MicroRNA ‑4530 suppresses cell proliferation and induces apoptosis by targeting RASA1 in human umbilical vein endothelial cells.
MicroRNA‑4530 suppresses cell proliferation and induces apoptosis by targeting RASA1 in human umbilical vein endothelial cells. Mol Med Rep. 2019 Mar 01;: Authors: Jing L, Li H, Zhang T, Lu J, Zhong L Abstract MicroRNAs (miRNAs/miRs) are a class of endogenous and non‑coding RNAs that are present in eukaryotes. In previous studies, miRNAs have been revealed to have an important role in cell growth and apoptosis. In the present study, the function of a novel and rarely studied miRNA, miR‑4530, was investigated in human umbilical vein endothelial cells (HUVECs). The expression level of miR‑45...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Rhizoma  Paridis saponins ameliorates hepatic fibrosis in rats by downregulating expression of angiogenesis‑associated growth factors.
Rhizoma Paridis saponins ameliorates hepatic fibrosis in rats by downregulating expression of angiogenesis‑associated growth factors. Mol Med Rep. 2019 Mar 05;: Authors: Han Y, Pan L, Ran S, Song Y, Sun FF, Wang YZ, Hong Y Abstract Previously, we demonstrated that Rhizoma Paridis saponins (RPS), the major active component of Rhizoma Paridis, may exhibit hepatoprotective effects. The present study aimed to identify the potential mechanism of RPS on hepatic injury and improvement in hepatic fibrosis (HF). A HF model was created in Sprague‑Dawley rats by administration of carbon tetrac...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effect of docetaxel on the regulation of proliferation and apoptosis of human prostate cancer cells.
Authors: Yang C, Zhang W, Wang J, Chen P, Jin J Abstract Prostate cancer is a common type of malignancy. Given the complexity of prostate cancer and the pressing challenge of chemoresistance, the current study was conducted to investigate the effect of docetaxel (Doc) on androgen receptor (AR)‑dependent and AR‑independent prostate cancers cells. Subsequent experiments were designed to explore the mechanism underlying the Doc‑induced apoptosis. Three different human prostate cancer cell lines, namely PC‑3, LNCaP and DU‑145, were exposed to various concentrations of Doc. The cytotoxic effects of Doc were ev...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effect of miR ‑145 on gastric cancer cells.
Effect of miR‑145 on gastric cancer cells. Mol Med Rep. 2019 Mar 06;: Authors: Wang J, Sun Z, Yan S, Gao F Abstract Gastric cancer is one of the most common malignant tumors in the world. Due to the lack of early diagnosis and effective treatment, the outcome of treatment and prognosis is poor. MicroRNA‑145 (miR‑145) is downregulated in various cancer types. In the present study, miR‑145 expression was detected by reverse transcription‑quantitative polymerase chain reaction in gastric cancer cell lines and normal gastric epithelial cells. The function of miR‑145 in the gastric cancer cell l...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of exosomal and non ‑exosomal microRNAs associated with the drug resistance of ovarian cancer.
In conclusion, the findings of the present study suggested several underlying miRNA targets for improving the chemotherapy sensitivity of OC. PMID: 30864705 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Dose and drug changes in chronic lymphocytic leukemia cell response in  vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors.
Dose and drug changes in chronic lymphocytic leukemia cell response in vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors. Mol Med Rep. 2019 Mar 05;: Authors: Kubczak M, Szustka A, Błoński JZ, Gucký T, Misiewicz M, Krystof V, Robak P, Rogalińska M Abstract Chronic lymphocytic leukemia (CLL) treatment is improving; however, some patients do not respond to therapy. Due to the high heterogeneity in disease development, there is an urgent need for personalization of therapy. In the present study, the response of leukemic mononuclear cells to ...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Resveratrol improves cognition and decreases amyloid plaque formation in Tg6799 mice.
In conclusion, this study suggested that Res may reduce Aβ‑induced neuronal damage, thus preventing memory loss. PMID: 30864708 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation.
