Bif ‑1 inhibits activation of inflammasome through autophagy regulatory mechanism
Mol Med Rep. 2024 Apr;29(4):67. doi: 10.3892/mmr.2024.13191. Epub 2024 Mar 8.ABSTRACTInflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine triphosphate (ATP)‑induced inflammatory model in J774A.1 cells, the effect of Bif‑1 on inflammasome activation and the underly...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Yuehui Zhang Wenhui Su Yaoyun Niu Hongli Zeng Lu Liu Lijun Wang Weidong Xie Source Type: research
[Retracted] Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
Mol Med Rep. 2024 May;29(5):68. doi: 10.3892/mmr.2024.13192. Epub 2024 Mar 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Huiying Qiao Haiyan Ren He Du Minfang Zhang Xiaofang Xiong Rong Lv Source Type: research
RICH1 is a novel key suppressor of isoproterenol ‑ or angiotensin II‑induced cardiomyocyte hypertrophy
Mol Med Rep. 2024 May;29(5):69. doi: 10.3892/mmr.2024.13193. Epub 2024 Mar 8.ABSTRACTCardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge, its role in cardiac hypertrophy remains unknown. In the present study, the role of RICH1 in cardiomyocyte hypertrophy was assessed. Cell ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Siqi Wang Xin Wang Li Ling Cairong Li Zhanhong Ren Source Type: research
Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress
In conclusion, NCTD induces apoptosis by activating ER stress and ultimately curtails the progression of cervical cancer.PMID:38456480 | DOI:10.3892/mmr.2024.13195 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Zhongbao Zhang Beibei Sun Jinqiu Lu Penglai Bai Yu Su Yanchun Li Source Type: research
[Corrigendum] Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):70. doi: 10.3892/mmr.2024.13194. Epub 2024 Mar 8.ABSTRACTSubsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerrning the Transwell cell migration and invasion assay data shown in Fig. 6A and B for the 786‑O cell line on p. 7206, the pcDNA3.1‑EGOT 'Migration' and 'Invasion' (a‑1 and b‑1) data panels appeared to contain overlapping sections of data, such that they were potentially derived from the same original source, where these panels were intended to show the results from differently performed experiments. The authors have r...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Lu Jin Jing Quan Xiang Pan Tao He Jia Hu Yifan Li Yaoting Gui Shangqi Yang Xiangming Mao Yun Chen Yongqing Lai Source Type: research
Bif ‑1 inhibits activation of inflammasome through autophagy regulatory mechanism
Mol Med Rep. 2024 Apr;29(4):67. doi: 10.3892/mmr.2024.13191. Epub 2024 Mar 8.ABSTRACTInflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine triphosphate (ATP)‑induced inflammatory model in J774A.1 cells, the effect of Bif‑1 on inflammasome activation and the underly...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Yuehui Zhang Wenhui Su Yaoyun Niu Hongli Zeng Lu Liu Lijun Wang Weidong Xie Source Type: research
[Retracted] Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
Mol Med Rep. 2024 May;29(5):68. doi: 10.3892/mmr.2024.13192. Epub 2024 Mar 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Huiying Qiao Haiyan Ren He Du Minfang Zhang Xiaofang Xiong Rong Lv Source Type: research
RICH1 is a novel key suppressor of isoproterenol ‑ or angiotensin II‑induced cardiomyocyte hypertrophy
Mol Med Rep. 2024 May;29(5):69. doi: 10.3892/mmr.2024.13193. Epub 2024 Mar 8.ABSTRACTCardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge, its role in cardiac hypertrophy remains unknown. In the present study, the role of RICH1 in cardiomyocyte hypertrophy was assessed. Cell ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Siqi Wang Xin Wang Li Ling Cairong Li Zhanhong Ren Source Type: research
Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress
