[Retracted] Activation of the LKB1 ‑SIK1 signaling pathway inhibits the TGF‑β‑mediated epithelial‑mesenchymal transition and apoptosis resistance of ovarian carcinoma cells
Mol Med Rep. 2024 Apr;29(4):56. doi: 10.3892/mmr.2024.13180. Epub 2024 Feb 9.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion and migration assay data shown in Figs. 2C and 3F were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article had already been published prior to its...
Source: Molecular Medicine Reports - February 9, 2024 Category: Molecular Biology Authors: Bo Hong Jianmei Zhang Wenlan Yang Source Type: research
Activation of AMPK pathway by low ‑dose donafenib and atorvastatin combination improves high‑fat diet‑induced metabolic dysfunction‑associated steatotic liver disease
Mol Med Rep. 2024 Mar;29(3):51. doi: 10.3892/mmr.2024.13175. Epub 2024 Feb 1.ABSTRACTMetabolic dysfunction‑associated steatotic liver disease (MASLD) is an increasingly significant global health burden for which there is currently no effective treatment. The present study aimed to explore the underlying mechanisms and investigate the effects of donafenib and atorvastatin in MASLD. The effects of donafenib and atorvastatin on the activity and lipid metabolism of HepG2 cells were analyzed in vitro. A rat model of MASLD was established induced by a high‑fat diet in vivo. H&E and Oil red O staining were used to observe...
Source: Molecular Medicine Reports - February 1, 2024 Category: Molecular Biology Authors: Yaowei Bai Kequan Chen Jiacheng Liu Yingliang Wang Chaoyang Wang Shuguang Ju Chen Zhou Wei Yao Bin Xiong Chuansheng Zheng Source Type: research
[Corrigendum] FKBP11 protects intestinal epithelial cells against inflammation ‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease
Mol Med Rep. 2024 Mar;29(3):50. doi: 10.3892/mmr.2024.13172. Epub 2024 Feb 1.ABSTRACTSubsequently to the publication of the above article, the authors realized that Fig. 4 in their paper had been assembled containing two erroneously placed gel slices; essentially, the GAPDH bands featured in Fig. 4A had also been included in Fig. 5, and the data for the FKBP11 bands in Fig. 4A had also been included to show the GRP78 bands in Fig. 4. The authors were able to revisit their original data and to correct the data that had been featured incorrectly in Fig. 4. The corrected version of Fig. 4, now showing the true data for the GR...
Source: Molecular Medicine Reports - February 1, 2024 Category: Molecular Biology Authors: Xiaotong Wang Xiaopeng Cui Chuanwu Zhu Ming Li Juan Zhao Zhongyi Shen Xiaohang Shan Liang Wang Han Wu Yanting Shen You Ni Dongmei Zhang Guoxiong Zhou Source Type: research
[Retracted] MicroRNA ‑509 acts as a tumor suppressor in tongue squamous cell carcinoma by targeting epidermal growth factor receptor
Mol Med Rep. 2024 Mar;29(3):52. doi: 10.3892/mmr.2024.13176. Epub 2024 Feb 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 2C on p. 7248 and Fig. 3G on p. 7249 were strikingly similar to data in different form in other articles written by different authors at different research institutes, which had either already been published (some of which have now been retracted), or had been submitted for publication at around the same time. Owing to the fact that certain of the data in the above articl...
Source: Molecular Medicine Reports - February 1, 2024 Category: Molecular Biology Authors: Chao Hou Yan Dong Fenghe Zhang Bo Du Source Type: research
[Retracted] MicroRNA ‑320 targets mitogen‑activated protein kinase 1 to inhibit cell proliferation and invasion in epithelial ovarian cancer
Mol Med Rep. 2024 Mar;29(3):45. doi: 10.3892/mmr.2024.13169. Epub 2024 Jan 26.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 5C on p. 8534 were strikingly similar to data that had already been published in different form in different articles written by different authors at different research institutes, or were submitted for publication at around the same time (several of which have now been retracted). Owing to the fact that some of the data in the above article had already been published pr...