Authors: Cao M, Zhang Z, Han S, Lu X Abstract Butyrate, a histone deacetylase inhibitor, is a typical short chain fatty acid produced by gut microbiota, the dysmetabolism of which has been consistently associated with colorectal diseases. However, its role in tumorigenesis and progression of colorectal cancer cells remains under‑investigated. The present study examined the antitumor function of butyrate in the colorectal cancer cell line HCT116 and investigated the underlying molecular mechanism. MTT assay was used to measure cell proliferation and ELISA assay was used to determine cell apoptosis by measuring his...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of hub genes in chronically hypoxic myocardium using bioinformatics analysis.
Authors: Wu F, Gao F, He S, Xiao Y Abstract Chronic hypoxia can be observed in the heart under physiological or pathophysiological states, including embryonic development or cyanotic congenital heart disease. The aim of the present study was to examine gene expression profiles of chronically hypoxic myocardium and to explore the pathophysiological mechanisms by which the heart adapts to chronic hypoxia. Raw data from the next‑generation sequencing data set GSE36761 were downloaded from the Gene Expression Omnibus database. The data set comprised 30 specimens, including 8 healthy myocardia and 22 tetralogy of...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Construction and dissection of the ceRNA ‑ceRNA network reveals critical modules in depression.
Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression. Mol Med Rep. 2019 Mar 05;: Authors: Lang Y, Zhang J, Yuan Z Abstract The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease. In the present study, ceRNA networks for depression and the corresponding normal physiological states were constructed. Further analysis of the ceRNA networks revealed that ceRNA reg...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Estrogen receptor β suppresses inflammation and the progression of prostate cancer.
In conclusion, ERβ suppressed the viability and migration of the PC‑3 and DU145 prostate cancer cell lines and induced apoptosis. Furthermore, it reduced inflammation and suppressed the activation of the NF‑κB pathway, suggesting that ERβ may serve roles as an anti‑inflammatory and anticancer agent in prostate cancer. PMID: 30864712 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

ER α and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis.
ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis. Mol Med Rep. 2019 Mar 01;: Authors: Ge L, Cui Y, Liu B, Yin X, Pang J, Han J Abstract Reports of the ameliorative effect of angelicin on sex hormone deficiency‑induced osteoporosis have highlighted this compound as a candidate for the treatment of osteoporosis. However, the molecular mechanisms of action of angelicin on osteoblast differentiation have not been thoroughly researched. The aim of the present study was to evaluate the effect of angelicin on the proliferation, differentia...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

CircRNA ‑0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting miR‑107.
CircRNA‑0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting miR‑107. Mol Med Rep. 2019 Mar 06;: Authors: Shen L, Hu Y, Lou J, Yin S, Wang W, Wang Y, Xia Y, Wu W Abstract Circular RNAs (circRNAs) are endogenous non‑coding RNAs implicated in atherosclerosis. The aim of the present study was to explore the function of circRNA‑0044073 in atherosclerosis. Reverse transcription quantitative polymerase chain reaction assays were used to measure the expression levels of circRNA‑0044073, microRNA (miRNA/miR)‑107, janus kinase 1 (JAK1), signal ...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

[Erratum] Chemoresistance ‑related long non‑coding RNA expression profiles in human breast cancer cells.
[Erratum] Chemoresistance‑related long non‑coding RNA expression profiles in human breast cancer cells. Mol Med Rep. 2019 Mar 01;: Authors: Huang L, Zeng L, Chu J, Xu P, Lv M, Xu J, Wen J, Li W, Wang L, Wu X, Fu Z, Xie H, Wang S Abstract Subsequently to the publication of this article, the authors have noted that the second and third named authors on the paper, Lihua Zeng and Jiahui Chu, were not accredited as being joint first authors on this paper, and equal contributors with Lei Huang. The elimination of the necessary asterisks occurred during the pre‑press stages. Therefore, the correct autho...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑708 inhibits the proliferation and invasion of osteosarcoma cells by directly targeting ZEB1.
