Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
[Retracted] Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR ‑145‑5p/TOP2A axis
Mol Med Rep. 2024 Jun;29(6):94. doi: 10.3892/mmr.2024.13218. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the tumour images shown in Fig. 6B on p. 8 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Mol...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Yi Du Xudong Zhang Hongwei Zhang Yiding Chen Shuying Zhu Jinjun Shu Hui Pan Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
[Retracted] Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR ‑145‑5p/TOP2A axis
Mol Med Rep. 2024 Jun;29(6):94. doi: 10.3892/mmr.2024.13218. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the tumour images shown in Fig. 6B on p. 8 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Mol...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Yi Du Xudong Zhang Hongwei Zhang Yiding Chen Shuying Zhu Jinjun Shu Hui Pan Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Octreotide attenuates intestinal barrier damage by maintaining basal autophagy in Caco2 cells
This article is based on a cell model of inflammation induced by lipopolysaccharide (LPS), aiming to explore the effects of OCT in protecting intestinal mucosal barrier function. A Cell Counting Kit‑8 assay was used to determine cell viability and evaluate the effectiveness of OCT. Gene silencing technology was used to reveal the mediated effect of somatostatin receptor 2 (SSTR2). The changes in intestinal permeability were detected through trans‑epithelial electrical resistance and fluorescein isothiocyanate‑dextran 4 experiments, and the alterations in tight junction proteins were detected using immunoblotting and ...
Source: Molecular Medicine Reports - April 5, 2024 Category: Molecular Biology Authors: Xiaoli Liu Yan Zhou Yu Zhang Xigang Cui Donglin Yang Yuling Li Source Type: research
Induction of the human < em > CDC45 < /em > gene promoter activity by natural compound < em > trans < /em > ‑resveratrol
Mol Med Rep. 2024 Jun;29(6):92. doi: 10.3892/mmr.2024.13216. Epub 2024 Apr 5.ABSTRACTGGAA motifs in the human TP53 and HELB gene promoters play a part in responding to trans‑resveratrol (Rsv) in HeLa S3 cells. This sequence is also present in the 5'‑upstream region of the human CDC45 gene, which encodes a component of CMG DNA helicase protein complex. The cells were treated with Rsv (20 µM), then transcripts and the translated protein were analyzed by quantitative RT‑PCR and western blotting, respectively. The results showed that the CDC45 gene and protein expression levels were induced after the treatment. To exami...
Source: Molecular Medicine Reports - April 5, 2024 Category: Molecular Biology Authors: Jun Arakawa Hikaru Kondoh Tokiyoshi Matsushita Yoko Ogino Masashi Asai Sei-Ichi Tanuma Fumiaki Uchiumi Source Type: research
Long non ‑coding RNA DANCR aggravates breast cancer through the miR‑34c/E2F1 feedback loop
Mol Med Rep. 2024 Jun;29(6):93. doi: 10.3892/mmr.2024.13217. Epub 2024 Apr 5.ABSTRACTEmerging scientific evidence has suggested that the long non‑coding (lnc)RNA differentiation antagonizing non‑protein coding RNA (DANCR) serves a significant role in human tumorigenesis and cancer progression; however, the precise mechanism of its function in breast cancer remains to be fully understood. Therefore, the objective of the present study was to manipulate DANCR expression in MCF7 and MDA‑MB‑231 cells using lentiviral vectors to knock down or overexpress DANCR. This manipulation, alongside the analysis of bioinformatics ...
Source: Molecular Medicine Reports - April 5, 2024 Category: Molecular Biology Authors: Shuai Yan Lizhi Teng Juntong Du Liang Ji Peng Xu Wenxi Zhao Weiyang Tao Source Type: research
Research progress on oncoprotein hepatitis B X ‑interacting protein (Review)
In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.PMID:38577934 | DOI:10.3892/mmr.2024.13213 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 5, 2024 Category: Molecular Biology Authors: Lei Cheng Lijuan Guo Teng Zou Yisong Yang Ran Tao Shuangping Liu Source Type: research