Source: Molecular Medicine Reports - January 26, 2024 Category: Molecular Biology Authors: Yongqian Xu Jian Hu Chunxia Zhang Yuanyuan Liu Source Type: research
Therapeutic strategies targeting the NLRP3 ‑mediated inflammatory response and pyroptosis in cerebral ischemia/reperfusion injury (Review)
Mol Med Rep. 2024 Mar;29(3):46. doi: 10.3892/mmr.2024.13170. Epub 2024 Jan 26.ABSTRACTIschemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need to be further clarified, and the associated treatment approaches require exploration. The NOD‑like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome serves an important role in causing CIRI, and its activation exacerbates the underlying injury. Activation of the NLRP3 inflammasome triggers the maturation and production of the inflammatory molecules IL‑1β and IL‑18, as ...
Source: Molecular Medicine Reports - January 26, 2024 Category: Molecular Biology Authors: Wan-Li Duan Xue-Jie Wang Ya-Ping Ma Zhi-Mei Sheng Hao Dong Li-Ying Zhang Bao-Gang Zhang Mao-Tao He Source Type: research
CAR ‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review)
Mol Med Rep. 2024 Mar;29(3):47. doi: 10.3892/mmr.2024.13171. Epub 2024 Jan 26.ABSTRACTChimeric antigen receptor (CAR)‑T cell therapy is an innovative approach to immune cell therapy that works by modifying the T cells of a patient to express the CAR protein on their surface, and thus induce their recognition and destruction of cancer cells. CAR‑T cell therapy has shown some success in treating hematological tumors, but it still faces a number of challenges in the treatment of solid tumors, such as antigen selection, tolerability and safety. In response to these issues, studies continue to improve the design of CAR‑T ...
Source: Molecular Medicine Reports - January 26, 2024 Category: Molecular Biology Authors: Dahua Sun Xiang Shi Sanyan Li Xiaohua Wang Xiao Yang Meiping Wan Source Type: research
Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload ‑induced heart failure in mice
Mol Med Rep. 2024 Mar;29(3):49. doi: 10.3892/mmr.2024.13174. Epub 2024 Jan 26.ABSTRACTHeart failure is a primary cause of global mortality. In the present study, whether larixyl acetate, an inhibitor of transient receptor potential cation channel subfamily C member 6, attenuates pressure overload‑induced heart failure in mice was investigated. To test this hypothesis, a transverse aortic constriction (TAC) animal model and an angiotensin II (Ang II)‑treated H9c2 cell model were used. Cardiac and cellular structure, function and the expression levels of hypertrophy, endoplasmic reticulum (ER) stress, apoptosis, autophag...
Source: Molecular Medicine Reports - January 26, 2024 Category: Molecular Biology Authors: Min Jia Wenxue Liu Keyin Zhang Zhigang Wang Ruisha Li Jun Pan Jianjun Yang Dongjin Wang Source Type: research
Excess phosphate promotes SARS ‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway
In conclusion, the present study identified that PI amplified SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation and lipogenic gene expression via the SCAP‑SREBP signaling pathway.PMID:38275129 | DOI:10.3892/mmr.2024.13173 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - January 26, 2024 Category: Molecular Biology Authors: Mi-Hua Liu Xiao-Long Lin Le-Le Xiao Source Type: research
Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long ‑term follow‑up: A case report
Mol Med Rep. 2024 Mar;29(3):44. doi: 10.3892/mmr.2024.13168. Epub 2024 Jan 26.ABSTRACTKeratoameloblastoma (KA) and solid variant of odontogenic keratocyst (SOKC) are rare odontogenic lesions, and their relationship and differences are unclear. The present study described a case that started as an odontogenic keratocyst (OKC) and transformed to SOKC/KA upon recurrence. Briefly, a 26‑year‑old man presented with swelling in the right cheek and was referred to the Department of Oral and Maxillofacial surgery, Hiroshima University Hospital (Hiroshima, Japan). At the initial visit, unicystic bone permeation was observed exte...