MicroRNA‑708 inhibits the proliferation and invasion of osteosarcoma cells by directly targeting ZEB1. Mol Med Rep. 2019 Mar 06;: Authors: He J, Xiang D, Lin Y Abstract Numerous microRNAs (miRNAs) have been identified as aberrantly expressed in osteosarcoma (OS). miRNAs serve important roles in the pathogenesis of OS as oncogenes or tumor suppressors. Recent studies revealed that miR‑708‑5p (miR‑708) was dysregulated in various types of human cancer; however, its roles and underlying molecular mechanisms in OS remain unknown. Therefore, the present study aimed to determine miR‑708 expression ...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑142‑3p inhibits trophoblast cell migration and invasion by disrupting the TGF‑β1/Smad3 signaling pathway.
MicroRNA‑142‑3p inhibits trophoblast cell migration and invasion by disrupting the TGF‑β1/Smad3 signaling pathway. Mol Med Rep. 2019 Mar 01;: Authors: Liu E, Liu Z, Zhou Y, Chen M, Wang L, Li J Abstract Insufficient invasion of trophoblasts is known to be associated with preeclampsia (PE) development. Recently, microRNAs (miRNAs) have been reported to serve important roles in the pathogenesis of PE. However, little is known regarding the regulation of trophoblastic invasion by miRNAs. The aim of the present study was to explore the role of miRNAs in trophoblastic invasion and the underlying ...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A new combination of transcription factors increases the harvesting efficiency of pacemaker ‑like cells.
A new combination of transcription factors increases the harvesting efficiency of pacemaker‑like cells. Mol Med Rep. 2019 Mar 06;: Authors: Zhang J, Huang C Abstract Biological pacemakers that combine cell‑based and gene‑based therapies are a promising treatment for sick sinus syndrome or severe atrioventricular block. The current study aimed to induce differentiation of adipose tissue‑derived stem cells (ADSCs) into cardiac pacemaker cells through co‑expression of the transcription factors insulin gene enhancer binding protein 1 (ISL‑1) and T‑box18 (Tbx18). ADSCs were transfected with gr...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Genome ‑wide profiling of lncRNA and mRNA expression in CRSwNP.
Genome‑wide profiling of lncRNA and mRNA expression in CRSwNP. Mol Med Rep. 2019 Mar 05;: Authors: Liu M, Guo P, An J, Guo C, Lu F, Lei Y Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most prevalent chronic diseases. In patients with CRSwNP, the present study performed comprehensive bioinformatics analyses to characterize the transcriptome profiles of mRNAs and long non‑coding RNAs (lncRNAs). A total of 265 differentially expressed lncRNAs and 994 mRNAs were identified. The majority of up‑ and downregulated differentially expressed genes were significantly enr...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR ‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3.
miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3. Mol Med Rep. 2019 Mar 05;: Authors: Hua M, Qin Y, Sheng M, Cui X, Chen W, Zhong J, Yan J, Chen Y Abstract MicroRNAs (miRNA/miRs) have been demonstrated to be critical post‑transcriptional modulators of gene expression during tumorigenesis. Numerous miRNAs have been revealed to be downregulated in human epithelial ovarian cancer (EOC). In the present study, it was observed that the expression of miR‑145 was decreased in EOC tissues and cell lines. Overexpression of miR‑145 inhibi...
Source: Molecular Medicine Reports - March 14, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Novel compound heterozygous mutations in the SPTA1 gene, causing hereditary spherocytosis in a neonate with Coombs ‑negative hemolytic jaundice.
In conclusion, the present study reports a rare case of autosomal‑recessive HS with a severe clinical phenotype, but normal MCHC and MCV. PMID: 30816434 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Resveratrol alleviates hypoxia/reoxygenation injury ‑induced mitochondrial oxidative stress in cardiomyocytes.
