and prevention of cardiovascular diseases. Efforts to develop functional foods that enhance the RAS have focused on inhibition of angiotensin‑converting enzyme (ACE) activity in the ACE‑angiotensin II (Ang II)‑Ang II type 1 receptor axis. ACE2 and the Mas receptor are important components of ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

[Retracted] Effects of the eukaryotic initiation factor 6 gene on expression levels of inflammatory mediators in M2 macrophages during scar repair.
Authors: Bai YQ, Feng JK, Zhang QF, Wu HZ, Du YR, Wei W Abstract Following the publication of this article, we regret to report that we have been unable to reproduce the results presented in the paper in our subsequent studies. At the present time, we have not been able to ascertain the reason behind this. Therefore, we would like to retract this article from publication. All the named authors agree to this retraction. We regret any inconvenience to the readers that this retraction will cause. [The original article was published in Molecular Medicine Reports 14: 819-824, 2016; DOI: 10.3892/mmr.2016.5294]. PMID:...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

PCDH9 acts as a tumor suppressor inducing tumor cell arrest at G0/G1 phase and is frequently methylated in hepatocellular carcinoma.
Authors: Lv J, Zhu P, Zhang X, Zhang L, Chen X, Lu F, Yu Z, Liu S Abstract Tumor suppressor genes (TSGs) are frequently involved in the pathogenesis of hepatocellular carcinoma (HCC). The epigenetic and genetic alterations of a novel TSG‑protocadherin 9 (PCDH9) and its functions in the pathogenesis of HCC were investigated. The methylation status of the PCDH9 promoter was quantitatively analyzed, and the PCDH9 expression was analyzed in HCC cell lines treated with 5‑azacytidine. The effects of PCDH9 re‑expression and knockdown on growth, proliferation and tumorigenic potential were determined. The results ind...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Bestrophin 1 gene analysis and associated clinical findings in a Chinese patient with Best vitelliform macular dystrophy.
In conclusion, BEST1 gene mutations and polymorphisms have been reported in diverse ethnic groups, and the present study identified a novel BEST1 gene mutation and an SNP that occurred simultaneously in a Chinese patient with BVMD. PMID: 28791410 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of Hotair suppresses proliferation and cell cycle progression in hepatocellular carcinoma cell by downregulating CCND1 expression.
Authors: Zhou JJ, Cheng D, He XY, Meng Z, Li WZ, Chen RF Abstract The long noncoding RNA, homeobox transcript antisense RNA (Hotair), has been demonstrated to have an important role in regulating various biological processes in various cancers, including hepatocellular carcinoma (HCC). However, the importance of Hotair in HCC proliferation and cell cycle progression remains to be elucidated. In the present study, knockdown of HOTAIR expression by RNA interference inhibited cell proliferation and induced G0/G1 cell cycle arrest in Huh7 hepatocellular carcinoma cells. In addition, the expression levels of CCND1 mRNA ...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Impacts of the serum containing total flavonoids of Ajuga on rat glomerular mesangial cells.
Authors: Nan L, Huang M, Lai W, Jia R, Zheng Y, Yang L, Xie Q, Peng W Abstract The aim of the current study was to investigate the impacts and possible mechanisms of total flavonoids of Ajuga (TFA) on glomerular mesangial cells (GMC) through in vitro observations of the impacts of TFA‑containing serum on GMC proliferation and extracellular matrix (ECM) secretion in lipopolysaccharides (LPS)‑induced rats. Rat GMC was cultured in vitro, using LPS to stimulate the proliferation of GMC and the secretion of ECM; meanwhile, TFA‑containing serum (TFA‑S) was used for the intervention. Methyl thiazolyl tet...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis.
Authors: Guo Y, Liang Z, Hou X, Zhang Z Abstract The aim of the present study was to perform comparative genomics using gene expression profile datasets of mice and humans who had been treated with anticancer drugs, to determine the similarities and differences in the antitumor mechanisms in the two mammals. This involved data mining of antitumor gene expression regulation, and screening of genetic loci from experimental mouse models of antitumor targets, to provide a theoretical basis of drug design. Subsequently, 9 overlapping genes with opposite expression patterns were identified across mouse and human cell lin...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Upregulation of nuclear factor ‑κB and acid sensing ion channel 3 in dorsal root ganglion following application of nucleus pulposus onto the nerve root in rats.
In conclusion, these results suggested that NF‑κB and ASIC3 may serve an important role in intervertebral disc degeneration caused by NP. PMID: 28765874 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 4, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research