Source: Molecular Medicine Reports - January 26, 2024 Category: Molecular Biology Authors: Sachiko Yamasaki Tomoaki Shintani Toshinori Ando Mutsumi Miyauchi Souichi Yanamoto Source Type: research
Essential contribution of the JAK/STAT pathway to carcinogenesis, lytic infection of herpesviruses and pathogenesis of COVID ‑19 (Review)
Mol Med Rep. 2024 Mar;29(3):39. doi: 10.3892/mmr.2024.13163. Epub 2024 Jan 19.ABSTRACTThe intracellular pathway of Janus kinase/signal transducer and activator of transcription (JAK/STAT) and modification of nucleosome histone marks regulate the expression of proinflammatory mediators, playing an essential role in carcinogenesis, antiviral immunity and the interaction of host proteins with Herpesviral particles. The pathway has also been suggested to play a vital role in the clinical course of the acute infection caused by severe acute respiratory syndrome coronavirus type 2 (SARS‑CoV‑2; known as coronavirus infectionâ...
Source: Molecular Medicine Reports - January 19, 2024 Category: Molecular Biology Authors: Wenkai Li Yunjing Zhuang Song-Jun Shao Pankaj Trivedi Biying Zheng Guo-Liang Huang Zhiwei He Xiangning Zhang Source Type: research
Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
Mol Med Rep. 2024 Mar;29(3):38. doi: 10.3892/mmr.2024.13162. Epub 2024 Jan 19.ABSTRACTCapsaicin, which is abundant in chili peppers, exerts antioxidative, antitumor, antiulcer and analgesic effects and it has demonstrated potential as a treatment for cardiovascular, gastrointestinal, oncological and dermatological conditions. Unique among natural irritants, capsaicin initially excites neurons but then 'calms' them into long‑lasting non‑responsiveness. Capsaicin can also promote weight loss, making it potentially useful for treating obesity. Several mechanisms have been proposed to explain the therapeutic effects of cap...
Source: Molecular Medicine Reports - January 19, 2024 Category: Molecular Biology Authors: Wei Zhang Yu Zhang Jinke Fan Zhiguo Feng Xinqiang Song Source Type: research
Advances in the relationship between periodontopathogens and respiratory diseases (Review)
Mol Med Rep. 2024 Mar;29(3):42. doi: 10.3892/mmr.2024.13166. Epub 2024 Jan 19.ABSTRACTPeriodontitis is a common chronic inflammatory and destructive disease in the mouth and is considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis is a risk factor for pulmonary diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, coronavirus disease 2019 (COVID‑19) and lung cancer. The presence of common periodontal pathogens has been detected in samples from a variety of pulmonary diseases. Periodontal pathogens can be involved in lung diseases by promotin...
Source: Molecular Medicine Reports - January 19, 2024 Category: Molecular Biology Authors: Zhiyi Zhang Siyi Wen Jiaohong Liu Yuanting Ouyang Zhikang Su Ding Chen Zitian Liang Yan Wang Tao Luo Qianzhou Jiang Lvhua Guo Source Type: research
Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)
Mol Med Rep. 2024 Mar;29(3):40. doi: 10.3892/mmr.2024.13164. Epub 2024 Jan 19.ABSTRACTLiver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive accumulation of extracellular matrix components and ongoing chronic inflammation. To date, early prevention of liver fibrosis remains challenging. As the most abundant non‑parenchymal hepatic cell population, liver sinusoidal endothelial cells (LSECs) are stabilizers that maintain the intrahepatic environment. Notably, LSECs dysfunction appears to ...
Source: Molecular Medicine Reports - January 19, 2024 Category: Molecular Biology Authors: Jiaqin Gao Bin Zuo Yang He Source Type: research
Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review)
Mol Med Rep. 2024 Mar;29(3):43. doi: 10.3892/mmr.2024.13167. Epub 2024 Jan 19.ABSTRACTEndometriosis (EM) is one of the most common diseases among women of reproductive age. The etiology and pathogenesis of EM remain unclear and therefore there is a lack of effective treatment measures, which affects physical and mental health, as well as the quality of life of patients with EM. Angiogenesis has become a hotspot for research on the pathogenesis of EM; the role of angiogenesis‑related serological markers and anti‑angiogenic therapy in the diagnosis and treatment of EM is promising for early diagnosis and treatment of EM....
Source: Molecular Medicine Reports - January 19, 2024 Category: Molecular Biology Authors: Caixia Bo Yunfei Wang Source Type: research