Resveratrol alleviates hypoxia/reoxygenation injury‑induced mitochondrial oxidative stress in cardiomyocytes. Mol Med Rep. 2019 Feb 07;: Authors: Li T, Chen L, Yu Y, Yang B, Li P, Tan XQ Abstract Resveratrol (RES) is a naturally occurring antioxidant compound found in red wine. Although it has been demonstrated to have a cardioprotective effect, the mechanism underlying this effect remains to be fully elucidated. The aim of the present study was to determine whether RES exerts a protective effect against mitochondrial oxidative stress and apoptosis in neonatal rat cardiomyocytes (NRCMs) induced by hy...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Liraglutide protects renal mesangial cells against hyperglycemia ‑mediated mitochondrial apoptosis by activating the ERK‑Yap signaling pathway and upregulating Sirt3 expression.
Liraglutide protects renal mesangial cells against hyperglycemia‑mediated mitochondrial apoptosis by activating the ERK‑Yap signaling pathway and upregulating Sirt3 expression. Mol Med Rep. 2019 Feb 08;: Authors: Li J, Li N, Yan S, Lu Y, Miao X, Gu Z, Shao Y Abstract Diabetic nephropathy results from hyperglycemia‑mediated renal glomerular cell death via mitochondrial apoptosis. There is an emerging requirement for novel approaches with mitochondrial protective effects that alleviate the hyperglycemia‑induced loss of functional cells during diabetic renal damage. Liraglutide, a type of glucagon...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑466 inhibits cell proliferation and invasion in osteosarcoma by directly targeting insulin receptor substrate 1.
MicroRNA‑466 inhibits cell proliferation and invasion in osteosarcoma by directly targeting insulin receptor substrate 1. Mol Med Rep. 2019 Feb 14;: Authors: Sun Y, Zhou J, Shi L, Li J, Chen J Abstract Accumulating evidence has demonstrated that microRNAs (miRNAs) are frequently dysregulated in osteosarcoma (OS), and the aberrant expression of miRNAs is associated with OS initiation and progression. Previous studies demonstrated that miRNA‑466 (miR‑466) is dysregulated, and serves important roles in various types of human cancer. However, the role of miR‑466 in the formation and progression of ...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Expression of autophagy ‑associated proteins in rat dental irreversible pulpitis.
Expression of autophagy‑associated proteins in rat dental irreversible pulpitis. Mol Med Rep. 2019 Feb 07;: Authors: Qi S, Qian J, Chen F, Zhou P, Yue J, Tang F, Zhang Y, Gong S, Shang G, Cui C, Xu Y Abstract Autophagy serves an important role in numerous diseases, as well as in infection and inflammation. Irreversible pulpitis (IP) is one of the most common inflammatory endodontic diseases, and autophagy has been reported to regulate IP in vitro. However, the level of autophagy in the IP pathogenic process in vivo remains unknown. The aim of the current study was, thus, to investigate...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Aberrant promoter  2 methylation‑mediated downregulation of protein tyrosine phosphatase, non‑receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Aberrant promoter 2 methylation‑mediated downregulation of protein tyrosine phosphatase, non‑receptor type 6, is associated with progression of esophageal squamous cell carcinoma. Mol Med Rep. 2019 Feb 19;: Authors: Liu L, Zhang S, Liu X, Liu J Abstract The human protein tyrosine phosphatase, non‑receptor type 6 (PTPN6) gene is located on chromosome 12p13 and encodes an Mr 68,000 non‑receptor type protein‑tyrosine phosphatase. The PTPN6 gene has been considered as a candidate tumor suppressor in hematological and solid malignancies, and promoter methylation may be an epige...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

[Corrigendum] IL ‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer.
[Corrigendum] IL‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer. Mol Med Rep. 2019 Feb 06;: Authors: Guo Y, Zang Y, Lv L, Cai F, Qian T, Zhang G, Feng Q Abstract After the publication of the above article, the authors have realized that the paper contained two errors concerning the address where the tissue samples were collected from and one of the subtitles in the Materials and methods section. First, on p. .9036, the Materials and methods section, "Tissue samples", in the first sentence it should have been stated that the t...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Construction and analysis of a spinal cord injury competitive endogenous RNA network based on the expression data of long noncoding, micro ‑ and messenger RNAs.