In conclusion, NCTD induces apoptosis by activating ER stress and ultimately curtails the progression of cervical cancer.PMID:38456480 | DOI:10.3892/mmr.2024.13195 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Zhongbao Zhang Beibei Sun Jinqiu Lu Penglai Bai Yu Su Yanchun Li Source Type: research
[Corrigendum] Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):70. doi: 10.3892/mmr.2024.13194. Epub 2024 Mar 8.ABSTRACTSubsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerrning the Transwell cell migration and invasion assay data shown in Fig. 6A and B for the 786‑O cell line on p. 7206, the pcDNA3.1‑EGOT 'Migration' and 'Invasion' (a‑1 and b‑1) data panels appeared to contain overlapping sections of data, such that they were potentially derived from the same original source, where these panels were intended to show the results from differently performed experiments. The authors have r...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Lu Jin Jing Quan Xiang Pan Tao He Jia Hu Yifan Li Yaoting Gui Shangqi Yang Xiangming Mao Yun Chen Yongqing Lai Source Type: research
Bif ‑1 inhibits activation of inflammasome through autophagy regulatory mechanism
Mol Med Rep. 2024 Apr;29(4):67. doi: 10.3892/mmr.2024.13191. Epub 2024 Mar 8.ABSTRACTInflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine triphosphate (ATP)‑induced inflammatory model in J774A.1 cells, the effect of Bif‑1 on inflammasome activation and the underly...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Yuehui Zhang Wenhui Su Yaoyun Niu Hongli Zeng Lu Liu Lijun Wang Weidong Xie Source Type: research
[Retracted] Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
Mol Med Rep. 2024 May;29(5):68. doi: 10.3892/mmr.2024.13192. Epub 2024 Mar 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Huiying Qiao Haiyan Ren He Du Minfang Zhang Xiaofang Xiong Rong Lv Source Type: research
RICH1 is a novel key suppressor of isoproterenol ‑ or angiotensin II‑induced cardiomyocyte hypertrophy
Mol Med Rep. 2024 May;29(5):69. doi: 10.3892/mmr.2024.13193. Epub 2024 Mar 8.ABSTRACTCardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge, its role in cardiac hypertrophy remains unknown. In the present study, the role of RICH1 in cardiomyocyte hypertrophy was assessed. Cell ...
Source: Molecular Medicine Reports - March 8, 2024 Category: Molecular Biology Authors: Siqi Wang Xin Wang Li Ling Cairong Li Zhanhong Ren Source Type: research
SFRP2 suppresses trophoblast cell migration by inhibiting the Wnt/ β‑catenin pathway
Mol Med Rep. 2024 Apr;29(4):66. doi: 10.3892/mmr.2024.13190. Epub 2024 Mar 1.ABSTRACTThe present study investigates the role of Secreted Frizzled‑Related Protein 2 (SFRP2) in trophoblast cells, a key factor in preeclampsia (PE) progression. Elevated levels of Secreted Frizzled‑Related Protein 1/3/4/5 (SFRP1/3/4/5) are associated with PE, but the role of SFRP2 is unclear. We analyzed SFRP2 expression in PE placental tissue using the GSE10588 dataset and overexpressed SFRP2 in JEG‑3 cells via lentiviral transfection. The viability, migration, apoptosis, and proliferation of SFRP2‑overexpressing JEG‑3 cells were ass...
Source: Molecular Medicine Reports - March 1, 2024 Category: Molecular Biology Authors: Ruihong Lan Yihong Yu Jie Song Mengdi Xue Humin Gong Source Type: research
[Retracted] Human HLA ‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer
Mol Med Rep. 2024 Apr;29(4):63. doi: 10.3892/mmr.2024.13187. Epub 2024 Mar 1.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the cellular morphological data in Fig. 1C, the immunofluorescence data shown in Fig. 1E, and certain of the scratch‑wound assay data shown in Fig. 2A were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been published. Owing to the fact that the contentious data in the above article had already been published prior to its submiss...
Source: Molecular Medicine Reports - March 1, 2024 Category: Molecular Biology Authors: Chen Li Zhenfan Wang Ninghan Feng Jian Dong Xiaoyan Deng Yin Yue Yuehong Guo Jianquan Hou Source Type: research
