miRNA ‑21 promotes the progression of acute liver failure via the KLF6/autophagy/IL‑23 signaling pathway
In conclusion, in the present study, baseline serum miR‑21 levels were highly upregulated in patients with ALF, antagomir‑21 attenuated LPS/GalN‑induced ALF in a mouse model, and miR‑21 could promote the expression of IL‑23 via inhibiting KLF6.PMID:38516774 | DOI:10.3892/mmr.2024.13205 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Suxia Bao Weiyang Zheng Rong Yan Jie Xu Source Type: research
Combining a glycolysis ‑related prognostic model based on scRNA‑Seq with experimental verification identifies ZFP41 as a potential prognostic biomarker for HCC
Mol Med Rep. 2024 May;29(5):78. doi: 10.3892/mmr.2024.13203. Epub 2024 Mar 22.ABSTRACTHepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis, and its heterogeneity affects the response to clinical treatments. Glycolysis is highly associated with HCC therapy and prognosis. The present study aimed to identify a novel biomarker for HCC by exploring the heterogeneity of glycolysis in HCC. The intersection of both marker genes of glycolysis‑related cell clusters from single‑cell RNA sequencing analysis and mRNA data of liver HCC from The Cancer Genome Atlas were used to construct a prognostic model thro...
Source: Molecular Medicine Reports - March 22, 2024 Category: Molecular Biology Authors: Yu Teng Jianrong Xu Yaoqun Wang Ningyuan Wen Hui Ye Bei Li Source Type: research
Pigment epithelium ‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum
Mol Med Rep. 2024 May;29(5):75. doi: 10.3892/mmr.2024.13199. Epub 2024 Mar 15.ABSTRACTPlacenta accreta spectrum (PAS) is one of the most dangerous complications in obstetrics, which can lead to severe postpartum bleeding and shock, and even necessitate uterine removal. The abnormal migration and invasion of extravillous trophoblast cells (EVTs) and enhanced neovascularization occurring in an uncontrolled manner in time and space are closely related to the abnormal expression of pro‑angiogenic and anti‑angiogenic factors. The pigment epithelium‑derived factor (PEDF) is a multifunctional regulatory factor that particip...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Rui Li Xiaoying Weng Xuyang Hu Junjun Wang Lin Zheng Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | PMC:PMC10955520 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Resveratrol ameliorates ulcerative colitis by upregulating Nrf2/HO ‑1 pathway activity: Integrating animal experiments and network pharmacology
In conclusion, Res treatment activated the Nrf2/HO‑1 pathway to decrease clinical symptoms, inflammatory responses, and intestinal mucosal barrier damage in experimental UC mice.PMID:38488031 | DOI:10.3892/mmr.2024.13201 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Xinya Yu Xiaoxi Li Yunchun Xu Yuwei Li Ye Zhou Junhua Zhang Le Guo Source Type: research
[Retracted] miR ‑34a is downregulated in human osteosarcoma stem‑like cells and promotes invasion, tumorigenic ability and self‑renewal capacity
Mol Med Rep. 2024 May;29(5):72. doi: 10.3892/mmr.2024.13196. Epub 2024 Mar 15.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 4B on p. 1635 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were submitted at around the same time. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medici...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Yonggen Zou Yuanshuai Huang Jiexiang Yang Jian Wu Cheng Luo Source Type: research
IFN ‑γ induces apoptosis in gemcitabine‑resistant pancreatic cancer cells
In conclusion, IFN‑γ exhibited antitumor immune properties by upregulating MRP and downregulating BCRP expression, reversing drug‑resistance gene expression, and reducing cell viability and migration, while promoting apoptosis in PANC‑1/GEM cells. IFN‑γ could potentially serve as a treatment option for patients with GEM‑resistant pancreatic cancer.PMID:38488034 | DOI:10.3892/mmr.2024.13200 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Xiangxin Kong Denglong Cheng Xu Xu Yuan Zhang Xin Li Wanlong Pan Source Type: research
Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Pigment epithelium ‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum
Mol Med Rep. 2024 May;29(5):75. doi: 10.3892/mmr.2024.13199. Epub 2024 Mar 15.ABSTRACTPlacenta accreta spectrum (PAS) is one of the most dangerous complications in obstetrics, which can lead to severe postpartum bleeding and shock, and even necessitate uterine removal. The abnormal migration and invasion of extravillous trophoblast cells (EVTs) and enhanced neovascularization occurring in an uncontrolled manner in time and space are closely related to the abnormal expression of pro‑angiogenic and anti‑angiogenic factors. The pigment epithelium‑derived factor (PEDF) is a multifunctional regulatory factor that particip...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Rui Li Xiaoying Weng Xuyang Hu Junjun Wang Lin Zheng Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Resveratrol ameliorates ulcerative colitis by upregulating Nrf2/HO ‑1 pathway activity: Integrating animal experiments and network pharmacology
In conclusion, Res treatment activated the Nrf2/HO‑1 pathway to decrease clinical symptoms, inflammatory responses, and intestinal mucosal barrier damage in experimental UC mice.PMID:38488031 | DOI:10.3892/mmr.2024.13201 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Xinya Yu Xiaoxi Li Yunchun Xu Yuwei Li Ye Zhou Junhua Zhang Le Guo Source Type: research
[Retracted] miR ‑34a is downregulated in human osteosarcoma stem‑like cells and promotes invasion, tumorigenic ability and self‑renewal capacity
Mol Med Rep. 2024 May;29(5):72. doi: 10.3892/mmr.2024.13196. Epub 2024 Mar 15.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 4B on p. 1635 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were submitted at around the same time. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medici...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Yonggen Zou Yuanshuai Huang Jiexiang Yang Jian Wu Cheng Luo Source Type: research
IFN ‑γ induces apoptosis in gemcitabine‑resistant pancreatic cancer cells
In conclusion, IFN‑γ exhibited antitumor immune properties by upregulating MRP and downregulating BCRP expression, reversing drug‑resistance gene expression, and reducing cell viability and migration, while promoting apoptosis in PANC‑1/GEM cells. IFN‑γ could potentially serve as a treatment option for patients with GEM‑resistant pancreatic cancer.PMID:38488034 | DOI:10.3892/mmr.2024.13200 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Xiangxin Kong Denglong Cheng Xu Xu Yuan Zhang Xin Li Wanlong Pan Source Type: research
Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Pigment epithelium ‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum
Mol Med Rep. 2024 May;29(5):75. doi: 10.3892/mmr.2024.13199. Epub 2024 Mar 15.ABSTRACTPlacenta accreta spectrum (PAS) is one of the most dangerous complications in obstetrics, which can lead to severe postpartum bleeding and shock, and even necessitate uterine removal. The abnormal migration and invasion of extravillous trophoblast cells (EVTs) and enhanced neovascularization occurring in an uncontrolled manner in time and space are closely related to the abnormal expression of pro‑angiogenic and anti‑angiogenic factors. The pigment epithelium‑derived factor (PEDF) is a multifunctional regulatory factor that particip...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Rui Li Xiaoying Weng Xuyang Hu Junjun Wang Lin Zheng Source Type: research