Construction and analysis of a spinal cord injury competitive endogenous RNA network based on the expression data of long noncoding, micro‑ and messenger RNAs. Mol Med Rep. 2019 Feb 22;: Authors: Wang L, Wang B, Liu J, Quan Z Abstract Spinal cord injury (SCI) results from trauma and predominantly affects the young male population. SCI imposes major and permanent life changes, and is associated with high future mortality and disability rates. Long non-coding RNAs (lncRNAs) have recently been demonstrated to serve critical roles in a broad range of biological processes and to be expressed in various di...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Rab7 ‑mediated autophagy regulates phenotypic transformation and behavior of smooth muscle cells via the Ras/Raf/MEK/ERK signaling pathway in human aortic dissection.
In conclusion, the results revealed that Rab7‑mediated autophagy regulated the behavior of SMCs and the phenotypic transformations in AD via activation of the Ras/Raf/MEK/ERK signaling pathway. The findings of the present study may improve understanding of the role Rab7 in the molecular etiology of AD and suggests the application of Rab7 as a novel therapeutic target in the treatment of human AD. PMID: 30816458 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

NEMO ‑binding domain peptide ameliorates inflammatory bone destruction in a Staphylococcus aureus‑induced chronic osteomyelitis model.
NEMO‑binding domain peptide ameliorates inflammatory bone destruction in a Staphylococcus aureus‑induced chronic osteomyelitis model. Mol Med Rep. 2019 Feb 20;: Authors: Lan Y, Xie H, Shi Y, Jin Q, Zhang X, Wang Y, Xie Z Abstract Osteomyelitis, which is characterized by progressive inflammatory bone destruction and resorption, is a difficult‑to‑treat infection. Staphylococcus aureus (S. aureus) is one of the major causes of this disease. This pathogenic microorganism possesses several characteristics, which facilitate its involvement in the occurrence and progression of osteomyel...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Prognostic significance of deregulated microRNAs in uveal melanomas.
Authors: Falzone L, Romano GL, Salemi R, Bucolo C, Tomasello B, Lupo G, Anfuso CD, Spandidos DA, Libra M, Candido S Abstract Uveal melanoma (UM) represents the most frequent primary tumor of the eye. Despite the development of new drugs and screening programs, the prognosis of patients with UM remains poor and no effective prognostic biomarkers are yet able to identify high‑risk patients. Therefore, in the present study, microRNA (miRNA or miR) expression data, contained in the TCGA UM (UVM) database, were analyzed in order to identify a set of miRNAs with prognostic significance to be used as biomarkers in clini...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally ‑induced diabetes mellitus.
Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally‑induced diabetes mellitus. Mol Med Rep. 2019 Feb 14;: Authors: Qi YH, Zhu R, Wang Q, Li Q, Liu YD, Qian ZY, Yang ZH, Mu ZH, Liu XJ, Zhang MY, Wang X, Liao XY, Wan Q, Lu D, Zou YY Abstract Glutamate‑induced excitotoxicity in the striatum has an important role in neurodegenerative diseases. It has been reported that diabetes mellitus (DM) induces excitotoxicity in striatal neurons, although the underlying mechanism remains to be fully elucidated. The present study aimed to investigate the effect of gast...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulation of ENDOCAN in myeloid leukemia cells inhibits proliferation and promotes apoptosis by suppressing nuclear factor ‑κB activity.
Downregulation of ENDOCAN in myeloid leukemia cells inhibits proliferation and promotes apoptosis by suppressing nuclear factor‑κB activity. Mol Med Rep. 2019 Feb 19;: Authors: Sun L, Sun C, Sun J, Yang W Abstract Previous studies have demonstrated that ENDOCAN is elevated in leukemia, and it has been reported to be associated with poor prognosis. However, the functional role of ENDOCAN in the development of leukemia remains to be fully elucidated. In the present study, the expression levels of ENDOCAN were detected in THP‑1, U937, HL‑60 and K562 cells, and it was found that ENDOCAN was inc...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Ovalbumin induces natural killer cells to secrete Th2 cytokines IL ‑5 and IL‑13 in a mouse model of asthma.
Ovalbumin induces natural killer cells to secrete Th2 cytokines IL‑5 and IL‑13 in a mouse model of asthma. Mol Med Rep. 2019 Feb 19;: Authors: Chen Z, Wang L Abstract Asthma is a chronic lung disease characterized by an imbalance of T‑helper (Th)1/Th2 cells and their cytokine profiles. Natural killer (NK) cells constitute a considerable subset of the lymphocyte population in the lungs, and provide protection against respiratory infection by fungi, bacteria and viruses. However, the mechanism by which NK cells are involved in asthma remains to be fully elucidated. The present study analyzed the dy...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

PADI4 ‑mediated epithelial‑mesenchymal transition in lung cancer cells.
PADI4‑mediated epithelial‑mesenchymal transition in lung cancer cells. Mol Med Rep. 2019 Feb 19;: Authors: Liu M, Qu Y, Teng X, Xing Y, Li D, Li C, Cai L Abstract Lung cancer is a complex disease involving multiple genetic and phenotypic alterations. As a histone modification enzyme, protein‑arginine deiminase type‑4 (PADI4) and its downstream signaling have been studied in the progression of a variety of types of human cancer, but data on PADI4‑mediated posttranslational modification in lung cancer are lacking. The aim of present study was to evaluate the expression of PADI4 and its associat...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Panax ginseng components and the pathogenesis of Alzheimer's disease (Review).
Authors: Razgonova MP, Veselov VV, Zakharenko AM, Golokhvast KS, Nosyrev AE, Cravotto G, Tsatsakis A, Spandidos DA Abstract Ginseng is one of the main representatives of traditional Chinese medicine and presents a wide range of pharmacological actions. Ginsenosides are the main class of active compounds found in ginseng. They demonstrate unique biological activity and medicinal value, namely anti-tumour, anti‑inflammatory and antioxidant properties, as well as anti-apoptotic properties. Increasing levels of stress in life are responsible for the increased incidence of nervous system diseases. Neurological disease...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Pretreatment with a grape seed proanthocyanidin extract downregulates proinflammatory cytokine expression in airway epithelial cells infected with respiratory syncytial virus.
Authors: Kim SJ, Lee JW, Eun YG, Lee KH, Yeo SG, Kim SW Abstract Respiratory syncytial virus (RSV) infections are associated with significant morbidity and mortality. Inflammation is mediated by cytokine secretion from RSV‑infected airway epithelial cells. Grape seed proanthocyanidin extract (GSPE) exhibits potent antioxidant capacity, as well as anti‑bacterial, anti‑viral, anti‑carcinogenic, anti‑inflammatory and anti‑allergic actions. However, few studies have explored the anti‑inflammatory effects of GSPE on airway epithelial cells infected with RSV. Airway epithelial A549 cells were pretreate...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Age ‑ and brain region‑associated alterations of cerebral blood flow in early Alzheimer's disease assessed in AβPPSWE/PS1ΔE9 transgenic mice using arterial spin labeling.
The objective of the present study was to evaluate CBF in four brain regions (the hippocampus, entorhinal cortex, frontoparietal cortex and thalamus) of mice in four age groups, to mimic the respective stages of AD in humans [2 months (pre‑clinical), 3.5 months (sub‑clinical), 5 months (early‑clinical) and 8 months (mid‑clinical)], to understand the age‑associated changes in selected brain regions and to elucidate the underlying vascular mechanisms. CBF was measured using magnetic resonance imaging‑arterial spin labelling (ASL) under identical conditions across the age groups of AβPPSWE/PS1&...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Repulsive guidance molecule a suppresses seizures and mossy fiber sprouting via the FAK ‑p120RasGAP‑Ras signaling pathway.
Repulsive guidance molecule a suppresses seizures and mossy fiber sprouting via the FAK‑p120RasGAP‑Ras signaling pathway. Mol Med Rep. 2019 Feb 14;: Authors: Song M, Tian F, Xia H, Xie Y Abstract Repulsive guidance molecule a (RGMa) is a membrane‑associated glycoprotein that regulates axonal guidance and inhibits axon outgrowth. In our previous study, we hypothesized that RGMa may be involved in temporal lobe epilepsy (TLE) via the repulsive guidance molecule a (RGMa)‑focal adhesion kinase (FAK)‑Ras signaling pathway. To investigate the role of RGMa in epilepsy, recombinant RGMa protein and F...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Role of bone marrow mesenchymal stem cells in the development of PQ ‑induced pulmonary fibrosis.
Role of bone marrow mesenchymal stem cells in the development of PQ‑induced pulmonary fibrosis. Mol Med Rep. 2019 Feb 20;: Authors: Chen J, Si L, Zhou L, Deng Y Abstract Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potential strategy for the treatment of fibrotic disease due to their anti‑inflammatory and immunosuppressive effects...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Overexpression of microRNA ‑101 causes anti‑tumor effects by targeting CREB1 in colon cancer.
Overexpression of microRNA‑101 causes anti‑tumor effects by targeting CREB1 in colon cancer. Mol Med Rep. 2019 Feb 14;: Authors: Yang Q, Yu W, Han X Abstract Accumulating evidence has demonstrated that aberrantly expressed microRNAs (miRNAs) are involved in the initiation and progression of numerous types of human cancer. Although a number of miRNAs have been demonstrated to be associated with the diagnosis, progression and prognosis of colon cancer, the function of miRNA‑101 (miR‑101) in colon cancer remains unclear, and the molecular mechanisms underlying the effects of miR‑101 in colon can...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Fasudil may induce the differentiation of bone marrow mesenchymal stem cells into neuron ‑like cells via the Wnt/β‑catenin pathway.
Fasudil may induce the differentiation of bone marrow mesenchymal stem cells into neuron‑like cells via the Wnt/β‑catenin pathway. Mol Med Rep. 2019 Feb 22;: Authors: Hu Y, Li X, Huang G, Wang J, Lu W Abstract Bone mesenchymal stem cells (MSCs) are an excellent donor graft source due to their potential for self‑renewal and multidirectional differentiation. However, it is difficult to obtain high quality MSCs and to induce them to differentiate into neuron‑like cells. Fasudil, a Rho kinase inhibitor, exhibits therapeutic potential in spinal cord injuries and stroke. The present study invest...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Pioglitazone increases VEGFR3 expression and promotes activation of M2 macrophages via the peroxisome proliferator ‑activated receptor γ.
Pioglitazone increases VEGFR3 expression and promotes activation of M2 macrophages via the peroxisome proliferator‑activated receptor γ. Mol Med Rep. 2019 Feb 07;: Authors: Zhang C, Zhang Y, Zhang C, Liu Y, Liu Y, Xu G Abstract The peroxisome proliferator‑activated receptor γ (PPARγ) agonist pioglitazone has been widely used in previous studies to ameliorate diabetes mellitus and regulate inflammation. However, the present study aimed to investigate the effect of pioglitazone on macrophages and determine its impact on renal fibrosis in vivo. Firstly, bone marrow‑derived mac...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of the antimicrobial peptide L12 against multidrug ‑resistant Staphylococcus aureus.
Effects of the antimicrobial peptide L12 against multidrug‑resistant Staphylococcus aureus. Mol Med Rep. 2019 Feb 26;: Authors: Xiong F, Dai X, Li YX, Wei R, An L, Wang Y, Chen Z Abstract Methicillin‑resistant Staphylococcus aureus (S. aureus; MRSA) is one of the most common bacterial pathogens and MRSA infections are characterized by high mortality rates. Antimicrobial peptides are considered one of the most promising drugs for the treatment of resistant strains of S. aureus. The present study aimed to examine the antimicrobial activity of L12 against numerous bacterial species using the...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

circRNA ‑CER mediates malignant progression of breast cancer through targeting the miR‑136/MMP13 axis.
circRNA‑CER mediates malignant progression of breast cancer through targeting the miR‑136/MMP13 axis. Mol Med Rep. 2019 Feb 18;: Authors: Qu Y, Dou P, Hu M, Xu J, Xia W, Sun H Abstract Chondrocyte extracellular matrix‑related circular RNAs (circRNA‑CER) have been demonstrated to be involved in various diseases. However, its role in the development of human breast cancer is not clearly understood. The aims of the present study were to assess circRNA‑CER expression in paired cancer tissue and adjacent non‑tumor tissue from 24 patients with breast cancer, and to explore the roles and...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer.
Authors: Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J Abstract Head and neck cancer (HNC) is the leading cancer in Sri Lankan males and second most common cancer among Sri Lankan females. This is the first study, to the best of our knowledge, that has focused on investigating the association between TP53 somatic DNA variants, with p53 protein expression and risk factors in a cohort of Sri Lankan patients with HNC. A total of 44 patients with cancer and 20 healthy controls were studied. In total, 36 genomic DNA sequence variants were found, including several novel va...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Curcumin and resveratrol suppress dextran sulfate sodium ‑induced colitis in mice.
Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice. Mol Med Rep. 2019 Feb 20;: Authors: Zhang L, Xue H, Zhao G, Qiao C, Sun X, Pang C, Zhang D Abstract Curcumin and resveratrol are two natural products, which have been described as potential anti‑inflammatory, anti‑tumor, and anti‑oxidant molecules. The aims of the present study were to investigate the protective effect of curcumin and resveratrol on dextran sulfate sodium (DSS)‑induced ulcerative colitis (UC) in mice, in addition to understanding the underlying molecular mechanisms. In order to accompl...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large ‑vessel ischemic stroke.
Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke. Mol Med Rep. 2019 Feb 25;: Authors: Janicki PK, Eyileten C, Ruiz-Velasco V, Pordzik J, Czlonkowska A, Kurkowska-Jastrzebska I, Sugino S, Imamura Kawasawa Y, Mirowska-Guzel D, Postula M Abstract The impact of rare and damaging variants in genes associated with platelet function in large‑vessel ischemic stroke (LVIS) remains unknown. The aim of this study was to investigate the contribution of some of these variants to the genetic susceptibility to LVIS in Polish patients using a deep r...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑186‑5p is expressed highly in ethanol‑induced cardiomyocytes and regulates apoptosis via the target gene XIAP.
This study provides a novel therapeutic target for the prevention and treatment of ACM. PMID: 30816481 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

High glucose promotes hepatic fibrosis via miR ‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition.
High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition. Mol Med Rep. 2019 Feb 25;: Authors: Li Q, Li Z, Lin Y, Che H, Hu Y, Kang X, Zhang Y, Wang L, Zhang Y Abstract Hepatic fibrosis is characterized by the aberrant production and deposition of extracellular matrix (ECM) proteins. Growing evidence indicates that the epithelial‑mesenchymal transition serves a crucial role in the progression of liver fibrogenesis. Although a subset of microRNAs (miRNAs or miRs) has recently been identified as essential regulators of the EMT gene expression, studies ...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of tyrosol and farnesol on Candida albicans biofilm.
Authors: Sebaa S, Boucherit-Otmani Z, Courtois P Abstract The present in vitro study examined the effects of the quorum‑sensing molecules farnesol and tyrosol on the development of Candida albicans biofilm in order to elucidate their role as novel adjuvants in oral hygiene. The investigation was conducted in C. albicans ATCC 10231 and C. albicans isolates from dentures and was performed in flat‑bottomed 96‑well polystyrene plates. Yeast growth and their capacity to form biofilms were evaluated following 24 and 48 h incubations at 37˚C in Sabouraud broth supplemented with 0.001‑3 mM...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research